Microfluidics produced ATRA-loaded PLGA NPs reduced tuberculosis burden in alveolar epithelial cells and enabled high delivered dose under simulated human breathing pattern in 3D printed head models

Authors: Bahlool, Ahmad Z., Cavanagh, Brenton, Sullivan, Andrew O’, MacLoughlin, Ronan, Keane, Joseph, Sullivan, Mary P O’, Cryan, Sally-Ann

Source: In European Journal of Pharmaceutical Sciences 1 May 2024 196

All trans retinoic acid as a host-directed immunotherapy for tuberculosis

Authors: Bahlool, Ahmad Z., Grant, Conor, Cryan, Sally-Ann, Keane, Joseph, O'Sullivan, Mary P.

Source: In Current Research in Immunology 2022 3:54-72

Human airway macrophages are metabolically reprogrammed by IFN-γ resulting in glycolysis-dependent functional plasticity.

Authors: Cox, Donal J., Connolly, Sarah A., Maoldomhnaigh, Cilian Ó., Brugman, Aenea A. I., Thomas, Olivia Sandby, Duffin, Emily, Gogan, Karl M., Gallchobhair, Oisin Ó., Murphy, Dearbhla M., O'Rourke, Sinead A., O'Connell, Finbarr, Nadarajan, Parthiban, Phelan, James J., Gleeson, Laura E., Basdeo, Sharee A., Keane, Joseph

Source: eLife; 12/2/2024, p1-21, 21p

Delayed Tuberculosis Paradoxical Reaction Associated with Tumor Necrosis Factor Inhibitors.

Authors: Roche, Suzanne M., Ottewill, Ciara, Mulpeter, Rachel, Brown, Kevin, Grant, Conor, Fraughen, Daniel D., Dolan, Lorraine, Gleeson, Laura E., McLaughlin, Anne Marie, Keane, Joseph

Source: American Journal of Respiratory & Critical Care Medicine; 10/15/2024, Vol. 210 Issue 8, p1061-1065, 5p

Subject Terms: LYMPHADENITIS, IMMUNE reconstitution inflammatory syndrome, TUMOR necrosis factors, DNA methylation, SUBMANDIBULAR gland, FRONTAL lobe, TUBERCULOSIS

Chronic IFNα treatment induces leukopoiesis, increased plasma succinate and immune cell metabolic rewiring

Authors: Yennemadi, Anjali S., Jameson, Gráinne, Glass, Mary, De Pasquale, Carolina, Keane, Joseph, Bianchi, Massimiliano, Leisching, Gina

Source: Cellular immunology. 390

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194221066.0x000001&indx=1&recIds=ETOCvdc_100194221066.0x000001

Mitochondrial bioenergetic changes in systemic lupus erythematosus immune cell subsets: Contributions to pathogenesis and clinical applications.

Authors: Yennemadi, Anjali S.¹, Keane, Joseph¹, Leisching, Gina¹ gina.leisching@tcd.ie

Source: Lupus. Apr2023, Vol. 32 Issue 5, p603-611. 9p.

Subject Terms: *SYSTEMIC lupus erythematosus, *CLINICAL medicine, *MITOCHONDRIA, *MITOCHONDRIAL DNA, *AUTOIMMUNE diseases, *T cells

Mycobacterium tuberculosis Limits Host Glycolysis and IL-1β by Restriction of PFK-M via MicroRNA-21

Authors: Hackett, Emer E., Charles-Messance, Hugo, O’Leary, Seónadh M., Gleeson, Laura E., Muñoz-Wolf, Natalia, Case, Sarah, Wedderburn, Anna, Johnston, Daniel G.W., Williams, Michelle A., Smyth, Alicia, Ouimet, Mireille, Moore, Kathryn J., Lavelle, Ed C., Corr, Sinéad C., Gordon, Stephen V., Keane, Joseph, Sheedy, Frederick J.

Source: In Cell Reports 7 January 2020 30(1):124-136

Prospective observational study of respiratory Aspergillus colonization or disease in patients with various stages of chronic obstructive pulmonary disease utilizing culture versus nonculture techniques

Authors: Waqas, Sarmad, Dunne, Katie, Talento, Alida Fe, Wilson, Graham, Martin-Loeches, Ignacio, Keane, Joseph, Rogers, Thomas R

Source: Medical mycology. 59(6):557-563

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100127022770.0x000001&indx=1&recIds=ETOCvdc_100127022770.0x000001

Interferon α and β induce differential transcriptional and functional metabolic phenotypes in human macrophages and blunt glycolysis in response to antigenic stimuli.

Authors: Leisching, Gina, Yennemadi, Anjali, Gogan, Karl, Keane, Joseph

Source: European Journal of Immunology; Sep2024, Vol. 54 Issue 9, p1-9, 9p

Subject Terms: TYPE I interferons, METABOLIC reprogramming, THERAPEUTICS, OXIDATIVE phosphorylation, OXYGEN consumption

Inhalable poly(lactic-co-glycolic acid) (PLGA) microparticles encapsulating all-trans-Retinoic acid (ATRA) as a host-directed, adjunctive treatment for Mycobacterium tuberculosis infection

Authors: O'Connor, Gemma, Krishnan, Nitya, Fagan-Murphy, Aidan, Cassidy, Joseph, O'Leary, Seonadh, Robertson, Brian D., Keane, Joseph, O'Sullivan, Mary P., Cryan, Sally-Ann

Source: In European Journal of Pharmaceutics and Biopharmaceutics January 2019 134:153-165

An open electromagnetic tracking framework applied to targeted liver tumour ablation

