Diastereodivergent Construction of Octahydrophenanthridinone and Octahydrophenanthridine Cores

Authors: Chunzhao Sun, Hiromichi Nishikawa, Tsubasa Inokuma, Ken-ichi Yamada

Source: Molecules, Vol 30, Iss 2, p 371 (2025)

Subject Terms: octahydrophenanthridinone, octahydrophenanthridine, alkaloid, stereodivergent synthesis, arylation, organocuprate, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/30/2/371; https://doaj.org/toc/1420-3049

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Construction of a screening system for lipid-derived radical inhibitors and validation of hit compounds to target retinal and cerebrovascular diseases

Authors: Ryota Mori, Masami Abe, Yuma Saimoto, Saki Shinto, Sara Jodai, Manami Tomomatsu, Kaho Tazoe, Minato Ishida, Masataka Enoki, Nao Kato, Tomohiro Yamashita, Yuki Itabashi, Ikuo Nakanishi, Kei Ohkubo, Sachiko Kaidzu, Masaki Tanito, Yuta Matsuoka, Kazushi Morimoto, Ken-ichi Yamada

Source: Redox Biology, Vol 73, Iss , Pp 103186- (2024)

Subject Terms: Oxidized lipids, Radical-trapping antioxidants, Methyldopa, Retinal damage, Bilateral common carotid artery stenosis, Medicine (General), R5-920, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2213231724001642; https://doaj.org/toc/2213-2317

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Inhibition of 7-dehydrocholesterol reductase prevents hepatic ferroptosis under an active state of sterol synthesis

Authors: Naoya Yamada, Tadayoshi Karasawa, Junya Ito, Daisuke Yamamuro, Kazushi Morimoto, Toshitaka Nakamura, Takanori Komada, Chintogtokh Baatarjav, Yuma Saimoto, Yuka Jinnouchi, Kazuhisa Watanabe, Kouichi Miura, Naoya Yahagi, Kiyotaka Nakagawa, Takayoshi Matsumura, Ken-ichi Yamada, Shun Ishibashi, Naohiro Sata, Marcus Conrad, Masafumi Takahashi

Source: Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/cf67912edd5e4955a7683d3553f31fd5

Triglyceride peroxidation progression in lipid droplets of hepatocytes in nonalcoholic steatohepatitis

Authors: Kota Saito, Yuta Matsuoka, Masami Abe, Nao Kato, Kazushi Morimoto, Ken-ichi Yamada

Source: Redox Experimental Medicine, Vol 2023, Iss 1, Pp 1-11 (2024)

Subject Terms: nonalcoholic steatohepatitis, lipid peroxidation, oxidised triglycerides, 4-hydroxy nonenal, lipid droplet, Physiology, QP1-981, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://rem.bioscientifica.com/view/journals/rem/2023/1/REM-22-0024.xml; https://doaj.org/toc/2755-158X

Access URL: https://doaj.org/article/ce3134d9d4eb44e6a44a8639ed4effb4

Deferasirox Targeting Ferroptosis Synergistically Ameliorates Myocardial Ischemia Reperfusion Injury in Conjunction With Cyclosporine A

Authors: Kosei Ishimaru, Masataka Ikeda, Hiroko Deguchi Miyamoto, Shun Furusawa, Ko Abe, Masatsugu Watanabe, Takuya Kanamura, Satoshi Fujita, Ryohei Nishimura, Takayuki Toyohara, Shouji Matsushima, Tomoko Koumura, Ken‐ichi Yamada, Hirotaka Imai, Hiroyuki Tsutsui, Tomomi Ide

Source: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 1 (2024)

Subject Terms: cyclosporin A, deferasirox, ferroptosis, ischemia reperfusion injury, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://doaj.org/toc/2047-9980

Access URL: https://doaj.org/article/dbaf2db9f0a143d98668818ad9250cb5

Ascorbic Acid Protects Bone Marrow from Oxidative Stress and Transient Elevation of Corticosterone Caused by X-ray Exposure in Akr1a-Knockout Mice

Authors: Tomoki Bo, Hidekazu Nohara, Ken-ichi Yamada, Satoshi Miyata, Junichi Fujii

Source: Antioxidants, Vol 13, Iss 2, p 152 (2024)

