Immune modulation to treat Alzheimer’s disease

Authors: Michael R. Duggan, David G. Morgan, Brittani R. Price, Binita Rajbanshi, Alfonso Martin-Peña, Malú Gámez Tansey, Keenan A. Walker

Source: Molecular Neurodegeneration, Vol 20, Iss 1, Pp 1-17 (2025)

Subject Terms: Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6

File Description: electronic resource

Relation: https://doaj.org/toc/1750-1326

Access URL: https://doaj.org/article/7f906209c3f94f6e8f6491cefd2214b9

Proteomic analysis of APOEε4 carriers implicates lipid metabolism, complement and lymphocyte signaling in cognitive resilience

Authors: Keenan A. Walker, Yang An, Abhay Moghekar, Ruin Moaddel, Michael R. Duggan, Zhongsheng Peng, Qu Tian, Luke C. Pilling, Shannon M. Drouin, Mark A. Espeland, Stephen R Rapp, Kathleen M Hayden, Aladdin H. Shadyab, Ramon Casanova, Madhav Thambisetty, Peter R. Rapp, Dimitrios Kapogiannis, Luigi Ferrucci, Susan M. Resnick

Source: Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-18 (2024)

Subject Terms: Alzheimer’s disease, APOE, Resilience, Cognition, Proteomics, Immunity, Lipids, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6

File Description: electronic resource

Relation: https://doaj.org/toc/1750-1326

Access URL: https://doaj.org/article/ee7fd18cf0994326a5954b2b904a2e34

Clinical-transcriptional prioritization of the circulating proteome in human heart failure

Authors: Andrew S. Perry, Kaushik Amancherla, Xiaoning Huang, Michelle L. Lance, Eric Farber-Eger, Priya Gajjar, Junedh Amrute, Lindsey Stolze, Shilin Zhao, Quanhu Sheng, Cassandra M. Joynes, Zhongsheng Peng, Toshiko Tanaka, Stavros G. Drakos, Kory J. Lavine, Craig Selzman, Joseph R. Visker, Thirupura S. Shankar, Luigi Ferrucci, Saumya Das, Jane Wilcox, Ravi B. Patel, Ravi Kalhan, Sanjiv J. Shah, Keenan A. Walker, Quinn Wells, Nathan Tucker, Matthew Nayor, Ravi V. Shah, Sadiya S. Khan

Source: Cell Reports Medicine, Vol 5, Iss 9, Pp 101704- (2024)

Subject Terms: heart failure, transcriptomics, proteomics, snRNA-seq, multiomics, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666379124004257; https://doaj.org/toc/2666-3791

Access URL: https://doaj.org/article/50bde58bdf8445a68ec76dff9c7c6f72

Association between retinal microvascular abnormalities and late-life brain amyloid-β deposition: the ARIC-PET study

Authors: Marco Egle, Jennifer A. Deal, Keenan A. Walker, Dean F. Wong, A. Richey Sharrett, Rebecca F. Gottesman

Source: Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-12 (2024)

Subject Terms: Aβ burden, Alzheimer’s disease, Amyloid burden, Biomarkers, Fundus retinal photography, Microvasculature, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1758-9193

Access URL: https://doaj.org/article/919fd71fdf8a4a90864f4457f71616b9

Biomarkers of Neurodegeneration and Alzheimer’s Disease Neuropathology in Adolescents and Young Adults with Youth-Onset Type 1 or Type 2 Diabetes: A Proof-of-Concept Study

Authors: Allison L. B. Shapiro, Christina Coughlan, Brianne M. Bettcher, Meghan E. Pauley, Jeongchul Kim, Petter Bjornstad, Benjamin Rajic, Jennifer Truong, Christopher Bell, Ye Ji Choi, Keenan A. Walker, Huntington Potter, Angela D. Liese, Dana Dabelea, Christopher T. Whitlow

Source: Endocrines, Vol 5, Iss 2, Pp 197-213 (2024)

Subject Terms: youth-onset diabetes, Alzheimer’s disease, neurodegeneration, plasma biomarkers, amyloid, tau, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

File Description: electronic resource

Relation: https://www.mdpi.com/2673-396X/5/2/14; https://doaj.org/toc/2673-396X

Access URL: https://doaj.org/article/1b500686e7d74e3cb3f6f79643b1424a

Alzheimer’s and neurodegenerative disease biomarkers in blood predict brain atrophy and cognitive decline

Authors: Heather E. Dark, Yang An, Michael R. Duggan, Cassandra Joynes, Christos Davatzikos, Guray Erus, Alexandria Lewis, Abhay R. Moghekar, Susan M. Resnick, Keenan A. Walker

Source: Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-11 (2024)

Subject Terms: Plasma biomarkers, Brain atrophy, Cognitive decline, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1758-9193

