UGGT1-mediated reglucosylation of N-glycan competes with ER-associated degradation of unstable and misfolded glycoproteins

Authors: Satoshi Ninagawa, Masaki Matsuo, Deng Ying, Shuichiro Oshita, Shinya Aso, Kazutoshi Matsushita, Mai Taniguchi, Akane Fueki, Moe Yamashiro, Kaoru Sugasawa, Shunsuke Saito, Koshi Imami, Yasuhiko Kizuka, Tetsushi Sakuma, Takashi Yamamoto, Hirokazu Yagi, Koichi Kato, Kazutoshi Mori

Source: eLife, Vol 12 (2024)

Subject Terms: ER protein quality control, protein folding, protein degradation, UGGT1, EDEM, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/93117; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/42d5cb3e54fd4c2c93fd5d5ac18d10e8

Fluorescence-microscopy-based assay assessing regulatory mechanisms of global genome nucleotide excision repair in cultured cells

Authors: Masayuki Kusakabe, Kaoru Sugasawa

Source: STAR Protocols, Vol 4, Iss 3, Pp 102378- (2023)

Subject Terms: Cell Biology, Cell Culture, Microscopy, Molecular Biology, Science (General), Q1-390

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666166723003453; https://doaj.org/toc/2666-1667

Access URL: https://doaj.org/article/cd8b22204e3545aaad3991113f4d10f2

Histone deacetylation regulates nucleotide excision repair through an interaction with the XPC protein

Authors: Masayuki Kusakabe, Erina Kakumu, Fumika Kurihara, Kazuki Tsuchida, Takumi Maeda, Haruto Tada, Kanako Kusao, Akari Kato, Takeshi Yasuda, Tomonari Matsuda, Mitsuyoshi Nakao, Masayuki Yokoi, Wataru Sakai, Kaoru Sugasawa

Source: iScience, Vol 25, Iss 4, Pp 104040- (2022)

Subject Terms: Molecular biology, Molecular interaction, Cell biology, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004222003108; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/6a9067f664a44449b7507f62bceb667c

USP44 Stabilizes DDB2 to Facilitate Nucleotide Excision Repair and Prevent Tumors

Authors: Ying Zhang, Imke K. Mandemaker, Syota Matsumoto, Oded Foreman, Christopher P. Holland, Whitney R. Lloyd, Kaoru Sugasawa, Wim Vermeulen, Jurgen A. Marteijn, Paul J. Galardy

Source: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

Subject Terms: ubiquitin, animal model, DNA damage, deubiquitinating enzyme, tumor supperssor gene, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2021.663411/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/17a9c7aa9a754973ad2586ee1f0bfdee

Importance of finding the bona fide target of the Fanconi anemia pathway

Authors: Wataru Sakai, Kaoru Sugasawa

Source: Genes and Environment, Vol 41, Iss 1, Pp 1-4 (2019)

Subject Terms: Fanconi anemia, Aldehyde, DNA damage, DNA repair, Ecology, QH540-549.5, Genetics, QH426-470

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s41021-019-0122-y; https://doaj.org/toc/1880-7062

Access URL: https://doaj.org/article/ee8d40720b9847c2ab32940d72c697bb

Mechanism and regulation of DNA damage recognition in nucleotide excision repair

Authors: Masayuki Kusakabe, Yuki Onishi, Haruto Tada, Fumika Kurihara, Kanako Kusao, Mari Furukawa, Shigenori Iwai, Masayuki Yokoi, Wataru Sakai, Kaoru Sugasawa

Source: Genes and Environment, Vol 41, Iss 1, Pp 1-6 (2019)

Subject Terms: Nucleotide excision repair, DNA damage recognition, XPC, TFIIH, XPA, UV-DDB, Ecology, QH540-549.5, Genetics, QH426-470

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s41021-019-0119-6; https://doaj.org/toc/1880-7062

Access URL: https://doaj.org/article/7461d487236b476c8be8dd7d7159e3d5

Tyrosyl-DNA phosphodiesterases are involved in mutagenic events at a ribonucleotide embedded into DNA in human cells.