Subject Terms: reactive oxygen species, adrenal, adrenocorticotropic hormone, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.mdpi.com/2076-3921/13/2/152; https://doaj.org/toc/2076-3921

Access URL: https://doaj.org/article/12bafdf87f684e69a99f583999c65f13

Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity

Authors: Tomonori Tadokoro, Masataka Ikeda, Tomomi Ide, Hiroko Deguchi, Soichiro Ikeda, Kosuke Okabe, Akihito Ishikita, Shouji Matsushima, Tomoko Koumura, Ken-ichi Yamada, Hirotaka Imai, Hiroyuki Tsutsui

Source: JCI Insight, Vol 8, Iss 6 (2023)

Subject Terms: Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2379-3708

Access URL: https://doaj.org/article/7a7e7c992029408aaa695690db67e138

Structural library and visualization of endogenously oxidized phosphatidylcholines using mass spectrometry-based techniques

Authors: Yuta Matsuoka, Masatomo Takahashi, Yuki Sugiura, Yoshihiro Izumi, Kazuhiro Nishiyama, Motohiro Nishida, Makoto Suematsu, Takeshi Bamba, Ken-ichi Yamada

Source: Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/37bab6945355410fb3f591261ec7e897

Hepatic resistance to cold ferroptosis in a mammalian hibernator Syrian hamster depends on effective storage of diet-derived α-tocopherol

Authors: Daisuke Anegawa, Yuki Sugiura, Yuta Matsuoka, Masamitsu Sone, Mototada Shichiri, Reo Otsuka, Noriko Ishida, Ken-ichi Yamada, Makoto Suematsu, Masayuki Miura, Yoshifumi Yamaguchi

Source: Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2399-3642

Access URL: https://doaj.org/article/5490d4cebb014a8388a70e5323d72017

Effects of Substituents on the Properties of Metal-Free MRI Contrast Agents

Authors: Ryoma Shiraishi, Tomoyo Kaneko, Kazuteru Usui, Tatsuya Naganuma, Naoko Iizuka, Kosuke Morishita, Shigeki Kobayashi, Yasufumi Fuchi, Yuta Matsuoka, Go Hirai, Ken-ichi Yamada, Satoru Karasawa

Source: ACS Omega, Vol 4, Iss 24, Pp 20715-20723 (2019)

Subject Terms: Chemistry, QD1-999

File Description: electronic resource

Relation: https://doaj.org/toc/2470-1343

Access URL: https://doaj.org/article/c699a10a7f86488280ea49a73739dda7

Low dose of sodium-glucose transporter 2 inhibitor ipragliflozin attenuated renal dysfunction and interstitial fibrosis in adenine-induced chronic kidney disease in mice without diabetes

Authors: Mayumi Yamato, Nao Kato, Ai Kakino, Ken-ichi Yamada, Toyoshi Inoguchi

Source: Metabolism Open, Vol 7, Iss , Pp 100049- (2020)

Subject Terms: Sodium-glucose transporter 2 inhibitor, Diabetes, Chronic kidney disease, Physiology, QP1-981, Biochemistry, QD415-436

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589936820300293; https://doaj.org/toc/2589-9368

Access URL: https://doaj.org/article/8ac8ac089e5a4070b6a8f2219566c377

Connexin 30 deficiency attenuates A2 astrocyte responses and induces severe neurodegeneration in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Parkinson’s disease animal model

Authors: Atsushi Fujita, Hiroo Yamaguchi, Ryo Yamasaki, Yiwen Cui, Yuta Matsuoka, Ken-ichi Yamada, Jun-ichi Kira

Source: Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-20 (2018)

Subject Terms: Parkinson’s disease, Dopaminergic neuron, Astrocyte, Connexin 30, MPTP, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12974-018-1251-0; https://doaj.org/toc/1742-2094

Access URL: https://doaj.org/article/fa59bb76569644a882e0026be274ad9b

TEMPOL increases NAD+ and improves redox imbalance in obese mice

Authors: Mayumi Yamato, Kimika Kawano, Yuki Yamanaka, Misako Saiga, Ken-ichi Yamada

Source: Redox Biology, Vol 8, Iss C, Pp 316-322 (2016)

Subject Terms: Obesity, Oxidative stress, Redox status, NAD+, Nitroxide, Medicine (General), R5-920, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2213231716300180; https://doaj.org/toc/2213-2317

