USP14 is crucial for proteostasis regulation and α-synuclein degradation in human SH-SY5Y dopaminergic cells

Authors: Srinivasan, Vignesh ^{a, b}, Soliymani, Rabah ^{a, c}, Ivanova, Larisa ^d, Eriksson, Ove ^{a, b}, Peitsaro, Nina ^a, Lalowski, Maciej ^{a, c, e}, Karelson, Mati ^d, Lindholm, Dan ^{a, b, f, ⁎}

Source: In Heliyon 15 February 2025 11(3)

The structure and function of YTHDF epitranscriptomic m6A readers

Authors: Sikorski, Vilbert, Selberg, Simona, Lalowski, Maciej, Karelson, Mati, Kankuri, Esko

Source: Trends in pharmacological sciences. 44(6):335-353

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190034178.0x000001&indx=1&recIds=ETOCvdc_100190034178.0x000001

MANF regulates neuronal survival and UPR through its ER-located receptor IRE1α

Authors: Kovaleva, Vera, Yu, Li-Ying, Ivanova, Larisa, Shpironok, Olesya, Nam, Jinhan, Eesmaa, Ave, Kumpula, Esa-Pekka, Sakson, Sven, Toots, Urve, Ustav, Mart, Huiskonen, Juha T., Voutilainen, Merja H., Lindholm, Päivi, Karelson, Mati, Saarma, Mart

Source: In Cell Reports 28 February 2023 42(2)

Epitranscriptomic regulation in fasting hearts: implications for cardiac health

Authors: Benak, Daniel, Holzerova, Kristyna, Hrdlicka, Jaroslav, Kolar, Frantisek, Olsen, Mark, Karelson, Mati, Hlavackova, Marketa

Source: RNA Biology; December 2024, Vol. 21 Issue: 1 p290-303, 14p

Glial Cell Line–Derived Neurotrophic Factor Receptor Rearranged During Transfection Agonist Supports Dopamine Neurons In Vitro and Enhances Dopamine Release In Vivo

Authors: Mahato, Arun Kumar, Kopra, Jaakko, Renko, Juho‐Matti, Visnapuu, Tanel, Korhonen, Ilari, Pulkkinen, Nita, Bespalov, Maxim M., Domanskyi, Andrii, Ronken, Eric, Piepponen, T. Petteri, Voutilainen, Merja H., Tuominen, Raimo K., Karelson, Mati, Sidorova, Yulia A., Saarma, Mart

Source: Movement disorders. 35(2):245-255

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100111109979.0x000001&indx=1&recIds=ETOCvdc_100111109979.0x000001

Discovery of Small Molecules that Activate RNA Methylation through Cooperative Binding to the METTL3-14-WTAP Complex Active Site

Authors: Selberg, Simona, Blokhina, Daria, Aatonen, Maria, Koivisto, Pertti, Siltanen, Antti, Mervaala, Eero, Kankuri, Esko, Karelson, Mati

Source: In Cell Reports 26 March 2019 26(13):3762-3771

The Impact of Software Used and the Type of Target Protein on Molecular Docking Accuracy.

Authors: Ivanova, Larisa¹ (AUTHOR) larisa.ivanova@ut.ee, Karelson, Mati¹ (AUTHOR)

Source: Molecules. Dec2022, Vol. 27 Issue 24, p9041. 20p.

Subject Terms: *MOLECULAR docking, *SIGNAL recognition particle receptor, *CHEMICAL libraries, *HIGH throughput screening (Drug development), *DRUG discovery

Indole-like Trk receptor antagonists

Authors: Tammiku-Taul, Jaana, Park, Rahel, Jaanson, Kaur, Luberg, Kristi, Dobchev, Dimitar A., Kananovich, Dzmitry, Noole, Artur, Mandel, Merle, Kaasik, Allen, Lopp, Margus, Timmusk, Tõnis, Karelson, Mati

Source: In European Journal of Medicinal Chemistry 4 October 2016 121:541-552

Chapter Seven - QSAR of Heterocyclic Compounds in Large Descriptor Spaces

Authors: Karelson, Mati, Dobchev, Dimitar A.

