Francisella tularensis Live Vaccine Strain training of murine alveolar and bone marrow-derived macrophages

Authors: Hamda Khan, Varunika Bhargava, Karen L. Elkins

Source: Microbiology Spectrum, Vol 12, Iss 8 (2024)

Subject Terms: Francisella LVS, macrophages, trained immunity, alveolar, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2165-0497

Access URL: https://doaj.org/article/65835976945041e5b8d23f0e83f84849

Working correlates of protection predict SchuS4-derived-vaccine candidates with improved efficacy against an intracellular bacterium, Francisella tularensis

Authors: Roberto De Pascalis, Blake Frey, Helen M. Rice, Varunika Bhargava, Terry H. Wu, Ross L. Peterson, J. Wayne Conlan, Anders Sjöstedt, Karen L. Elkins

Source: npj Vaccines, Vol 7, Iss 1, Pp 1-14 (2022)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2059-0105

Access URL: https://doaj.org/article/45867fd5b2b64f7ea1f1656039948dd5

Host Genetic Background Influences BCG-Induced Antibodies Cross-Reactive to SARS-CoV-2 Spike Protein

Authors: Aubrey G. Specht, Melanie Ginese, Sherry L. Kurtz, Karen L. Elkins, Harrison Specht, Gillian Beamer

Source: Vaccines, Vol 12, Iss 3, p 242 (2024)

Subject Terms: BCG, SARS-CoV-2, diversity outbred, genetic background, cross reactive antibodies, heterologous immunity, Medicine

File Description: electronic resource

Relation: https://www.mdpi.com/2076-393X/12/3/242; https://doaj.org/toc/2076-393X

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In vivo and in vitro immune responses against Francisella tularensis vaccines are comparable among Fischer 344 rat substrains

Authors: Roberto De Pascalis, Varunika Bhargava, Scott Espich, Terry H. Wu, H. Carl Gelhaus, Karen L. Elkins

Source: Frontiers in Microbiology, Vol 14 (2023)

Subject Terms: Francisella tularensis, tularemia, Fischer 344 rats, intracellular bacteria, vaccines, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmicb.2023.1224480/full; https://doaj.org/toc/1664-302X

Access URL: https://doaj.org/article/4726494384c1437eadcf0523c2e454f5

The Diversity Outbred Mouse Population Is an Improved Animal Model of Vaccination against Tuberculosis That Reflects Heterogeneity of Protection

Authors: Sherry L. Kurtz, Amy P. Rossi, Gillian L. Beamer, Dan M. Gatti, Igor Kramnik, Karen L. Elkins

Source: mSphere, Vol 5, Iss 2 (2020)

Subject Terms: Mycobacterium tuberculosis, animal models, Diversity Outbred, immunization, tuberculosis vaccines, vaccines, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2379-5042

Access URL: https://doaj.org/article/cddfce89436a43de9a56f36b303402dc

Modern Development and Production of a New Live Attenuated Bacterial Vaccine, SCHU S4 ΔclpB, to Prevent Tularemia

Authors: J. Wayne Conlan, Anders Sjöstedt, H. Carl Gelhaus, Perry Fleming, Kevan McRae, Ronald R. Cobb, Roberto De Pascalis, Karen L. Elkins

Source: Pathogens, Vol 10, Iss 7, p 795 (2021)

Subject Terms: tularemia, Francisella tularensis, live attenuated vaccine, product development, Medicine

File Description: electronic resource

Relation: https://www.mdpi.com/2076-0817/10/7/795; https://doaj.org/toc/2076-0817

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Models Derived from In Vitro Analyses of Spleen, Liver, and Lung Leukocyte Functions Predict Vaccine Efficacy against the Francisella tularensis Live Vaccine Strain (LVS)

Authors: Roberto De Pascalis, Alicia Y. Chou, Patrik Ryden, Nikki J. Kennett, Anders Sjöstedt, Karen L. Elkins

Source: mBio, Vol 5, Iss 2 (2014)

Subject Terms: Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2150-7511

Access URL: https://doaj.org/article/5765e28e0d5d4a9591b63f0287921cd5

Systems genetics uncover new loci containing functional gene candidates in Mycobacterium tuberculosis-infected Diversity Outbred mice.

