Therapeutic strategy for spinal muscular atrophy by combining gene supplementation and genome editing

Authors: Fumiyuki Hatanaka, Keiichiro Suzuki, Kensaku Shojima, Jingting Yu, Yuta Takahashi, Akihisa Sakamoto, Javier Prieto, Maxim Shokhirev, Estrella Nuñez Delicado, Concepcion Rodriguez Esteban, Juan Carlos Izpisua Belmonte

Source: Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/10b9828b196546fa8165e5097af9a12a

Lipid Nanoparticles Enable Efficient In Vivo DNA Knock-In via HITI-Mediated Genome Editing

Authors: Jun Hirose, Emi Aizawa, Shogo Yamamoto, Mingyao Xu, Shigenori Iwai, Keiichiro Suzuki

Source: Biomolecules, Vol 14, Iss 12, p 1558 (2024)

Subject Terms: genome editing, lipid nanoparticle (LNP), homology-independent targeted integration (HITI), knock-in, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-273X/14/12/1558; https://doaj.org/toc/2218-273X

Access URL: https://doaj.org/article/198dd1759f3e48fba1700157a0a51797

Comprehensive High-Depth Proteomic Analysis of Plasma Extracellular Vesicles Containing Preparations in Rett Syndrome

Authors: Sho Hagiwara, Tadashi Shiohama, Satoru Takahashi, Masaki Ishikawa, Yusuke Kawashima, Hironori Sato, Daisuke Sawada, Tomoko Uchida, Hideki Uchikawa, Hironobu Kobayashi, Megumi Shiota, Shin Nabatame, Keita Tsujimura, Hiromichi Hamada, Keiichiro Suzuki

Source: Biomedicines, Vol 12, Iss 10, p 2172 (2024)

Subject Terms: Rett syndrome, extracellular vesicles containing preparations, high-depth proteome analysis, PI3K/AKT/mTOR signaling pathway, UBE3B, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2227-9059/12/10/2172; https://doaj.org/toc/2227-9059

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Transduction and Genome Editing of the Heart with Adeno-Associated Viral Vectors Loaded onto Electrospun Polydioxanone Nonwoven Fabrics

Authors: Kotoko Furuno, Keiichiro Suzuki, Shinji Sakai

Source: Biomolecules, Vol 14, Iss 4, p 506 (2024)

Subject Terms: polydioxanone, electrospinning, gene delivery, genome editing, electrospun nonwoven fabrics, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-273X/14/4/506; https://doaj.org/toc/2218-273X

Access URL: https://doaj.org/article/1efe07450ab541adaa83fb7c2c8b1244

Wiskott-Aldrich syndrome protein forms nuclear condensates and regulates alternative splicing

Authors: Baolei Yuan, Xuan Zhou, Keiichiro Suzuki, Gerardo Ramos-Mandujano, Mengge Wang, Muhammad Tehseen, Lorena V. Cortés-Medina, James J. Moresco, Sarah Dunn, Reyna Hernandez-Benitez, Tomoaki Hishida, Na Young Kim, Manal M. Andijani, Chongwei Bi, Manching Ku, Yuta Takahashi, Jinna Xu, Jinsong Qiu, Ling Huang, Christopher Benner, Emi Aizawa, Jing Qu, Guang-Hui Liu, Zhongwei Li, Fei Yi, Yanal Ghosheh, Changwei Shao, Maxim Shokhirev, Patrizia Comoli, Francesco Frassoni, John R. Yates, Xiang-Dong Fu, Concepcion Rodriguez Esteban, Samir Hamdan, Mo Li, Juan Carlos Izpisua Belmonte

Source: Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/42d4032a62a14197874f6f1fa9c583d6

Establishment of mouse model of inherited PIGO deficiency and therapeutic potential of AAV-based gene therapy

Authors: Ryoko Kuwayama, Keiichiro Suzuki, Jun Nakamura, Emi Aizawa, Yoshichika Yoshioka, Masahito Ikawa, Shin Nabatame, Ken-ichi Inoue, Yoshiari Shimmyo, Keiichi Ozono, Taroh Kinoshita, Yoshiko Murakami

Source: Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/279353779621470d85a9bf09f282cfcc

miR-514a promotes neuronal development in human iPSC-derived neurons

Authors: Yuichi Akaba, Satoru Takahashi, Keiichiro Suzuki, Kenjiro Kosaki, Keita Tsujimura

Source: Frontiers in Cell and Developmental Biology, Vol 11 (2023)

