Endothelial derived, secreted long non-coding RNAs Gadlor1 and Gadlor2 aggravate cardiac remodeling

Authors: Merve Keles, Steve Grein, Natali Froese, Dagmar Wirth, Felix A. Trogisch, Rhys Wardman, Shruthi Hemanna, Nina Weinzierl, Philipp-Sebastian Koch, Stefanie Uhlig, Santosh Lomada, Gesine M. Dittrich, Malgorzata Szaroszyk, Ricarda Haustein, Jan Hegermann, Abel Martin-Garrido, Johann Bauersachs, Derk Frank, Norbert Frey, Karen Bieback, Julio Cordero, Gergana Dobreva, Thomas Wieland, Joerg Heineke

Source: Molecular Therapy: Nucleic Acids, Vol 35, Iss 3, Pp 102306- (2024)

Subject Terms: MT:Non-coding RNAs, extracellular vesicles, hypertrophy, heart failure, calcium/calmodulin-dependent protein kinase type II, cardiac angiogenesis, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2162253124001938; https://doaj.org/toc/2162-2531

Access URL: https://doaj.org/article/35dc9f1f1a1a4ecda9219b0bc2786a74

Optimization of extracellular vesicles preparation from saliva of head and neck cancer patients

Authors: Luisa Tengler, Moritz Tiedtke, Julia Schütz, Karen Bieback, Stefanie Uhlig, Marie-Nicole Theodoraki, Katja Nitschke, Thomas Stefan Worst, Elena Seiz, Claudia Scherl, Nicole Rotter, Sonja Ludwig

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/85dae743409c4b7ab7ae3db9fd7f4118

Adipose stromal cells bioproducts as cell-free therapies: manufacturing and therapeutic dose determine in vitro functionality

Authors: Renata Skovronova, Eleonora Scaccia, Sandra Calcat-i-Cervera, Benedetta Bussolati, Timothy O’Brien, Karen Bieback

Source: Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-16 (2023)

Subject Terms: Mesenchymal stromal cells, Secretome, Immune modulation, Angiogenesis, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1479-5876

Access URL: https://doaj.org/article/e00065f93b3f4c43885f9053132042a9

Clinical-grade human skin-derived ABCB5+ mesenchymal stromal cells exert anti-apoptotic and anti-inflammatory effects in vitro and modulate mRNA expression in a cisplatin-induced kidney injury murine model

Authors: Erika Rendra, Adriana Torres Crigna, Cristina Daniele, Carsten Sticht, Maike Cueppers, Mark Andreas Kluth, Christoph Ganss, Markus H. Frank, Norbert Gretz, Karen Bieback

Source: Frontiers in Immunology, Vol 14 (2024)

Subject Terms: mesenchymal stromal cells, ABCB5, cisplatin, kidney injury, PBMC, macrophage, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1228928/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/eda2ae136f194118a0671792b264cd29

Harmonised culture procedures minimise but do not eliminate mesenchymal stromal cell donor and tissue variability in a decentralised multicentre manufacturing approach

Authors: Sandra Calcat-i-Cervera, Erika Rendra, Eleonora Scaccia, Francesco Amadeo, Vivien Hanson, Bettina Wilm, Patricia Murray, Timothy O’Brien, Arthur Taylor, Karen Bieback

Source: Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-17 (2023)

Subject Terms: Mesenchymal stromal cells (MSCs), Tissue source, Multicentre comparison, Manufacturing, Harmonisation, Angiogenesis, Medicine (General), R5-920, Biochemistry, QD415-436

File Description: electronic resource

Relation: https://doaj.org/toc/1757-6512

Access URL: https://doaj.org/article/6e677206ca534025a0e639dd69a926f4

Adipose Stromal Cell-Derived Secretome Attenuates Cisplatin-Induced Injury In Vitro Surpassing the Intricate Interplay between Proximal Tubular Epithelial Cells and Macrophages

Authors: Erika Rendra, Stefanie Uhlig, Isabell Moskal, Corinna Thielemann, Harald Klüter, Karen Bieback

Source: Cells, Vol 13, Iss 2, p 121 (2024)

Subject Terms: MSC secretome, proximal tubular epithelial cells, cisplatin, macrophages, acute kidney injury, oxidative stress, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/13/2/121; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/e9143bf765834f4cbae752f9fd2f22f1

Expression of ADP receptor P2Y12, thromboxane A2 receptor and C-type lectin-like receptor 2 in cord blood-derived megakaryopoiesis

