Clinical Evidence of a Photoreceptor Origin in Diabetic Retinal Disease

Authors: Rajagopal, Rithwick ^{1, ∗}, Kern, Timothy ²

Source: In Ophthalmology Science January-February 2025 5(1)

A Randomized Trial of Photobiomodulation Therapy for Center-Involved Diabetic Macular Edema with Good Visual Acuity (Protocol AE)

Authors: Kim, Judy E., Glassman, Adam R., Josic, Kristin, Melia, Michele, Aiello, Lloyd P., Baker, Carl, Eells, Janis T., Jampol, Lee M., Kern, Timothy S., Marcus, Dennis, Salehi-Had, Hani, Shah, Sandeep N., Martin, Daniel F., Stockdale, Cynthia R., Sun, Jennifer K.

Source: In Ophthalmology Retina April 2022 6(4):298-307

Regulation of Adrenergic, Serotonin, and Dopamine Receptors to Inhibit Diabetic Retinopathy: Monotherapies versus Combination Therapies

Authors: Kern, Timothy S. ^*, Du, Yunpeng, Tang, Jie, Lee, Chieh Allen, Liu, Haitao, Dreffs, Alyssa, Leinonen, Henri, Antonetti, David A., Palczewski, Krzysztof

Source: In Molecular Pharmacology November 2021 100(5):470-479

Photoreceptor Cell Calcium Dysregulation and Calpain Activation Promote Pathogenic Photoreceptor Oxidative Stress and Inflammation in Prodromal Diabetic Retinopathy

Authors: Saadane, Aicha, Du, Yunpeng, Thoreson, Wallace B., Miyagi, Masaru, Lessieur, Emma M., Kiser, Jianying, Wen, Xiangyi, Berkowitz, Bruce A., Kern, Timothy S.

Source: In The American Journal of Pathology October 2021 191(10):1805-1821

Photoreceptor cells and RPE contribute to the development of diabetic retinopathy

Authors: Tonade, Deoye, Kern, Timothy S.

Source: In Progress in Retinal and Eye Research July 2021 83

Formulation and efficacy of ECO/pRHO-ABCA4-SV40 nanoparticles for nonviral gene therapy of Stargardt disease in a mouse model

Authors: Sun, Da, Sun, Wenyu, Gao, Song-Qi, Wei, Cheng, Naderi, Amirreza, Schilb, Andrew L., Scheidt, Josef, Lee, Sangjoon, Kern, Timothy S., Palczewski, Krzysztof, Lu, Zheng-Rong

Source: In Journal of Controlled Release 10 February 2021 330:329-340

Fatty acid oxidation and photoreceptor metabolic needs

Authors: Fu, Zhongjie, Kern, Timothy S., Hellström, Ann, Smith, Lois E.H.

Source: In Journal of Lipid Research 2021 62

Non-viral Gene Therapy for Stargardt Disease with ECO/pRHO-ABCA4 Self-Assembled Nanoparticles

Authors: Sun, Da ^{1, 3}, Schur, Rebecca M. ^{1, 3}, Sears, Avery E. ^{2, 4}, Gao, Song-Qi ¹, Vaidya, Amita ¹, Sun, Wenyu ¹, Maeda, Akiko ², Kern, Timothy ^{2, 4}, Palczewski, Krzysztof ^{2, 4}, Lu, Zheng-Rong ^{1, ∗}

Source: In Molecular Therapy 8 January 2020 28(1):293-303

Diabetes induces IL-17A-Act1-FADD-dependent retinal endothelial cell death and capillary degeneration

Authors: Lindstrom, Sarah I., Sigurdardottir, Sigrun, Zapadka, Thomas E., Tang, Jie, Liu, Haitao, Taylor, Brooklyn E., Smith, Dawn G., Lee, Chieh A., DeAngelis, John, Kern, Timothy S., Taylor, Patricia R.