Authors: Ayuna Takeishi, Hiroyuki Kogashi, Mizuki Odagiri, Hiroyuki Sasanuma, Shunichi Takeda, Manabu Yasui, Masamitsu Honma, Tetsuya Suzuki, Hiroyuki Kamiya, Kaoru Sugasawa, Kiyoe Ura, Akira Sassa

Source: PLoS ONE, Vol 15, Iss 12, p e0244790 (2020)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/d653b045ca4047c8bc158c4aafc822ad

DGCR8 Mediates Repair of UV-Induced DNA Damage Independently of RNA Processing

Authors: Philamer C. Calses, Kiranjit K. Dhillon, Nyka Tucker, Yong Chi, Jen-wei Huang, Masaoki Kawasumi, Paul Nghiem, Yemin Wang, Bruce E. Clurman, Celine Jacquemont, Philip R. Gafken, Kaoru Sugasawa, Masafumi Saijo, Toshiyasu Taniguchi

Source: Cell Reports, Vol 19, Iss 1, Pp 162-174 (2017)

Subject Terms: DGCR8, Drosha, UV radiation, transcription-coupled nucleotide excision repair, JNK, microRNA, DNA repair, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124717303388; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/d2a0ebcac7f646e3b21efe404b0f2b3c

Novel function of HATs and HDACs in homologous recombination through acetylation of human RAD52 at double-strand break sites.

Authors: Takeshi Yasuda, Wataru Kagawa, Tomoo Ogi, Takamitsu A Kato, Takehiro Suzuki, Naoshi Dohmae, Kazuya Takizawa, Yuka Nakazawa, Matthew D Genet, Mika Saotome, Michio Hama, Teruaki Konishi, Nakako Izumi Nakajima, Masaharu Hazawa, Masanori Tomita, Manabu Koike, Katsuko Noshiro, Kenichi Tomiyama, Chizuka Obara, Takaya Gotoh, Ayako Ui, Akira Fujimori, Fumiaki Nakayama, Fumio Hanaoka, Kaoru Sugasawa, Ryuichi Okayasu, Penny A Jeggo, Katsushi Tajima

Source: PLoS Genetics, Vol 14, Iss 3, p e1007277 (2018)

Subject Terms: Genetics, QH426-470

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC5891081?pdf=render; https://doaj.org/toc/1553-7390; https://doaj.org/toc/1553-7404

Access URL: https://doaj.org/article/e1679cb73def4710aa1a8cba50af9b31

FANCD2 Binds CtIP and Regulates DNA-End Resection during DNA Interstrand Crosslink Repair

Authors: Junya Unno, Akiko Itaya, Masato Taoka, Koichi Sato, Junya Tomida, Wataru Sakai, Kaoru Sugasawa, Masamichi Ishiai, Tsuyoshi Ikura, Toshiaki Isobe, Hitoshi Kurumizaka, Minoru Takata

Source: Cell Reports, Vol 7, Iss 4, Pp 1039-1047 (2014)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124714002927; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/e36387d2c5d74315a6dd602ff2eac987

The DNA repair-ubiquitin-associated HR23 proteins are constituents of neuronal inclusions in specific neurodegenerative disorders without hampering DNA repair

Authors: Steven Bergink, Lies-Anne Severijnen, Nils Wijgers, Kaoru Sugasawa, Humaira Yousaf, Johan M. Kros, John van Swieten, Ben A. Oostra, Jan H. Hoeijmakers, Wim Vermeulen, Rob Willemsen

Source: Neurobiology of Disease, Vol 23, Iss 3, Pp 708-716 (2006)

Subject Terms: HR23B, Neurodegenerative disorders, Ubiquitin, Inclusions, DNA repair, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0969996106001458; https://doaj.org/toc/1095-953X

Access URL: https://doaj.org/article/3745910c010e4c4ea7ef66e775436bb7

Stimulation of DNA Glycosylase Activities by XPC Protein Complex: Roles of Protein-Protein Interactions

