Cab45G trafficking through the insulin secretory pathway is altered in human type 2 diabetes

Authors: Germanos, Mark ^{1, 7}, Yau, Belinda ^{1, 7}, Taper, Matthew ¹, Yeoman, Cara ¹, Wilson, Amy ¹, An, Yousun ¹, Cattin-Ortolá, Jerome ², Masler, Drew ³, Tong, Jason ¹, Naghiloo, Sheyda ¹, Needham, Elise J ⁴, van der Kraan, A Gabrielle ¹, Sun, Kitty ¹, Loudovaris, Thomas ⁵, Diaz-Vegas, Alexis ⁴, Larance, Mark ¹, Thomas, Helen ⁵, von Blume, Julia ⁶, Thorn, Peter ¹, Ailion, Michael ², Asensio, Cedric ³, Kebede, Melkam Alamerew ^{1, 8, ∗}

Source: In iScience 21 February 2025 28(2)

Deletion of miPEP in adipocytes protects against obesity and insulin resistance by boosting muscle metabolism

Authors: Diaz-Vegas, Alexis, Cooke, Kristen C., Cutler, Harry B., Yau, Belinda, Masson, Stewart W.C., Harney, Dylan, Fuller, Oliver K., Potter, Meg, Madsen, Søren, Craw, Niamh R., Zhang, Yiju, Moreno, Cesar L., Kebede, Melkam A., Neely, G. Gregory, Stöckli, Jacqueline, Burchfield, James G., James, David E.

Source: In Molecular Metabolism August 2024 86

What the BTBR/J mouse has taught us about diabetes and diabetic complications

Authors: Keller, Mark P., Hudkins, Kelly L., Shalev, Anath, Bhatnagar, Sushant, Kebede, Melkam A., Merrins, Matthew J., Davis, Dawn Belt, Alpers, Charles E., Kimple, Michelle E., Attie, Alan D.

Source: In iScience 21 July 2023 26(7)

β-cell function is regulated by metabolic and epigenetic programming of islet-associated macrophages, involving Axl, Mertk, and TGFβ receptor signaling

Authors: Thai, Le May ¹, O’Reilly, Liam ¹, Reibe-Pal, Saskia ¹, Sue, Nancy ¹, Holliday, Holly ¹, Small, Lewin ¹, Schmitz-Peiffer, Carsten ^{1, 2, 4}, Dhenni, Rama ¹, Wang-Wei Tsai, Vicky ³, Norris, Nicholas ⁴, Yau, Belinda ³, Zhang, Xuan ¹, Lee, Kailun ¹, Yan, Chenxu ¹, Shi, Yan-Chuan ^{1, 2}, Kebede, Melkam A. ⁴, Brink, Robert ^{1, 2}, Cooney, Gregory J. ^{1, 2, 4}, Irvine, Katharine M. ⁵, Breit, Samuel N. ^{2, 3}, Phan, Tri G. ^{1, 2}, Swarbrick, Alexander ^{1, 2}, Biden, Trevor J. ^{1, 2, 6, ∗}

Source: In iScience 21 April 2023 26(4)

Targeting the insulin granule for modulation of insulin exocytosis

Authors: Yau, Belinda, Hocking, Samantha, Andrikopoulos, Sofianos, Kebede, Melkam A

Source: In Biochemical Pharmacology December 2021 194

Proteomic pathways to metabolic disease and type 2 diabetes in the pancreatic islet

Authors: Yau, Belinda, Naghiloo, Sheyda, Diaz-Vegas, Alexis, Carr, Austin V., Van Gerwen, Julian, Needham, Elise J., Jevon, Dillon, Chen, Sing-Young, Hoehn, Kyle L., Brandon, Amanda E., Macia, Laurence, Cooney, Gregory J., Shortreed, Michael R., Smith, Lloyd M., Keller, Mark P., Thorn, Peter, Larance, Mark, James, David E., Humphrey, Sean J., Kebede, Melkam A.

