Gnao1 is a molecular switch that regulates the Rho signaling pathway in differentiating neurons

Authors: Ryoji Taira, Satoshi Akamine, Sayaka Okuzono, Fumihiko Fujii, Eriko Hatai, Kousuke Yonemoto, Ryuichi Takemoto, Hiroki Kato, Keiji Masuda, Takahiro A. Kato, Ryutaro Kira, Keita Tsujimura, Kenichiro Yamamura, Norio Ozaki, Shouichi Ohga, Yasunari Sakai

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)

Subject Terms: GNAO1, Developmental and epileptic encephalopathy, Differentiation, Organoids, Molecular pathway, Rho-associated kinase, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/d8d36bc2a350495790ccaae44b9b9ab7

Comprehensive High-Depth Proteomic Analysis of Plasma Extracellular Vesicles Containing Preparations in Rett Syndrome

Authors: Sho Hagiwara, Tadashi Shiohama, Satoru Takahashi, Masaki Ishikawa, Yusuke Kawashima, Hironori Sato, Daisuke Sawada, Tomoko Uchida, Hideki Uchikawa, Hironobu Kobayashi, Megumi Shiota, Shin Nabatame, Keita Tsujimura, Hiromichi Hamada, Keiichiro Suzuki

Source: Biomedicines, Vol 12, Iss 10, p 2172 (2024)

Subject Terms: Rett syndrome, extracellular vesicles containing preparations, high-depth proteome analysis, PI3K/AKT/mTOR signaling pathway, UBE3B, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2227-9059/12/10/2172; https://doaj.org/toc/2227-9059

Access URL: https://doaj.org/article/b85688b676e941a1bfce11dbfee50f4d

Integration of structural MRI and epigenetic analyses hint at linked cellular defects of the subventricular zone and insular cortex in autism: Findings from a case study

Authors: Emi Takahashi, Nina Allan, Rafael Peres, Alpen Ortug, Andre J. W. van der Kouwe, Briana Valli, Elizabeth Ethier, Jacob Levman, Nicole Baumer, Keita Tsujimura, Nauru Idalia Vargas-Maya, Trevor A. McCracken, Rosa Lee, Alika K. Maunakea

Source: Frontiers in Neuroscience, Vol 16 (2023)

Subject Terms: epigenetic, MRI, SVZ, cortex, autism, DNA methylation, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fnins.2022.1023665/full; https://doaj.org/toc/1662-453X

Access URL: https://doaj.org/article/aa3b78fd3832434c8d3830acc64912aa

miR-514a promotes neuronal development in human iPSC-derived neurons

Authors: Yuichi Akaba, Satoru Takahashi, Keiichiro Suzuki, Kenjiro Kosaki, Keita Tsujimura

Source: Frontiers in Cell and Developmental Biology, Vol 11 (2023)

Subject Terms: microRNA, miR-514a, IPSC, neuronal development, dendrite, mTOR, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2023.1096463/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/2a0ae5a9f74c4f67ba4360eb455b8550

A Brain Morphometry Study with Across-Site Harmonization Using a ComBat-Generalized Additive Model in Children and Adolescents

Authors: Tadashi Shiohama, Norihide Maikusa, Masahiro Kawaguchi, Jun Natsume, Yoshiyuki Hirano, Keito Saito, Jun-ichi Takanashi, Jacob Levman, Emi Takahashi, Koji Matsumoto, Hajime Yokota, Shinya Hattori, Keita Tsujimura, Daisuke Sawada, Tomoko Uchida, Tomozumi Takatani, Katsunori Fujii, Shinji Naganawa, Noriko Sato, Hiromichi Hamada

Source: Diagnostics, Vol 13, Iss 17, p 2774 (2023)

Subject Terms: ComBat-GAM, structural brain MRI, voxel-based morphometry, CIVET, normal reference values, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.mdpi.com/2075-4418/13/17/2774; https://doaj.org/toc/2075-4418

Access URL: https://doaj.org/article/2939a0b7ceda4137a91c9ec416ce940e

Comprehensive Volumetric Analysis of Mecp2-Null Mouse Model for Rett Syndrome by T2-Weighted 3D Magnetic Resonance Imaging

Authors: Yuichi Akaba, Tadashi Shiohama, Yuji Komaki, Fumiko Seki, Alpen Ortug, Daisuke Sawada, Wataru Uchida, Koji Kamagata, Keigo Shimoji, Shigeki Aoki, Satoru Takahashi, Takeshi Suzuki, Jun Natsume, Emi Takahashi, Keita Tsujimura

Source: Frontiers in Neuroscience, Vol 16 (2022)

Subject Terms: Rett syndrome, methyl-CpG-binding protein 2, magnetic resonance imaging, brain structure, volumetric analysis, neurodevelopmental disorder, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fnins.2022.885335/full; https://doaj.org/toc/1662-453X

Access URL: https://doaj.org/article/ccd0261a04494ceba7566949cb74c6ff

Quantitative Structural Brain Magnetic Resonance Imaging Analyses: Methodological Overview and Application to Rett Syndrome

