1025 Tumor-specific CD8+ T cells epigenetically licensed by IL-7R are critical for anti-tumor immunity in melanoma

Authors: Harriet Kluger, Nikhil Joshi, Marcus Bosenberg, Lilach Aizenbud, Noah Hornick, Esen Sefik, Goran Micevic, Andrew Daniels, Karine Flem-Karlsen, Koonam Park, Ronan Talty, Meaghan McGeary, Haris Mirza, Holly N Blackburn, Julie F Cheung, Akiko Iwasaki, Richard Flavell

Source: Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/18f6bffe16e3475ea18d151820853ec1

Progress and challenges for the machine learning-based design of fit-for-purpose monoclonal antibodies

Authors: Rahmad Akbar, Habib Bashour, Puneet Rawat, Philippe A. Robert, Eva Smorodina, Tudor-Stefan Cotet, Karine Flem-Karlsen, Robert Frank, Brij Bhushan Mehta, Mai Ha Vu, Talip Zengin, Jose Gutierrez-Marcos, Fridtjof Lund-Johansen, Jan Terje Andersen, Victor Greiff

Source: mAbs, Vol 14, Iss 1 (2022)

Subject Terms: Machine learning, artificial intelligence, antibody, antigen, developability, drug design, Therapeutics. Pharmacology, RM1-950, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://doaj.org/toc/1942-0862; https://doaj.org/toc/1942-0870

Access URL: https://doaj.org/article/aa3c08b3fb154e0dafa6136e2d38c0d4

Heterogeneous Expression and Subcellular Localization of Pyruvate Dehydrogenase Complex in Prostate Cancer

Authors: Caroline E. Nunes-Xavier, Janire Mingo, Maite Emaldi, Karine Flem-Karlsen, Gunhild M. Mælandsmo, Øystein Fodstad, Roberto Llarena, José I. López, Rafael Pulido

Source: Frontiers in Oncology, Vol 12 (2022)

Subject Terms: prostate cancer (PCa), pyruvate dehydrogenase (PDH), pyruvate dehydrogenase kinase (PDK), androgen receptor (AR), dichloroacetate (DCA), Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2022.873516/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/060cb01a32194d9ab44dea2f0e95b000

Antibody variable sequences have a pronounced effect on cellular transport and plasma half-life

Authors: Algirdas Grevys, Rahel Frick, Simone Mester, Karine Flem-Karlsen, Jeannette Nilsen, Stian Foss, Kine Marita Knudsen Sand, Thomas Emrich, Jens Andre Alexander Fischer, Victor Greiff, Inger Sandlie, Tilman Schlothauer, Jan Terje Andersen

Source: iScience, Vol 25, Iss 2, Pp 103746- (2022)

Subject Terms: Biological sciences, Immunology, Biophysics, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004222000165; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/af03cd0842d240c99a1d1d9176bb39cf

A Three-dimensional Ex Vivo Viability Assay Reveals a Strong Correlation Between Response to Targeted Inhibitors and Mutation Status in Melanoma Lymph Node Metastases

Authors: Vivi Ann Flørenes, Karine Flem-Karlsen, Erin McFadden, Inger Riise Bergheim, Vigdis Nygaard, Vegard Nygård, Inger Nina Farstad, Geir Frode Øy, Elisabeth Emilsen, Karianne Giller-Fleten, Anne Hansen Ree, Kjersti Flatmark, Hans Petter Gullestad, Robert Hermann, Truls Ryder, Patrik Wernhoff, Gunhild Mari Mælandsmo

Source: Translational Oncology, Vol 12, Iss 7, Pp 951-958 (2019)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1936523318306144; https://doaj.org/toc/1936-5233

Access URL: https://doaj.org/article/5e33a627a4a3411eb74675f0d94b0c59

Soluble AXL as a marker of disease progression and survival in melanoma.

Authors: Karine Flem-Karlsen, Marta Nyakas, Inger Nina Farstad, Erin McFadden, Patrik Wernhoff, Kari Dolven Jacobsen, Vivi Ann Flørenes, Gunhild Mari Mælandsmo

Source: PLoS ONE, Vol 15, Iss 1, p e0227187 (2020)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/6d25b75e3c324aac915021869a7e4931