Authors: Yuichiro Shimizu, Yasuhiro Uchimura, Naoshi Dohmae, Hisato Saitoh, Fumio Hanaoka, Kaoru Sugasawa

Source: Journal of Nucleic Acids, Vol 2010 (2010)

Subject Terms: Genetics, QH426-470, Biochemistry, QD415-436

File Description: electronic resource

Relation: https://doaj.org/toc/2090-021X

Access URL: https://doaj.org/article/dc4fb6dfe1124927a3c374d2a336ce5e

Fluorescence detection of cellular nucleotide excision repair of damaged DNA.

Authors: Tatsuya Toga, Isao Kuraoka, Shun Watanabe, Eiji Nakano, Seiji Takeuchi, Chikako Nishigori, Kaoru Sugasawa, Shigenori Iwai

Source: Scientific Reports; 7/4/2014, p1-7, 7p

Subject Terms: NUCLEOTIDES, DNA damage, SURGICAL excision, HELA cells, GENE transfection, FLUORESCENCE microscopy, THERAPEUTICS

Thymine-rich single-stranded DNA activates Mcm4/6/7 helicase on Y-fork and bubble-like substrates.

Authors: Zhiying You, Yukio Ishimi, Takeshi Mizuno, Kaoru Sugasawa, Fumio Hanaoka, Hisao Masai

Source: EMBO Journal; 11/17/2003, Vol. 22 Issue 22, p6148, 13p

Subject Terms: DNA, ADENINE, THYMINE, ADENOSINE triphosphatase

XPC and human homologs of RAD23: intracellular localization and relationship to other nucleotide excision repair complexes.

Authors: van der Spek, Peter J., Eker, André, Rademakers, Suzanne, Visser, Cécile, Kaoru Sugasawa, Chikahide Masutani, Fumio Hanaoka, Bootsma, Dirk, Hoeijmakers, Jan H. J.

Source: Nucleic Acids Research; 1996, Vol. 24 Issue 13, p2551-2559, 9p, 1 Color Photograph, 7 Black and White Photographs

A formamidopyrimidine derivative from the deoxyguanosine adduct produced by food contaminant acrylamide induces DNA replication block and mutagenesis.

Authors: Jun-ichi Akagi¹ jun@nihs.go.jp, Masayuki Yokoi², Yumi Miyake³, Tsuyoshi Shirai⁴, Tomohiro Baba⁵, Young-Man Cho¹, Fumio Hanaoka^2,6, Kaoru Sugasawa², Shigenori Iwai⁵, Kumiko Ogawa¹

Source: Journal of Biological Chemistry. Aug2023, Vol. 299 Issue 8, p1-16. 16p.

Subject Terms: *DNA replication, *DEOXYGUANOSINE, *MUTAGENESIS, *DNA synthesis, *HUMAN DNA, *DNA polymerases, *ACRYLAMIDE, *DNA adducts

Structure-Specific Endonucleases Xpf and Mus81 Play Overlapping but Essential Roles in DNA Repair by Homologous Recombination.

Authors: Koji Kikuchi¹, Takeo Narita¹, Pham, Van T.¹, Junko Iijima¹, Kouji Hirota¹, Keka, Islam Shamima¹, Mohiuddin¹, Katsuya Okawa², Tetsuya Hori³, Tatsuo Fukagawa³, Essers, Jeroen^4,5,6, Kanaar, Roland^5,6, Whitby, Matthew C.⁷, Kaoru Sugasawa⁸, Yoshihito Taniguchi¹, Katsumi Kitagawa⁹, Shunichi Takeda¹ stakeda@rg.med.kyoto-u.ac.jp

Source: Cancer Research. Jul2013, Vol. 73 Issue 14, p4362-4371. 10p.

Subject Terms: *CANCER research, *DNA, *SISTER chromatid exchange, *CAMPTOTHECIN, *CHROMATIDS