ArfGAP2 promotes STING proton channel activity, cytokine transit, and autoinflammation

Authors: Poddar, Subhajit ^{1, 14}, Chauvin, Samuel D. ^{1, 14}, Archer, Christopher H. ^{2, 14}, Qian, Wei ^{3, 14}, Castillo-Badillo, Jean A. ², Yin, Xin ^{4, 5}, Disbennett, W. Miguel ¹, Miner, Cathrine A. ¹, Holley, Joe A. ¹, Naismith, Teresa V. ², Stinson, W. Alexander ³, Wei, Xiaochao ³, Ning, Yue ¹, Fu, Jiayuan ¹, Ochoa, Trini A. ¹, Surve, Nehalee ¹, Zaver, Shivam A. ¹, Wodzanowski, Kimberly A. ⁶, Balka, Katherine R. ⁷, Venkatraman, Rajan ⁷, Liu, Canyu ¹, Rome, Kelly ⁸, Bailis, Will ⁸, Shiba, Yoko ⁹, Cherry, Sara ^{10, 11}, Shin, Sunny ⁶, Semenkovich, Clay F. ³, De Nardo, Dominic ⁷, Yoh, Sunnie ⁴, Roberson, Elisha D.O. ^{3, 12}, Chanda, Sumit K. ⁴, Kast, David J. ^{2, ∗}, Miner, Jonathan J. ^{1, 3, 6, 10, 13, 15, ∗∗}

Source: In Cell 20 March 2025 188(6):1605-1622

DFCP1 is a regulator of starvation-driven ATGL-mediated lipid droplet lipolysis

Authors: Ismail, Victoria A. ^{1, ∗}, Schuetz, Meg ^{1, ∗}, Baker, Zak N. ¹, Castillo-Badillo, Jean A. ¹, Naismith, Teri V. ¹, Pagliarini, David J. ^{1, 2, 3, 4}, Kast, David J. ^{1, ∗}

Source: In Journal of Lipid Research January 2025 66(1)

Purification of modified mammalian actin isoforms for in vitro reconstitution assays

Authors: Kast, David J., Jansen, Silvia

Source: In European Journal of Cell Biology December 2023 102(4)

The Cytoskeleton–Autophagy Connection

Authors: Kast, David J., Dominguez, Roberto

Source: In Current Biology 24 April 2017 27(8):R318-R326

IST1 regulates select recycling pathways.

Authors: Clippinger, Amy K., Naismith, Teresa V., Yoo, Wonjin, Jansen, Silvia, Kast, David J., Hanson, Phyllis I.

Source: Traffic; Jan2024, Vol. 25 Issue 1, p1-20, 20p

Subject Terms: TRANSFERRIN receptors, ENDOSOMES, CELL membranes, CLATHRIN, MEMBRANE proteins, MANNOSE

Subunit Rtt102 Controls the Conformation of the Arp7/9 Heterodimer and Its Interactions with Nucleotide and the Catalytic Subunit of SWI/SNF Remodelers

Authors: Turegun, Bengi, Kast, David J., Dominguez, Roberto

Source: In Journal of Biological Chemistry 13 December 2013 288(50):35758-35768

Mechanism of IRSp53 inhibition by 14-3-3

Authors: Kast, David J., Dominguez, Roberto

Source: Nature communications. 10(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100132531353.0x000001&indx=1&recIds=ETOCvdc_100132531353.0x000001

WHAMM links actin assembly via the Arp2/3 complex to autophagy

Authors: Kast, David J, Dominguez, Roberto

Source: Autophagy. 11(9):1702-1704

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCETOCvdc_100028995499.0x000001&indx=1&recIds=ETOCETOCvdc_100028995499.0x000001

Mechanism of IRSp53 inhibition and combinatorial activation by Cdc42 and downstream effectors.

Authors: Kast, David J¹, Yang, Changsong², Disanza, Andrea³, Boczkowska, Malgorzata¹, Madasu, Yadaiah¹, Scita, Giorgio⁴, Svitkina, Tatyana², Dominguez, Roberto¹

Source: Nature Structural & Molecular Biology. Apr2014, Vol. 21 Issue 4, p413-422. 10p.

Subject Terms: *GTPASE-activating protein, *BIOCHEMICAL mechanism of action, *MICROFILAMENT proteins, *ACTIN-related proteins, *ACTIN depolymerizing factors, *PROTEIN binding, *ENZYME activation

WHAMM Directs the Arp2/3 Complex to the ER for Autophagosome Biogenesis through an Actin Comet Tail Mechanism

Authors: Kast, David J., Zajac, Allison L., Holzbaur, Erika L.F., Ostap, E. Michael, Dominguez, Roberto

Source: In Current Biology 29 June 2015 25(13):1791-1797

IRSp53 coordinates AMPK and 14-3-3 signaling to regulate filopodia dynamics and directed cell migration

Authors: Kast, David J., Dominguez, Roberto

Source: Molecular Biology of the Cell; May 2019, Vol. 30 Issue: 11 p1285-1297, 13p

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Atomic-Level Visualization of Smooth Muscle Activation by Phosphorylation of the Myosin Regulatory Light Chain

Authors: Colson, Brett A., Mauseth, Matthew A., Kast, David J., Espinoza-Fonseca, L. Michel, Roopnarine, Osha, Thomas, David D.

Source: In Biophysical Journal 28 January 2014 106(2) Supplement 1:161a-162a

A Novel Mechanism of Actin Nucleation by Rickettsia Sca2

Authors: Madasu, Yadaiah, Kast, David J., Suarez, Cristian, Cardwell, Marissa, Martinez, Juan J., Kovar, David R., Dominguez, Roberto

Source: In Biophysical Journal 29 January 2013 104(2) Supplement 1:645a-646a

Interactions of Nuclear Actin-Related Proteins with SWI/SNF Chromatin-Remodeling Complexes

Authors: Turegun, Bengi, Kast, David J., Dominguez, Roberto

Source: In Biophysical Journal 29 January 2013 104(2) Supplement 1:582a-582a

Structural and Functional Bases for the Regulation of IRSp53 by Cdc42

Authors: Kast, David J., Madasu, Yadaiah, Yang, Changsong, Boczkowska, Malgorzata, Svitkina, Tatyana, Dominguez, Roberto

Source: In Biophysical Journal 29 January 2013 104(2) Supplement 1:139a-139a

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