A decade of experience with genetically tailored pig models for diabetes and metabolic research

Authors: Zettler, Silja, Renner, Simone, Kemter, Elisabeth, Hinrichs, Arne, Klymiuk, Nikolai, Backman, Mattias, Riedel, Evamaria Olga, Mueller, Christiane, Streckel, Elisabeth, Braun-Reichhart, Christina, Martins, Ana Sofia, Kurome, Mayuko, Keßler, Barbara, Zakhartchenko, Valeri, Flenkenthaler, Florian, Arnold, Georg Josef, Fröhlich, Thomas, Blum, Helmut, Blutke, Andreas, Wanke, Rüdiger, Wolf, Eckhard

Source: Animal Reproduction. January 2020 17(3)

Subject Terms: pig model, diabetes, biobank, xenotransplantation

File Description: text/html

Access URL: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-31432020000300504

EGR1 regulates oxidative stress and aldosterone production in adrenal cells and aldosterone-producing adenomas

Authors: Pang, Yingxian ^a, Gong, Siyuan ^{a, 1}, Tetti, Martina ^{a, 1}, Sun, Zhuolun ^a, Mir-Bashiri, Sanas ^a, Bidlingmaier, Martin ^a, Knösel, Thomas ^b, Wolf, Eckhard ^c, Reincke, Martin ^a, Kemter, Elisabeth ^c, Williams, Tracy Ann ^{a, ⁎}

Source: In Redox Biology March 2025 80

Phenotypic features of dystrophin gene knockout pigs harboring a human artificial chromosome containing the entire dystrophin gene

Authors: Watanabe, Masahito, Miyamoto, Hitomaru, Okamoto, Kazutoshi, Nakano, Kazuaki, Matsunari, Hitomi, Kazuki, Kanako, Hasegawa, Koki, Uchikura, Ayuko, Takayanagi, Shuko, Umeyama, Kazuhiro, Hiramuki, Yosuke, Kemter, Elisabeth, Klymuik, Nikolai, Kurome, Mayuko, Kessler, Barbara, Wolf, Eckhard, Kazuki, Yasuhiro, Nagashima, Hiroshi

Source: In Molecular Therapy - Nucleic Acids 12 September 2023 33:444-453

Maternal hyperglycemia induces alterations in hepatic amino acid, glucose and lipid metabolism of neonatal offspring: Multi-omics insights from a diabetic pig model

Authors: Shashikadze, Bachuki, Valla, Libera, Lombardo, Salvo Danilo, Prehn, Cornelia, Haid, Mark, Riols, Fabien, Stöckl, Jan Bernd, Elkhateib, Radwa, Renner, Simone, Rathkolb, Birgit, Menche, Jörg, Hrabĕ de Angelis, Martin, Wolf, Eckhard, Kemter, Elisabeth, Fröhlich, Thomas

Source: In Molecular Metabolism September 2023 75

A transcriptional cross species map of pancreatic islet cells

Authors: Tritschler, Sophie, Thomas, Moritz, Böttcher, Anika, Ludwig, Barbara, Schmid, Janine, Schubert, Undine, Kemter, Elisabeth, Wolf, Eckhard, Lickert, Heiko, Theis, Fabian J.

Source: In Molecular Metabolism December 2022 66

Sequential in vivo labeling of insulin secretory granule pools in INS-SNAP transgenic pigs

Authors: Kemter, Elisabeth, Müller, Andreas, Neukam, Martin, Ivanova, Anna, Klymiuk, Nikolai, Renner, Simone, Yang, Kaiyuan, Broichhagen, Johannes, Kurome, Mayuko, Zakhartchenko, Valeri, Kessler, Barbara, Knoch, Klaus-Peter, Bickle, Marc, Ludwig, Barbara, Johnsson, Kai, Lickert, Heiko, Kurth, Thomas, Wolf, Eckhard, Solimena, Michele

Source: Proceedings of the National Academy of Sciences of the United States of America, 2021 Sep . 118(37), 1-8.