Authors: Catharina Gerhards, Stefanie Uhlig, Mani Etemad, Foteini Christodoulou, Karen Bieback, Harald Klüter, Peter Bugert

Source: Platelets, Vol 32, Iss 5, Pp 618-625 (2021)

Subject Terms: inherited platelet disorder, megakaryopoiesis, platelet function, receptor expression, Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://doaj.org/toc/0953-7104; https://doaj.org/toc/1369-1635

Access URL: https://doaj.org/article/9884826746f2417a8154d131d691d601

Pooled human bone marrow-derived mesenchymal stromal cells with defined trophic factors cargo promote dermal wound healing in diabetic rats by improved vascularization and dynamic recruitment of M2-like macrophages

Authors: Hélène Willer, Gabriele Spohn, Kimberly Morgenroth, Corinna Thielemann, Susanne Elvers-Hornung, Peter Bugert, Bruno Delorme, Melanie Giesen, Thomas Schmitz-Rixen, Erhard Seifried, Christiane Pfarrer, Richard Schäfer, Karen Bieback

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: mesenchymal stromal cells (MSCs), pooling, chronic wound healing, potency, efficacy, clinical scale production, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.976511/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/5373656f19b54ecbaf9a6cac11c3bbdb

Dopamine D1/D5 Receptor Signaling Is Involved in Arrhythmogenesis in the Setting of Takotsubo Cardiomyopathy

Authors: Mengying Huang, Zhen Yang, Yingrui Li, Huan Lan, Lukas Cyganek, Goekhan Yuecel, Siegfried Lang, Karen Bieback, Ibrahim El-Battrawy, Xiaobo Zhou, Martin Borggrefe, Ibrahim Akin

Source: Frontiers in Cardiovascular Medicine, Vol 8 (2022)

Subject Terms: Takotsubo cardiomyopathy, arrhythmia, catecholamine excess, D1/D5 dopamine receptor, human-induced pluripotent stem cell-derived cardiomyocytes, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcvm.2021.777463/full; https://doaj.org/toc/2297-055X

Access URL: https://doaj.org/article/46a51c62bf4f42b48abde5c498af22c7

Quantitation of progenitor cell populations and growth factors after bone marrow aspirate concentration

Authors: Richard Schäfer, Malcolm R. DeBaun, Erika Fleck, Christopher J. Centeno, Daniela Kraft, Johannes Leibacher, Karen Bieback, Erhard Seifried, Jason L. Dragoo

Source: Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-9 (2019)

Subject Terms: Bone marrow aspirate concentrate, Bone marrow aspiration, BMAC, Growth factors, Mesenchymal stem cell, Stem cell, Medicine

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12967-019-1866-7; https://doaj.org/toc/1479-5876

Access URL: https://doaj.org/article/60d47976869149f2b8f9e18ef747ff9f

Editorial: Current Progress in Mesenchymal Stem/Stromal Cell Research

Authors: Lindolfo da Silva Meirelles, Karen Bieback, Marcela F. Bolontrade

Source: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

Subject Terms: mesenchymal stem cells, mesenchymal stromal (or stem) cells, mesenchymal stromal cells, basic research, MSC therapies, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2021.658903/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/1a9ef9fdd3c247a3ba0eca1192913d73

Modulating endothelial adhesion and migration impacts stem cell therapies efficacy

Authors: Richard Schäfer, Matthias Schwab, Georg Siegel, Andreas von Ameln-Mayerhofer, Marine Buadze, Ali Lourhmati, Hans-Peter Wendel, Torsten Kluba, Marcel A. Krueger, Carsten Calaminus, Eva Scheer, Massimo Dominici, Giulia Grisendi, Thorsten R. Doeppner, Jana Schlechter, Anne Kathrin Finzel, Dominic Gross, Roland Klaffschenkel, Frank K. Gehring, Gabriele Spohn, Anja Kretschmer, Karen Bieback, Eva-Maria Krämer-Albers, Kerstin Barth, Anne Eckert, Stefanie Elser, Joerg Schmehl, Claus D. Claussen, Erhard Seifried, Dirk M. Hermann, Hinnak Northoff, Lusine Danielyan

Source: EBioMedicine, Vol 60, Iss , Pp 102987- (2020)

Subject Terms: Stem cells, Migration, Adhesion, Homing, Stroke, Glioma, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396420303637; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/cfdc3c5617b54f99af3c86514beec666

Effects of ASC Application on Endplate Regeneration Upon Glycerol-Induced Muscle Damage

Authors: Matteo Rigon, Sarah Janice Hörner, Tatjana Straka, Karen Bieback, Norbert Gretz, Mathias Hafner, Rüdiger Rudolf

