Metabolomic signatures of ideal cardiovascular health in black adults

Authors: Shabatun J. Islam, Chang Liu, Appesh N. Mohandas, Kimberly Rooney, Aditi Nayak, Anurag Mehta, Yi-An Ko, Jeong Hwan Kim, Yan V. Sun, Sandra B. Dunbar, Tené T. Lewis, Herman A. Taylor, Karan Uppal, Dean P. Jones, Arshed A. Quyyumi, Charles D. Searles

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/9d997d7e6b21456babd9d95fccc5b720

The neonatal blood spot metabolome in retinoblastoma

Authors: Qi Yan, Di He, Douglas I. Walker, Karan Uppal, Xuexia Wang, Helen T. Orimoloye, Dean P. Jones, Beate R. Ritz, Julia E. Heck

Source: EJC Paediatric Oncology, Vol 2, Iss , Pp 100123- (2023)

Subject Terms: Retinoblastoma, Energy metabolism, Inflammation, Arachidonic acid, Tyrosine metabolism, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2772610X23001216; https://doaj.org/toc/2772-610X

Access URL: https://doaj.org/article/2a0c8f04ca524389ac0369a6205dc85b

MaHPIC malaria systems biology data from Plasmodium cynomolgi sporozoite longitudinal infections in macaques

Authors: Jeremy D. DeBarry, Mustafa V. Nural, Suman B. Pakala, Vishal Nayak, Susanne Warrenfeltz, Jay Humphrey, Stacey A. Lapp, Monica Cabrera-Mora, Cristiana F. A. Brito, Jianlin Jiang, Celia L. Saney, Allison Hankus, Hannah M. Stealey, Megan B. DeBarry, Nicolas Lackman, Noah Legall, Kevin Lee, Yan Tang, Anuj Gupta, Elizabeth D. Trippe, Robert R. Bridger, Daniel Brent Weatherly, Mariko S. Peterson, Xuntian Jiang, ViLinh Tran, Karan Uppal, Luis L. Fonseca, Chester J. Joyner, Ebru Karpuzoglu, Regina J. Cordy, Esmeralda V. S. Meyer, Lance L. Wells, Daniel S. Ory, F. Eun-Hyung Lee, Rabindra Tirouvanziam, Juan B. Gutiérrez, Chris Ibegbu, Tracey J. Lamb, Jan Pohl, Sarah T. Pruett, Dean P. Jones, Mark P. Styczynski, Eberhard O. Voit, Alberto Moreno, Mary R. Galinski, Jessica C. Kissinger

Source: Scientific Data, Vol 9, Iss 1, Pp 1-43 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2052-4463

Access URL: https://doaj.org/article/8706a9e9716845819613fdcc3852e381

Intratumoral delivery of TransCon™ TLR7/8 Agonist promotes sustained anti-tumor activity and local immune cell activation while minimizing systemic cytokine induction

Authors: Luis Alejandro Zúñiga, Torben Leßmann, Karan Uppal, Nicola Bisek, Enping Hong, Caroline E. Rasmussen, Jens-Jakob Karlsson, Joachim Zettler, Lars Holten-Andersen, Kathy Bang, Dhruv Thakar, Yu-Chi Lee, Salomon Martinez, Simran Singh Sabharwal, Sebastian Stark, Frank Faltinger, Oliver Kracker, Samuel Weisbrod, Robin Müller, Tobias Voigt, Kornelia Bigott, Mohammad Tabrizifard, Vibeke Miller Breinholt, Amer M. Mirza, David B. Rosen, Kennett Sprogøe, Juha Punnonen

Source: Cancer Cell International, Vol 22, Iss 1, Pp 1-17 (2022)

Subject Terms: Toll-like receptor, Tumor microenvironment, Innate immunity, Adaptive immunity, Intratumoral treatment, Intratumoral injection, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/1475-2867