Source: In Advances in Heterocyclic Chemistry 2016 120:237-273

Have artificial neural networks met expectations in drug discovery as implemented in QSAR framework?

Authors: Dobchev, Dimitar, Karelson, Mati

Source: Expert opinion on drug discovery. 11(7):627-639

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100102904104.0x000001&indx=1&recIds=ETOCvdc_100102904104.0x000001

Theoretical Modeling of HPV: QSAR and Novodesign with Fragment Approach

Authors: Pillai, Girinath G., Sikk, Lauri, Tamm, Tarmo, Karelson, Mati, Burk, Peeter, Tamm, Kaido

Source: Current computer-aided drug design. 10(4):303-314

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCETOCvdc_100027015497.0x000001&indx=1&recIds=ETOCETOCvdc_100027015497.0x000001

Prediction of Cell-Penetrating Peptides

Authors: Hällbrink, Mattias, Karelson, Mati

Source: Methods in molecular biology. 1324:39-58

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN602323717&indx=1&recIds=ETOCRN602323717

Prediction of peptide IMS cross sections from extended molecular connectivity

Authors: Oliferenko, Alexander A., Tian, Feifei, Karelson, Mati, Katritzky, Alan R.

Source: In International Journal of Mass Spectrometry 15 March 2012 314:1-5

In Silico Machine Learning Methods in Drug Development

Authors: Dobchev, Dimitar A., Pillai, Girinath G., Karelson, Mati

Source: Current topics in medicinal chemistry. 14(16):1913-1922

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100083476467.0x000001&indx=1&recIds=ETOCvdc_100083476467.0x000001

Fragment-Based Development of HCV Protease Inhibitors for the Treatment of Hepatitis C

Authors: Karelson, Mati, A. Dobchev, Dimitar, Karelson, Gunnar, Tamm, Tarmo, Tamm, Kaido, Nikonov, Andrei, Mutso, Margit, Merits, Andres

Source: Current computer-aided drug design. 8(1):55-61

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100083460549.0x000001&indx=1&recIds=ETOCvdc_100083460549.0x000001

Estimating the toxicities of organic chemicals in activated sludge process

Authors: Katritzky, Alan R., Kasemets, Kalev, Slavov, Svetoslav, Radzvilovits, Maksim, Tämm, Kaido, Karelson, Mati

Source: In Water Research 2010 44(8):2451-2460

Quantitative structure–activity relationship modeling of bioconcentration factors of polychlorinated biphenyls

Authors: Katritzky, Alan R., Radzvilovits, Maksim, Slavov, Svetoslav, Kasemets, Kalev, Tämm, Kaido, Karelson, Mati

Source: Toxicological and environmental chemistry. 92(7):1233-1247

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100112079462.0x000001&indx=1&recIds=ETOCvdc_100112079462.0x000001

QSPR study of the first and second critical micelle concentrations of cationic surfactants

Authors: Katritzky, Alan R., Pacureanu, Liliana M., Slavov, Svetoslav H., Dobchev, Dimitar A., Shah, Dinesh O., Karelson, Mati

Source: In Computers and Chemical Engineering 2009 33(1):321-332

QSAR modeling of the antifungal activity against Candida albicans for a diverse set of organic compounds

Authors: Katritzky, Alan R., Slavov, Svetoslav H., Dobchev, Dimitar A., Karelson, Mati

Source: In Bioorganic & Medicinal Chemistry 2008 16(14):7055-7069

The proposal of architecture for chemical splitting to optimize QSAR models for aquatic toxicity

Authors: Colombo, Andrea, Benfenati, Emilio, Karelson, Mati, Maran, Uko

Source: In Chemosphere 2008 72(5):772-780