Source: In Journal of Diabetes and Its Complications September 2019 33(9):668-674

Targeting CD6 for the treatment of experimental autoimmune uveitis

Authors: Zhang, Lingjun, Li, Yan, Qiu, Wen, Bell, Brent A., Dvorina, Nina, Baldwin, William M., III, Singer, Nora, Kern, Timothy, Caspi, Rachel R., Fox, David A., Lin, Feng

Source: In Journal of Autoimmunity June 2018 90:84-93

A Combination of G Protein–Coupled Receptor Modulators Protects Photoreceptors from Degeneration

Authors: Orban, Tivadar ¹, Leinonen, Henri ¹, Getter, Tamar, Dong, Zhiqian, Sun, Wenyu, Gao, Songqi, Veenstra, Alexander, Heidari-Torkabadi, Hossein, Kern, Timothy S., Kiser, Philip D., Palczewski, Krzysztof ^*

Source: In The Journal of Pharmacology and Experimental Therapeutics February 2018 364(2):207-220

DAF in diabetic patients is subject to glycation/inactivation at its active site residues

Authors: Flückiger, Rudolf, Cocuzzi, Enzo, Nagaraj, Ram H., Shoham, Menachem, Kern, Timothy S., Medof, M. Edward

Source: In Molecular Immunology January 2018 93:246-252

Pathophysiology of Diabetic Retinopathy: Contribution and Limitations of Laboratory Research

Authors: Kern, Timothy S., Antonetti, David A., Smith, Lois E.H.

Source: OPHTHALMIC RESEARCH. 62(4):196-202

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100093396015.0x000001&indx=1&recIds=ETOCvdc_100093396015.0x000001

Noninvasive Two-Photon Microscopy Imaging of Mouse Retina and Retinal Pigment Epithelium

Authors: Palczewska, Grazyna, Kern, Timothy S., Palczewski, Krzysztof

Source: Methods in molecular biology. 1834:333-344

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN617867873&indx=1&recIds=ETOCRN617867873

Neutrophil elastase contributes to the pathological vascular permeability characteristic of diabetic retinopathy

Authors: Liu, Haitao, Lessieur, Emma M., Saadane, Aicha, Lindstrom, Sarah I., Taylor, Patricia R., Kern, Timothy S.

Source: Diabetologia. 62(12):2365-2374

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100125285513.0x000001&indx=1&recIds=ETOCvdc_100125285513.0x000001

Do photoreceptor cells cause the development of retinal vascular disease?

Authors: Kern, Timothy S.

Source: In Vision Research October 2017 139:65-71

Mechanistic Insights into Pathological Changes in the Diabetic Retina: Implications for Targeting Diabetic Retinopathy

Authors: Roy, Sayon, Kern, Timothy S., Song, Brian, Stuebe, Caren

Source: In The American Journal of Pathology January 2017 187(1):9-19

Abstract 2265 Neutrophil-derived extracellular vesicles from diabetic mice promote retinal endothelial cell cytotoxicity via NE-GSDMD axis

Authors: Contreras, Emma Lessieur, Gao, Fangyuan, Du, Yunpeng, Jiyacharoen, Jirote, Kiser, Jianying, Kern, Timothy

Source: In Journal of Biological Chemistry March 2024 300(3) Supplement

Amelioration of Vascular Dysfunctions in Diabetic Rats by an Oral PKC β Inhibitor

Authors: Ishii, Hidehiro, Jirousek, Michael R., Koya, Daisuke, Takagi, Chikako, Xia, Pu, Clermont, Allen, Bursell, Sven-Erik, Kern, Timothy S., Ballas, Lawrence M., Heath, William F., Stramm, Lawrence E., Feener, Edward P., King, George L.

Source: Science, 1996 May 01. 272(5262), 728-731.

Access URL: https://www.jstor.org/stable/2889449

Mechanical Regulation of Retinal Vascular Inflammation and Degeneration in Diabetes.

Authors: Chandrakumar, Sathishkumar, Santiago Tierno, Irene, Agarwal, Mahesh, Lessieur, Emma M., Du, Yunpeng, Tang, Jie, Kiser, Jianying, Yang, Xiao, Rodriguez, Anthony, Kern, Timothy S., Ghosh, Kaustabh

Source: Diabetes; Feb2024, Vol. 73 Issue 2, p280-291, 12p

Subject Terms: LYSYL oxidase, LEUKOCYTE elastase, DIABETIC retinopathy, CONTRAST sensitivity (Vision), DIABETES complications