Access URL: https://doaj.org/article/9c07ff8778c14891ac4c75977cba6fba

A scalable workflow to characterize the human exposome

Authors: Xin Hu, Douglas I. Walker, Yongliang Liang, Matthew Ryan Smith, Michael L. Orr, Brian D. Juran, Chunyu Ma, Karan Uppal, Michael Koval, Greg S. Martin, David C. Neujahr, Carmen J. Marsit, Young-Mi Go, Kurt D. Pennell, Gary W. Miller, Konstantinos N. Lazaridis, Dean P. Jones

Source: Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/4d62c49b878b4caf97797da50f1ea5a1

TransCon IL-2 β/γ: a novel long-acting prodrug with sustained release of an IL-2Rβ/γ-selective IL-2 variant with improved pharmacokinetics and potent activation of cytotoxic immune cells for the treatment of cancer

Authors: Anne Månsson Kvarnhammar, Juha Punnonen, Enping Hong, Diana Reich, Karan Uppal, Kathy Bang, David B Rosen, Burkhardt Laufer, Thomas Knappe, Jens Jakob Karlsson, Yu-Chi Lee, Dhruv Thakar, Luis Alejandro Zúñiga, Simran Singh Sabharwal, Janne Damm Olling, Kristian Kjaergaard, Thomas Kurpiers, Meike Schnabel, Philipp Glock, Joachim Zettler, Mathias Krusch, Ana Bernhard, Stefan Heinig, Valentino Konjik, Thomas Wegge, Yvonne Hehn, Steffen Killian, Laura Viet, Josefine Runz, Frank Faltinger, Mohammad Tabrizi, Kristin Laura Abel, Vibeke Miller Breinholt, Stina M Singel, Kennett Sprogøe

Source: Journal for ImmunoTherapy of Cancer, Vol 10, Iss 7 (2022)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/10/7/e004991.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/c5975468cd0f4febb405f737118e732f

Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome

Authors: Gizem Inak, Agnieszka Rybak-Wolf, Pawel Lisowski, Tancredi M. Pentimalli, René Jüttner, Petar Glažar, Karan Uppal, Emanuela Bottani, Dario Brunetti, Christopher Secker, Annika Zink, David Meierhofer, Marie-Thérèse Henke, Monishita Dey, Ummi Ciptasari, Barbara Mlody, Tobias Hahn, Maria Berruezo-Llacuna, Nikos Karaiskos, Michela Di Virgilio, Johannes A. Mayr, Saskia B. Wortmann, Josef Priller, Michael Gotthardt, Dean P. Jones, Ertan Mayatepek, Werner Stenzel, Sebastian Diecke, Ralf Kühn, Erich E. Wanker, Nikolaus Rajewsky, Markus Schuelke, Alessandro Prigione

Source: Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/7c5258ec4a0c4d51b4034db5722f87a1

CERC: an interactive content extraction, recognition, and construction tool for clinical and biomedical text

Authors: Eva K. Lee, Karan Uppal

Source: BMC Medical Informatics and Decision Making, Vol 20, Iss S14, Pp 1-14 (2020)

Subject Terms: Automatic summarization, Content extraction and recognition, Extractive summarization, Indicative summarization, Sentence extraction and ranking, Extracting salient information, Computer applications to medicine. Medical informatics, R858-859.7

File Description: electronic resource

Relation: https://doaj.org/toc/1472-6947

Access URL: https://doaj.org/article/b9b02e0a193d42cd97878651cb00f00c

Addressing the batch effect issue for LC/MS metabolomics data in data preprocessing

Authors: Qin Liu, Douglas Walker, Karan Uppal, Zihe Liu, Chunyu Ma, ViLinh Tran, Shuzhao Li, Dean P. Jones, Tianwei Yu

Source: Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/b7e4a35c4a4445a4849e3d300e5b7365