Authors: Hinds, Stephen, Jaeger, Herman Alexander, Burke, Richard, O'Sullivan, Brodie, Keane, Joseph, Trauzettel, Fabian, Marques, Bruno, Cotin, Stéphane, Bird, Brian, Leira, Håkon Olav, Hofstad, Erlend Fagertun, Solberg, Ole Vegard, Langø, Thomas, Cantillon-Murphy, Pádraig

Source: International journal of computer assisted radiology and surgery. 14(9):1475-1484

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100124997475.0x000001&indx=1&recIds=ETOCvdc_100124997475.0x000001

Phenolic Glycolipid Facilitates Mycobacterial Escape from Microbicidal Tissue-Resident Macrophages

Authors: Cambier, C.J., O’Leary, Seónadh M., O’Sullivan, Mary P., Keane, Joseph, Ramakrishnan, Lalita

Source: In Immunity 19 September 2017 47(3):552-565

Human Natural Killer cell expression of ULBP2 is associated with a mature functional phenotype

Authors: Brennan, Kiva, McSharry, Brian P., Keating, Sinéad, Petrasca, Andreea, O’Reilly, Vincent P., Keane, Joseph, Doherty, Derek G., Gardiner, Clair M.

Source: In Human Immunology October 2016 77(10):876-885

Sharpening nature's tools for efficient tuberculosis control: A review of the potential role and development of host-directed therapies and strategies for targeted respiratory delivery

Authors: O'Connor, Gemma, Gleeson, Laura E., Fagan-Murphy, Aidan, Cryan, Sally-Ann, O'Sullivan, Mary P., Keane, Joseph

Source: In Advanced Drug Delivery Reviews 1 July 2016 102:33-54

Official American Thoracic Society/Infectious Diseases Society of America/Centers for Disease Control and Prevention Clinical Practice Guidelines: Diagnosis of Tuberculosis in Adults and Children

Authors: Lewinsohn, David M., Leonard, Michael K., LoBue, Philip A., Cohn, David L., Daley, Charles L., Desmond, Ed, Keane, Joseph, Lewinsohn, Deborah A., Loeffler, Ann M., Mazurek, Gerald H., O'Brien, Richard J., Pai, Madhukar, Richeldi, Luca, Salfinger, Max, Shinnick, Thomas M., Sterling, Timothy R., Warshauer, David M., Woods, Gail L.

Source: Clinical Infectious Diseases, 2017 Jan . 64(2), 111-115.

Access URL: https://www.jstor.org/stable/26373729

Lysosomal Disorders Drive Susceptibility to Tuberculosis by Compromising Macrophage Migration

Authors: Berg, Russell D., Levitte, Steven, O’Sullivan, Mary P., O’Leary, Seónadh M., Cambier, C.J., Cameron, James, Takaki, Kevin K., Moens, Cecilia B., Tobin, David M., Keane, Joseph, Ramakrishnan, Lalita

Source: In Cell 24 March 2016 165(1):139-152

A Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling

Authors: Ní Cheallaigh, Clíona, Sheedy, Frederick J., Harris, James, Muñoz-Wolf, Natalia, Lee, Jinhee, West, Kim, McDermott, Eva Palsson, Smyth, Alicia, Gleeson, Laura E., Coleman, Michelle, Martinez, Nuria, Hearnden, Claire H.A., Tynan, Graham A., Carroll, Elizabeth C., Jones, Sarah A., Corr, Sinéad C., Bernard, Nicholas J., Hughes, Mark M., Corcoran, Sarah E., O’Sullivan, Mary, Fallon, Ciara M., Kornfeld, Hardy, Golenbock, Douglas, Gordon, Stephen V., O’Neill, Luke A.J., Lavelle, Ed C., Keane, Joseph

Source: In Immunity 16 February 2016 44(2):368-379

The Link Between Dysregulated Immunometabolism and Vascular Damage: Implications for the Development of Atherosclerosis in Systemic Lupus Erythematosus and Other Rheumatic Diseases.

Authors: Yennemadi, Anjali S., Jordan, Natasha, Diong, Sophie, Keane, Joseph, Leisching, Gina

Source: Journal of Rheumatology; Mar2024, Vol. 51 Issue 3, p234-241, 8p

Human Macrophages Activate Bystander Neutrophils' Metabolism and Effector Functions When Challenged with Mycobacterium tuberculosis.

Authors: Murphy, Dearbhla M., Walsh, Anastasija, Stein, Laura, Petrasca, Andreea, Cox, Donal J., Brown, Kevin, Duffin, Emily, Jameson, Gráinne, Connolly, Sarah A., O'Connell, Fiona, O'Sullivan, Jacintha, Basdeo, Sharee A., Keane, Joseph, Phelan, James J.

Source: International Journal of Molecular Sciences; Mar2024, Vol. 25 Issue 5, p2898, 24p

Subject Terms: IMMUNE response, MYCOBACTERIUM tuberculosis, NEUTROPHILS, METABOLISM, MACROPHAGES

Molybdenum complexes of chiral C2-symmetric picchxn-type ligands: Synthesis, characterization, and structural studies

Authors: Bennov, Rachel R., Berko, David A., Burgess, Samantha A., DiMeglio, John L., Kalman, Steven E., Ludlum, Jeffrey M., Nash, Bradley W., Palomaki, Peter K.B., Perlow, Daniel B., Rubin, Jacob A., Saunders, Janet E., Scarselletta, Sarah V., Kastner, Margaret E., Pike, Robert D., Sabat, Michal, Keane, Joseph M.

Source: In Inorganica Chimica Acta 1 November 2015 438:64-75