A method to isolate syncytiotrophoblast-derived medium-large extracellular vesicle small RNA from maternal plasma

Authors: Cooke, William R., Zhang, Wei, Kandzija, Neva, Jones, Gabriel Davis, Redman, Christopher WG., Vatish, Manu

Source: In Placenta March 2024

Placental capillary pericytes release excess extracellular vesicles under hypoxic conditions inducing a pro-angiogenic profile in term pregnancy

Authors: Kandzija, Neva, Rahbar, Maryam, Jones, Gabriel Davis, Motta-Mejia, Carolina, Zhang, Wei, Couch, Yvonne, Neuhaus, Ain A., Kishore, Uday, Sutherland, Brad A., Redman, Christopher, Vatish, Manu

Source: Biochemical and biophysical research communications. 651:20-29

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Protein Profiling of Placental Extracellular Vesicles in Gestational Diabetes Mellitus.

Authors: Kandzija, Neva¹ (AUTHOR) neva.kandzija@wrh.ox.ac.uk, Payne, Sophie¹ (AUTHOR) sophie.payne@queens.ox.ac.uk, Cooke, William R.¹ (AUTHOR) william.cooke@wrh.ox.ac.uk, Seedat, Faheem¹ (AUTHOR) faheem.seedat@wrh.ox.ac.uk, Fischer, Roman² (AUTHOR) roman.fischer@ndm.ox.ac.uk, Vatish, Manu¹ (AUTHOR) manu.vatish@wrh.ox.ac.uk

Source: International Journal of Molecular Sciences. Feb2024, Vol. 25 Issue 4, p1947. 18p.

Subject Terms: *PREGNANCY proteins, *EXTRACELLULAR vesicles, *PREGNANCY, *GESTATIONAL diabetes, *INSULIN resistance, *INSULIN, *PLACENTAL growth factor, *PROTEOMICS, *GESTATIONAL age

Geographic Terms: UNITED Kingdom

Syncytiotrophoblast‐derived extracellular vesicles carry apolipoprotein‐E and affect lipid synthesis of liver cells in vitro

Authors: Tersigni, Chiara, Furqan Bari, Muhammad, Cai, Shijei, Zhang, Wei, Kandzija, Neva, Buchan, Alice, Miranda, Fabrizio, Di Simone, Nicoletta, Redman, Christopher W., Bastie, Claire, Vatish, Manu

Source: Journal of cellular and molecular medicine. 26(1):123-132

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100138828588.0x000001&indx=1&recIds=ETOCvdc_100138828588.0x000001

Neuropilin-1 is uniquely expressed on small syncytiotrophoblast extracellular vesicles but not on medium/large vesicles from preeclampsia and normal placentae

Authors: Awoyemi, Toluwalase, Iaccarino, Daniela A., Motta-Mejia, Carolina, Raiss, Sina, Kandzija, Neva, Zhang, Wei, Vatish, Manu

Source: Biochemical and biophysical research communications. 619:151-158

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100169699006.0x000001&indx=1&recIds=ETOCvdc_100169699006.0x000001

Placental small extracellular vesicles from normal pregnancy and gestational diabetes increase insulin gene transcription and content in β cells.

Authors: Seedat, Faheem^1,2 faheem.seedat@wrh.ox.ac.uk, Kandzija, Neva², Ellis, Michael J.¹, Shuhan Jiang², Sarbalina, Asselzhan², Bancroft, James¹, Drydale, Edward¹, Hester, Svenja S.³, Fischer, Roman³, Wade, Alisha N.^4,5, Stefana, M. Irina¹, Todd, John A.¹, Vatish, Manu^1,2 manu.vatish@wrh.ox.ac.uk

Source: Clinical Science. Nov2024, Vol. 138 Issue 22, p1481-1502. 22p.

Subject Terms: *HUMAN biology, *EXTRACELLULAR vesicles, *INSULIN synthesis, *ISLANDS of Langerhans, *GENE expression

Adverse drug reactions that arise from the use of medicinal products outside the terms of the marketing authorisation

Authors: Mirosevic Skvrce, Nikica, Galic, Iva, Pacadi, Carmen, Kandzija, Neva, Mucalo, Iva

Source: In Research in Social and Administrative Pharmacy July 2020 16(7):928-934

Glycosylated Siglec-6 expression in syncytiotrophoblast-derived extracellular vesicles from preeclampsia placentas

Authors: Awoyemi, Toluwalase, Tannetta, Dionne, Zhang, Wei, Kandzija, Neva, Motta-Mejia, Carolina, Fischer, Roman, Heilig, Raphael, Raiss, Sina, Redman, Christopher, Vatish, Manu

Source: Biochemical and biophysical research communications. 533(4):838-844

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100135594656.0x000001&indx=1&recIds=ETOCvdc_100135594656.0x000001

Maternal circulating syncytiotrophoblast-derived extracellular vesicles contain biologically active 5'-tRNA halves

Authors: Cooke, William R., Cribbs, Adam, Zhang, Wei, Kandzija, Neva, Motta-Mejia, Carolina, Dombi, Eszter, Ri, Rannya, Cerdeira, Ana Sofia, Redman, Christopher, Vatish, Manu

Source: Biochemical and biophysical research communications. 518(1):107-113

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100087286387.0x000001&indx=1&recIds=ETOCvdc_100087286387.0x000001

Placental Syncytiotrophoblast-Derived Extracellular Vesicles Carry Active NEP (Neprilysin) and Are Increased in Preeclampsia

Authors: Gill, Manjot, Motta-Mejia, Carolina, Kandzija, Neva, Cooke, William, Zhang, Wei, Cerdeira, Ana Sofia, Bastie, Claire, Redman, Christopher, Vatish, Manu

Source: Hypertension. 73(5):1112-1119

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100176812770.0x000001&indx=1&recIds=ETOCvdc_100176812770.0x000001

Delivery of Riboflavin-5′-Monophosphate Into the Cornea: Can Liposomes Provide Any Enhancement Effects?

