Olgotrelvir, a dual inhibitor of SARS-CoV-2 Mpro and cathepsin L, as a standalone antiviral oral intervention candidate for COVID-19

Authors: Mao, Long, Shaabani, Namir, Zhang, Xiaoying, Jin, Can, Xu, Wanhong, Argent, Christopher, Kushnareva, Yulia, Powers, Colin, Stegman, Karen, Liu, Jia, Xie, Hui, Xu, Changxu, Bao, Yimei, Xu, Lijun, Zhang, Yuren, Yang, Haigang, Qian, Shengdian, Hu, Yong, Shao, Jianping, Zhang, Can, Li, Tingting, Li, Yi, Liu, Na, Lin, Zhenhao, Wang, Shanbo, Wang, Chao, Shen, Wei, Lin, Yuanlong, Shu, Dan, Zhu, Zhenhong, Kotoi, Olivia, Kerwin, Lisa, Han, Qing, Chumakova, Ludmila, Teijaro, John, Royal, Mike, Brunswick, Mark, Allen, Robert, Ji, Henry, Lu, Hongzhou, Xu, Xiao

Source: In Med 12 January 2024 5(1):42-61

Discovery and intranasal administration of a SARS-CoV-2 broadly acting neutralizing antibody with activity against multiple Omicron subvariants

Authors: Duty, J. Andrew, Kraus, Thomas, Zhou, Heyue, Zhang, Yanliang, Shaabani, Namir, Yildiz, Soner, Du, Na, Singh, Alok, Miorin, Lisa, Li, Donghui, Stegman, Karen, Ophir, Sabrina, Cao, Xia, Atanasoff, Kristina, Lim, Reyna, Mena, Ignacio, Bouvier, Nicole M., Kowdle, Shreyas, Carreño, Juan Manuel, Rivero-Nava, Laura, Raskin, Ariel, Moreno, Elena, Johnson, Sachi, Rathnasinghe, Raveen, Pai, Chin I., Kehrer, Thomas, Cabral, Elizabeth Paz, Jangra, Sonia, Healy, Laura, Singh, Gagandeep, Warang, Prajakta, Simon, Viviana, Sordillo, Emilia Mia, van Bakel, Harm, Liu, Yonghong, Sun, Weina, Kerwin, Lisa, Teijaro, John, Schotsaert, Michael, Krammer, Florian, Bresson, Damien, García-Sastre, Adolfo, Fu, Yanwen, Lee, Benhur, Powers, Colin, Moran, Thomas, Ji, Henry, Tortorella, Domenico, Allen, Robert

Source: In Med 14 October 2022 3(10):705-721

SARS-CoV-2 monoclonal antibodies with therapeutic potential: Broad neutralizing activity and No evidence of antibody-dependent enhancement

Authors: Wang, Ying-Ting, Allen, Robert D., III, Kim, Kenneth, Shafee, Norazizah, Gonzalez, Andrew J., Nguyen, Michael N., Valentine, Kristen M., Cao, Xia, Lu, Lucy, Pai, Chin-I, Johnson, Sachi, Kerwin, Lisa, Zhou, Heyue, Zhang, Yanliang, Shresta, Sujan

Source: In Antiviral Research November 2021 195

Unbiased approach to identify and assess efficacy of human SARS-CoV-2 neutralizing antibodies.

Authors: Cao, Xia, Maruyama, Junki, Zhou, Heyue, Fu, Yanwen, Kerwin, Lisa, Powers, Colin, Sattler, Rachel A., Manning, John T., Singh, Alok, Lim, Reyna, Healy, Laura D., Johnson, Sachi, Paz Cabral, Elizabeth, Li, Donghui, Lu, Lucy, Ledesma, Arthur, Lee, Daniel, Richards, Susan, Rivero-Nava, Laura, Li, Yan

Source: Scientific Reports; 9/15/2022, Vol. 12 Issue 1, p1-12, 12p

Subject Terms: COVID-19, SARS-CoV-2

Immunoglobulins can utilize riboflavin (Vitamin B2) to activate the antibody-catalyzed water oxidation pathway

Authors: Nieva, Jorge, Kerwin, Lisa, Wentworth, Anita D., Lerner, Richard A., Wentworth, Paul, Jr.

Source: In Immunology Letters 2006 103(1):33-38

A Novel Affinity Engineered Anti-CD47 Antibody With Improved Therapeutic Index That Preserves Erythrocytes and Normal Immune Cells.

Authors: Thaker, Youg R., Rivera, Ianne, Pedros, Christophe, Singh, Alok R., Rivero-Nava, Laura, Zhou, Heyue, Swanson, Barbara A., Kerwin, Lisa, Zhang, Yanliang, Gray, J. Dixon, Kaufmann, Gunnar F., Ji, Henry, Allen, Robert D., Bresson, Damien

Source: Frontiers in Oncology; 5/19/2022, Vol. 12, p1-14, 14p

Subject Terms: ERYTHROCYTES, RITUXIMAB, IMMUNOTECHNOLOGY, SMALL molecules, KRA, DARATUMUMAB

PSMA-targeted bispecific Fab conjugates that engage T cells

Authors: Patterson, James T., Isaacson, Jason, Kerwin, Lisa, Atassi, Ghazi, Duggal, Rohit, Bresson, Damien, Zhu, Tong, Zhou, Heyue, Fu, Yanwen, Kaufmann, Gunnar F.

Source: In Bioorganic & Medicinal Chemistry Letters 15 December 2017 27(24):5490-5495

Chemically generated IgG2 bispecific antibodies through disulfide bridging

Authors: Patterson, James T., Gros, Edwige, Zhou, Heyue, Atassi, Ghazi, Kerwin, Lisa, Carmody, Lisa, Zhu, Tong, Jones, Bryan, Fu, Yanwen, Kaufmann, Gunnar F.

Source: In Bioorganic & Medicinal Chemistry Letters 15 August 2017 27(16):3647-3652

Visualizing antibody-Catalyzed retro-Aldol-Retro-Michael reactions

Authors: Tanaka, Fujie, Kerwin, Lisa, Kubitz, Diane, Lerner, Richard A., Barbas, Carlos F., III

Source: In Bioorganic & Medicinal Chemistry Letters 2001 11(22):2983-2986