A critical role for HNF4α in polymicrobial sepsis-associated metabolic reprogramming and death

Authors: Céline Van Dender, Steven Timmermans, Ville Paakinaho, Tineke Vanderhaeghen, Jolien Vandewalle, Maarten Claes, Bruno Garcia, Bart Roman, Jan De Waele, Siska Croubels, Karolien De Bosscher, Philip Meuleman, Antoine Herpain, Jorma J Palvimo, Claude Libert

Source: EMBO Molecular Medicine, Vol 16, Iss 10, Pp 2485-2515 (2024)

Subject Terms: Acute Phase Response Failure, HNF4α Dysfunction, Liver, PPARα-mediated Lipid Dysfunction, Sepsis, Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1757-4684

Access URL: https://doaj.org/article/a06f4ebf50eb4404b264053ba4838ecb

Leveraging a self-cleaving peptide for tailored control in proximity labeling proteomics

Authors: Louis Delhaye, George D. Moschonas, Daria Fijalkowska, Annick Verhee, Delphine De Sutter, Tessa Van de Steene, Margaux De Meyer, Hanna Grzesik, Laura Van Moortel, Karolien De Bosscher, Thomas Jacobs, Sven Eyckerman

Source: Cell Reports: Methods, Vol 4, Iss 7, Pp 100818- (2024)

Subject Terms: CP: Biotechnology, Biotechnology, TP248.13-248.65, Biochemistry, QD415-436, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2667237524001838; https://doaj.org/toc/2667-2375

Access URL: https://doaj.org/article/23617f47cc47455eb8fa9874ec8082a9

Crosstalk interactions between transcription factors ERRα and PPARα assist PPARα-mediated gene expression

Authors: Sofie J. Desmet, Jonathan Thommis, Tineke Vanderhaeghen, Edmee M.F. Vandenboorn, Dorien Clarisse, Yunkun Li, Steven Timmermans, Daria Fijalkowska, Dariusz Ratman, Evelien Van Hamme, Lode De Cauwer, Bart Staels, Luc Brunsveld, Frank Peelman, Claude Libert, Jan Tavernier, Karolien De Bosscher

Source: Molecular Metabolism, Vol 84, Iss , Pp 101938- (2024)

Subject Terms: Nuclear receptor, Nuclear receptor crosstalk, PPARα, ERRα, Protein–protein interaction, PGC1α, Internal medicine, RC31-1245

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2212877824000693; https://doaj.org/toc/2212-8778

Access URL: https://doaj.org/article/1e23832839bc4f67a6376a644117993b

Zinc inhibits lethal inflammatory shock by preventing microbe‐induced interferon signature in intestinal epithelium

Authors: Jolien Souffriau, Steven Timmermans, Tineke Vanderhaeghen, Charlotte Wallaeys, Kelly Van Looveren, Lindsy Aelbrecht, Sylviane Dewaele, Jolien Vandewalle, Evy Goossens, Serge Verbanck, Filip Boyen, Melanie Eggermont, Lindsey De Commer, Riet De Rycke, Michiel De Bruyne, Raul Tito, Marlies Ballegeer, Sofie Vandevyver, Tiago Velho, Luis Ferreira Moita, Tino Hochepied, Karolien De Bosscher, Jeroen Raes, Filip Van Immerseel, Rudi Beyaert, Claude Libert

Source: EMBO Molecular Medicine, Vol 12, Iss 10, Pp 1-21 (2020)

Subject Terms: genetics, inflammation, microbiota, nutrient, regulation, Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1757-4676; https://doaj.org/toc/1757-4684

Access URL: https://doaj.org/article/3e993b5bbeaf4e78b2bc46c529806814

The Biologist’s Guide to the Glucocorticoid Receptor’s Structure

Authors: Nick Deploey, Laura Van Moortel, Inez Rogatsky, Frank Peelman, Karolien De Bosscher

Source: Cells, Vol 12, Iss 12, p 1636 (2023)

Subject Terms: glucocorticoid receptor, glucocorticoids, structure, nuclear receptor, N-terminal domain, DNA-binding domain, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/12/12/1636; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/84adc5f436cf4ec88cb1374d76b39a4e