Authors: Kandzija, Neva, Khutoryanskiy, Vitaliy V.

Source: In Journal of Pharmaceutical Sciences October 2017 106(10):3041-3049

Placental Vesicles Carry Active Endothelial Nitric Oxide Synthase and Their Activity is Reduced in Preeclampsia

Authors: Motta-Mejia, Carolina, Kandzija, Neva, Zhang, Wei, Mhlomi, Vuyane, Cerdeira, Ana Sofia, Burdujan, Alexandra, Tannetta, Dionne, Dragovic, Rebecca, Sargent, Ian L., Redman, Christopher W., Kishore, Uday, Vatish, Manu

Source: Hypertension. 70(2):372-381

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100049596995.0x000001&indx=1&recIds=ETOCvdc_100049596995.0x000001

Using isolated mitochondria to improve placental bioenergetics: A potential treatment for Fetal Growth Restriction (FGR)

Authors: Kandzija, Neva, Matsumiya, Yosuke, Hutchinson, Sarah, Mazey, Emily, Zhang, Wei, Bancroft, James, Drydale, Edward, Chow, Michael, James, Tim, Ota, Hisashi, Morten, Karl, Vatish, Manu

Source: In Placenta 7 September 2023 140

In vivo evidence of significant placental growth factor release by normal pregnancy placentas

Authors: Cerdeira, Ana Sofia, Kandzija, Neva, Pargmae, Pille, Tome, Mariana, Zhang, Wei, Cooke, William R., Agrawal, Swati, James, Tim, Redman, Christopher, Vatish, Manu

Source: Scientific reports. 10(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100130094257.0x000001&indx=1&recIds=ETOCvdc_100130094257.0x000001

Placental extracellular vesicles express active dipeptidyl peptidase IV; levels are increased in gestational diabetes mellitus

Authors: Kandzija, Neva, Zhang, Wei, Motta‐Mejia, Carolina, Mhlomi, Vuyane, McGowan‐Downey, Jennifer, James, Tim, Cerdeira, Ana Sofia, Tannetta, Dionne, Sargent, Ian, Redman, Christopher W., Bastie, Claire C., Vatish, Manu

Source: Journal of extracellular vesicles. 8(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100122432718.0x000001&indx=1&recIds=ETOCvdc_100122432718.0x000001

Investigating the Roles of Small STBEV's Micrornas in the Pathogenesis of Early-Onset Preeclampsia through Bioinformatics.

Authors: Awoyemi, Toluwalase, Zhang, Wei, Tanetta, Dionne, Collett, Gavin, Logenthiran, Prassana, Kandzija, Neva, Rahbar, Maryam, Jiang, Shuhan, Redman, Chris, Vatish, Manu

Source: Placenta. 112:e24-e24

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100137146217.0x000001&indx=1&recIds=ETOCvdc_100137146217.0x000001

5'-tRNA-halves: circulating syncytiotrophoblast RNA signals in early-onset preeclampsia

Authors: Cooke, William, Jiang, Peiyong, Ji, Lu, Jones, Gabriel, Zhang, Wei, Kandzija, Neva, Cerdeira, Ana Sofia, Lo, Dennis, Redman, Christopher, Vatish, Manu

Source: Placenta. 112:e57-e57

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100137145998.0x000001&indx=1&recIds=ETOCvdc_100137145998.0x000001

SYNCYTIOTROPHOBLAST AND SYNCYTIOTROPHOBLAST DERIVED EXTRACELLULAR VESICLES EXPRESS KYNURENINE METABOLISING ENZYMES

Authors: Logenthiran, Prassana, Awoyemi, Toluwalase, Jiang, Shuhan, Rahbar, Maryam, Kandzija, Neva, Zhang, Wei, Cerdeira, Sofia, Vatish, Manu

Source: Placenta. 112:e83-e83

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100137145796.0x000001&indx=1&recIds=ETOCvdc_100137145796.0x000001

Circulating soluble fms-like tyrosine kinase-1 is placentally derived in normal pregnancy: First in vivo evidence

Authors: Cerdeira, Ana Sofia, Kandzija, Neva, Pargmae, Pille, Cooke, William, James, Tim, Redman, Christopher, Vatish, Manu

Source: In Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health April 2019 16:145-147

Syncytiotrophoblast extracellular vesicles express functional insulin receptor capable of binding insulin; circulating levels are increased in Gestational Diabetes Mellitus

Authors: Kandzija, Neva, Shahjahan, Sylvia, Zhang, Wei, Cerdeira, Sofia, Mejia, Carolina Motta, Sanchez, Veronica, Daaboul, George, Redman, Christopher W., Vatish, Manu

Source: Placenta. 83:e95-e96

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100087486964.0x000001&indx=1&recIds=ETOCvdc_100087486964.0x000001