Development of an OATP1-humanized transchromosomic mouse model for prediction of hepatic drug uptake in humans

Authors: Koishikawa, Tomoki ¹, Kazuki, Kanako ², Ohnishi, Rina ³, Okita, Koki ¹, Mizuno, Tadahaya ¹, Abe, Satoshi ², Nanchi, Isamu ⁴, Masago, Yusaku ⁴, Yamazaki, Kyotaro ⁵, Ohzeki, Jun-ichiro ⁵, Kusuhara, Hiroyuki ^{1, ∗}, Kazuki, Yasuhiro ^{2, 3, 5, 6, ∗}

Source: In Drug Metabolism and Disposition February 2025 53(2)

Human artificial chromosome carrying R-spondin1 and IL-22 expression cassettes in rejuvenated MSCs enhances therapeutic efficacy in ulcerative colitis model mice

Authors: Wang, Yayan ^{a, b}, Kazuki, Kanako ^b, Hichiwa, Genki ^{a, b}, Hiratsuka, Masaharu ^c, Ogihara, Ryohei ^b, Abe, Satoshi ^b, Tu, Haochen ^{a, b}, Li, Yanze ^d, Gao, Xu ^d, Oshimura, Mitsuo ^e, Tomizuka, Kazuma ^{f, ⁎}, Kazuki, Yasuhiro ^{a, b, c, g, ⁎⁎}

Source: In Biomedicine & Pharmacotherapy January 2025 182

Mice carrying the full-length human immunoglobulin loci produce antigen-specific human antibodies with the lambda light chain

Authors: Shimoya, Kazuto ¹, Moriwaki, Takashi ^{2, 3}, Kazuki, Kanako ², Okada, Akane ², Baba, Shigenori ³, Masuda, Yuana ³, Abe, Satoshi ^{2, ∗}, Kazuki, Yasuhiro ^{1, 2, 3, 4, 5, ∗∗}

Source: In iScience 20 December 2024 27(12)

Microcell-mediated chromosome transfer between non-identical human iPSCs

Authors: Uno, Narumi, Miyamoto, Hitomaru, Yamazaki, Kyotaro, Egawa, Masaya, Kobayashi, Hiroaki, Kazuki, Kanako, Osaki, Mitsuhiko, Suzuki, Teruhiko, Hamamichi, Shusei, Oshimura, Mitsuo, Tomizuka, Kazuma, Kazuki, Yasuhiro

Source: In Molecular Therapy - Nucleic Acids 10 December 2024 35(4)

Vincristine Disposition and Neurotoxicity Are Unchanged in Humanized CYP3A5 Mice

Authors: Li, Yang, Kazuki, Yasuhiro, Drabison, Thomas, Kobayashi, Kaoru, Fujita, Ken-ichi, Xu, Yue, Jin, Yan, Ahmed, Eman, Li, Junan, Eisenmann, Eric D., Baker, Sharyn D., Cavaletti, Guido, Sparreboom, Alex, Hu, Shuiying ^*

Source: In Drug Metabolism and Disposition February 2024 52(2):80-85

Neocortical neuronal production and maturation defects in the TcMAC21 mouse model of Down syndrome

Authors: Kurabayashi, Nobuhiro ^{1, 2, 3, ∗}, Fujii, Kazuki ^{1, 3}, Otobe, Yuta ^{2, 4}, Hiroki, Shingo ², Hiratsuka, Masaharu ^{5, 6}, Yoshitane, Hikari ^{2, 4}, Kazuki, Yasuhiro ^{5, 6, 7}, Takao, Keizo ^{1, 3, 8, ∗∗}

Source: In iScience 15 December 2023 26(12)

Phenotypic features of dystrophin gene knockout pigs harboring a human artificial chromosome containing the entire dystrophin gene

Authors: Watanabe, Masahito, Miyamoto, Hitomaru, Okamoto, Kazutoshi, Nakano, Kazuaki, Matsunari, Hitomi, Kazuki, Kanako, Hasegawa, Koki, Uchikura, Ayuko, Takayanagi, Shuko, Umeyama, Kazuhiro, Hiramuki, Yosuke, Kemter, Elisabeth, Klymuik, Nikolai, Kurome, Mayuko, Kessler, Barbara, Wolf, Eckhard, Kazuki, Yasuhiro, Nagashima, Hiroshi