Authors: Daniel M Gatti, Anna L Tyler, J Matthew Mahoney, Gary A Churchill, Bulent Yener, Deniz Koyuncu, Metin N Gurcan, Mk Khalid Niazi, Thomas Tavolara, Adam Gower, Denise Dayao, Emily McGlone, Melanie L Ginese, Aubrey Specht, Anas Alsharaydeh, Philipe A Tessier, Sherry L Kurtz, Karen L Elkins, Igor Kramnik, Gillian Beamer

Source: PLoS Pathogens, Vol 20, Iss 6, p e1011915 (2024)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1011915&type=printable; https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/246e29eeda0645fb9c62413a584ed97b

Multiple genetic loci influence vaccine-induced protection against Mycobacterium tuberculosis in genetically diverse mice.

Authors: Sherry L Kurtz, Richard E Baker, Frederick J Boehm, Chelsea C Lehman, Lara R Mittereder, Hamda Khan, Amy P Rossi, Daniel M Gatti, Gillian Beamer, Christopher M Sassetti, Karen L Elkins

Source: PLoS Pathogens, Vol 20, Iss 3, p e1012069 (2024)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1012069&type=printable; https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/9c187474d19c4dabbe2e763936c269ab

IL-12p40 is essential but not sufficient for Francisella tularensis LVS clearance in chronically infected mice.

Authors: Lara R Mittereder, Jonathan Swoboda, Roberto De Pascalis, Karen L Elkins

Source: PLoS ONE, Vol 18, Iss 3, p e0283161 (2023)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/795a9836485b4038a4c423df36e203da

Deficiency in CCR2 increases susceptibility of mice to infection with an intracellular pathogen, Francisella tularensis LVS, but does not impair development of protective immunity.

Authors: Sherry L Kurtz, Roberto De Pascalis, Anda I Meierovics, Karen L Elkins

Source: PLoS ONE, Vol 16, Iss 3, p e0249142 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0249142&type=printable; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/40c254739e9d45658cb6084bc8db9235

Production of IFN-γ by splenic dendritic cells during innate immune responses against Francisella tularensis LVS depends on MyD88, but not TLR2, TLR4, or TLR9.

Authors: Roberto De Pascalis, Amy P Rossi, Lara Mittereder, Kazuyo Takeda, Adovi Akue, Sherry L Kurtz, Karen L Elkins

Source: PLoS ONE, Vol 15, Iss 8, p e0237034 (2020)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/a2ed8fdb6e5040ad9e4817799e1499a2

A panel of correlates predicts vaccine-induced protection of rats against respiratory challenge with virulent Francisella tularensis.

Authors: Roberto De Pascalis, Andrew Hahn, Helen M Brook, Patrik Ryden, Nathaniel Donart, Lara Mittereder, Blake Frey, Terry H Wu, Karen L Elkins

Source: PLoS ONE, Vol 13, Iss 5, p e0198140 (2018)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC5969757?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/ca1e6c3957f348d9b85a34749eae8b6e

Francisella tularensis Vaccines Elicit Concurrent Protective T- and B-Cell Immune Responses in BALB/cByJ Mice.

Authors: Roberto De Pascalis, Lara Mittereder, Alicia Y Chou, Nikki J Kennett, Karen L Elkins

Source: PLoS ONE, Vol 10, Iss 5, p e0126570 (2015)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/c83be5255fb7464b8809c78a7cfa3357

IL-23 p19 knockout mice exhibit minimal defects in responses to primary and secondary infection with Francisella tularensis LVS.

Authors: Sherry L Kurtz, Alicia Y Chou, Klara Kubelkova, Daniel J Cua, Karen L Elkins

Source: PLoS ONE, Vol 9, Iss 10, p e109898 (2014)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC4190412?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/01c59501a5724b1baf036646b4da0c73

Development of functional and molecular correlates of vaccine-induced protection for a model intracellular pathogen, F. tularensis LVS.

Authors: Roberto De Pascalis, Alicia Y Chou, Catharine M Bosio, Chiung-Yu Huang, Dean A Follmann, Karen L Elkins

Source: PLoS Pathogens, Vol 8, Iss 1, p e1002494 (2012)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3262015?pdf=render; https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/8ec97ec5a78249b8855c2bfbca479214