Dizocilpine derivatives as neuroprotective NMDA receptor antagonists without psychomimetic side effects

Authors: Konecny, Jan, Misiachna, Anna, Chvojkova, Marketa, Kleteckova, Lenka, Kolcheva, Marharyta, Novak, Martin, Prchal, Lukas, Ladislav, Marek, Hemelikova, Katarina, Netolicky, Jakub, Hrabinova, Martina, Kobrlova, Tereza, Karasova, Jana Zdarova, Pejchal, Jaroslav, Fibigar, Jakub, Vecera, Zbynek, Kucera, Tomas, Jendelova, Pavla, Zahumenska, Petra, Langore, Emily, Doderovic, Jovana, Pang, Yuan-Ping, Vales, Karel, Korabecny, Jan, Soukup, Ondrej, Horak, Martin

Source: In European Journal of Medicinal Chemistry 15 December 2024 280

Phenoxytacrine derivatives: Low-toxicity neuroprotectants exerting affinity to ifenprodil-binding site and cholinesterase inhibition

Authors: Misiachna, Anna, Svobodova, Barbora, Netolicky, Jakub, Chvojkova, Marketa, Kleteckova, Lenka, Prchal, Lukas, Novak, Martin, Hrabinova, Martina, Kucera, Tomas, Muckova, Lubica, Moravcova, Zuzana, Karasova, Jana Zdarova, Pejchal, Jaroslav, Blazek, Filip, Malinak, David, Hakenova, Kristina, Krausova, Barbora Hrcka, Kolcheva, Marharyta, Ladislav, Marek, Korabecny, Jan, Pahnke, Jens, Vales, Karel, Horak, Martin, Soukup, Ondrej

Source: In European Journal of Medicinal Chemistry 15 February 2024 266

Development of submicromolar 17β-HSD10 inhibitors and their in vitro and in vivo evaluation

Authors: Benek, Ondrej, Vaskova, Michaela, Miskerikova, Marketa, Schmidt, Monika, Andrys, Rudolf, Rotterova, Aneta, Skarka, Adam, Hatlapatkova, Jana, Karasova, Jana Zdarova, Medvecky, Matej, Hroch, Lukas, Vinklarova, Lucie, Fisar, Zdenek, Hroudova, Jana, Handl, Jiri, Capek, Jan, Rousar, Tomas, Kobrlova, Tereza, Dolezal, Rafael, Soukup, Ondrej, Aitken, Laura, Gunn-Moore, Frank, Musilek, Kamil

Source: In European Journal of Medicinal Chemistry 5 October 2023 258

The measured CSF/plasma donepezil concentration ratio but not individually measured CSF and plasma concentrations significantly increase over 24 h after donepezil treatment in patients with Alzheimer’s disease

Authors: Valis, Martin, Dlabkova, Alzbeta, Hort, Jakub, Angelucci, Francesco, Pejchal, Jaroslav, Kuca, Kamil, Pavelek, Zbysek, Karasova, Jana Zdarova, Novotny, Michal

Source: In Biomedicine & Pharmacotherapy March 2023 159

Novel D2/5-HT receptor modulators related to cariprazine with potential implication to schizophrenia treatment

Authors: Juza, Radomir, Vojtechova, Iveta, Stefkova-Mazochova, Kristyna, Dehaen, Wim, Petrasek, Tomas, Prchal, Lukas, Kobrlova, Tereza, Janousek, Jiri, Vlcek, Premysl, Mezeiova, Eva, Svozil, Daniel, Karasova, Jana Zdarova, Pejchal, Jaroslav, Stark, Holger, Satala, Grzegorz, Bojarski, Andrzej J., Kubacka, Monika, Mogilski, Szczepan, Randakova, Alena, Musilek, Kamil, Soukup, Ondrej, Korabecny, Jan

Source: In European Journal of Medicinal Chemistry 15 March 2022 232

Structure-activity relationships of dually-acting acetylcholinesterase inhibitors derived from tacrine on N-methyl-d-Aspartate receptors

Authors: Gorecki, Lukas, Misiachna, Anna, Damborsky, Jiri, Dolezal, Rafael, Korabecny, Jan, Cejkova, Lada, Hakenova, Kristina, Chvojkova, Marketa, Karasova, Jana Zdarova, Prchal, Lukas, Novak, Martin, Kolcheva, Marharyta, Kortus, Stepan, Vales, Karel, Horak, Martin, Soukup, Ondrej

Source: In European Journal of Medicinal Chemistry 5 July 2021 219

Determination of K869, a Novel Oxime Reactivator of Acetylcholinesterase, in Rat Body Fluids and Tissues by Liquid-Chromatography Methods: Pharmacokinetic Study

Authors: Vanova, Nela, Hojna, Anna, Pejchal, Jaroslav, Herman, David, Malinak, David, Prchalova, Eliska, Musilek, Kamil, Karasova, Jana Zdarova

Source: In Journal of Pharmaceutical Sciences April 2021 110(4):1842-1852

Corrigendum to 'The measured CSF/plasma donepezil concentration ratio but not individually measured CSF and plasma concentrations significantly increase over 24 h after donepezil treatment in patients with Alzheimer's disease' [Biomed. Pharmacother. 159 (2023) 114223]

Authors: Valis, Martin, Dlabkova, Alzbeta, Hort, Jakub, Angelucci, Francesco, Pejchal, Jaroslav, Kuca, Kamil, Pavelek, Zbysek, Karasova, Jana Zdarova, Novotny, Michal

Source: Biomedicine and pharmacotherapy. 165

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100196448780.0x000001&indx=1&recIds=ETOCvdc_100196448780.0x000001

Pyridostigmine bromide and its relation to Gulf War illness

Authors: Karasova, Jana Zdarova, Hroch, Milos, Pohanka, Miroslav, Hepnarova, Vendula, Pejchal, Jaroslav, Kuca, Kamil

Source: Toxin reviews. 39(2):138-146

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100110758130.0x000001&indx=1&recIds=ETOCvdc_100110758130.0x000001

Brominated oxime nucleophiles are efficiently reactivating cholinesterases inhibited by nerve agents.

