Sarcoma classification by DNA methylation profiling

Authors: Christian Koelsche, Daniel Schrimpf, Damian Stichel, Martin Sill, Felix Sahm, David E. Reuss, Mirjam Blattner, Barbara Worst, Christoph E. Heilig, Katja Beck, Peter Horak, Simon Kreutzfeldt, Elke Paff, Sebastian Stark, Pascal Johann, Florian Selt, Jonas Ecker, Dominik Sturm, Kristian W. Pajtler, Annekathrin Reinhardt, Annika K. Wefers, Philipp Sievers, Azadeh Ebrahimi, Abigail Suwala, Francisco Fernández-Klett, Belén Casalini, Andrey Korshunov, Volker Hovestadt, Felix K. F. Kommoss, Mark Kriegsmann, Matthias Schick, Melanie Bewerunge-Hudler, Till Milde, Olaf Witt, Andreas E. Kulozik, Marcel Kool, Laura Romero-Pérez, Thomas G. P. Grünewald, Thomas Kirchner, Wolfgang Wick, Michael Platten, Andreas Unterberg, Matthias Uhl, Amir Abdollahi, Jürgen Debus, Burkhard Lehner, Christian Thomas, Martin Hasselblatt, Werner Paulus, Christian Hartmann, Ori Staszewski, Marco Prinz, Jürgen Hench, Stephan Frank, Yvonne M. H. Versleijen-Jonkers, Marije E. Weidema, Thomas Mentzel, Klaus Griewank, Enrique de Álava, Juan Díaz Martín, Miguel A. Idoate Gastearena, Kenneth Tou-En Chang, Sharon Yin Yee Low, Adrian Cuevas-Bourdier, Michel Mittelbronn, Martin Mynarek, Stefan Rutkowski, Ulrich Schüller, Viktor F. Mautner, Jens Schittenhelm, Jonathan Serrano, Matija Snuderl, Reinhard Büttner, Thomas Klingebiel, Rolf Buslei, Manfred Gessler, Pieter Wesseling, Winand N. M. Dinjens, Sebastian Brandner, Zane Jaunmuktane, Iben Lyskjær, Peter Schirmacher, Albrecht Stenzinger, Benedikt Brors, Hanno Glimm, Christoph Heining, Oscar M. Tirado, Miguel Sáinz-Jaspeado, Jaume Mora, Javier Alonso, Xavier Garcia del Muro, Sebastian Moran, Manel Esteller, Jamal K. Benhamida, Marc Ladanyi, Eva Wardelmann, Cristina Antonescu, Adrienne Flanagan, Uta Dirksen, Peter Hohenberger, Daniel Baumhoer, Wolfgang Hartmann, Christian Vokuhl, Uta Flucke, Iver Petersen, Gunhild Mechtersheimer, David Capper, David T. W. Jones, Stefan Fröhling, Stefan M. Pfister, Andreas von Deimling

Source: Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/c88e43d5043848c8bc27777e780e6d5b

Management of a Kaposiform haemangioendothelioma of the kidney with Kasabach-Meritt phenomenon without chemotherapy

Authors: Mya Soe Nwe, Marc Weijie Ong, Joyce Ching Mei Lam, Kenneth Tou-En Chang, Marielle V. Fortier, Olivia Wijeweera, Ah Moy Tan, Amos Hong Pheng Loh

Source: Pediatric Hematology Oncology Journal, Vol 1, Iss 4, Pp 89-92 (2016)

Subject Terms: Kaposiform hemangioendothelioma, Kidney, Kasabach-Merritt syndrome, Rotational thromboelastography, Pediatrics, RJ1-570

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2468124517300013; https://doaj.org/toc/2468-1245

Access URL: https://doaj.org/article/e58ad1133ea14875831533c75981eeab

Identifying Genetic Mutations in Vascular Anomalies Using a Sequencing Panel for Childhood Cancers: A Pilot Study

Authors: Elis Yuexian Lee, Yi Shan Ang, Chik Hong Kuick, Yingting Mok, Kenneth Tou En Chang, Luke Han Wei Toh, Mei Yoke Chan, Mark Jean Aan Koh

Source: Journal of Vascular Anomalies, Vol 5, Iss 3, p e094 (2024)