Access URL: https://doaj.org/article/435d93af750b483f9d41dc29695b2a1f

Cloning and Expression of a Perilla frutescens Cytochrome P450 Enzyme Catalyzing the Hydroxylation of Phenylpropenes

Authors: Mariko Baba, Ken-ichi Yamada, Michiho Ito

Source: Plants, Vol 9, Iss 5, p 577 (2020)

Subject Terms: phenylpropanoid, volatile compound, molecular cloning, cytochrome P450, biosynthetic pathway, perilla, Botany, QK1-989

File Description: electronic resource

Relation: https://www.mdpi.com/2223-7747/9/5/577; https://doaj.org/toc/2223-7747

Access URL: https://doaj.org/article/ed199ee4d8cb4ad7920fff1f81de9ce5

Fluorescence Tumor-Imaging Using a Thermo-Responsive Molecule with an Emissive Aminoquinoline Derivative

Authors: Takeru Araki, Yasufumi Fuchi, Shuhei Murayama, Ryoma Shiraishi, Tokimi Oyama, Mariko Aso, Ichio Aoki, Shigeki Kobayashi, Ken-ichi Yamada, Satoru Karasawa

Source: Nanomaterials, Vol 8, Iss 10, p 782 (2018)

Subject Terms: nanoparticles, lower critical solution temperature, fluorescence, self-assembly, tumor-imaging, Chemistry, QD1-999

File Description: electronic resource

Relation: http://www.mdpi.com/2079-4991/8/10/782; https://doaj.org/toc/2079-4991

Access URL: https://doaj.org/article/95b46e29817c4d0d8b2de4fde5152a24

Overexpression of TFAM or twinkle increases mtDNA copy number and facilitates cardioprotection associated with limited mitochondrial oxidative stress.

Authors: Masataka Ikeda, Tomomi Ide, Takeo Fujino, Shinobu Arai, Keita Saku, Takamori Kakino, Henna Tyynismaa, Toshihide Yamasaki, Ken-Ichi Yamada, Dongchon Kang, Anu Suomalainen, Kenji Sunagawa

Source: PLoS ONE, Vol 10, Iss 3, p e0119687 (2015)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC4379048?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/b125064fd97d40ff81e80a49101b6a23

MRP1-Dependent Extracellular Release of Glutathione Induces Cardiomyocyte Ferroptosis After Ischemia-Reperfusion.

Authors: Genki Ichihara, Yoshinori Katsumata, Yuki Sugiura, Yuta Matsuoka, Rae Maeda, Jin Endo, Atsushi Anzai, Kohsuke Shirakawa, Hidenori Moriyama, Hiroki Kitakata, Takahiro Hiraide, Shinichi Goto, Seien Ko, Yuji Iwasawa, Kazuhisa Sugai, Kyohei Daigo, Shinya Goto, Kazuki Sato, Ken-ichi Yamada, Makoto Suematsu

Source: Circulation Research; 10/27/2023, Vol. 133 Issue 10, p861-876, 16p

Helical Nanographenes Embedded with Contiguous Azulene Units.

Authors: Naoki Ogawa, Yousuke Yamaoka, Hiroshi Takikawa, Ken-ichi Yamada, Kiyosei Takasu

Source: Journal of the American Chemical Society; 8/5/2020, Vol. 142 Issue 31, p13322-13327, 6p

Rapid Assembly of Protoilludane Skeleton through Tandem Catalysis: Total Synthesis of Paesslerin A and Its Structural Revision.

Authors: Yuzo Mogi, Kazato Inanaga, Hidetoshi Tokuyama, Masataka Ihara, Yousuke Yamaoka, Ken-ichi Yamada, Kiyosei Takasu

Source: Organic Letters; Jun2019, Vol. 21 Issue 11, p3954-3958, 5p

Asymmetric Formal Synthesis of (+)-Catharanthine via Desymmetrization of Isoquinuclidine.

Authors: Masato Kono, Shingo Harada, Tomoyuki Nozaki, Yoshinori Hashimoto, Shun-ichi Murata, Gröger, Harald, Yusuke Kuroda, Ken-ichi Yamada, Kiyosei Takasu, Yasumasa Hamada, Tetsuhiro Nemoto

Source: Organic Letters; May2019, Vol. 21 Issue 10, p3750-3754, 5p