Discovery and optimization of novel constrained pyrrolopyridone BET family inhibitors

Authors: Fidanze, Steven D., Liu, Dachun, Mantei, Robert A., Hasvold, Lisa A., Pratt, John K., Sheppard, George S., Wang, Le, Holms, James H., Dai, Yujia, Aguirre, Ana, Bogdan, Andrew, Dietrich, Justin D., Marjanovic, Jasmina, Park, Chang H., Hutchins, Charles W., Lin, Xiaoyu, Bui, Mai H., Huang, Xiaoli, Wilcox, Denise, Li, Leiming, Wang, Rongqi, Kovar, Peter, Magoc, Terrance J., Rajaraman, Ganesh, Albert, Daniel H., Shen, Yu, Kati, Warren M., McDaniel, Keith F.

Source: Bioorganic & medicinal chemistry letters. 28(10):1804-1810

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100116328499.0x000001&indx=1&recIds=ETOCvdc_100116328499.0x000001

Methylpyrrole inhibitors of BET bromodomains

Authors: Hasvold, Lisa A., Sheppard, George S., Wang, Le, Fidanze, Steven D., Liu, Dachun, Pratt, John K., Mantei, Robert A., Wada, Carol K., Hubbard, Robbert, Shen, Yu, Lin, Xiaoyu, Huang, Xiaoli, Warder, Scott E., Wilcox, Denise, Li, Leiming, Buchanan, F. Greg, Smithee, Lauren, Albert, Daniel H., Magoc, Terrance J., Park, Chang H., Petros, Andrew M., Panchal, Sanjay C., Sun, Chaohong, Kovar, Peter, Soni, Nirupama B., Elmore, Steven W., Kati, Warren M., McDaniel, Keith F.

Source: Bioorganic & medicinal chemistry letters. 27(10):2225-2233

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100053251051.0x000001&indx=1&recIds=ETOCvdc_100053251051.0x000001

Discovery of fluorobenzimidazole HCV NS5A inhibitors

Authors: Randolph, John T., Flentge, Charles A., Donner, Pamela, Rockway, Todd W., Patel, Sachin V., Nelson, Lissa, Hutchinson, Douglas K., Mondal, Rubina, Mistry, Neeta, Reisch, Thomas, Dekhtyar, Tatyana, Krishnan, Preethi, Pilot-Matias, Tami, Stolarik, Deanne F., Beno, David W.A., Wagner, Rolf, Maring, Clarence, Kati, Warren M.

Source: Bioorganic & medicinal chemistry letters. 26(22):5462-5467

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100066184005.0x000001&indx=1&recIds=ETOCvdc_100066184005.0x000001

Anti-viral compounds

Anti-viral compounds

Anti-viral compounds

Antiviral compounds and uses thereof

Antiviral compounds and uses thereof

Mechanism of Inhibition of HIV-1 Reverse Transcriptase by Nonnucleoside Inhibitors

Authors: Spence, Rebecca A., Kati, Warren M., Anderson, Karen S., Johnson, Kenneth A.

Source: Science, 1995 Feb . 267(5200), 988-993.

Access URL: https://www.jstor.org/stable/2886285

ABT-538 is a Potent Inhibitor of Human Immunodeficiency Virus Protease and has High Oral Bioavailability in Humans

Authors: Kempf, Dale J., Marsh, Kennan C., Denissen, Jon F., McDonald, Edith, Vasavanonda, Sudthida, Flentge, Charles A., Green, Brian E., Fino, Lynnmarie, Park, Chang H., Kong, Xiang-Peng, Wideburg, Norman E., Saldivar, Ayda, Ruiz, Lisa, Kati, Warren M., Sham, Hing L., Robins, Terry, Stewart, Kent D., Hsu, Ann, Plattner, Jacob J., Leonard, John M., Norbeck, Daniel W.

Source: Proceedings of the National Academy of Sciences of the United States of America, 1995 Mar . 92(7), 2484-2488.

Access URL: https://www.jstor.org/stable/2367144

Methods to measure the intracellular concentration of unlabeled compounds within cultured cells using liquid chromatography/tandem mass spectrometry

Authors: Colletti, Lynn M., Liu, Yaya, Koev, Gennadiy, Richardson, Paul L., Chen, Chih-Ming, Kati, Warren

Source: In Analytical Biochemistry 2008 383(2):186-193

Anti-viral compounds

Anti-infective agents and uses thereof

Anti-viral compounds

Anti-infective agents and uses thereof

Replication efficiency of chimeric replicon containing NS5A–5B genes derived from HCV-infected patient sera

Authors: Tripathi, Rakesh L., Krishnan, Preethi, He, Yupeng, Middleton, Tim, Pilot-Matias, Tami, Chen, Chih-Ming, Lau, Daryl T.Y., Lemon, Stanley M., Mo, Hongmei, Kati, Warren, Molla, Akhteruzzaman

Source: In Antiviral Research January 2007 73(1):40-49

A replicon-based shuttle vector system for assessing the phenotype of HCV NS5B polymerase genes isolated from patient populations

Authors: Middleton, Tim, He, Yupeng, Pilot-Matias, Tami, Tripathi, Rakesh, Lim, Ben Hock, Roth, Andrew, Chen, Chih-Ming, Koev, Gennadiy, Ng, Teresa I., Krishnan, Preethi, Pithawalla, Ron, Mondal, Rubina, Dekhtyar, Tatyana, Lu, Liangjun, Mo, Hongmei, Kati, Warren M., Molla, Akhteruzzaman

Source: In Journal of Virological Methods 2007 145(2):137-145

Longer wavelength fluorescence resonance energy transfer depsipeptide substrates for hepatitis C virus NS3 protease

Authors: Konstantinidis, Alex K., Richardson, Paul L., Kurtz, Kevin A., Tripathi, Rakesh, Chen, Chih-Ming, Huang, Peggy, Randolph, John, Towne, Danli, Donnelly, Jennifer, Warrior, Usha, Middleton, Tim, Kati, Warren M.

Source: In Analytical Biochemistry 2007 368(2):156-167

ANTI-INFECTIVE AGENTS AND USES THEREOF

Anti-Viral Compounds