Access URL: https://doaj.org/article/c023ded60de74a87a1c5dcf68511c572

Associations between genetically predicted plasma protein levels and Alzheimer’s disease risk: a study using genetic prediction models

Authors: Jingjing Zhu, Shuai Liu, Keenan A. Walker, Hua Zhong, Dalia H. Ghoneim, Zichen Zhang, Praveen Surendran, Sarah Fahle, Adam Butterworth, Md Ashad Alam, Hong-Wen Deng, Chong Wu, Lang Wu

Source: Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-16 (2024)

Subject Terms: Genetic instrument, Protein biomarker, Alzheimer’s disease, Risk, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1758-9193

Access URL: https://doaj.org/article/9809b45fd9a347d1b2f020ba0d3123a1

Identification of circulating proteins associated with general cognitive function among middle-aged and older adults

Authors: Adrienne Tin, Alison E. Fohner, Qiong Yang, Jennifer A. Brody, Gail Davies, Jie Yao, Dan Liu, Ilana Caro, Joni V. Lindbohm, Michael R. Duggan, Osorio Meirelles, Sarah E. Harris, Valborg Gudmundsdottir, Adele M. Taylor, Albert Henry, Alexa S. Beiser, Ali Shojaie, Annabell Coors, Annette L. Fitzpatrick, Claudia Langenberg, Claudia L. Satizabal, Colleen M. Sitlani, Eleanor Wheeler, Elliot M. Tucker-Drob, Jan Bressler, Josef Coresh, Joshua C. Bis, Julián Candia, Lori L. Jennings, Maik Pietzner, Mark Lathrop, Oscar L. Lopez, Paul Redmond, Robert E. Gerszten, Stephen S. Rich, Susan R. Heckbert, Thomas R. Austin, Timothy M. Hughes, Toshiko Tanaka, Valur Emilsson, Ramachandran S. Vasan, Xiuqing Guo, Yineng Zhu, Christophe Tzourio, Jerome I. Rotter, Keenan A. Walker, Luigi Ferrucci, Mika Kivimäki, Monique M. B. Breteler, Simon R. Cox, Stephanie Debette, Thomas H. Mosley, Vilmundur G. Gudnason, Lenore J. Launer, Bruce M. Psaty, Sudha Seshadri, Myriam Fornage

Source: Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2399-3642

Access URL: https://doaj.org/article/8eb6e400abed4b8eba3c10d3a6a5024b

Social relationships, amyloid burden, and dementia: The ARIC‐PET study

Authors: Renée C. Groechel, Albert C. Liu, Chelsea Liu, David S. Knopman, Silvia Koton, Anna M. Kucharska‐Newton, Pamela L. Lutsey, Thomas H. Mosley Jr., Priya Palta, A. Richey Sharrett, Keenan A. Walker, Dean F. Wong, Rebecca F. Gottesman

Source: Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 16, Iss 2, Pp n/a-n/a (2024)

Subject Terms: amyloid beta, Atherosclerosis Risk in Communities study, dementia, mid‐life, positron emission tomography, social relationships, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6

File Description: electronic resource

Relation: https://doaj.org/toc/2352-8729

Access URL: https://doaj.org/article/41e6a1bfc6ae494d96effb22bb784b87

The role of peripheral inflammatory insults in Alzheimer’s disease: a review and research roadmap

Authors: Keenan A. Walker, Lydia M. Le Page, Niccolò Terrando, Michael R. Duggan, Michael T. Heneka, Brianne M. Bettcher

Source: Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-19 (2023)

Subject Terms: Dementia, Inflammation, Neuroinflammation, Systemic inflammation, Peripheral inflammation, Infection, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6

File Description: electronic resource

Relation: https://doaj.org/toc/1750-1326

Access URL: https://doaj.org/article/e802924568ac4636b16e3e427e39b8cc

MRI and fluid biomarkers reveal determinants of myelin and axonal loss with aging

Authors: Keenan A. Walker, Michael R. Duggan, Zhaoyuan Gong, Heather E. Dark, John P. Laporte, Mary E. Faulkner, Yang An, Alexandria Lewis, Abhay R. Moghekar, Susan M. Resnick, Mustapha Bouhrara

Source: Annals of Clinical and Translational Neurology, Vol 10, Iss 3, Pp 397-407 (2023)

Subject Terms: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2328-9503

Access URL: https://doaj.org/article/481274eabc7648558c51e292b9640162

Assessment of variability in the plasma 7k SomaScan proteomics assay

Authors: Julián Candia, Gulzar N. Daya, Toshiko Tanaka, Luigi Ferrucci, Keenan A. Walker

Source: Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/c92a703bf61a4a508f40d17cadb1ebb2

Signatures and Discriminative Abilities of Multi-Omics between States of Cognitive Decline

Authors: Filippos Anagnostakis, Michail Kokkorakis, Keenan A. Walker, Christos Davatzikos