Subject Terms: Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/JOVA.0000000000000094; https://doaj.org/toc/2690-2702

Access URL: https://doaj.org/article/d32f6af8d23b473c9ac1ac905c5678c7

CNS embryonal tumour with concomitant novel BRD4::CTRC1 fusion and BCOR internal tandem duplication – evidence for synergism and non-mutually exclusive alterations in CNS embryonal tumours

Authors: Sze Jet Aw, Enrica Ee Kar Tan, Sharon Yin Yee Low, Chik Hong Kuick, Jian Yuan Goh, Kenneth Tou En Chang

Source: Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-4 (2024)

Subject Terms: Central nervous system embryonal tumours, BRD4-LEUTX fusion, BCOR internal tandem duplication, DNA methylation profiling, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2051-5960

Access URL: https://doaj.org/article/f005fe1e903b47f1a94df46a79b8336d

Exosomal mRNA Cargo are biomarkers of tumor and immune cell populations in pediatric osteosarcoma

Authors: Jonathan Lian K Ong, Nur Fatimah Farzanah Jalaludin, Meng Kang Wong, Sheng Hui Tan, Clara Angelina, Sarvesh A. Sukhatme, Trifanny Yeo, Chwee Teck Lim, York Tien Lee, Shui Yen Soh, Tony K.H. Lim, Timothy Kwang Yong Tay, Kenneth Tou En Chang, Zhi Xiong Chen, Amos HP Loh

Source: Translational Oncology, Vol 46, Iss , Pp 102008- (2024)

Subject Terms: Osteosarcoma, Exosome, THBS1, MS4A1, TCL1A, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1936523324001359; https://doaj.org/toc/1936-5233

Access URL: https://doaj.org/article/54b2622737fc48fb9fbca253f177061f

Case report of an infant with congenital mesoblastic nephroma leading to pulmonary metastasis

Authors: Arjuna Salinda Athapathu, Sameera M Wijayawardhana, Jithmal Meegoda, Sandini A Gunaratne, Mahendra Somathilaka, Kenneth Tou En Chang, Pujitha Wickramasinghe

Source: SAGE Open Medical Case Reports, Vol 11 (2023)

Subject Terms: Medicine (General), R5-920

File Description: electronic resource

Relation: https://doaj.org/toc/2050-313X

Access URL: https://doaj.org/article/74b00ef443e345f0a93bde0d267dc666

Validation of long mononucleotide repeat markers for microsatellite instability testing in paediatric tumours.

Authors: Chik Hong Kuick, Wan Wan Chen, Huiyi Chen, Kenneth Tou En Chang, Yingting Mok

Source: Journal of Clinical Pathology; Mar2023, Vol. 76 Issue 3, p214-216, 3p

Subject Terms: DNA mismatch repair, MICROSATELLITE repeats, FACIOSCAPULOHUMERAL muscular dystrophy, LUNGS, TUMORS, ANAPLASTIC large-cell lymphoma

TFE3-Expressing Epithelioid Rich Perivascular Epithelioid Cell Neoplasm (PEComa) of the Bladder with Unusual Benign Course.

Authors: Xiu Fen Chen, Joe Yeong, Kenneth Tou En Chang, Alvin Soon Tiong Lim, Chik Hong Kuick, Tse Hui Lim, Sudhanshi, Jain, Selvarajan, Sathiyamoorthy, Valerie Huei Li Gan, Li Yan Khor

Source: Annals of Clinical & Laboratory Science; Jan/Feb2018, Vol. 48 Issue 1, p110-115, 6p

Novel Karyotypes and Cydin D1 Immunoreactivity in Clear Cell Sarcoma of the Kidney.

