Where Do Plasma Biomarkers fit in With Current Alzheimer's Disease Detection?

Authors: Gildengers, Ariel ^{a, ⁎}, Weinstein, Andrea M. ^a, Gujral, Swathi ^a, Zeng, Xuemei ^a, Diaz, Jihui L. ^a, Lafferty, Tara K. ^a, Cowie, Matthew ^a, Emanuel, James E. ^a, Lopez, Oscar ^b, Royse, Sarah K. ^c, Lopresti, Brian ^c, Karikari, Thomas K. ^a

Source: In The American Journal of Geriatric Psychiatry April 2025 33(4):428-437

Proteome-wide analysis identifies plasma immune regulators of amyloid-beta progression

Authors: Duggan, Michael R., Gomez, Gabriela T., Joynes, Cassandra M., Bilgel, Murat, Chen, Jingsha, Fattorelli, Nicola, Hohman, Timothy J., Mancuso, Renzo, Cordon, Jenifer, Castellano, Tonnar, Koran, Mary Ellen I., Candia, Julián, Lewis, Alexandria, Moghekar, Abhay, Ashton, Nicholas J., Kac, Przemysław R., Karikari, Thomas K., Blennow, Kaj, Zetterberg, Henrik, Martinez-Muriana, Anna, De Strooper, Bart, Thambisetty, Madhav, Ferrucci, Luigi, Gottesman, Rebecca F., Coresh, Josef, Resnick, Susan M., Walker, Keenan A.

Source: In Brain Behavior and Immunity August 2024 120:604-619

Vascular risk burden is a key player in the early progression of Alzheimer’s disease

Authors: Ferrari-Souza, João Pedro, Brum, Wagner S., Hauschild, Lucas A., Da Ros, Lucas U., Ferreira, Pâmela C.L., Bellaver, Bruna, Leffa, Douglas T., Bieger, Andrei, Tissot, Cécile, Lussier, Firoza Z., De Bastiani, Marco Antônio, Povala, Guilherme, Benedet, Andréa L., Therriault, Joseph, Wang, Yi-Ting, Ashton, Nicholas J., Zetterberg, Henrik, Blennow, Kaj, Martins, Sheila O., Souza, Diogo O., Rosa-Neto, Pedro, Karikari, Thomas K., Pascoal, Tharick A., Zimmer, Eduardo R.

Source: In Neurobiology of Aging April 2024 136:88-98

Plasma p‐tau231 and p‐tau217 inform on tau tangles aggregation in cognitively impaired individuals

Authors: Ferreira, Pamela C. L., Therriault, Joseph, Tissot, Cécile, Ferrari‐Souza, João Pedro, Benedet, Andréa L., Povala, Guilherme, Bellaver, Bruna, Leffa, Douglas T., Brum, Wagner S., Lussier, Firoza Z., Bezgin, Gleb, Servaes, Stijn, Vermeiren, Marie, Macedo, Arthur C., Cabrera, Arlec, Stevenson, Jenna, Triana‐Baltzer, Gallen, Kolb, Hartmuth, Rahmouni, Nesrine, Klunk, William E., Lopez, Oscar L., Villemagne, Victor L., Cohen, Ann, Tudorascu, Dana L., Zimmer, Eduardo R., Karikari, Thomas K., Ashton, Nicholas J., Zetterberg, Henrik, Blennow, Kaj, Gauthier, Serge, Rosa‐Neto, Pedro, Pascoal, Tharick A.

Source: Alzheimer's & dementia. 19(10):4463-4474

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100195333484.0x000001&indx=1&recIds=ETOCvdc_100195333484.0x000001

Preanalytical stability of plasma/serum brain‐derived tau

Authors: Gonzalez‐Ortiz, Fernando, Dias, Alexandre, Turton, Michael, Magalhães, Rui, Kac, Przemysław R., Correia, Manuel, Harrison, Peter, Zetterberg, Henrik, Maia, Luís F., Blennow, Kaj, Karikari, Thomas K.

Source: Alzheimer's & dementia. 19(10):4764-4770

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100195333427.0x000001&indx=1&recIds=ETOCvdc_100195333427.0x000001

Longitudinal changes in Alzheimer's‐related plasma biomarkers and brain amyloid

Authors: Bilgel, Murat, An, Yang, Walker, Keenan A., Moghekar, Abhay R., Ashton, Nicholas J., Kac, Przemysław R., Karikari, Thomas K., Blennow, Kaj, Zetterberg, Henrik, Jedynak, Bruno M., Thambisetty, Madhav, Ferrucci, Luigi, Resnick, Susan M.

Source: Alzheimer's & dementia. 19(10):4335-4345

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100195333418.0x000001&indx=1&recIds=ETOCvdc_100195333418.0x000001

Plasma biomarkers identify older adults at risk of Alzheimer's disease and related dementias in a real‐world population‐based cohort

Authors: Ferreira, Pamela C. L., Zhang, Yingjin, Snitz, Beth, Chang, Chung‐Chou H., Bellaver, Bruna, Jacobsen, Erin, Kamboh, M. Ilyas, Zetterberg, Henrik, Blennow, Kaj, Pascoal, Tharick A., Villemagne, Victor L., Ganguli, Mary, Karikari, Thomas K.