Subject Terms: microRNA, miR-514a, IPSC, neuronal development, dendrite, mTOR, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2023.1096463/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/2a0ae5a9f74c4f67ba4360eb455b8550

Outcomes of Pain Management Training for the Fourth- and Fifth-Year Medical Students

Authors: Ayano Saeki, Yumiko Takao, Keiichiro Suzuki, Munetaka Hirose

Source: Pain Research and Management, Vol 2023 (2023)

Subject Terms: Medicine (General), R5-920

File Description: electronic resource

Relation: https://doaj.org/toc/1918-1523

Access URL: https://doaj.org/article/dbe5916b0e4143b0a52d3069da9e9c68

Activation of the mitogen‐activated protein kinase ERK1/2 signaling pathway suppresses the expression of ChREBPα and β in HepG2 cells

Authors: Lan Li, Haruhiko Sakiyama, Hironobu Eguchi, Daisaku Yoshihara, Noriko Fujiwara, Keiichiro Suzuki

Source: FEBS Open Bio, Vol 11, Iss 7, Pp 2008-2018 (2021)

Subject Terms: ChREBPα, ChREBPβ, ERK, oxidative stress, staurosporine, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2211-5463

Access URL: https://doaj.org/article/c1b434e9ebbc49e587ee72619e59ebee

Editorial: Developmental models 2.0

Authors: Alessandra Giorgetti, Ying Gu, Keiichiro Suzuki, Mo Li

Source: Frontiers in Cell and Developmental Biology, Vol 10 (2022)

Subject Terms: pluripotent stem cell, blastoid, organoid, regenerative medicine, 3D cell culture, single-cell “omics”, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2022.1055139/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/4fe2b190d3144fffa63b6934c88b3acb

Gelatin-Based Electrospun Fibers Insolubilized by Horseradish Peroxidase-Catalyzed Cross-Linking for Biomedical Applications

Authors: Kotoko Furuno, Jing Wang, Keiichiro Suzuki, Masaki Nakahata, Shinji Sakai

Source: ACS Omega, Vol 5, Iss 33, Pp 21254-21259 (2020)

Subject Terms: Chemistry, QD1-999

File Description: electronic resource

Relation: https://doaj.org/toc/2470-1343

Access URL: https://doaj.org/article/b335f94783904d9a90a6cedba883dcaf

Gelatin-Based Electrospun Nanofibers Cross-Linked Using Horseradish Peroxidase for Plasmid DNA Delivery

Authors: Kotoko Furuno, Keiichiro Suzuki, Shinji Sakai

Source: Biomolecules, Vol 12, Iss 11, p 1638 (2022)

Subject Terms: gene delivery system, nanofiber, electrospinning, gelatin, horseradish peroxidase, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-273X/12/11/1638; https://doaj.org/toc/2218-273X

Access URL: https://doaj.org/article/b6cdae0f2d524ba2babeef2990d1dbe8

Author Correction: Wiskott-Aldrich syndrome protein forms nuclear condensates and regulates alternative splicing

Authors: Baolei Yuan, Xuan Zhou, Keiichiro Suzuki, Gerardo Ramos-Mandujano, Mengge Wang, Muhammad Tehseen, Lorena V. Cortés-Medina, James J. Moresco, Sarah Dunn, Reyna Hernandez-Benitez, Tomoaki Hishida, Na Young Kim, Manal M. Andijani, Chongwei Bi, Manching Ku, Yuta Takahashi, Jinna Xu, Jinsong Qiu, Ling Huang, Christopher Benner, Emi Aizawa, Jing Qu, Guang-Hui Liu, Zhongwei Li, Fei Yi, Yanal Ghosheh, Changwei Shao, Maxim Shokhirev, Patrizia Comoli, Francesco Frassoni, John R. Yates, Xiang-Dong Fu, Concepcion Rodriguez Esteban, Samir Hamdan, Juan Carlos Izpisua Belmonte, Mo Li

Source: Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/fe63d9b64eec47f49dc6e724eaff5a8b

Differential stem cell aging kinetics in Hutchinson-Gilford progeria syndrome and Werner syndrome

Authors: Zeming Wu, Weiqi Zhang, Moshi Song, Wei Wang, Gang Wei, Wei Li, Jinghui Lei, Yu Huang, Yanmei Sang, Piu Chan, Chang Chen, Jing Qu, Keiichiro Suzuki, Juan Carlos Izpisua Belmonte, Guang-Hui Liu

Source: Protein & Cell, Vol 9, Iss 4, Pp 333-350 (2018)