Authors: SZE JET AW, CHIK HONG KUICK, MIN HWEE YONG, DERRICK WEN QUAN LIAN, SHI WANG, ALWIN HWAI LIANG LOH, SHARON LING, GUAT LIAN PEH, SHUI YEN SOH, AMOS HONG PHENG LOH, PUAY HOON TAN, KENNETH TOU EN CHANG

Source: Pediatric & Developmental Pathology; Jul/Aug2015, Vol. 18 Issue 4, p297-304, 8p

Subject Terms: KARYOTYPES, NEPHROBLASTOMA, SARCOMA, CYCLIN-dependent kinase inhibitors, IMMUNOHISTOCHEMISTRY, POLYMERASE chain reaction

Gastroduodenal Polyposis Secondary to Extrahepatic Portal Venous Obstruction

Authors: Christopher Wen Wei Ho, Kenneth Tou En Chang, Fang Kuan Chiou

Source: JGH Open, Vol 8, Iss 11, Pp n/a-n/a (2024)

Subject Terms: children, gastrointestinal bleed, polyp, portal hypertension, Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: https://doaj.org/toc/2397-9070

Access URL: https://doaj.org/article/e2191e96fada428c8b414481e44aabea

Exploiting frequent and specific expression of PRL3 in pediatric solid tumors for first-in-child use of PRL3-zumab humanized antibody

Authors: Amos Hong Pheng Loh, Min Thura, Abhishek Gupta, Sheng Hui Tan, Kelvin Kam Yew Kuan, Koon Hwee Ang, Khurshid Merchant, Kenneth Tou En Chang, Hui Yi Yon, Yong Chen, Mathew Hern Wang Cheng, Arjandas Mahadev, Matthew Chau Hsien Ng, Michaela Su-Fern Seng, Prasad Iyer, Pei Ling Chia, Shui Yen Soh, Qi Zeng

Source: Molecular Therapy: Oncolytics, Vol 30, Iss , Pp 153-166 (2023)

Subject Terms: PRL3, PTP4A3, PRL3-zumab, pediatric tumors, neuroblastoma, rhabdomyosarcoma, non-rhabdomyosarcoma soft tissue sarcoma, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S237277052300061X; https://doaj.org/toc/2372-7705

Access URL: https://doaj.org/article/de65b776c23d4d7cb7d07c8b6584356a

Paediatric BCOR‐associated sarcomas with a novel long spliced internal tandem duplication of BCOR exon 15

Authors: Jian Yuan Goh, Chik Hong Kuick, Masahiro Sugiura, Sze Jet Aw, Manli Zhao, Hongfeng Tang, Sandini Gunaratne, Fucun Zhu, Lin Cai, Bin Tean Teh, Paul S Thorner, Kenneth Tou En Chang

Source: The Journal of Pathology: Clinical Research, Vol 8, Iss 5, Pp 470-480 (2022)

Subject Terms: clear cell sarcoma of kidney, primitive myxoid mesenchymal tumour of infancy, BCOR, internal tandem duplication, splicing, Pathology, RB1-214

File Description: electronic resource

Relation: https://doaj.org/toc/2056-4538

Access URL: https://doaj.org/article/4dac882e8cc042cfab36d2273f2584be

Molecular exploration of paediatric intracranial germinomas from multi-ethnic Singapore

Authors: Sharon Yin Yee Low, He Cheng, Ruiyang Zou, Lee Ping Ng, Chik Hong Kuick, Nurfarhanah Bte Syed Sulaiman, Kenneth Tou En Chang, David Chyi Yeu Low, Lihan Zhou, Wan Tew Seow

Source: BMC Neurology, Vol 20, Iss 1, Pp 1-10 (2020)

Subject Terms: Intracranial germinomas, KIT, miRNA, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12883-020-01981-0; https://doaj.org/toc/1471-2377

Access URL: https://doaj.org/article/d8513f3f738e471b9ac2d554c0cb66a9

Experimental evidence for a high rate of maternal-fetal transmission of dengue virus in the presence of antibodies in immunocompromised mice

Authors: Satoru Watanabe, Kitti Wing Ki Chan, Nicole Wei Wen Tan, Maharah Binte Abdul Mahid, Avisha Chowdhury, Kenneth Tou En Chang, Subhash G. Vasudevan

Source: EBioMedicine, Vol 77, Iss , Pp 103930- (2022)

Subject Terms: Dengue virus, Pregnant mouse model, Vertical transmission, Zika virus, Placenta, Decidua, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396422001141; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/59a7900ca57048709b59a5f06ade3c13

Ectopic CD137 expression by rhabdomyosarcoma provides selection advantages but allows immunotherapeutic targeting

