Selective targeting of chemically modified miR-34a to prostate cancer using a small molecule ligand and an endosomal escape agent

Authors: Abdelaal, Ahmed M., Sohal, Ikjot S., Iyer, Shreyas G., Sudarshan, Kasireddy, Orellana, Esteban A., Ozcan, Kenan E., dos Santos, Andrea P., Low, Philip S., Kasinski, Andrea L.

Source: In Molecular Therapy - Nucleic Acids 11 June 2024 35(2)

MicroRNA Biomarkers in Canine Diffuse Large B-Cell Lymphoma

Authors: Elshafie, Nelly O., do Nascimento, Naila C., Lichti, Nathanael I., Kasinski, Andrea L., Childress, Michael O., dos Santos, Andrea P.

Source: Veterinary pathology. 58(1):34-41

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN625991503&indx=1&recIds=ETOCRN625991503

InVivo Cancer-Based Functional Genomics

Authors: Li, Chennan, Kasinski, Andrea L.

Source: In Trends in Cancer December 2020 6(12):1002-1017

Enhancing MicroRNA Activity through Increased Endosomal Release Mediated by Nigericin

Authors: Orellana, Esteban A., Abdelaal, Ahmed M., Rangasamy, Loganathan, Tenneti, Srinivasarao, Myoung, Sunghyun, Low, Philip S., Kasinski, Andrea L.

Source: In Molecular Therapy - Nucleic Acids 7 June 2019 16:505-518

MicroRNA-223 Suppresses the Canonical NF-κB Pathway in Basal Keratinocytes to Dampen Neutrophilic Inflammation

Authors: Zhou, Wenqing, Pal, Arpita S., Hsu, Alan Yi-Hui, Gurol, Theodore, Zhu, Xiaoguang, Wirbisky-Hershberger, Sara E., Freeman, Jennifer L., Kasinski, Andrea L., Deng, Qing

Source: In Cell Reports 13 February 2018 22(7):1810-1823

Identification and validation of microRNAs that synergize with miR-34a – a basis for combinatorial microRNA therapeutics

Authors: Orellana, Esteban A., Li, Chennan, Lisevick, Alexa, Kasinski, Andrea L.

Source: Cell cycle. 18(15):1798-1811

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100084617981.0x000001&indx=1&recIds=ETOCvdc_100084617981.0x000001

New Mechanism for Release of Endosomal Contents: Osmotic Lysis via Nigericin-Mediated K+/H+ Exchange

Authors: Rangasamy, Loganathan, Chelvam, Venkatesh, Kanduluru, Ananda Kumar, Srinivasarao, Madduri, Bandara, N. Achini, You, Fei, Orellana, Esteban A., Kasinski, Andrea L., Low, Philip S.

Source: Bioconjugate chemistry. 29(4):1047-1059

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Developing Folate-Conjugated miR-34a Therapeutic for Prostate Cancer: Challenges and Promises.

Authors: Li, Wen, Wang, Yunfei, Liu, Xiaozhuo, Wu, Shan, Wang, Moyi, Turowski, Steven G., Spernyak, Joseph A., Tracz, Amanda, Abdelaal, Ahmed M., Sudarshan, Kasireddy, Puzanov, Igor, Chatta, Gurkamal, Kasinski, Andrea L., Tang, Dean G.

Source: International Journal of Molecular Sciences; Feb2024, Vol. 25 Issue 4, p2123, 19p

Subject Terms: ANDROGEN receptors, PROSTATE cancer, CANCER stem cells, LUNG cancer, CANCER cells, DRUG resistance, T cells

Animal Models to Study MicroRNA Function

Authors: Pal, Arpita S., Kasinski, Andrea L.

Source: Advances in cancer research. 135:53-118

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN615100430&indx=1&recIds=ETOCRN615100430

Aberrant Regulation and Function of MicroRNAs in Cancer

Authors: Adams, Brian D., Kasinski, Andrea L., Slack, Frank J.

Source: In Current Biology 18 August 2014 24(16):R762-R776

Histone 4 lysine 20 tri-methylation: a key epigenetic regulator in chromatin structure and disease.