Source: Alzheimer's & dementia. 19(10):4507-4519

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100195333248.0x000001&indx=1&recIds=ETOCvdc_100195333248.0x000001

Blood‐brain barrier integrity impacts the use of plasma amyloid‐β as a proxy of brain amyloid‐β pathology

Authors: Bellaver, Bruna, Puig‐Pijoan, Albert, Ferrari‐Souza, João Pedro, Leffa, Douglas T., Lussier, Firoza Z., Ferreira, Pamela C. L., Tissot, Cécile, Povala, Guilherme, Therriault, Joseph, Benedet, Andréa L., Ashton, Nicholas J., Servaes, Stijn, Chamoun, Mira, Stevenson, Jenna, Rahmouni, Nesrine, Vermeiren, Marie, Macedo, Arthur C., Fernández‐Lebrero, Aida, García‐Escobar, Greta, Navalpotro‐Gómez, Irene, Lopez, Oscar, Tudorascu, Dana L., Cohen, Ann, Villemagne, Victor L., Klunk, William E., Gauthier, Serge, Zimmer, Eduardo R., Karikari, Thomas K., Blennow, Kaj, Zetterberg, Henrik, Suárez‐Calvet, Marc, Rosa‐Neto, Pedro, Pascoal, Tharick A.

Source: Alzheimer's & dementia. 19(9):3815-3825

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100192658463.0x000001&indx=1&recIds=ETOCvdc_100192658463.0x000001

Hippocampal GFAP-positive astrocyte responses to amyloid and tau pathologies

Authors: De Bastiani, Marco Antônio, Bellaver, Bruna, Brum, Wagner S., Souza, Debora G., Ferreira, Pamela C.L., Rocha, Andreia S., Povala, Guilherme, Ferrari-Souza, João Pedro, Benedet, Andrea L., Ashton, Nicholas J., Karikari, Thomas K., Zetterberg, Henrik, Blennow, Kaj, Rosa-Neto, Pedro, Pascoal, Tharick A., Zimmer, Eduardo R.

Source: Brain behavior and immunity. 110:175-184

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100188374044.0x000001&indx=1&recIds=ETOCvdc_100188374044.0x000001

Plasma biomarkers for neurodegenerative disorders: ready for prime time?

Authors: Balogun, Wasiu G., Zetterberg, Henrik, Blennow, Kaj, Karikari, Thomas K.

Source: Current opinion in psychiatry. 36(2):112-118

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100186827590.0x000001&indx=1&recIds=ETOCvdc_100186827590.0x000001

Plasma and CSF biomarkers in a memory clinic: Head‐to‐head comparison of phosphorylated tau immunoassays

Authors: Ashton, Nicholas J., Puig‐Pijoan, Albert, Milà‐Alomà, Marta, Fernández‐Lebrero, Aida, García‐Escobar, Greta, González‐Ortiz, Fernándo, Kac, Przemysław R., Brum, Wagner S., Benedet, Andréa L., Lantero‐Rodriguez, Juan, Day, Theresa A., Vanbrabant, Jeroen, Stoops, Erik, Vanmechelen, Eugeen, Triana‐Baltzer, Gallen, Moughadam, Setareh, Kolb, Hartmuth, Ortiz‐Romero, Paula, Karikari, Thomas K., Minguillon, Carolina, Hernández Sánchez, Juan José, Navalpotro‐Gómez, Irene, Grau‐Rivera, Oriol, María Manero, Rosa, Puente‐Periz, Víctor, Torre, Rafael, Roquer, Jaume, Dage, Jeff L., Zetterberg, Henrik, Blennow, Kaj, Suárez‐Calvet, Marc

Source: Alzheimer's & dementia. 19(5):1913-1924

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100182439622.0x000001&indx=1&recIds=ETOCvdc_100182439622.0x000001

Functional Applications of Stable Tau Oligomers in Cell Biology and Electrophysiology Studies

Authors: Hill, Emily, Moffat, Kevin G., Wall, Mark J., Zetterberg, Henrik, Blennow, Kaj, Karikari, Thomas K.

Source: Methods in molecular biology. 2551:147-162

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN630544360&indx=1&recIds=ETOCRN630544360

A Validated Method to Prepare Stable Tau Oligomers

Authors: Hill, Emily, Moffat, Kevin G., Wall, Mark J., Zetterberg, Henrik, Blennow, Kaj, Karikari, Thomas K.

Source: Methods in molecular biology. 2551:203-224

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN630544395&indx=1&recIds=ETOCRN630544395

Head-to-head comparison of plasma p-tau181, p-tau231 and glial fibrillary acidic protein in clinically unimpaired elderly with three levels of APOE4-related risk for Alzheimer's disease

Authors: Snellman, Anniina, Ekblad, Laura L., Ashton, Nicholas J., Karikari, Thomas K., Lantero-Rodriguez, Juan, Pietilä, Elina, Koivumäki, Mikko, Helin, Semi, Karrasch, Mira, Zetterberg, Henrik, Blennow, Kaj, Rinne, Juha O.