Source: Frontiers in Molecular Neuroscience, Vol 13 (2020)

Subject Terms: glycerol, skeletal muscle, NMJ, ASC, regeneration, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fnmol.2020.00107/full; https://doaj.org/toc/1662-5099

Access URL: https://doaj.org/article/d156ea304c954fe28179130a3ff494ce

Pro-angiogenic Activity Discriminates Human Adipose-Derived Stromal Cells From Retinal Pericytes: Considerations for Cell-Based Therapy of Diabetic Retinopathy

Authors: Heiner Kremer, Julian Gebauer, Susanne Elvers-Hornung, Stefanie Uhlig, Hans-Peter Hammes, Elena Beltramo, Lothar Steeb, Martin C. Harmsen, Carsten Sticht, Harald Klueter, Karen Bieback, Agnese Fiori

Source: Frontiers in Cell and Developmental Biology, Vol 8 (2020)

Subject Terms: human adipose-derived stromal cells, human retinal pericytes, diabetic retinopathy, angiogenesis, vascular–endothelial growth factor, angiopoietin, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fcell.2020.00387/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/3063a80153f147c88bea1a1299e3a2c9

3D models of the hematopoietic stem cell niche under steady-state and active conditions

Authors: Lisa Rödling, Ivo Schwedhelm, Saskia Kraus, Karen Bieback, Jan Hansmann, Cornelia Lee-Thedieck

Source: Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/4375f52eee9a49e89c5477d4f7a5411c

The effect of adipose tissue-derived stem cells in a middle cerebral artery occlusion stroke model depends on their engraftment rate

Authors: Saskia Grudzenski, Sebastian Baier, Anne Ebert, Pim Pullens, Andreas Lemke, Karen Bieback, Rick M. Dijkhuizen, Lothar R. Schad, Angelika Alonso, Michael G. Hennerici, Marc Fatar

Source: Stem Cell Research & Therapy, Vol 8, Iss 1, Pp 1-14 (2017)

Subject Terms: Adipose tissue-derived stem cell, Cell tracking, Cell engraftment, Focal ischaemia, High-field MRI, MCA occlusion, Medicine (General), R5-920, Biochemistry, QD415-436

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13287-017-0545-y; https://doaj.org/toc/1757-6512

Access URL: https://doaj.org/article/e910120c6ee843efab3ae5c8a7061920

Recent advances in understanding mesenchymal stromal cells [version 1; peer review: 3 approved]

Authors: Erika Rendra, Eleonora Scaccia, Karen Bieback

Source: F1000Research, Vol 9 (2020)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://f1000research.com/articles/9-156/v1; https://doaj.org/toc/2046-1402

Access URL: https://doaj.org/article/32fc48ceebcc4babbe417029ebeb1603

Bioreactor for mobilization of mesenchymal stem/stromal cells into scaffolds under mechanical stimulation: Preliminary results.

Authors: Carolina Gamez, Barbara Schneider-Wald, Andy Schuette, Michael Mack, Luisa Hauk, Arif Ul Maula Khan, Norbert Gretz, Marcus Stoffel, Karen Bieback, Markus L Schwarz

Source: PLoS ONE, Vol 15, Iss 1, p e0227553 (2020)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0227553&type=printable; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/6a0ffcc4a2214535b13c30f49c8535f2

Human Adipose Tissue-Derived Mesenchymal Stromal Cells Inhibit CD4+ T Cell Proliferation and Induce Regulatory T Cells as Well as CD127 Expression on CD4+CD25+ T Cells

Authors: Agnese Fiori, Stefanie Uhlig, Harald Klüter, Karen Bieback

Source: Cells, Vol 10, Iss 1, p 58 (2021)

Subject Terms: mesenchymal stromal cells, CD4 T cells, immunomodulation, regulatory T cells, CD127, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/10/1/58; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/a9804e1be57946219a4cdd8de00d3b6f

Human Adipose Tissue-Derived Stromal Cells Suppress Human, but Not Murine Lymphocyte Proliferation, via Indoleamine 2,3-Dioxygenase Activity

Authors: Adriana Torres Crigna, Stefanie Uhlig, Susanne Elvers-Hornung, Harald Klüter, Karen Bieback

Source: Cells, Vol 9, Iss 11, p 2419 (2020)

Subject Terms: mesenchymal stromal cells, immunomodulation, IDO, extracellular vesicles, allogeneic, xenogeneic, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/9/11/2419; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/c4690001c02a4fe0ac10df66cb14c740