Source: In iScience 22 October 2021 24(10)

FUT10 and FUT11 are protein O-fucosyltransferases that modify protein EMI domains

Authors: Hao, Huilin, Yuan, Youxi, Ito, Atsuko, Eberand, Benjamin M., Tjondro, Harry, Cielesh, Michelle, Norris, Nicholas, Moreno, Cesar L., Maxwell, Joshua W. C., Neely, G. Gregory, Payne, Richard J., Kebede, Melkam A., Urbauer, Ramona J. Bieber, Passam, Freda H., Larance, Mark, Haltiwanger, Robert S.

Source: Nature Chemical Biology; 20250101, Issue: Preprints p1-13, 13p

Enhanced structure and function of human pluripotent stem cell‐derived beta‐cells cultured on extracellular matrix

Authors: Singh, Reena, Cottle, Louise, Loudovaris, Thomas, Xiao, Di, Yang, Pengyi, Thomas, Helen E., Kebede, Melkam A., Thorn, Peter

Source: Stem cells translational medicine. 10(3):492-505

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100115939351.0x000001&indx=1&recIds=ETOCvdc_100115939351.0x000001

Structural and functional polarisation of human pancreatic beta cells in islets from organ donors with and without type 2 diabetes

Authors: Cottle, Louise, Gan, Wan Jun, Gilroy, Ian, Samra, Jaswinder S., Gill, Anthony J., Loudovaris, Thomas, Thomas, Helen E., Hawthorne, Wayne J., Kebede, Melkam A., Thorn, Peter

Source: Diabetologia. 64(3):618-629

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194180725.0x000001&indx=1&recIds=ETOCvdc_100194180725.0x000001

Optimized Proteomic Analysis of Insulin Granules From MIN6 Cells Identifies Scamp3, a Novel Regulator of Insulin Secretion and Content.

Authors: Norris, Nicholas, Yau, Belinda, Famularo, Carlo, Webster, Hayley, Loudovaris, Thomas, Thomas, Helen E., Larance, Mark, Senior, Alistair M., Kebede, Melkam A.

Source: Diabetes; 12/1/2024, Vol. 73 Issue 12, p2045-2054, 10p

Subject Terms: PEPTIDE hormones, SECRETORY granules, ISLANDS of Langerhans, INSULIN regulation, PROTEIN structure

A fluorescent timer reporter enables sorting of insulin secretory granules by age

Authors: Yau, Belinda, Hays, Lori, Liang, Cassandra, Laybutt, D. Ross, Thomas, Helen E., Gunton, Jenny E., Williams, Lindy, Hawthorne, Wayne J., Thorn, Peter, Rhodes, Christopher J., Kebede, Melkam A. ^*

Source: In Journal of Biological Chemistry 3 July 2020 295(27):8901-8911

ABHD15 regulates adipose tissue lipolysis and hepatic lipid accumulation

Authors: Stöckli, Jacqueline, Zadoorian, Armella, Cooke, Kristen C., Deshpande, Vinita, Yau, Belinda, Herrmann, Gaia, Kebede, Melkam A., Humphrey, Sean J., James, David E.

Source: In Molecular Metabolism July 2019 25:83-94

TRAIL-Expressing Monocyte/Macrophages Are Critical for Reducing Inflammation and Atherosclerosis

Authors: Cartland, Siân P., Genner, Scott W., Martínez, Gonzalo J., Robertson, Stacy, Kockx, Maaike, Lin, Ruby CY., O'Sullivan, John F., Koay, Yen Chin, Manuneedhi Cholan, Pradeep, Kebede, Melkam A., Murphy, Andrew J., Masters, Seth, Bennett, Martin R., Jessup, Wendy, Kritharides, Leonard, Geczy, Carolyn, Patel, Sanjay, Kavurma, Mary M.

