Widespread association of the Argonaute protein AGO2 with meiotic chromatin suggests a distinct nuclear function in mammalian male reproduction

Authors: Griffin, Kimberly N., Walters, Benjamin William, Li, Haixin, Wang, Huafeng, Biancon, Giulia, Tebaldi, Toma, Kaya, Carolyn B., Kanyo, Jean, Lam, TuKiet T., Cox, Andy L.

Source: Genome research. 32(9):1655-1668

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN630313415&indx=1&recIds=ETOCRN630313415

Mycobacterium tuberculosis encodes a YhhN family membrane protein with lysoplasmalogenase activity that protects against toxic host lysolipids

Authors: Jurkowitz, Marianne S., Azad, Abul K., Monsma, Paula C., Keiser, Tracy L., Kanyo, Jean, Lam, TuKiet T., Bell, Charles E., Schlesinger, Larry S.

Source: In Journal of Biological Chemistry May 2022 298(5)

Photochemical Oxidation of Substrate Water Analogs and Halides by Photosystem II.

Authors: Shin, Jieun¹ (AUTHOR), Kanyo, Jean² (AUTHOR), Debus, Richard J.³ (AUTHOR), Brudvig, Gary W.¹ (AUTHOR) gary.brudvig@yale.edu

Source: Advanced Energy Materials. 10/11/2024, Vol. 14 Issue 38, p1-13. 13p.

Subject Terms: *PHOTOSYSTEMS, *BIOAVAILABILITY, *OXIDATION of water, *BIOCHEMICAL substrates, *SMALL molecules

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Preincubation With Everolimus and Sirolimus Reduces Organic Anion-Transporting Polypeptide (OATP)1B1- and 1B3-Mediated Transport Independently of mTOR Kinase Inhibition: Implication in Assessing OATP1B1- and OATP1B3-Mediated Drug-Drug Interactions

Authors: Farasyn, Taleah, Crowe, Alexandra, Hatley, Oliver, Neuhoff, Sibylle, Alam, Khondoker, Kanyo, Jean, Lam, TuKiet T., Ding, Kai, Yue, Wei

Source: In Journal of Pharmaceutical Sciences October 2019 108(10):3443-3456

Bioactive Plasma Mitochondrial DNA Is Associated With Disease Progression in Scleroderma‐Associated Interstitial Lung Disease

Authors: Ryu, Changwan, Walia, Anjali, Ortiz, Vivian, Perry, Carrighan, Woo, Sam, Reeves, Benjamin C., Sun, Huanxing, Winkler, Julia, Kanyo, Jean E., Wang, Weiwei, Vukmirovic, Milica, Ristic, Nicholas, Stratton, Eric A., Meena, Sita Ram, Minasyan, Maksym, Kurbanov, Daniel, Liu, Xinran, Lam, TuKiet T., Farina, Giuseppina, Gomez, Jose L., Gulati, Mridu, Herzog, Erica L.

Source: Arthritis & rheumatology. 72(11):1905-1915

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100109290171.0x000001&indx=1&recIds=ETOCvdc_100109290171.0x000001

Phosphorylation of the nuclear poly(A) binding protein (PABPN1) during mitosis protects mRNA from hyperadenylation and maintains transcriptome dynamics.

Authors: Gordon, Jackson M, Phizicky, David V, Schärfen, Leonard, Brown, Courtney L, Arias Escayola, Dahyana, Kanyo, Jean, Lam, TuKiet T, Simon, Matthew D, Neugebauer, Karla M

Source: Nucleic Acids Research; 9/9/2024, Vol. 52 Issue 16, p9886-9903, 18p

Abstract 1091 The biochemical mechanism of SARS-CoV-2 nucleocapsid protein hyperphosphorylation

Authors: Ha, Ya, Chen, Song, He, Zunyu, Kanyo, Jean, Lam, Tukiet, Ha, Grace, Lindenbach, Brett

Source: In Journal of Biological Chemistry March 2024 300(3) Supplement

Dual regulation of SLC25A39 by AFG3L2 and iron controls mitochondrial glutathione homeostasis

Authors: Shi, Xiaojian, DeCiucis, Marisa, Grabinska, Kariona A., Kanyo, Jean, Liu, Adam, Lam, Tukiet T., Shen, Hongying

Source: In Molecular Cell 15 February 2024 84(4):802-810

Reaction products of hexamethylene diisocyanate vapors with 'self' molecules in the airways of rabbits exposed via tracheostomy

Authors: Wisnewski, Adam V., Kanyo, Jean, Asher, Jennifer, Goodrich, James A., Barnett, Grace, Patrylak, Lyn, Liu, Jian, Redlich, Carrie A., Nassar, Ala F.

Source: Xenobiotica. 48(5):488-497

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100111090830.0x000001&indx=1&recIds=ETOCvdc_100111090830.0x000001

A versatile new tool derived from a bacterial deubiquitylase to detect and purify ubiquitylated substrates and their interacting proteins.

Authors: Zhang, Mengwen¹, Berk, Jason M.², Mehrtash, Adrian B.³, Kanyo, Jean⁴, Hochstrasser, Mark^2,3, mark.hochstrasser@yale.edu

Source: PLoS Biology; 6/30/2022, Vol. 20 Issue 6, p1-32, 32p, 4 Black and White Photographs, 2 Diagrams

MAP4K4 Is a Threonine Kinase That Phosphorylates FARP1

Authors: Schwaid, Adam G., Su, Chunyan, Loos, Paula, Wu, Jiang, Nguyen, Chuong, Stone, Kathryn L., Kanyo, Jean, Geoghegan, Kieran F., Bhattacharya, Samit K., Dow, Robert L.

