Counteracting tabun inhibition by reactivation by pyridinium aldoximes that interact with active center gorge mutants of acetylcholinesterase

Authors: Kovarik, Zrinka, Maček Hrvat, Nikolina, Kalisiak, Jarosław, Katalinić, Maja, Sit, Rakesh K., Zorbaz, Tamara, Radić, Zoran, Fokin, Valery V., Sharpless, K. Barry, Taylor, Palmer

Source: In Toxicology and Applied Pharmacology 1 June 2019 372:40-46

Evaluation of high-affinity phenyltetrahydroisoquinoline aldoximes, linked through anti-triazoles, as reactivators of phosphylated cholinesterases

Authors: Maček Hrvat, Nikolina, Kalisiak, Jarosław, Šinko, Goran, Radić, Zoran, Sharpless, K. Barry, Taylor, Palmer, Kovarik, Zrinka

Source: Toxicology letters. 321:83-89

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100095925846.0x000001&indx=1&recIds=ETOCvdc_100095925846.0x000001

Reversal of Tabun Toxicity Enabled by a Triazole‐Annulated Oxime Library—Reactivators of Acetylcholinesterase

Authors: Kovarik, Zrinka, Kalisiak, Jarosław, Hrvat, Nikolina Maček, Katalinić, Maja, Zorbaz, Tamara, Žunec, Suzana, Green, Carol, Radić, Zoran, Fokin, Valery V., Sharpless, K. Barry, Taylor, Palmer

Source: Chemistry. 25(16):4100-4114

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100082925914.0x000001&indx=1&recIds=ETOCvdc_100082925914.0x000001

Expanded therapeutic potential in activity space of next-generation 5-nitroimidazole antimicrobials with broad structural diversity

Authors: Miyamoto, Yukiko, Kalisiak, Jarosław, Korthals, Keith, Lauwaet, Tineke, Cheung, Dae Young, Lozano, Ricardo, Cobo, Eduardo R., Upcroft, Peter, Upcroft, Jacqueline A., Berg, Douglas E., Gillin, Frances D., Fokin, Valery V., Sharpless, K. Barry, Eckmann, Lars

Source: Proceedings of the National Academy of Sciences of the United States of America, 2013 Oct . 110(43), 17564-17569.

Access URL: https://www.jstor.org/stable/23753272

Oxime-assisted Acetylcholinesterase Catalytic Scavengers of Organophosphates That Resist Aging

Authors: Cochran, Rory, Kalisiak, Jarosław, Küçükkılınç, Tuba, Radić, Zoran, Garcia, Edzna, Zhang, Limin, Ho, Kwok-Yiu, Amitai, Gabriel, Kovarik, Zrinka, Fokin, Valery V., Sharpless, K. Barry, Taylor, Palmer

Source: In Journal of Biological Chemistry 26 August 2011 286(34):29718-29724

Interaction kinetics of oximes with native, phosphylated and aged human acetylcholinesterase

Authors: Radić, Zoran, Kalisiak, Jaroslaw, Fokin, Valery V., Sharpless, K. Barry, Taylor, Palmer

Source: In Chemico-Biological Interactions 2010 187(1):163-166

Investigating the structural influence of surface mutations on acetylcholinesterase inhibition by organophosphorus compounds and oxime reactivation

Authors: Küçükkilinç, Tuba, Cochran, Rory, Kalisiak, Jaroslaw, Garcia, Edzna, Valle, Anne, Amitai, Gabi, Radić, Zoran, Taylor, Palmer

Source: In Chemico-Biological Interactions 2010 187(1):238-240

Structural studies and binding properties of pendant diazacoronands—precursors to macrocyclic compounds of planar chirality

Authors: Kalisiak, Jarosław, Kalisiak, Ewa, Jurczak, Janusz

Source: In Tetrahedron 2006 62(25):5905-5914

Identification of a New Endogenous Metabolite and the Characterization of Its Protein Interactions through an Immobilization Approach.

Authors: Kalisiak, Jarosław, Trauger, Sunia A., Kalisiak, Ewa

Source: Journal of the American Chemical Society; January 14 2009, Vol. 131 Issue 1, p378-386, 9p

Click chemistry-facilitated comprehensive identification of proteins adducted by antimicrobial 5-nitroimidazoles for discovery of alternative drug targets against giardiasis.

Authors: Lauwaet, Tineke, Miyamoto, Yukiko, Ihara, Sozaburo, Le, Christine, Kalisiak, Jarosław, Korthals, Keith, Ghassemian, Majid, Smith, Diane K., Sharpless, K. Barry, Fokin, Valery V., Eckmann, Lars

Source: PLoS Neglected Tropical Diseases; 4/178/2020, Vol. 14 Issue 4, p1-27, 27p

Subject Terms: PROTEOMICS, DRUG target, HEAT shock proteins, DRUG resistance in microorganisms, ARGININE deiminase

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Amidine−Oximes: Reactivators for Organophosphate Exposure

Authors: Kalisiak, Jarosław, Ralph, Erik C., Zhang, Jun, Cashman, John R.

Source: Journal of Medicinal Chemistry; 20240101, Issue: Preprints

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