Plasmodium knowlesi Cytoadhesion Involves SICA Variant Proteins

Authors: Mariko S. Peterson, Chester J. Joyner, Stacey A. Lapp, Jessica A. Brady, Jennifer S. Wood, Monica Cabrera-Mora, Celia L. Saney, Luis L. Fonseca, Wayne T. Cheng, Jianlin Jiang, Stephanie R. Soderberg, Mustafa V. Nural, Allison Hankus, Deepa Machiah, Ebru Karpuzoglu, Jeremy D. DeBarry, MaHPIC-Consortium, Rabindra Tirouvanziam, Jessica C. Kissinger, Alberto Moreno, Sanjeev Gumber, Eberhard O. Voit, Juan B. Gutierrez, Regina Joice Cordy, Mary R. Galinski, Dave C. Anderson, Ferhat Ay, Cristiana F. A. Brito, John W. Barnwell, Megan DeBarry, Steven E. Bosinger, Jung-Ting Chien, Jinho Choi, Anuj Gupta, Jay C. Humphrey, Chris Ibegbu, Xuntian Jiang, Dean P. Jones, Nicolas Lackman, Tracey J. Lamb, Frances E.-H. Lee, Karine Gaelle Le Roche, Shuzhao Li, Esmeralda V.S. Meyer, Diego M. Moncada-Giraldo, Dan Ory, Jan Pohl, Saeid Safaei, Ignacio Sanz, Maren Smith, Gregory Tharp, ViLinh Tran, Elizabeth D. Trippe, Karan Uppal, Susanne Warrenfeltz, Tyrone Williams, Zerotti L. Woods

Source: Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)

Subject Terms: malaria, antigenic variation, rhesus monkey (Macaca mulatta), gastritis, anemia, infected erythrocytes, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcimb.2022.888496/full; https://doaj.org/toc/2235-2988

Access URL: https://doaj.org/article/f9d42a57757a4753b7d629da228ac99f

Multiomics Analysis of Structural Magnetic Resonance Imaging of the Brain and Cerebrospinal Fluid Metabolomics in Cognitively Normal and Impaired Adults

Authors: Ronald C. Eldridge, Karan Uppal, Mahsa Shokouhi, M. Ryan Smith, Xin Hu, Zhaohui S. Qin, Dean P. Jones, Ihab Hajjar

Source: Frontiers in Aging Neuroscience, Vol 13 (2022)

Subject Terms: MRI imaging, metabolomics (OMICS), multiomics analysis, mild cognition impairment, amino acids (AA), Alzheimer’s disease, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fnagi.2021.796067/full; https://doaj.org/toc/1663-4365

Access URL: https://doaj.org/article/d9ed96ecf70c489c905dfa652a01582d

Antagonistic Interactions in Mitochondria ROS Signaling Responses to Manganese

Authors: Jolyn Fernandes, Karan Uppal, Ken H. Liu, Xin Hu, Michael Orr, ViLinh Tran, Young-Mi Go, Dean P. Jones

Source: Antioxidants, Vol 12, Iss 4, p 804 (2023)

Subject Terms: mitochondria, antioxidants, oxidative phosphorylation, redox regulation, exposome, integrated omics, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.mdpi.com/2076-3921/12/4/804; https://doaj.org/toc/2076-3921

Access URL: https://doaj.org/article/73bcf93c41c042fa9f6d6e022c5ee543

An atlas of metallome and metabolome interactions and associations with incident diabetes in the Strong Heart Family Study

Authors: Tiffany R. Sanchez, Xin Hu, Jinying Zhao, ViLinh Tran, Nancy Loiacono, Young-Mi Go, Walter Goessler, Shelley Cole, Jason Umans, Dean P. Jones, Ana Navas-Acien, Karan Uppal

Source: Environment International, Vol 157, Iss , Pp 106810- (2021)

Subject Terms: Integrative omics, Metabolomics, Metals, Metallomics, Metal-mixtures, Diabetes, Environmental sciences, GE1-350

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0160412021004359; https://doaj.org/toc/0160-4120

Access URL: https://doaj.org/article/5d10ff955b8f42c5861aa65456d65af6

16 Tumor growth inhibition mediated by a single dose of intratumoral TransCon™ TLR7/8 agonist was associated with activated circulating T and B cells and sustained low levels of systemic cytokines

Authors: Amer Mirza, David Rosen, Juha Punnonen, Enping Hong, Luis Zuniga, Karan Uppal, Kathy Bang, Simran Sabharwal, Yuchi Lee, Salomon Martinez

Source: Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/ab51cf4acb4a48fda431edd435e3dc09