Authors: Tadashi Shiohama, Keita Tsujimura

Source: Frontiers in Neuroscience, Vol 16 (2022)

Subject Terms: quantitative analysis, voxel based morphometry, surface based morphometry, diffusion-weighted MRI tractography, rett syndrome (RTT), Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fnins.2022.835964/full; https://doaj.org/toc/1662-453X

Access URL: https://doaj.org/article/cc85730f05e74559bea1585b0571f9a0

MeCP2 controls neural stem cell fate specification through miR-199a-mediated inhibition of BMP-Smad signaling

Authors: Hideyuki Nakashima, Keita Tsujimura, Koichiro Irie, Takuya Imamura, Cleber A. Trujillo, Masataka Ishizu, Masahiro Uesaka, Miao Pan, Hirofumi Noguchi, Kanako Okada, Kei Aoyagi, Tomoko Andoh-Noda, Hideyuki Okano, Alysson R. Muotri, Kinichi Nakashima

Source: Cell Reports, Vol 35, Iss 7, Pp 109124- (2021)

Subject Terms: Rett syndrome, MeCP2, neural stem cell, differentiation, miR-199a, Smad, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124721004630; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/0fed81b11b5247d3a98746060e307b29

microRNA Biology on Brain Development and Neuroimaging Approach

Authors: Keita Tsujimura, Tadashi Shiohama, Emi Takahashi

Source: Brain Sciences, Vol 12, Iss 10, p 1366 (2022)

Subject Terms: miRNAs, gene expression, brain development, migration, neuronal development, neurodevelopmental disorder, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.mdpi.com/2076-3425/12/10/1366; https://doaj.org/toc/2076-3425

Access URL: https://doaj.org/article/2d149db34ba84ef49238ab813d38eb63

Reduced Adult Hippocampal Neurogenesis and Cognitive Impairments following Prenatal Treatment of the Antiepileptic Drug Valproic Acid

Authors: Berry Juliandi, Kentaro Tanemura, Katsuhide Igarashi, Takashi Tominaga, Yusuke Furukawa, Maky Otsuka, Noriko Moriyama, Daigo Ikegami, Masahiko Abematsu, Tsukasa Sanosaka, Keita Tsujimura, Minoru Narita, Jun Kanno, Kinichi Nakashima

Source: Stem Cell Reports, Vol 5, Iss 6, Pp 996-1009 (2015)

Subject Terms: Medicine (General), R5-920, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2213671115003094; https://doaj.org/toc/2213-6711

Access URL: https://doaj.org/article/ea9827071bd54aa0b3657d46e1f92136

miR-199a Links MeCP2 with mTOR Signaling and Its Dysregulation Leads to Rett Syndrome Phenotypes

Authors: Keita Tsujimura, Koichiro Irie, Hideyuki Nakashima, Yoshihiro Egashira, Yoichiro Fukao, Masayuki Fujiwara, Masayuki Itoh, Masahiro Uesaka, Takuya Imamura, Yasukazu Nakahata, Yui Yamashita, Takaya Abe, Shigeo Takamori, Kinichi Nakashima

Source: Cell Reports, Vol 12, Iss 11, Pp 1887-1901 (2015)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124715008992; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/686c56aae0c14514844775a62c0f01ca

VPA alleviates neurological deficits and restores gene expression in a mouse model of Rett syndrome.

Authors: Weixiang Guo, Keita Tsujimura, Maky Otsuka I, Koichiro Irie, Katsuhide Igarashi, Kinichi Nakashima, Xinyu Zhao

Source: PLoS ONE, Vol 9, Iss 6, p e100215 (2014)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC4072629?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/f5c2536904d84b9a826d98f080248c89

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Canonical TGF-β Signaling Negatively Regulates Neuronal Morphogenesis through TGIF/Smad Complex-Mediated CRMP2 Suppression.

Authors: Hideyuki Nakashima¹, Keita Tsujimura^1,2,3 tsujimura@med.nagoya-u.ac.jp, Koichiro Irie¹, Masataka Ishizu¹, Miao Pan¹, Tomonori Kameda¹, Kinichi Nakashima¹ kin1@scb.med.kyushu-u.ac.jp

Source: Journal of Neuroscience. 5/16/2018, Vol. 38 Issue 20, p4791-4810. 20p.

Subject Terms: *MORPHOGENESIS, *NEURON development, *TRANSFORMING growth factors-beta, *THERAPEUTIC use of cytokines, *PROTEIN expression

MicroRNA-214 Promotes Dendritic Development by Targeting the Schizophrenia-associated Gene Quaking (Qki).

Authors: Koichiro Irie¹, Keita Tsujimura¹ tsujimura@med.nagoya-u.ac.jp, Hideyuki Nakashima¹, Kinichi Nakashima¹ kin1@scb.med.kyushu-u.ac.jp

Source: Journal of Biological Chemistry. 6/24/2016, Vol. 291 Issue 26, p13891-13904. 14p.

Subject Terms: *MICRORNA, *DENDRITES, *NEURON development, *GENETIC overexpression, *GENETICS of schizophrenia, *GENES, *MORPHOGENESIS

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