AAV9-mediated MYBPC3 gene therapy with optimized expression cassette enhances cardiac function and survival in MYBPC3 cardiomyopathy models

Authors: Amara Greer-Short, Anna Greenwood, Elena C. Leon, Tawny Neal Qureshi, Konor von Kraut, Justin Wong, Jonathan H. Tsui, Christopher A. Reid, Ze Cheng, Emilee Easter, Jin Yang, Jaclyn Ho, Stephanie Steltzer, Ana Budan, Marie Cho, Rishikesan Chandrakumar, Olga Cisne-Thompson, Charles Feathers, Tae Won Chung, Neshel Rodriguez, Samantha Jones, Chris Alleyne-Levy, Jun Liu, Frank Jing, William S. Prince, JianMin Lin, Kathryn N. Ivey, Whittemore G. Tingley, Timothy Hoey, Laura M. Lombardi

Source: Nature Communications, Vol 16, Iss 1, Pp 1-18 (2025)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/ecb50ce58491405ab016a69b15a647af

AAV9:PKP2 improves heart function and survival in a Pkp2-deficient mouse model of arrhythmogenic right ventricular cardiomyopathy

Authors: Iris Wu, Aliya Zeng, Amara Greer-Short, J. Alex Aycinena, Anley E. Tefera, Reva Shenwai, Farshad Farshidfar, Melissa Van Pell, Emma Xu, Chris Reid, Neshel Rodriguez, Beatriz Lim, Tae Won Chung, Joseph Woods, Aquilla Scott, Samantha Jones, Cristina Dee-Hoskins, Carolina G. Gutierrez, Jessie Madariaga, Kevin Robinson, Yolanda Hatter, Renee Butler, Stephanie Steltzer, Jaclyn Ho, James R. Priest, Xiaomei Song, Frank Jing, Kristina Green, Kathryn N. Ivey, Timothy Hoey, Jin Yang, Zhihong Jane Yang

Source: Communications Medicine, Vol 4, Iss 1, Pp 1-19 (2024)

Subject Terms: Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2730-664X

Access URL: https://doaj.org/article/44e0349c7b784de384ccd674ac140a80

microRNA-1 regulates sarcomere formation and suppresses smooth muscle gene expression in the mammalian heart

Authors: Amy Heidersbach, Chris Saxby, Karen Carver-Moore, Yu Huang, Yen-Sin Ang, Pieter J de Jong, Kathryn N Ivey, Deepak Srivastava

Source: eLife, Vol 2 (2013)

Subject Terms: microRNA-1, cardiac, sarcomere, Telokin, Myocardin, smooth muscle gene expression, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/01323; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/7e574b2d00aa47e2b8ec607b379d5148