Source: In iScience 22 February 2019 12:41-52

High dietary fat and sucrose result in an extensive and time-dependent deterioration in health of multiple physiological systems in mice

Alternate Title: Caloric excess and multiple health defects in mice (English)

Authors: Burchfield, James G., Kebede, Melkam A., Meoli, Christopher C., Stöckli, Jacqueline, Whitworth, P. Tess, Wright, Amanda L., Hoffman, Nolan J., Minard, Annabel Y., Ma, Xiuquan, Krycer, James R., Nelson, Marin E., Tan, Shi-Xiong, Yau, Belinda, Thomas, Kristen C., Wee, Natalie K.Y., Khor, Ee-Cheng, Enriquez, Ronaldo F., Vissel, Bryce, Biden, Trevor J., Baldock, Paul A., Hoehn, Kyle L., Cantley, James, Cooney, Gregory J., James, David E., Fazakerley, Daniel J.

Source: In Journal of Biological Chemistry 13 April 2018 293(15):5731-5745

Branched-chain amino acids impact health and lifespan indirectly via amino acid balance and appetite control

Authors: Solon-Biet, Samantha M., Cogger, Victoria C., Pulpitel, Tamara, Wahl, Devin, Clark, Ximonie, Bagley, Elena E., Gregoriou, Gabrielle C., Senior, Alistair M., Wang, Qiao-Ping, Brandon, Amanda E., Perks, Ruth, O'Sullivan, John, Koay, Yen Chin, Bell-Anderson, Kim, Kebede, Melkam, Yau, Belinda, Atkinson, Clare, Svineng, Gunbjorg, Dodgson, Tim, Wali, Jibran A., Piper, Matthew D. W., Juricic, Paula, Partridge, Linda, Rose, Adam J., Raubenheimer, David, Cooney, Gregory J., Le Couteur, David G., Simpson, Stephen J.

Source: Nature metabolism. 1(5):532-545

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100125163991.0x000001&indx=1&recIds=ETOCvdc_100125163991.0x000001

Genetics and diet shape the relationship between islet function and whole body metabolism.

Authors: Yau, Belinda, Madsen, Søren, Nelson, Marin E., Cooke, Kristen C., Fritzen, Andreas M., Thorius, Ida H., Stöckli, Jacqueline, James, David E., Kebede, Melkam A.

Source: American Journal of Physiology: Endocrinology & Metabolism; May2024, Vol. 326 Issue 5, pE663-E672, 10p

Subject Terms: HIGH-fat diet, WESTERN diet, ISLANDS, GLUCOSE metabolism, GENETICS, KETOGENIC diet, GLUCOSE intolerance

Proteomic pathways to metabolic disease and type 2 diabetes in the pancreatic islet

Authors: Yau, Belinda, Naghiloo, Sheyda, Diaz-Vegas, Alexis, Carr, Austin V., Van Gerwen, Julian, Needham, Elise J., Jevon, Dillon, Chen, Sing-Young, Hoehn, Kyle L., Brandon, Amanda E., Macia, Laurence, Cooney, Gregory J., Shortreed, Michael R., Smith, Lloyd M., Keller, Mark P., Thorn, Peter, Larance, Mark, James, David E., Humphrey, Sean J. ^∗, Kebede, Melkam A. ^∗∗

Source: In iScience 19 January 2024 27(1)

Insights into obesity and diabetes at the intersection of mouse and human genetics

Authors: Kebede, Melkam A., Attie, Alan D.

Source: In Trends in Endocrinology & Metabolism October 2014 25(10):493-501

Abstract 1767: Isolation and Proteomics of the Insulin Secretory Granule

Authors: Norris, Nicholas, Yau, Belinda, Kebede, Melkam

Source: In Journal of Biological Chemistry 2023 299(3) Supplement

Free Fatty Acid Receptor 1: A New Drug Target for Type 2 Diabetes?

Authors: Ferdaoussi, Mourad, Bergeron, Valérie, Kebede, Melkam, Mancini, Arturo, Alquier, Thierry, Poitout, Vincent

Source: In Canadian Journal of Diabetes October 2012 36(5):275-280