Subject Terms: WRN, lamin, HGPS, Werner syndrome, stem cell, aging, Cytology, QH573-671, Animal biochemistry, QP501-801

File Description: electronic resource

Relation: http://link.springer.com/article/10.1007/s13238-018-0517-8; https://doaj.org/toc/1674-800X; https://doaj.org/toc/1674-8018

Access URL: https://doaj.org/article/fa5e38d6b9c94afd97abd5c6d669be4f

CRISPR-Cas9 mediated one-step disabling of pancreatogenesis in pigs

Authors: Jun Wu, Marcela Vilarino, Keiichiro Suzuki, Daiji Okamura, Yanina Soledad Bogliotti, Insung Park, Joan Rowe, Bret McNabb, Pablo Juan Ross, Juan Carlos Izpisua Belmonte

Source: Scientific Reports, Vol 7, Iss 1, Pp 1-6 (2017)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/e5179872561d480fb6dfc184638202f4

CRISPR/Cas9-mediated targeted gene correction in amyotrophic lateral sclerosis patient iPSCs

Authors: Lixia Wang, Fei Yi, Lina Fu, Jiping Yang, Si Wang, Zhaoxia Wang, Keiichiro Suzuki, Liang Sun, Xiuling Xu, Yang Yu, Jie Qiao, Juan Carlos Izpisua Belmonte, Ze Yang, Yun Yuan, Jing Qu, Guang-Hui Liu

Source: Protein & Cell, Vol 8, Iss 5, Pp 365-378 (2017)

Subject Terms: ALS, CRISPR/Cas9, gene correction, iPSC disease modeling, Cytology, QH573-671, Animal biochemistry, QP501-801

File Description: electronic resource

Relation: http://link.springer.com/article/10.1007/s13238-017-0397-3; https://doaj.org/toc/1674-800X; https://doaj.org/toc/1674-8018

Access URL: https://doaj.org/article/03c21c7236ee47a1b946381efb2f0805

Cu/Zn-superoxide dismutase forms fibrillar hydrogels in a pH-dependent manner via a water-rich extended intermediate state.

Authors: Noriko Fujiwara, Michiru Wagatsuma, Naoto Oba, Daisaku Yoshihara, Eiichi Tokuda, Haruhiko Sakiyama, Hironobu Eguchi, Motoko Ichihashi, Yoshiaki Furukawa, Tadashi Inoue, Keiichiro Suzuki

Source: PLoS ONE, Vol 13, Iss 10, p e0205090 (2018)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC6173426?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/fafd3531ad144209893b1df555792c6f

The potential role of Osteopontin in the maintenance of commensal bacteria homeostasis in the intestine.

Authors: Koyu Ito, Akira Nakajima, Yuji Fukushima, Keiichiro Suzuki, Keiko Sakamoto, Yoko Hamazaki, Kouetsu Ogasawara, Nagahiro Minato, Masakazu Hattori

Source: PLoS ONE, Vol 12, Iss 3, p e0173629 (2017)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC5351998?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/e66601b8327b45309a80dc35f81f676f

Novel Human Adenovirus Strain, Bangladesh

Authors: Yuki Matsushima, Hideaki Shimizu, Atsuko Kano, Etsuko Nakajima, Yoko Ishimaru, Shuvra Kanti Dey, Yuki Watanabe, Fuyuka Adachi, Keiichiro Suzuki, Kohnosuke Mitani, Tsuguto Fujimoto, Tung Gia Phan, Hiroshi Ushijima

Source: Emerging Infectious Diseases, Vol 18, Iss 5, Pp 846-848 (2012)

Subject Terms: Adenovirus, viruses, acute gastroenteritis, diarrhea, recombination, Bangladesh, Medicine, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: https://wwwnc.cdc.gov/eid/article/18/5/11-1584_article; https://doaj.org/toc/1080-6040; https://doaj.org/toc/1080-6059

Access URL: https://doaj.org/article/f2a0972b95944163b96c54bad9700221

Activation-induced cytidine deaminase expression in CD4+ T cells is associated with a unique IL-10-producing subset that increases with age.

Authors: Hongyan Qin, Keiichiro Suzuki, Mikiyo Nakata, Shunsuke Chikuma, Nakako Izumi, Le Thi Huong, Mikako Maruya, Sidonia Fagarasan, Meinrad Busslinger, Tasuku Honjo, Hitoshi Nagaoka

Source: PLoS ONE, Vol 6, Iss 12, p e29141 (2011)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3247255?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/21bdde7dbf1646fe8566f589a732102e