Invention of novel 3-aminopiperidin-2-ones as calcitonin gene-related peptide receptor antagonists

Authors: Staas, Donnette D., Bell, Ian M., Burgey, Christopher S., Deng, James Z., Gallicchio, Steven N., Lim, John J., Paone, Daniel V., Potteiger, Craig M., Shaw, Anthony W., Stevenson, Heather, Stump, Craig A., Blair Zartman, C., Moore, Eric L., Bruno, Joseph G., Mosser, Scott D., White, Rebecca B., Kane, Stefanie A., Salvatore, Christopher A., Graham, Samuel L., Williams, Theresa M., Selnick, Harold G., Fraley, Mark E.

Source: In Bioorganic & Medicinal Chemistry Letters 1 November 2024 112

Identification of second-generation P2X3 antagonists for treatment of pain

Authors: Ginnetti, Anthony T., Paone, Daniel V., Stauffer, Shaun R., Potteiger, Craig M., Shaw, Anthony W., Deng, James, Mulhearn, James J., Nguyen, Diem N., Segerdell, Carolyn, Anquandah, Juliana, Calamari, Amy, Cheng, Gong, Leitl, Michael D., Liang, Annie, Moore, Eric, Panigel, Jacqueline, Urban, Mark, Wang, Jixin, Fillgrove, Kerry, Tang, Cuyue, Cook, Sean, Kane, Stefanie, Salvatore, Christopher A., Graham, Samuel L., Burgey, Christopher S.

Source: Bioorganic & medicinal chemistry letters. 28(8):1392-1396

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100064017967.0x000001&indx=1&recIds=ETOCvdc_100064017967.0x000001

Discovery of MK-1832, a Kv1.5 inhibitor with improved selectivity and pharmacokinetics

Authors: Wolkenberg, Scott E., Nolt, M. Brad, Bilodeau, Mark T., Trotter, B. Wesley, Manley, Peter J., Kett, Nathan R., Nanda, Kausik K., Wu, Zhicai, Cato, Matthew J., Kane, Stefanie A., Kiss, Laszlo, Spencer, Robert H., Wang, Jixin, Lynch, Joseph J., Regan, Christopher P., Stump, Gary L., Li, Bing, White, Rebecca, Yeh, Suzie, Dinsmore, Christopher J., Lindsley, Craig W., Hartman, George D.

Source: Bioorganic & medicinal chemistry letters. 27(4):1062-1069

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100064797012.0x000001&indx=1&recIds=ETOCvdc_100064797012.0x000001

In Vivo Quantification of Calcitonin Gene-Related Peptide Receptor Occupancy by Telcagepant in Rhesus Monkey and Human Brain Using the Positron Emission Tomography Tracer [11C]MK-4232

Authors: Hostetler, Eric D. ^*, Joshi, Aniket D., Sanabria-Bohórquez, Sandra, Fan, Hong, Zeng, Zhizhen, Purcell, Mona, Gantert, Liza, Riffel, Kerry, Williams, Mangay, O’Malley, Stacey, Miller, Patricia, Selnick, Harold G., Gallicchio, Steven N., Bell, Ian M., Salvatore, Christopher A., Kane, Stefanie A., Li, Chi-Chung, Hargreaves, Richard J., de Groot, Tjibbe, Bormans, Guy, Van Hecken, Anne, Derdelinckx, Inge, de Hoon, Jan, Reynders, Tom, Declercq, Ruben, De Lepeleire, Inge, Kennedy, W.P., Blanchard, Rebecca, Marcantonio, Eugene E., Sur, Cyrille, Cook, Jacquelynn J., Van Laere, Koen, Evelhoch, Jeffrey L.

Source: In The Journal of Pharmacology and Experimental Therapeutics November 2013 347(2):478-486

Novel oxazolidinone calcitonin gene-related peptide (CGRP) receptor antagonists for the acute treatment of migraine

Authors: Crowley, Brendan M., Stump, Craig A., Nguyen, Diem N., Potteiger, Craig M., McWherter, Melody A., Paone, Daniel V., Quigley, Amy G., Bruno, Joseph G., Cui, Dan, Culberson, J. Christopher, Danziger, Andrew, Fandozzi, Christine, Gauvreau, Danny, Kemmerer, Amanda L., Menzel, Karsten, Moore, Eric L., Mosser, Scott D., Reddy, Vijay, White, Rebecca B., Salvatore, Christopher A., Kane, Stefanie A., Bell, Ian M., Selnick, Harold G., Fraley, Mark E., Burgey, Christopher S.

Source: Bioorganic & medicinal chemistry letters. 25(21):4777-4781

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100064270260.0x000001&indx=1&recIds=ETOCvdc_100064270260.0x000001

Pharmacological Properties of MK-3207, a Potent and Orally Active Calcitonin Gene-Related Peptide Receptor Antagonist

Authors: Salvatore, Christopher A. ^*, Moore, Eric L., Calamari, Amy, Cook, Jacquelynn J., Michener, Maria S., O'Malley, Stacey, Miller, Patricia J., Sur, Cyrille, Williams, David L., Jr., Zeng, Zhizhen, Danziger, Andrew, Lynch, Joseph J., Regan, Christopher P., Fay, John F., Tang, Yui S., Li, Chi-Chung, Pudvah, Nicole T., White, Rebecca B., Bell, Ian M., Gallicchio, Steven N., Graham, Samuel L., Selnick, Harold G., Vacca, Joseph P., Kane, Stefanie A.