Access URL: https://www.jstor.org/stable/27075774

Pig models for Duchenne muscular dystrophy – from disease mechanisms to validation of new diagnostic and therapeutic concepts

Authors: Stirm, Michael, Fonteyne, Lina Marie, Shashikadze, Bachuki, Stöckl, Jan B., Kurome, Mayuko, Keßler, Barbara, Zakhartchenko, Valeri, Kemter, Elisabeth, Blum, Helmut, Arnold, Georg J., Matiasek, Kaspar, Wanke, Rüdiger, Wurst, Wolfgang, Nagashima, Hiroshi, Knieling, Ferdinand, Walter, Maggie C., Kupatt, Christian, Fröhlich, Thomas, Klymiuk, Nikolai, Blutke, Andreas, Wolf, Eckhard

Source: NEUROMUSCULAR DISORDERS. 32(7):543-556

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100188934056.0x000001&indx=1&recIds=ETOCvdc_100188934056.0x000001

TSPAN12 (Tetraspanin 12) Is a Novel Negative Regulator of Aldosterone Production in Adrenal Physiology and Aldosterone-Producing Adenomas

Authors: Gong, Siyuan, Tetti, Martina, Kemter, Elisabeth, Peitzsch, Mirko, Mulatero, Paolo, Bidlingmaier, Martin, Eisenhofer, Graeme, Wolf, Eckhard, Reincke, Martin, Williams, Tracy Ann

Source: Hypertension. 80(2):440-450

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100178276821.0x000001&indx=1&recIds=ETOCvdc_100178276821.0x000001

Spheroids Composed of Reaggregated Neonatal Porcine Islets and Human Endothelial Cells Accelerate Development of Normoglycemia in Diabetic Mice.

Authors: Honarpisheh, Mohsen, Lei, Yutian, Follenzi, Antonia, Cucci, Alessia, Olgasi, Cristina, Berishvili, Ekaterine, Lebreton, Fanny, Bellofatto, Kevin, Piemonti, Lorenzo, Citro, Antonio, Campo, Francesco, Pignatelli, Cataldo, Thaunat, Olivier, Kemter, Elisabeth, Kraetzl, Martin, Wolf, Eckhard, Seissler, Jochen, Wolf-van Buerck, Lelia

Source: Cells (2073-4409); Mar2025, Vol. 14 Issue 5, p366, 12p

Subject Terms: ENDOTHELIAL cells, ISLANDS of Langerhans, CORD blood, XENOTRANSPLANTATION, GENE expression

ATP2A3 in Primary Aldosteronism: Machine Learning-Based Discovery and Functional Validation.

Authors: Sun, Zhuolun, Kemter, Elisabeth, Pang, Yingxian, Bidlingmaier, Martin, Wolf, Eckhard, Reincke, Martin, Williams, Tracy Ann

Source: Hypertension (0194911X); Feb2025, Vol. 82 Issue 2, p319-332, 14p

A new method for physical disector analyses of numbers and mean volumes of immunohistochemically labeled cells in paraffin sections

Authors: Hofmann, Isabel, Kemter, Elisabeth, Fiedler, Sonja, Theobalt, Natalie, Fonteyne, Lina, Wolf, Eckhard, Wanke, Rüdiger, Blutke, Andreas

Source: In Journal of Neuroscience Methods 1 September 2021 361

What Genetic Modifications of Source Pigs Are Essential and Sufficient for Cell, Tissue, and Organ Xenotransplantation?

Authors: Ali, Asghar, Kurome, Mayuko, Kessler, Barbara, Kemter, Elisabeth, Wolf, Eckhard

Source: Transplant International; 2024, p1-10, 10p

Subject Terms: PRESERVATION of organs, tissues, etc., GENE expression, XENOGRAFTS, GENOME editing, GENE knockout

Decreased β-cell volume and insulin secretion but preserved glucose tolerance in a growth hormone insensitive pig model.

Authors: Laane, Laeticia, Renner, Simone, Kemter, Elisabeth, Stirm, Michael, Rathkolb, Birgit, Blutke, Andreas, Bidlingmaier, Martin, de Angelis, Martin Hrabĕ, Wolf, Eckhard, Hinrichs, Arne

Source: Pituitary; Oct2024, Vol. 27 Issue 5, p567-576, 10p

Xeno-organ donor pigs with multiple genetic modifications – the more the better?

Authors: Kemter, Elisabeth, Schnieke, Angelika, Fischer, Konrad, Cowan, Peter J, Wolf, Eckhard

Source: In Current Opinion in Genetics & Development October 2020 64:60-65

Progressive Proteome Changes in the Myocardium of a Pig Model for Duchenne Muscular Dystrophy

Authors: Tamiyakul, Hathaichanok, Kemter, Elisabeth, Kösters, Miwako, Ebner, Stefanie, Blutke, Andreas, Klymiuk, Nikolai, Flenkenthaler, Florian, Wolf, Eckhard, Arnold, Georg J., Fröhlich, Thomas

Source: In iScience 25 September 2020 23(9)

Pig-to-non-human primate heart transplantation: The final step toward clinical xenotransplantation?