How the glucocorticoid receptor contributes to platinum-based therapy resistance in solid cancer

Authors: Dorien Clarisse, Karolien De Bosscher

Source: Nature Communications, Vol 12, Iss 1, Pp 1-3 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/654e0ecf4dbe442bb12413eb1bce88ce

Carboxylic Acid Bioisosteres in Medicinal Chemistry: Synthesis and Properties

Authors: Kato Bredael, Silke Geurs, Dorien Clarisse, Karolien De Bosscher, Matthias D’hooghe

Source: Journal of Chemistry, Vol 2022 (2022)

Subject Terms: Chemistry, QD1-999

File Description: electronic resource

Relation: https://doaj.org/toc/2090-9071

Access URL: https://doaj.org/article/eb869c0ebaac4e67ad6db4ac4c90d702

ZBTB32 performs crosstalk with the glucocorticoid receptor and is crucial in glucocorticoid responses to starvation

Authors: Lise Van Wyngene, Tineke Vanderhaeghen, Ioanna Petta, Steven Timmermans, Katrien Corbeels, Bart Van der Schueren, Jolien Vandewalle, Kelly Van Looveren, Charlotte Wallaeys, Melanie Eggermont, Sylviane Dewaele, Leen Catrysse, Geert van Loo, Rudi Beyaert, Roman Vangoitsenhoven, Toshinori Nakayama, Jan Tavernier, Karolien De Bosscher, Claude Libert

Source: iScience, Vol 24, Iss 7, Pp 102790- (2021)

Subject Terms: biological sciences, physiology, animal physiology, Endocrinology, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004221007586; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/3a3b104cdfd748ce878d5705d4550412

Improved Glucocorticoid Receptor Ligands: Fantastic Beasts, but How to Find Them?

Authors: Laura Van Moortel, Kris Gevaert, Karolien De Bosscher

Source: Frontiers in Endocrinology, Vol 11 (2020)

Subject Terms: glucocorticoids, glucocorticoid receptor, selective GR modulators, drug discovery, inflammation, assay development, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fendo.2020.559673/full; https://doaj.org/toc/1664-2392

Access URL: https://doaj.org/article/d92d8d0d83364516aca362c67a4de3b9

Adrenal hormones mediate disease tolerance in malaria

Authors: Leen Vandermosten, Thao-Thy Pham, Sofie Knoops, Charlotte De Geest, Natacha Lays, Kristof Van der Molen, Christopher J. Kenyon, Manu Verma, Karen E. Chapman, Frans Schuit, Karolien De Bosscher, Ghislain Opdenakker, Philippe E. Van den Steen

Source: Nature Communications, Vol 9, Iss 1, Pp 1-18 (2018)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/4a46f7525e7d4cd28340e26b10d771de

Glucocorticoid Receptor-mediated transactivation is hampered by Striatin-3, a novel interaction partner of the receptor

Authors: Ioanna Petta, Nadia Bougarne, Jolien Vandewalle, Lien Dejager, Sofie Vandevyver, Marlies Ballegeer, Sofie Desmet, Jonathan Thommis, Lode De Cauwer, Sam Lievens, Claude Libert, Jan Tavernier, Karolien De Bosscher

Source: Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/77db01aba2e84ce3beeed9e7bccc5c85

Interleukin-17 receptor A (IL-17RA) as a central regulator of the protective immune response against Giardia

Authors: Oonagh Paerewijck, Brecht Maertens, Leentje Dreesen, Frederik Van Meulder, Iris Peelaers, Dariusz Ratman, Robert W. Li, Erik Lubberts, Karolien De Bosscher, Peter Geldhof

Source: Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/ec19a01cba2d4ea98f63a20818ac59a8

Mechanisms Underlying the Functional Cooperation Between PPARα and GRα to Attenuate Inflammatory Responses

Authors: Nadia Bougarne, Viacheslav Mylka, Dariusz Ratman, Ilse M. Beck, Jonathan Thommis, Lode De Cauwer, Jan Tavernier, Bart Staels, Claude Libert, Karolien De Bosscher

Source: Frontiers in Immunology, Vol 10 (2019)

Subject Terms: PPARα, GRα, crosstalk, molecular mechanism, inflammation, MSK1, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fimmu.2019.01769/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/b4797e86643448b58cc92f2a7121f594

Effect of combining glucocorticoids with Compound A on glucocorticoid receptor responsiveness in lymphoid malignancies.

