Genomic and phenotypic stability of fusion-driven pediatric sarcoma cell lines

Authors: Merve Kasan, Florian H. Geyer, Jana Siebenlist, Martin Sill, Rupert Öllinger, Tobias Faehling, Enrique de Álava, Didier Surdez, Uta Dirksen, Ina Oehme, Katia Scotlandi, Olivier Delattre, Martina Müller-Nurasyid, Roland Rad, Konstantin Strauch, Thomas G. P. Grünewald, Florencia Cidre-Aranaz

Source: Nature Communications, Vol 16, Iss 1, Pp 1-9 (2025)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/497e714d13fb4bfd8bdef6c539a4e9a1

Osteosarcoma and Ewing Sarcoma of Bone: An Italian Mono-Institutional Epidemiological Study

Authors: Cristina Ferrari, Giovanna Magagnoli, Roberta Laranga, Giuseppe Bianchi, Elisa Carretta, Marilena Cesari, Katia Scotlandi, Nicola Baldini, Davide Maria Donati, Marco Gambarotti

Source: Diagnostics, Vol 15, Iss 3, p 328 (2025)

Subject Terms: bone osteosarcoma, ewing sarcoma of bone, geographic pattern, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.mdpi.com/2075-4418/15/3/328; https://doaj.org/toc/2075-4418

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Evaluating Circulating Biomarkers for Diagnosis, Prognosis, and Tumor Monitoring in Pediatric Sarcomas: Recent Advances and Future Directions

Authors: Joaquín J. Maqueda, Alessandra De Feo, Katia Scotlandi

Source: Biomolecules, Vol 14, Iss 10, p 1306 (2024)

Subject Terms: liquid biopsies, pediatric sarcomas, biomarkers, diagnosis, prognosis, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-273X/14/10/1306; https://doaj.org/toc/2218-273X

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Phospholipase Cδ-4 (PLCδ4) Acts as a Nuclear Player to Influence Cyclin B Expression in the Embryonal Rhabdomyosarcoma Cell Lines RD and A204

Authors: Sara Salucci, Alberto Bavelloni, Ilaria Versari, Sabrina Burattini, Francesco Bavelloni, Pietro Gobbi, Alessandro Fanzani, Silvia Codenotti, William Blalock, Katia Scotlandi, Irene Faenza

Source: Biomolecules, Vol 14, Iss 9, p 1180 (2024)

Subject Terms: human rhabdomyosarcoma, PLCδ4, cyclin B1, Akt, immunolocalization, proteome array, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-273X/14/9/1180; https://doaj.org/toc/2218-273X

Access URL: https://doaj.org/article/3f27de51a5ce437fa12ac8451df1caf7

EHD1-dependent traffic of IGF-1 receptor to the cell surface is essential for Ewing sarcoma tumorigenesis and metastasis

Authors: Sukanya Chakraborty, Aaqib M. Bhat, Insha Mushtaq, Haitao Luan, Achyuth Kalluchi, Sameer Mirza, Matthew D. Storck, Nagendra Chaturvedi, Jose Antonio Lopez-Guerrero, Antonio Llombart-Bosch, Isidro Machado, Katia Scotlandi, Jane L. Meza, Gargi Ghosal, Donald W. Coulter, M. Jordan Rowley, Vimla Band, Bhopal C. Mohapatra, Hamid Band

Source: Communications Biology, Vol 6, Iss 1, Pp 1-21 (2023)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2399-3642

Access URL: https://doaj.org/article/09e76c7a25c7457f98d7a6fdc6e884ba

Targeting DNA Methylation Machinery in Pediatric Solid Tumors

Authors: Camilla Cristalli, Katia Scotlandi

Source: Cells, Vol 13, Iss 14, p 1209 (2024)

Subject Terms: DNA methylation, pediatric solid cancers, DNMT inhibitors, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/13/14/1209; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/ed9eb99892be4769b61f1a157ffeb672

Profilin 1 deficiency drives mitotic defects and reduces genome stability

Authors: Federica Scotto di Carlo, Sharon Russo, Francesc Muyas, Maria Mangini, Lorenza Garribba, Laura Pazzaglia, Rita Genesio, Flavia Biamonte, Anna Chiara De Luca, Stefano Santaguida, Katia Scotlandi, Isidro Cortés-Ciriano, Fernando Gianfrancesco

Source: Communications Biology, Vol 6, Iss 1, Pp 1-15 (2023)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2399-3642