Source: In Molecular Therapy - Nucleic Acids 12 September 2023 33:444-453

Treatment of CHO cells with Taxol and reversine improves micronucleation and microcell-mediated chromosome transfer efficiency

Authors: Uno, Narumi, Satofuka, Hiroyuki, Miyamoto, Hitomaru, Honma, Kazuhisa, Suzuki, Teruhiko, Yamazaki, Kyotaro, Ito, Ryota, Moriwaki, Takashi, Hamamichi, Shusei, Tomizuka, Kazuma, Oshimura, Mitsuo, Kazuki, Yasuhiro

Source: In Molecular Therapy - Nucleic Acids 12 September 2023 33:391-403

ncBAF enhances PXR-mediated transcriptional activation in the human and mouse liver

Authors: Kurosawa, Kiamu, Nakano, Masataka, Yokoseki, Itsuki, Nagaoka, Mai, Takemoto, Seiya, Sakai, Yoshiyuki, Kobayashi, Kaoru, Kazuki, Yasuhiro, Fukami, Tatsuki, Nakajima, Miki

Source: In Biochemical Pharmacology September 2023 215

Increased propensity for infantile spasms and altered neocortical excitation-inhibition balance in a mouse model of down syndrome carrying human chromosome 21

Authors: Shao, Li-Rong, Gao, Feng, Chinnasamy, Viveka, Kazuki, Yasuhiro, Oshimura, Mistuo, Reeves, Roger H., Stafstrom, Carl E.

Source: In Neurobiology of Disease August 2023 184

Significance of Basal Membrane Permeability of Epithelial Cells in Predicting Intestinal Drug Absorption

Authors: Yoshitomo, Aoi, Asano, Satoshi, Hozuki, Shizuka, Tamemoto, Yuta, Shibata, Yukihiro, Hashimoto, Natsumi, Takahashi, Keita, Sasaki, Yoko, Ozawa, Naoka, Kageyama, Michiharu, Iijima, Takeshi, Kazuki, Yasuhiro, Sato, Hiromi, Hisaka, Akihiro ^*

Source: In Drug Metabolism and Disposition March 2023 51(3):318-328

Metabolic Disposition of Triazolam and Clobazam in Humanized CYP3A Mice with a Double-Knockout Background of Mouse Cyp2c and Cyp3a Genes

Authors: Kobayashi, Kaoru ^*, Minegishi, Genki, Kuriyama, Nina, Miyajima, Atsushi, Abe, Satoshi, Kazuki, Kanako, Kazuki, Yasuhiro ^**

Source: In Drug Metabolism and Disposition February 2023 51(2):174-182

A transchromosomic rat model with human chromosome 21 shows robust Down syndrome features

Authors: Kazuki, Yasuhiro, Gao, Feng J., Yamakawa, Miho, Hirabayashi, Masumi, Kazuki, Kanako, Kajitani, Naoyo, Miyagawa-Tomita, Sachiko, Abe, Satoshi, Sanbo, Makoto, Hara, Hiromasa, Kuniishi, Hiroshi, Ichisaka, Satoshi, Hata, Yoshio, Koshima, Moeka, Takayama, Haruka, Takehara, Shoko, Nakayama, Yuji, Hiratsuka, Masaharu, Iida, Yuichi, Matsukura, Satoko, Noda, Naohiro, Li, Yicong, Moyer, Anna J., Cheng, Bei, Singh, Nandini, Richtsmeier, Joan T., Oshimura, Mitsuo, Reeves, Roger H.

Source: American journal of human genetics. 109(2):328-344

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100180434063.0x000001&indx=1&recIds=ETOCvdc_100180434063.0x000001

Influence of MDR1 gene polymorphism (2677G>T) on expression and function of P-glycoprotein at the blood-brain barrier: utilizing novel P-glycoprotein humanized mice with mutation

Authors: Yamasaki, Yuki, Moriwaki, Takashi, Ogata, Seiryo, Ito, Shingo, Ohtsuki, Sumio, Minegishi, Genki, Abe, Satoshi, Ohta, Yumi, Kazuki, Kanako, Kobayashi, Kaoru, Kazuki, Yasuhiro

Source: Pharmaocogenetics and genomics. 32(8):288-292

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100170829342.0x000001&indx=1&recIds=ETOCvdc_100170829342.0x000001

Structural and virological identification of neutralizing antibody footprint provides insights into therapeutic antibody design against SARS-CoV-2 variants.