Authors: Agredo, Alejandra, Kasinski, Andrea L.

Source: Frontiers in Genetics; 2023, p1-16, 16p

Subject Terms: CHROMATIN, EPIGENETICS, HISTONES, LYSINE, GENE expression, POST-translational modification, EPIGENOMICS

Emerging diversity in extracellular vesicles and their roles in cancer.

Authors: Sohal, Ikjot S., Kasinski, Andrea L.

Source: Frontiers in Oncology; 2023, p1-21, 21p

Subject Terms: EXTRACELLULAR vesicles, EXTRACELLULAR matrix, CANCER invasiveness, IMMUNOREGULATION, TUMOR classification

A first-in-class fully modified version of miR-34a with outstanding stability, activity, and anti-tumor efficacy

Authors: Abdelaal, Ahmed M., Sohal, Ikjot S., Iyer, Shreyas, Sudarshan, Kasireddy, Kothandaraman, Harish, Lanman, Nadia A., Low, Philip S., Kasinski, Andrea L.

Source: Oncogene; September 2023, Vol. 42 Issue: 40 p2985-2999, 15p

Inhibition of IκB Kinase-Nuclear Factor-κB Signaling Pathway by 3,5-Bis(2-flurobenzylidene)piperidin-4-one (EF24), a Novel Monoketone Analog of Curcumin

Authors: Kasinski, Andrea L., Du, Yuhong, Thomas, Shala L., Zhao, Jing, Sun, Shi-Yong, Khuri, Fadlo R., Wang, Cun-Yu, Shoji, Mamoru, Sun, Aiming, Snyder, James P., Liotta, Dennis, Fu, Haian ^*

Source: In Molecular Pharmacology September 2008 74(3):654-661

Extracellular vesicles released by non-small cell lung cancer cells drive invasion and permeability in non-tumorigenic lung epithelial cells.

Authors: Hasan, Humna, Sohal, Ikjot Singh, Soto-Vargas, Zulaida, Byappanahalli, Anjali M., Humphrey, Sean E., Kubo, Hana, Kitdumrongthum, Sarunya, Copeland, Sarah, Tian, Feng, Chairoungdua, Arthit, Kasinski, Andrea L.

Source: Scientific Reports; 2/14/2022, Vol. 12 Issue 1, p1-18, 18p

Subject Terms: NON-small-cell lung carcinoma, EXTRACELLULAR vesicles, EPITHELIAL cells, PERMEABILITY

MicroRNAs in Cancer: A Historical Perspective on the Path from Discovery to Therapy.

Authors: Orellana, Esteban A.^1,2, Kasinski, Andrea L.¹ akasinski@purdue.edu

Source: Cancers. 2015, Vol. 7 Issue 3, p1388-1405. 18p.

Ligand-mediated delivery of RNAi-based therapeutics for the treatment of oncological diseases.

Authors: Abdelaal, Ahmed M., Kasinski, Andrea L.

Source: NAR Cancer; Sep2021, Vol. 3 Issue 3, p1-23, 23p

RNA-guided CRISPR-Cas technologies for genome-scale investigation of disease processes.

Authors: Humphrey, Sean E.¹, Kasinski, Andrea L.¹ akasinski@purdue.edu

Source: Journal of Hematology & Oncology. 2015, Vol. 8 Issue 1, p1-9. 9p.

Subject Terms: *CRISPRS, *IMMUNE system, *GENOME editing, *MEDICAL genetics, *RNA, *GENETIC research

Chapter Three - Animal Models to Study MicroRNA Function

Authors: Pal, Arpita S. ^*, Kasinski, Andrea L.

Source: In Advances in Cancer Research 2017 135:53-118

Arresting the Culprit: Targeted Antagomir Delivery to Sequester Oncogenic miR-221 in HCC

Authors: Kasinski, Andrea L, Slack, Frank J

Source: Molecular therapy.Nucleic acids. 1(C)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100059200497.0x000001&indx=1&recIds=ETOCvdc_100059200497.0x000001