769 A single dose of intratumoral TransCon™ TLR7/8 agonist monotherapy promoted sustained activation of antigen presenting cells resulting in CD4+ and CD8+ T cell activation and tumor growth inhibition

Authors: Amer Mirza, David Rosen, Juha Punnonen, Enping Hong, Luis Zuniga, Karan Uppal, Kathy Bang, Simran Sabharwal, Yuchi Lee, Solomon Martinez

Source: Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/2213c1af161a460dae21110d56f96d23

Perturbations of the arginine metabolome following exposures to traffic-related air pollution in a panel of commuters with and without asthma

Authors: Donghai Liang, Chandresh N. Ladva, Rachel Golan, Tianwei Yu, Douglas I. Walker, Stefanie E. Sarnat, Roby Greenwald, Karan Uppal, ViLinh Tran, Dean P. Jones, Armistead G. Russell, Jeremy A. Sarnat

Source: Environment International, Vol 127, Iss , Pp 503-513 (2019)

Subject Terms: Environmental sciences, GE1-350

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0160412019304209; https://doaj.org/toc/0160-4120

Access URL: https://doaj.org/article/cd2545ca758447499347c24397d0fb79

Low-dose cadmium potentiates lung inflammatory response to 2009 pandemic H1N1 influenza virus in mice

Authors: Joshua D. Chandler, Xin Hu, Eun-Ju Ko, Soojin Park, Jolyn Fernandes, Young-Tae Lee, Michael L. Orr, Li Hao, M. Ryan Smith, David C. Neujahr, Karan Uppal, Sang-Moo Kang, Dean P. Jones, Young-Mi Go

Source: Environment International, Vol 127, Iss , Pp 720-729 (2019)

Subject Terms: Environmental sciences, GE1-350

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0160412018332045; https://doaj.org/toc/0160-4120

Access URL: https://doaj.org/article/fa1e14a497ea4787818f02b4a82c4a54

N8‐Acetylspermidine: A Polyamine Biomarker in Ischemic Cardiomyopathy With Reduced Ejection Fraction

Authors: Aditi Nayak, Chang Liu, Anurag Mehta, Yi‐An Ko, Ayman S. Tahhan, Devinder S. Dhindsa, Karan Uppal, Dean P. Jones, Javed Butler, Alanna A. Morris, Arshed A. Quyyumi

Source: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 11 (2020)

Subject Terms: biomarker, ischemic cardiomyopathy, risk prediction, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://doaj.org/toc/2047-9980

Access URL: https://doaj.org/article/03fe52a71c1546be8c95ca009775a71a

Cardiovascular Risk and Resilience Among Black Adults: Rationale and Design of the MECA Study

Authors: Shabatun J. Islam, Jeong Hwan Kim, Matthew Topel, Chang Liu, Yi‐An Ko, Mahasin S. Mujahid, Mario Sims, Mohamed Mubasher, Kiran Ejaz, Jan Morgan‐Billingslea, Kia Jones, Edmund K. Waller, Dean Jones, Karan Uppal, Sandra B. Dunbar, Priscilla Pemu, Viola Vaccarino, Charles D. Searles, Peter Baltrus, Tené T. Lewis, Arshed A. Quyyumi, Herman Taylor

Source: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 9 (2020)

Subject Terms: cardiovascular disease prevention, disparities, race and ethnicity, risk factor, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://doaj.org/toc/2047-9980

Access URL: https://doaj.org/article/329832846c674defa5bc478c642ea6e9

Plasma Metabolomics of Intermediate and Neovascular Age-Related Macular Degeneration Patients

Authors: Sabrina L. Mitchell, Chunyu Ma, William K. Scott, Anita Agarwal, Margaret A. Pericak-Vance, Jonathan L. Haines, Dean P. Jones, Karan Uppal, Milam A. Brantley

Source: Cells, Vol 10, Iss 11, p 3141 (2021)

Subject Terms: age-related macular degeneration, IAMD, NVAMD, metabolomics, acylcarnitines, carnitine shuttle, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/10/11/3141; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/1988585a959e449fb6547ea6a03ac1c2