Authors: Anraku, Yuki, Kita, Shunsuke, Onodera, Taishi, Sato, Akihiko, Tadokoro, Takashi, Ito, Shiori, Adachi, Yu, Kotaki, Ryutaro, Suzuki, Tateki, Sasaki, Jiei, Shiwa-Sudo, Nozomi, Iwata-Yoshikawa, Naoko, Nagata, Noriyo, Kobayashi, Souta, Kazuki, Yasuhiro, Oshimura, Mitsuo, Nomura, Takao, Sasaki, Michihito, Orba, Yasuko, Suzuki, Tadaki

Source: Communications Biology; 3/22/2025, Vol. 8 Issue 1, p1-12, 12p

Generation of Monosomy 21q Human iPS Cells by CRISPR/Cas9‐Mediated Interstitial Megabase Deletion.

Authors: Egawa, Masaya, Uno, Narumi, Komazaki, Rina, Ohkame, Yusuke, Yamazaki, Kyotaro, Yoshimatsu, Chihiro, Ishizu, Yuki, Okano, Yusaku, Miyamoto, Hitomaru, Osaki, Mitsuhiko, Suzuki, Teruhiko, Hosomichi, Kazuyoshi, Aizawa, Yasunori, Kazuki, Yasuhiro, Tomizuka, Kazuma

Source: Genes to Cells; Jan2025, Vol. 30 Issue 1, p1-14, 14p

Synthesis and evaluation of tofacitinib analogs designed to mitigate metabolic activation

Authors: Tateishi, Yasuhiro, Shibazaki, Chikako, Takahashi, Kyoko, Nakamura, Shigeo, Kazuki, Yasuhiro, Mashino, Tadahiko, Ohe, Tomoyuki

Source: In Drug Metabolism and Pharmacokinetics April 2022 43

An improved TK-NOG mouse as a novel platform for humanized liver that overcomes limitations in both male and female animals

Authors: Uehara, Shotaro, Higuchi, Yuichiro, Yoneda, Nao, Kawai, Kenji, Yamamoto, Masafumi, Kamimura, Hidetaka, Iida, Yuichi, Oshimura, Mitsuo, Kazuki, Yasuhiro, Yamazaki, Hiroshi, Hikita, Hayato, Takehara, Tetsuo, Suemizu, Hiroshi

Source: In Drug Metabolism and Pharmacokinetics February 2022 42

A SARS-CoV-2 antibody broadly neutralizes SARS-related coronaviruses and variants by coordinated recognition of a virus-vulnerable site

Authors: Onodera, Taishi, Kita, Shunsuke, Adachi, Yu, Moriyama, Saya, Sato, Akihiko, Nomura, Takao, Sakakibara, Shuhei, Inoue, Takeshi, Tadokoro, Takashi, Anraku, Yuki, Yumoto, Kohei, Tian, Cong, Fukuhara, Hideo, Sasaki, Michihito, Orba, Yasuko, Shiwa, Nozomi, Iwata, Naoko, Nagata, Noriyo, Suzuki, Tateki, Sasaki, Jiei, Sekizuka, Tsuyoshi, Tonouchi, Keisuke, Sun, Lin, Fukushi, Shuetsu, Satofuka, Hiroyuki, Kazuki, Yasuhiro, Oshimura, Mitsuo, Kurosaki, Tomohiro, Kuroda, Makoto, Matsuura, Yoshiharu, Suzuki, Tadaki, Sawa, Hirofumi, Hashiguchi, Takao, Maenaka, Katsumi, Takahashi, Yoshimasa

Source: In Immunity 12 October 2021 54(10):2385-2398

Evaluation of Parent- and Metabolite-Induced Mitochondrial Toxicities Using CYP-Introduced HepG2 cells

Authors: Takemura, Akinori, Gong, Simin, Sato, Tomoyuki, Kawaguchi, Moemi, Sekine, Shuichi, Kazuki, Yasuhiro, Horie, Toru, Ito, Kousei

Source: In Journal of Pharmaceutical Sciences September 2021 110(9):3306-3312