Access URL: https://doaj.org/article/8609517adcae44f0a77a5dd393eabeec

Single-nucleotide polymorphism profiling by multimodal-targeted next-generation sequencing in methotrexate-resistant and -sensitive human osteosarcoma cell lines

Authors: Chiara Casotti, Claudia Maria Hattinger, Maria Pia Patrizio, Silvia Luppi, Leonardo Fantoni, Michela Pasello, Katia Scotlandi, Toni Ibrahim, Massimo Serra

Source: Frontiers in Pharmacology, Vol 14 (2023)

Subject Terms: osteosarcoma, methotrexate resistance, next-generation sequencing, single-nucleotide polymorphism, pharmacogenomics, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2023.1294873/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/8139d9c37b0e48caa53e1ce404be4871

Lamin A and the LINC complex act as potential tumor suppressors in Ewing Sarcoma

Authors: Francesca Chiarini, Francesca Paganelli, Tommaso Balestra, Cristina Capanni, Antonietta Fazio, Maria Cristina Manara, Lorena Landuzzi, Stefania Petrini, Camilla Evangelisti, Pier-Luigi Lollini, Alberto M. Martelli, Giovanna Lattanzi, Katia Scotlandi

Source: Cell Death and Disease, Vol 13, Iss 4, Pp 1-13 (2022)

Subject Terms: Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2041-4889

Access URL: https://doaj.org/article/5d5b516d43e64786927cb4086677f8b3

IL-1 Family Members in Bone Sarcomas

Authors: Lorena Landuzzi, Francesca Ruzzi, Evelin Pellegrini, Pier-Luigi Lollini, Katia Scotlandi, Maria Cristina Manara

Source: Cells, Vol 13, Iss 3, p 233 (2024)

Subject Terms: tumor microenvironment, immune escape, macrophages, cytokines, osteosarcoma, Ewing sarcoma, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/13/3/233; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/37e7102f6f0643f9abbda2d0185d716d

miR-486-5p expression is regulated by DNA methylation in osteosarcoma

Authors: Heidi M. Namløs, Magne Skårn, Deeqa Ahmed, Iwona Grad, Kim Andresen, Stine H. Kresse, Else Munthe, Massimo Serra, Katia Scotlandi, Antonio Llombart-Bosch, Ola Myklebost, Guro E. Lind, Leonardo A. Meza-Zepeda

Source: BMC Genomics, Vol 23, Iss 1, Pp 1-13 (2022)

Subject Terms: miRNA, Bone, cancer, Cell line, Epigenetic, Sarcoma, Biotechnology, TP248.13-248.65, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2164

Access URL: https://doaj.org/article/b508152fbe6b4d9db3a0cc3f2bf17690

Therapeutic vulnerability to PARP1,2 inhibition in RB1-mutant osteosarcoma

Authors: Georgia Zoumpoulidou, Carlos Alvarez-Mendoza, Caterina Mancusi, Ritika-Mahmuda Ahmed, Milly Denman, Christopher D. Steele, Maxime Tarabichi, Errin Roy, Lauren R. Davies, Jiten Manji, Camilla Cristalli, Katia Scotlandi, Nischalan Pillay, Sandra J. Strauss, Sibylle Mittnacht

Source: Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/29d2b65339524853a5548dbf68b35ca4

Polymorphic variants of IGF2BP3 and SENCR have an impact on predisposition and/or progression of Ewing sarcoma

Authors: Marcella Martinelli, Caterina Mancarella, Luca Scapoli, Annalisa Palmieri, Paola De Sanctis, Cristina Ferrari, Michela Pasello, Cinzia Zucchini, Katia Scotlandi

Source: Frontiers in Oncology, Vol 12 (2022)

Subject Terms: Ewing sarcoma, polymorphisms, IGF2BP3, SENCR, cancer predisposition, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2022.968884/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/6c93665eb071432c98f9d047c591bada

Novel Targeting of DNA Methyltransferase Activity Inhibits Ewing Sarcoma Cell Proliferation and Enhances Tumor Cell Sensitivity to DNA Damaging Drugs by Activating the DNA Damage Response

Authors: Camilla Cristalli, Maria Cristina Manara, Sergio Valente, Evelin Pellegrini, Alberto Bavelloni, Alessandra De Feo, William Blalock, Elisabetta Di Bello, David Piñeyro, Angelika Merkel, Manel Esteller, Oscar M. Tirado, Antonello Mai, Katia Scotlandi