Source: Biomedicines, Vol 12, Iss 5, p 941 (2024)

Subject Terms: dementia, lipidomics, metabolomics, proteomics, predictions, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2227-9059/12/5/941; https://doaj.org/toc/2227-9059

Access URL: https://doaj.org/article/900ae8591dea471f81fb4363910f0a9f

Connecting aging biology and inflammation in the omics era

Authors: Keenan A. Walker, Nathan Basisty, David M. Wilson III, Luigi Ferrucci

Source: The Journal of Clinical Investigation, Vol 132, Iss 14 (2022)

Subject Terms: Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1558-8238

Access URL: https://doaj.org/article/ff49be569c304d4088a3814852c16391

Multidomain cognitive dysfunction after minor stroke suggests generalized disruption of cognitive networks

Authors: Elisabeth B. Marsh, Sheena Khan, Rafael H. Llinas, Keenan A. Walker, Jason Brandt

Source: Brain and Behavior, Vol 12, Iss 5, Pp n/a-n/a (2022)

Subject Terms: cognition, dementia, minor stroke, outcomes, recovery, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://doaj.org/toc/2162-3279

Access URL: https://doaj.org/article/b181d3585d7a49aea4f78a6eb8d1ada4

38 Plasma proteomic signature of motoric cognitive risk syndrome

Authors: Gabriela T. Gomez, Sanish Sathyan, Jingsha Chen, Myriam Fornage, Pascal Schlosser, Zhongsheng Peng, Jenifer Cordon, Priya Palta, Kevin J. Sullivan, Adrienne Tin, B. Gwen Windham, Rebecca F. Gottesman, Josef Coresh, Nir Barzilai, Sofiya Milman, Joe Verghese, Keenan A. Walker

Source: Journal of Clinical and Translational Science, Vol 7, Pp 10-10 (2023)

Subject Terms: Medicine

File Description: electronic resource

Relation: https://www.cambridge.org/core/product/identifier/S2059866123001310/type/journal_article; https://doaj.org/toc/2059-8661

Access URL: https://doaj.org/article/fbdc928e85a849eb9ef49be079ad8157

Brain White Matter Structure and Amyloid Deposition in Black and White Older Adults: The ARIC‐PET Study

Authors: Keenan A. Walker, Noah Silverstein, Yun Zhou, Timothy M. Hughes, Clifford R. Jack, David S. Knopman, A. Richey Sharrett, Dean F. Wong, Thomas H. Mosley, Rebecca F. Gottesman

Source: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 17 (2021)

Subject Terms: Alzheimer disease, amyloid, cerebral microbleeds, dementia, white matter disease, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://doaj.org/toc/2047-9980

Access URL: https://doaj.org/article/061ea9ad775f47268aedb011feccf55b

Association of Hypertension According to New American College of Cardiology/American Heart Association Blood Pressure Guidelines With Incident Dementia in the ARIC Study Cohort

Authors: Jeffrey D. Hodis, Rebecca F. Gottesman, B. Gwen Windham, David S. Knopman, Pamela L. Lutsey, Keenan A. Walker, Alvaro Alonso

Source: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 22 (2020)

Subject Terms: dementia, epidemiology, hypertension, population attributable fraction, practice guideline, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://doaj.org/toc/2047-9980

Access URL: https://doaj.org/article/f4e34a0efeb04d618cf7ca7e9167ecd8

Aortic Stiffness and White Matter Microstructural Integrity Assessed by Diffusion Tensor Imaging: The ARIC‐NCS

Authors: Jingkai Wei, Priya Palta, Michelle L. Meyer, Anna Kucharska‐Newton, Brian W. Pence, Allison E. Aiello, Melinda C. Power, Keenan A. Walker, A. Richey Sharrett, Hirofumi Tanaka, Clifford R. Jack, Thomas H. Mosley, Robert I. Reid, Denise A. Reyes, Gerardo Heiss

Source: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 6 (2020)

Subject Terms: aortic stiffness, diffusion tensor imaging, white matter integrity, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://doaj.org/toc/2047-9980

Access URL: https://doaj.org/article/ea018cba0f2144178a2c25394201de74

Plasma Markers of Inflammation Linked to Clinical Progression and Decline During Preclinical AD

Authors: Alden L. Gross, Keenan A. Walker, Abhay R. Moghekar, Corinne Pettigrew, Anja Soldan, Marilyn S. Albert, Jeremy D. Walston

Source: Frontiers in Aging Neuroscience, Vol 11 (2019)

Subject Terms: preclinical AD, inflammation, cytokines, cognitive decline, biomarkers, TNFR1, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fnagi.2019.00229/full; https://doaj.org/toc/1663-4365

Access URL: https://doaj.org/article/48782f6672544e428d6d590be8c029ec