In Silico and In Vitro Search for Dual Inhibitors of the Trypanosoma brucei and Leishmania major Pteridine Reductase 1 and Dihydrofolate Reductase

Authors: Katharina Possart, Fabian C. Herrmann, Joachim Jose, Thomas J. Schmidt

Source: Molecules, Vol 28, Iss 22, p 7526 (2023)

Subject Terms: Trypanosoma brucei, Leishmania major, human African trypanosomiasis, cutaneous leishmaniasis, pteridine reductase 1 inhibitor, dihydrofolate reductase inhibitor, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/28/22/7526; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/cbaacb37f326440b8709319782792014

Sesquiterpene Lactones with Dual Inhibitory Activity against the Trypanosoma brucei Pteridine Reductase 1 and Dihydrofolate Reductase

Authors: Katharina Possart, Fabian C. Herrmann, Joachim Jose, Maria P. Costi, Thomas J. Schmidt

Source: Molecules, Vol 27, Iss 1, p 149 (2021)

Subject Terms: Trypanosoma brucei, human African trypanosomiasis, pteridine reductase 1 inhibitor, dihydrofolate reductase inhibitor, sesquiterpene lactones, natural products, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/27/1/149; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/26cc09c1452d4a9b83a962ed2f04d95f