Authors: Reichart, Bruno, Längin, Matthias, Radan, Julia, Mokelke, Maren, Buttgereit, Ines, Ying, Jiawei, Fresch, Ann Kathrin, Mayr, Tanja, Issl, Lara, Buchholz, Stefan, Michel, Sebastian, Ellgass, Reinhard, Mihalj, Maks, Egerer, Stefanie, Baehr, Andrea, Kessler, Barbara, Kemter, Elisabeth, Kurome, Mayuko, Zakhartchenko, Valeri, Steen, Stig, Sjöberg, Trygve, Paskevicius, Audrius, Krüger, Luise, Fiebig, Uwe, Denner, Joachim, Godehardt, Antonia W., Tönjes, Ralf R., Milusev, Anastasia, Rieben, Robert, Sfriso, Riccardo, Walz, Christoph, Kirchner, Thomas, Ayares, David, Lampe, Karen, Schönmann, Uwe, Hagl, Christian, Wolf, Eckhard, Klymiuk, Nikolai, Abicht, Jan-Michael, Brenner, Paolo

Source: In Journal of Heart and Lung Transplantation August 2020 39(8):751-757

Functional changes of the liver in the absence of growth hormone (GH) action – Proteomic and metabolomic insights from a GH receptor deficient pig model

Authors: Riedel, Evamaria O., Hinrichs, Arne, Kemter, Elisabeth, Dahlhoff, Maik, Backman, Mattias, Rathkolb, Birgit, Prehn, Cornelia, Adamski, Jerzy, Renner, Simone, Blutke, Andreas, de Angelis, Martin Hrabĕ, Bidlingmaier, Martin, Schopohl, Jochen, Arnold, Georg J., Fröhlich, Thomas, Wolf, Eckhard

Source: In Molecular Metabolism June 2020 36

Glycocalyx dynamics and the inflammatory response of genetically modified porcine endothelial cells

Authors: Milusev, Anastasia, Ren, Jianfang, Despont, Alain, Shaw, Jane, Längin, Matthias, Bender, Martin, Abicht, Jan‐Michael, Mokelke, Maren, Radan, Julia, Neumann, Elisabeth, Kemter, Elisabeth, Klymiuk, Nikolai, Ayares, David, Wolf, Eckhard, Reichart, Bruno, Sorvillo, Nicoletta, Rieben, Robert

Source: Xenotransplantation. 30(5)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100193718617.0x000001&indx=1&recIds=ETOCvdc_100193718617.0x000001

Cellular and Molecular Probing of Intact Human Organs

Authors: Zhao, Shan, Todorov, Mihail Ivilinov, Cai, Ruiyao, -Maskari, Rami AI, Steinke, Hanno, Kemter, Elisabeth, Mai, Hongcheng, Rong, Zhouyi, Warmer, Martin, Stanic, Karen, Schoppe, Oliver, Paetzold, Johannes Christian, Gesierich, Benno, Wong, Milagros N., Huber, Tobias B., Duering, Marco, Bruns, Oliver Thomas, Menze, Bjoern, Lipfert, Jan, Puelles, Victor G., Wolf, Eckhard, Bechmann, Ingo, Ertürk, Ali

Source: In Cell 20 February 2020 180(4):796-812

Effect of Dietary Sodium Modulation on Pig Adrenal Steroidogenesis and Transcriptome Profiles

Authors: Vohra, Twinkle, Kemter, Elisabeth, Sun, Na, Dobenecker, Britta, Hinrichs, Arne, Burrello, Jacopo, Gomez-Sanchez, Elise P., Gomez-Sanchez, Celso E., Wang, Jun, Kinker, Isabella-Sabrina, Teupser, Daniel, Fischer, Konrad, Schnieke, Angelika, Peitzsch, Mirko, Eisenhofer, Graeme, Walch, Axel, Reincke, Martin, Wolf, Eckhard, Williams, Tracy Ann

Source: Hypertension. 76(6):1769-1777

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100176819223.0x000001&indx=1&recIds=ETOCvdc_100176819223.0x000001