Source: ACS chemical biology. 10(12):2667-2671

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN604250005&indx=1&recIds=ETOCRN604250005

Natural isoaspartyl protein modification of ZAP70 alters T cell responses in lupus.

Authors: Yang, Mei-Ling, Lam, TuKiet T., Kanyo, Jean, Kang, Insoo, Zhou, Zhaohui Sunny, Clarke, Steven G., Mamula, Mark J.

Source: Autoimmunity; 2023, Vol. 56 Issue 1, p1-13, 13p

Subject Terms: T cells, PROTEIN-tyrosine kinases, POST-translational modification, SYSTEMIC lupus erythematosus, ANTIGEN receptors, METHYLGUANINE

Carbonyl Posttranslational Modification Associated With Early-Onset Type 1 Diabetes Autoimmunity.

Authors: Yang, Mei-Ling, Connolly, Sean E., Gee, Renelle J., Lam, TuKiet T., Kanyo, Jean, Peng, Jian, Guyer, Perrin, Syed, Farooq, Tse, Hubert M., Clarke, Steven G., Clarke, Catherine F., James, Eddie A., Speake, Cate, Evans-Molina, Carmella, Arvan, Peter, Herold, Kevan C., Wen, Li, Mamula, Mark J.

Source: Diabetes; Sep2022, Vol. 71 Issue 9, p1979-1993, 15p

Subject Terms: PROTEIN metabolism, PROTEINS, ANIMAL experimentation, TYPE 1 diabetes, ISLANDS of Langerhans, INSULIN, PROINSULIN, IMMUNITY, RESEARCH funding, MICE, ANTIGENS

USP7-Specific Inhibitors Target and Modify the Enzyme's Active Site via Distinct Chemical Mechanisms

Authors: Pozhidaeva, Alexandra, Valles, Gabrielle, Wang, Feng, Wu, Jian, Sterner, David E., Nguyen, Phuong, Weinstock, Joseph, Kumar, K.G. Suresh, Kanyo, Jean, Wright, Dennis, Bezsonova, Irina

Source: Cell chemical biology. 24(12):1501-1512.e5

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100053263718.0x000001&indx=1&recIds=ETOCvdc_100053263718.0x000001

Citrullination of glucokinase is linked to autoimmune diabetes.

Authors: Yang, Mei-Ling, Horstman, Sheryl, Gee, Renelle, Guyer, Perrin, Lam, TuKiet T., Kanyo, Jean, Perdigoto, Ana L., Speake, Cate, Greenbaum, Carla J., Callebaut, Aïsha, Overbergh, Lut, Kibbey, Richard G., Herold, Kevan C., James, Eddie A., Mamula, Mark J.

Source: Nature Communications; 4/6/2022, Vol. 13 Issue 1, p1-11, 11p

Subject Terms: GLUCOKINASE, AUTOANTIBODIES, TYPE 1 diabetes, PANCREATIC beta cells, POST-translational modification, GLYCOLYSIS, REACTIVE oxygen species

Simple, Single-Shot Phosphoproteomic Analysis of Heat-Stable Tau Identifies Age-Related Changes in pS235- and pS396-Tau Levels in Non-human Primates.

Authors: Leslie, Shannon N., Kanyo, Jean, Datta, Dibyadeep, Wilson, Rashaun S., Zeiss, Caroline, Duque, Alvaro, Lam, TuKiet T., Arnsten, Amy F. T., Nairn, Angus C.

Source: Frontiers in Aging Neuroscience; 11/18/2021, Vol. 13, p1-11, 11p

Subject Terms: TAU proteins, DISEASE risk factors, TANDEM mass spectrometry, RHESUS monkeys, PROTEIN domains

Fluorescence emission of ethidium bromide intercalated in defined DNA duplexes: evaluation of hydrodynamics components.

Authors: Duhamel, Jean, Kanyo, Jean, Dinter-Gottlieb, Gail

Source: Biochemistry; December 24 1996, Vol. 35, p16687-16697, 11p

SUBCELLULAR ORGANELLE FRACTIONATION FOR PROTEOMIC ANALYSIS IN POSTMORTEM ALZHEIMER'S DISEASE TISSUE

Authors: Kandigian, Savannah E., Trombetta, Bianca A., Kanyo, Jean E., Arnold, Steven E., Carlyle, Becky C.

Source: Alzheimer's & dementia. 15(7):P1341-P1341

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100091204472.0x000001&indx=1&recIds=ETOCvdc_100091204472.0x000001

Phosphorylation of human placental aromatase CYP19A1.

Authors: Ghosh, Debashis, Egbuta, Chinaza, Kanyo, Jean E., Lam, TuKiet T.

Source: Biochemical Journal; Nov2019, Vol. 476 Issue 21, p3313-3331, 19p

Subject Terms: NEUROTRANSMITTER receptors, POST-translational modification, ESTROGEN, ESTROGEN receptors, PHOSPHORYLATION, AROMATASE, CENTRAL nervous system, ENDOCRINE system