Source: In The Journal of Pharmacology and Experimental Therapeutics April 2010 333(1):152-160

Calcitonin Gene-Related Peptide Receptor Antagonism Does Not Affect the Severity of Myocardial Ischemia during Atrial Pacing in Dogs with Coronary Artery Stenosis

Authors: Regan, Christopher P., Stump, Gary L., Kane, Stefanie A., Lynch, Joseph J., Jr. ^*

Source: In The Journal of Pharmacology and Experimental Therapeutics February 2009 328(2):571-578

Antinociceptive effects of the non-selective cannabinoid receptor agonist CP 55,940 are absent in CB1 −/− and not CB2 −/− mice in models of acute and persistent pain

Authors: Sain, Nova M.H., Liang, Annie, Kane, Stefanie A., Urban, Mark O.

Source: In Neuropharmacology 2009 57(3):235-241

Effects of the prototype serotonin 5-HT 1B/1D receptor agonist sumatriptan and the calcitonin gene-related peptide (CGRP) receptor antagonist CGRP 8–37 on myocardial reactive hyperemic response in conscious dogs

Authors: Lynch, Joseph J., Shen, You-Tang, Pittman, Tamara J., Anderson, Kenneth D., Koblan, Kenneth S., Gould, Robert J., Regan, Christopher P., Kane, Stefanie A.

Source: In European Journal of Pharmacology 2009 623(1):96-102

Examining the binding properties of MK-0974: A CGRP receptor antagonist for the acute treatment of migraine

Authors: Moore, Eric L., Burgey, Christopher S., Paone, Daniel V., Shaw, Anthony W., Tang, Yui S., Kane, Stefanie A., Salvatore, Christopher A.

Source: In European Journal of Pharmacology 2009 602(2):250-254

Analogs of MK-499 are differentially affected by a mutation in the S6 domain of the hERG K+ channel

Authors: Karczewski, Jerzy, Wang, Jixin, Kane, Stefanie A., Kiss, Laszlo, Koblan, Kenneth S., Culberson, J. Christopher, Spencer, Robert H.

Source: In Biochemical Pharmacology 2009 77(10):1602-1611

High-throughput analysis of drug binding interactions for the human cardiac channel, Kv1.5

Authors: Karczewski, Jerzy, Kiss, Laszlo, Kane, Stefanie A., Koblan, Kenneth S., Lynch, Robert J., Spencer, Robert H.

Source: In Biochemical Pharmacology 2009 77(2):177-185

Pharmacological Characterization of MK-0974 [N-[(3 R,6 S)-6-(2,3-Difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(2-oxo-2,3-dihydro-1 H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide], a Potent and Orally Active Calcitonin Gene-Related Peptide Receptor Antagonist for the Treatment of Migraine

Authors: Salvatore, Christopher A. ^*, Hershey, James C., Corcoran, Halea A., Fay, John F., Johnston, Victor K., Moore, Eric L., Mosser, Scott D., Burgey, Christopher S., Paone, Daniel V., Shaw, Anthony W., Graham, Samuel L., Vacca, Joseph P., Williams, Theresa M., Koblan, Kenneth S., Kane, Stefanie A.

Source: In The Journal of Pharmacology and Experimental Therapeutics February 2008 324(2):416-421

Nucleic Acids Encoding a Functional Mammalin Purinoreceptor, P2X3, Methods of Production and Use Thereof

Isolated DNA molecules encoding humanized calcitonin gene-related peptide receptor, related non-human transgenic animals and assay methods

In vitro characterization of novel NR2B selective NMDA receptor antagonists

Authors: Kiss, Laszlo ^*, Cheng, Gong, Bednar, Bohumil, Bednar, Rodney A., Bennett, Paul B., Kane, Stefanie A., McIntyre, Charles J., McCauley, John A., Koblan, Kenneth S.

Source: In Neurochemistry International 2005 46(6):453-464

Investigation of the species selectivity of a nonpeptide CGRP receptor antagonist using a novel pharmacodynamic assay

Authors: Hershey, James C. ^*, Corcoran, Halea A., Baskin, Elizabeth P., Salvatore, Christopher A., Mosser, Scott, Williams, Theresa M., Koblan, Kenneth S., Hargreaves, Richard J., Kane, Stefanie A.

Source: In Regulatory Peptides 2005 127(1):71-77

Photo-potentiation of cisplatin chemotherapy

Guanosine-specific DNA damage by a Co(II)·bithiazole complex.

Authors: Kane, Stefanie A., Sasaki, Hideaki, Hecht, Sidney M.

Source: Journal of the American Chemical Society; September 13 1995, Vol. 117, p9107-9118, 12p

Photoreactivity of platinum(II) in cisplatin-modified DNA affords specific cross-links to HMG domain proteins.

Authors: Kane, Stefanie A., Lippard, Stephen J.

Source: Biochemistry; February 20 1996, Vol. 35, p2180-2188, 9p