Authors: Kang Yi Lee, Hiu Yi Wong, Qun Zeng, Jia Le Lin, Man Si Cheng, Chik Hong Kuick, Kenneth Tou En Chang, Amos Hong Pheng Loh, Herbert Schwarz

Source: OncoImmunology, Vol 10, Iss 1 (2021)

Subject Terms: rhabdomyosarcoma, immune evasion, trogocytosis, cd137, il-6, il-8, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-402X

Access URL: https://doaj.org/article/fecc1db05df049e5b7d9e2a1cbcdad2f

Humanized Mouse as a Tool to Predict Immunotoxicity of Human Biologics

Authors: Kylie Su Mei Yong, Zhisheng Her, Sue Yee Tan, Wilson Wei Sheng Tan, Min Liu, Fritz Lai, Shi Min Heng, Yong Fan, Kenneth Tou En Chang, Cheng-I Wang, Jerry Kok Yen Chan, Jianzhu Chen, Qingfeng Chen

Source: Frontiers in Immunology, Vol 11 (2020)

Subject Terms: cytokine storm, biologic testing, humanized mice, immunotoxicity, inflammation, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fimmu.2020.553362/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/e059cd582d4042109dc81c80f743b7b8

CD4+ T Cells Mediate the Development of Liver Fibrosis in High Fat Diet-Induced NAFLD in Humanized Mice

Authors: Zhisheng Her, Joel Heng Loong Tan, Yee-Siang Lim, Sue Yee Tan, Xue Ying Chan, Wilson Wei Sheng Tan, Min Liu, Kylie Su Mei Yong, Fritz Lai, Erica Ceccarello, Zhiqiang Zheng, Yong Fan, Kenneth Tou En Chang, Lei Sun, Shih Chieh Chang, Chih-Liang Chin, Guan Huei Lee, Yock Young Dan, Yun-Shen Chan, Seng Gee Lim, Jerry Kok Yen Chan, K. George Chandy, Qingfeng Chen

Source: Frontiers in Immunology, Vol 11 (2020)

Subject Terms: humanized mouse model, NAFLD, NASH, liver fibrosis, CD4+ T cells, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fimmu.2020.580968/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/7ac32ad7c9604b1b8f09edab482babd4

ZC3H7B-BCOR high-grade endometrial stromal sarcoma with osseous metaplasia: Unique feature in a recently defined entity

Authors: Jerry C. Nagaputra, Ronald Chin Hong Goh, Chik Hong Kuick, Kenneth Tou En Chang, Kesavan Sittampalam

Source: Human Pathology: Case Reports, Vol 15, Iss , Pp 54-58 (2019)

Subject Terms: Pathology, RB1-214

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2214330018301111; https://doaj.org/toc/2214-3300

Access URL: https://doaj.org/article/f866a5698a4a4e8fa8312b0f484edf81

Uncovering the mystery of opposite circadian rhythms between mouse and human leukocytes in humanized mice.

Authors: Yue Zhao¹, Min Liu¹, Xue Ying Chan¹, Sue Yee Tan¹, Subramaniam, Sharrada¹, Yong Fan², Eva Loh³, Kenneth Tou En Chang^3,4, Thiam Chye Tan^4,5, Qingfeng Chen^1,2,6 qchen@imcb.a-star.edu.sg

Source: Blood. 11/2/2017, Vol. 130 Issue 18, p1995-2005. 11p.

Subject Terms: *CIRCADIAN rhythms, *LEUKOCYTES, *LABORATORY mice, *HUMAN genes, *ARYL hydrocarbon receptors, *REACTIVE oxygen species, *MAMMALS

Hepatitis C virus mediated chronic inflammation and tumorigenesis in the humanised immune system and liver mouse model.

Authors: Zhiqiang Zheng, Ching Wooen Sze, Choong Tat Keng, Muthafar Al-Haddawi, Min Liu, Sue Yee Tan, Hwee Ling Kwek, Zhisheng Her, Xue Ying Chan, Bhaskar Barnwal, Eva Loh, Kenneth Tou En Chang, Thiam Chye Tan, Yee-Joo Tan, Qingfeng Chen

Source: PLoS ONE, Vol 12, Iss 9, p e0184127 (2017)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0184127&type=printable; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/ac19de7e4a79454eaa1acad4216c4cf1