Authors: Prchalova, Eliska, Andrys, Rudolf, Pejchal, Jaroslav, Kohoutova, Zuzana, Knittelova, Karolina, Hofmanova, Tereza, Skarka, Adam, Dlabkova, Alzbeta, Psotka, Miroslav, Prchal, Lukas, Musilek, Kamil, Karasova, Jana Zdarova, Malinak, David

Source: Archives of Toxicology; Sep2024, Vol. 98 Issue 9, p2937-2952, 16p

Subject Terms: NERVE gases, BUTYRYLCHOLINESTERASE, OXIMES, CHOLINESTERASES, NUCLEOPHILIC reactions

Memantine and Its Combination with Acetylcholinesterase Inhibitors in Pharmacological Pretreatment of Soman Poisoning in Mice.

Authors: Kassa, Jiri¹ (AUTHOR), Karasova, Jana Zdarova¹ (AUTHOR) zdarova.jana@gmail.com

Source: Neurotoxicity Research. Oct2021, Vol. 39 Issue 5, p1487-1494. 8p.

Subject Terms: *ACETYLCHOLINESTERASE inhibitors, *MEMANTINE, *NERVE gases, *POISONING, *ACETYLCHOLINESTERASE, *POISONS, *ATROPINE

Activity of cholinesterases in a young and healthy middle-European population: Relevance for toxicology, pharmacology and clinical praxis

Authors: Karasova, Jana Zdarova, Maderycova, Zuzana, Tumova, Martina, Jun, Daniel, Rehacek, Vit, Kuca, Kamil, Misik, Jan

Source: Toxicology letters. 277:24-31

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100064867058.0x000001&indx=1&recIds=ETOCvdc_100064867058.0x000001

Pharmacokinetic profile of promising acetylcholinesterase reactivators K027 and K203 in experimental pigs

Authors: Karasova, Jana Zdarova, Kvetina, Jaroslav, Tacheci, Ilja, Radochova, Vera, Musilek, Kamil, Kuca, Kamil, Bures, Jan

Source: Toxicology letters. 273:20-25

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100053134068.0x000001&indx=1&recIds=ETOCvdc_100053134068.0x000001

Neuroprotective efficacy of newly developed oximes in comparison with currently available oximes in tabun-poisoned rats

Authors: Kassa, Jiri, Misik, Jan, Karasova, Jana Zdarova

Source: In Journal of Applied Biomedicine February 2015 13(1):39-46

Comparison of the neuroprotective effects of a novel bispyridinium oxime KR-22934 with the oxime K203 and obidoxime in tabun-poisoned male rats

Authors: Kassa, Jiří, Karasová, Jana Žďárová, Kuča, Kamil, Musílek, Kamil, Jung, Young-Sik

Source: In Journal of Applied Biomedicine April 2014 12(2):111-117

Donepezil and Rivastigmine: Pharmacokinetic Profile and Brain-targeting After Intramuscular Administration in Rats.

Authors: Karasova, Jana Zdarova^1,2 zdarova.jana@gmail.com, Hrabinova, Martina¹, Krejciova, Marketa¹, Jun, Daniel^1,2, Kuca, Kamil³

Source: Iranian Journal of Pharmaceutical Research. Summer2020, Vol. 19 Issue 3, p95-102. 8p.

Subject Terms: *DONEPEZIL, *CENTRAL nervous system, *PHARMACOKINETICS, *ALZHEIMER'S disease, *RIVASTIGMINE, *TACRINE

Prophylaxis and Post-exposure Treatment of Intoxications Caused by Nerve Agents and Organophosphorus Pesticides

Authors: Kuca, Kamil, Jun, Daniel, Musilek, Kamil, Pohanka, Miroslav, Karasova, Jana Zdarova, Soukup, Ondrej

Source: Mini-reviews in medicinal chemistry. 13(14):2102-2115

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCETOCvdc_100027181856.0x000001&indx=1&recIds=ETOCETOCvdc_100027181856.0x000001

Combined approach to demonstrate acetylcholinesterase activity changes in the rat brain following tabun intoxication and its treatment

Authors: Bajgar, Jiri, Hajek, Petr, Kassa, Jiri, Slizova, Dasa, Krs, Otakar, Karasova, Jana Zdarova, Fusek, Josef, Capek, Lukas, Voicu, Victor A.

Source: Toxicology mechanisms and methods. 22(1):60-66

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100105337740.0x000001&indx=1&recIds=ETOCvdc_100105337740.0x000001

Passive diffusion of acetylcholinesterase oxime reactivators through the blood–brain barrier: Influence of molecular structure

Authors: Karasova, Jana Zdarova, Pohanka, Miroslav, Musilek, Kamil, Zemek, Filip, Kuca, Kamil

Source: In Toxicology in Vitro 2010 24(6):1838-1844

Colorimetric dipstick for assay of organophosphate pesticides and nerve agents represented by paraoxon, sarin and VX

Authors: Pohanka, Miroslav, Karasova, Jana Zdarova, Kuca, Kamil, Pikula, Jiri, Holas, Ondrej, Korabecny, Jan, Cabal, Jiri

Source: In Talanta 2010 81(1):621-624