Source: In Neurobiology of Disease July 2023 183

Plasma and cerebrospinal fluid glial fibrillary acidic protein levels in adults with Down syndrome: a longitudinal cohort study

Authors: Montoliu-Gaya, Laia, Alcolea, Daniel, Ashton, Nicholas J., Pegueroles, Jordi, Levin, Johannes, Bosch, Beatriz, Lantero-Rodriguez, Juan, Carmona-Iragui, María, Wagemann, Olivia, Balasa, Mircea, Kac, Przemyslaw Radoslaw, Barroeta, Isabel, Lladó, Albert, Brum, Wagner S., Videla, Laura, Gonzalez-Ortiz, Fernando, Benejam, Bessy, Arranz Martínez, Javier José, Karikari, Thomas K., Nübling, Georg, Bejanin, Alexandre, Benedet, Andrea L., Blesa, Rafael, Lleó, Alberto, Blennow, Kaj, Sánchez-Valle, Raquel, Zetterberg, Henrik, Fortea, Juan

Source: In eBioMedicine April 2023 90

CSF biomarkers and plasma p‐tau181 as predictors of longitudinal tau accumulation: Implications for clinical trial design

Authors: Moscoso, Alexis, Karikari, Thomas K., Grothe, Michel J., Ashton, Nicholas J., Lantero‐Rodriguez, Juan, Snellman, Anniina, Zetterberg, Henrik, Blennow, Kaj, Schöll, Michael

Source: Alzheimer's & dementia. 18(12):2614-2626

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100169086700.0x000001&indx=1&recIds=ETOCvdc_100169086700.0x000001

Effect of Race on Prediction of Brain Amyloidosis by Plasma Aβ42/Aβ40, Phosphorylated Tau, and Neurofilament Light

Authors: Schindler, Suzanne E., Karikari, Thomas K., Ashton, Nicholas J., Henson, Rachel L., Yarasheski, Kevin E., West, Tim, Meyer, Mathew R., Kirmess, Kristopher M., Li, Yan, Saef, Benjamin, Moulder, Krista L., Bradford, David, Fagan, Anne M., Gordon, Brian A., Benzinger, Tammie L.S., Balls-Berry, Joyce, Bateman, Randall J., Xiong, Chengjie, Zetterberg, Henrik, Blennow, Kaj, Morris, John C.

Source: Neurology. 99(3):e245-e257

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100167479767.0x000001&indx=1&recIds=ETOCvdc_100167479767.0x000001

Alzheimer's Disease Plasma Biomarkers Distinguish Clinical Diagnostic Groups in Memory Clinic Patients

Authors: Gerards, Michelle, Schild, Ann-Katrin, Meiberth, Dix, Rostamzadeh, Ayda, Vehreschild, Jörg Janne, Wingen-Heimann, Sebastian, Johannis, Wibke, Martino Adami, Pamela, Onur, Oezguer A., Ramirez, Alfredo, Karikari, Thomas K., Ashton, Nicholas J., Zetterberg, Henrik, Blennow, Kaj, Maier, Franziska, Jessen, Frank

Source: Dementia and geriatric cognitive disorders. 51(2):182-192

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100152531398.0x000001&indx=1&recIds=ETOCvdc_100152531398.0x000001

Diagnostic and prognostic plasma biomarkers for preclinical Alzheimer's disease

Authors: Chatterjee, Pratishtha, Pedrini, Steve, Ashton, Nicholas J., Tegg, Michelle, Goozee, Kathryn, Singh, Abhay K., Karikari, Thomas K., Simrén, Joel, Vanmechelen, Eugeen, Armstrong, Nicola J., Hone, Eugene, Asih, Prita R., Taddei, Kevin, Doré, Vincent, Villemagne, Victor L., Sohrabi, Hamid R., Zetterberg, Henrik, Masters, Colin L., Blennow, Kaj, Martins, Ralph N.

Source: Alzheimer's & dementia. 18(6):1141-1154

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100151699138.0x000001&indx=1&recIds=ETOCvdc_100151699138.0x000001

Plasma p‐tau181 shows stronger network association to Alzheimer's disease dementia than neurofilament light and total tau

Authors: Frank, Brandon, Ally, Madeline, Brekke, Bailee, Zetterberg, Henrik, Blennow, Kaj, Sugarman, Michael A., Ashton, Nicholas J., Karikari, Thomas K., Tripodis, Yorghos, Martin, Brett, Palmisano, Joseph N., Steinberg, Eric G., Simkina, Irene, Turk, Katherine W., Budson, Andrew E., O'Connor, Maureen K., Au, Rhoda, Goldstein, Lee E., Jun, Gyungah R., Kowall, Neil W., Stein, Thor D., McKee, Ann C., Killiany, Ronald, Qiu, Wei Qiao, Stern, Robert A., Mez, Jesse, Alosco, Michael L.

Source: Alzheimer's & dementia. 18(8):1523-1536

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100158173466.0x000001&indx=1&recIds=ETOCvdc_100158173466.0x000001