Source: Frontiers in Endocrinology, Vol 13 (2022)

Subject Terms: ewing sarcoma, epigenetic therapies, DNA methylation, DNMT inhibitors, DNA damage, Drug synergism, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fendo.2022.876602/full; https://doaj.org/toc/1664-2392

Access URL: https://doaj.org/article/72d7fec2ed6148faa9ae41cddd9e0221

From single gene analysis to single cell profiling: a new era for precision medicine

Authors: Maria Teresa Di Martino, Stefania Meschini, Katia Scotlandi, Chiara Riganti, Enrico De Smaele, Francesca Zazzeroni, Massimo Donadelli, Carlo Leonetti, Michele Caraglia

Source: Journal of Experimental & Clinical Cancer Research, Vol 39, Iss 1, Pp 1-11 (2020)

Subject Terms: Biomarkers, Single-cell, Functional omics, Tumor profiling, Personalized therapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13046-020-01549-3; https://doaj.org/toc/1756-9966

Access URL: https://doaj.org/article/9de877396e9b457095db2f29af5d3a24

ROCK2 deprivation leads to the inhibition of tumor growth and metastatic potential in osteosarcoma cells through the modulation of YAP activity

Authors: Cinzia Zucchini, Maria Cristina Manara, Camilla Cristalli, Marianna Carrabotta, Sara Greco, Rosa Simona Pinca, Cristina Ferrari, Lorena Landuzzi, Michela Pasello, Pier-Luigi Lollini, Marco Gambarotti, Davide Maria Donati, Katia Scotlandi

Source: Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-14 (2019)

Subject Terms: Osteosarcoma, ROCK2, YAP, Verteporfin, Metastasis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-9966

Access URL: https://doaj.org/article/5cd4ab50637442cbb9538299c71ce2ac

Bone sarcoma patient-derived xenografts are faithful and stable preclinical models for molecular and therapeutic investigations

Authors: Patrizia Nanni, Lorena Landuzzi, Maria Cristina Manara, Alberto Righi, Giordano Nicoletti, Camilla Cristalli, Michela Pasello, Alessandro Parra, Marianna Carrabotta, Manuela Ferracin, Arianna Palladini, Marianna L. Ianzano, Veronica Giusti, Francesca Ruzzi, Mauro Magnani, Davide Maria Donati, Piero Picci, Pier-Luigi Lollini, Katia Scotlandi

Source: Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/520fd06572ac4ed78a2083b0e3a1fa0d

Sunitinib Exerts In Vitro Immunomodulatory Activity on Sarcomas via Dendritic Cells and Synergizes With PD-1 Blockade

Authors: Darina Ocadlikova, Mariangela Lecciso, Javier Martin Broto, Katia Scotlandi, Michele Cavo, Antonio Curti, Emanuela Palmerini

Source: Frontiers in Immunology, Vol 12 (2021)

Subject Terms: osteosarcoma, synovial sarcoma, tyrosine kinase inhibitor (TKI), nivolumab (PubChem SID: 178103907), sunitinib (PubChem CID: 5329102), immunomodulation, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2021.577766/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/f47503fa1f334b9dbe83c6daf7a0ec6b

Insulin-Like Growth Factor 2 mRNA-Binding Protein 3 Modulates Aggressiveness of Ewing Sarcoma by Regulating the CD164-CXCR4 Axis

Authors: Caterina Mancarella, Giulia Caldoni, Irene Ribolsi, Alessandro Parra, Maria Cristina Manara, Arthur M. Mercurio, Andrea Morrione, Katia Scotlandi

Source: Frontiers in Oncology, Vol 10 (2020)

Subject Terms: IGF2BP3, metastases, CD164, CXCR4, Ewing sarcoma, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fonc.2020.00994/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/8ae829f2208f4f71b10f634e0f07b997

Cell communication and signaling: how to turn bad language into positive one

Authors: Claudia Chiodoni, Maria Teresa Di Martino, Francesca Zazzeroni, Michele Caraglia, Massimo Donadelli, Stefania Meschini, Carlo Leonetti, Katia Scotlandi

Source: Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-11 (2019)

Subject Terms: microRNAs, Extracellular vesicles, Exosomes, Tumor microenvironment, Cancer therapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13046-019-1122-2; https://doaj.org/toc/1756-9966

Access URL: https://doaj.org/article/5b98510de3a9479fb1c5acdfec9f2bdb