Authors: Dorien Clarisse, Karlien Van Wesemael, Jan Tavernier, Fritz Offner, Ilse M Beck, Karolien De Bosscher

Source: PLoS ONE, Vol 13, Iss 5, p e0197000 (2018)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC5940183?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/324635f5e56c4638ba365ff33716d759

Selective Glucocorticoid Receptor Properties of GSK866 Analogs with Cysteine Reactive Warheads

Authors: Chandra S. Chirumamilla, Ajay Palagani, Balu Kamaraj, Ken Declerck, Marinus W. C. Verbeek, Ryabtsova Oksana, Karolien De Bosscher, Nadia Bougarne, Bart Ruttens, Kris Gevaert, René Houtman, Winnok H. De Vos, Jurgen Joossens, Pieter Van Der Veken, Koen Augustyns, Xaveer Van Ostade, Annemie Bogaerts, Hans De Winter, Wim Vanden Berghe

Source: Frontiers in Immunology, Vol 8 (2017)

Subject Terms: glucocorticoid receptor, SEGRA, NFkB, electrophilic, covalent warhead, cysteine, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: http://journal.frontiersin.org/article/10.3389/fimmu.2017.01324/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/f904b8d98f0241f082ac224164430591

Plasmodium berghei NK65 in Combination with IFN-γ Induces Endothelial Glucocorticoid Resistance via Sustained Activation of p38 and JNK

Authors: Karolina A. Zielińska, Lode de Cauwer, Sofie Knoops, Kristof Van der Molen, Alexander Sneyers, Jonathan Thommis, J. Brian De Souza, Ghislain Opdenakker, Karolien De Bosscher, Philippe E. Van den Steen

Source: Frontiers in Immunology, Vol 8 (2017)

Subject Terms: malaria, glucocorticoids, endothelium, MAPK, interferon-γ, dexamethasone, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: http://journal.frontiersin.org/article/10.3389/fimmu.2017.01199/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/104868bcbf6d4a04bce0e710cbc344be

The nature of the GRE influences the screening for GR-activity enhancing modulators.

Authors: Karen Dendoncker, Steven Timmermans, Kelly Van Looveren, Lode De Cauwer, Karolien De Bosscher, Claude Libert

Source: PLoS ONE, Vol 12, Iss 7, p e0181101 (2017)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC5501670?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/16b6b5460f4a49a090882cad264c261c

Endothelial response to glucocorticoids in inflammatory diseases

Authors: Karolina A Zielinska, Laura Van Moortel, Ghislain Opdenakker, Karolien De Bosscher, Philippe E Van Den Steen

Source: Frontiers in Immunology, Vol 7 (2016)

Subject Terms: Cytokines, Endothelium, Glucocorticoids, Inflammation, Tight Junctions, Adhesion molecules, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00592/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/7de96e15fdf3402aa02bbb81d7cd891c

Differential cytokine profiles upon comparing selective versus classic glucocorticoid receptor modulation in human peripheral blood mononuclear cells and inferior turbinate tissue.

Authors: Ilse M Beck, Koen Van Crombruggen, Gabriele Holtappels, François Daubeuf, Nelly Frossard, Claus Bachert, Karolien De Bosscher

Source: PLoS ONE, Vol 10, Iss 4, p e0123068 (2015)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC4395417?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/724fcfb63e25415990de787bf7b23af8

Pharmacological levels of Withaferin A (Withania somnifera) trigger clinically relevant anticancer effects specific to triple negative breast cancer cells.

Authors: Katarzyna Szarc vel Szic, Ken Op de Beeck, Dariusz Ratman, An Wouters, Ilse M Beck, Ken Declerck, Karen Heyninck, Erik Fransen, Marc Bracke, Karolien De Bosscher, Filip Lardon, Guy Van Camp, Wim Vanden Berghe

Source: PLoS ONE, Vol 9, Iss 2, p e87850 (2014)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3912072?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/606a1d5280a2482984e244e0f871c4dd