CC-4066 therapy delivered to kidneys during cold storage and assessed with normothermic reperfusion is feasible and safe

Authors: Pommelien Meertens, Azita Mellati, Richard Dumbill, M. Letizia Lo Faro, Kaithlyn Rozenberg, John Mulvey, Hans Fliri, Rutger Ploeg, James Hunter

Source: Frontiers in Transplantation, Vol 2 (2023)

Subject Terms: normothermic machine perfusion, CC4066, cyclophilin, inflammation, transplantation, ischemia-reperfusion injury, Specialties of internal medicine, RC581-951

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/frtra.2023.1166661/full; https://doaj.org/toc/2813-2440

Access URL: https://doaj.org/article/3f6eb3fc42354483ae2a357f4ed961db

Kidney Normothermic Machine Perfusion Can Be Used as a Preservation Technique and a Model of Reperfusion to Deliver Novel Therapies and Assess Inflammation and Immune Activation

Authors: Azita Mellati, Letizia Lo Faro, Richard Dumbill, Pommelien Meertens, Kaithlyn Rozenberg, Sadr Shaheed, Corinna Snashall, Hannah McGivern, Rutger Ploeg, James Hunter

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: normothermic machine perfusion, alpha-1 antitrypsin, inflammatory response, immune activation, cytokines, ischaemia–reperfusion injury, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.850271/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/7dc7c7723017416db25f7154fc50023e

Effects of Normothermic Machine Perfusion Conditions on Mesenchymal Stromal Cells

Authors: Jesus M. Sierra Parraga, Kaithlyn Rozenberg, Marco Eijken, Henri G. Leuvenink, James Hunter, Ana Merino, Cyril Moers, Bjarne K. Møller, Rutger J. Ploeg, Carla C. Baan, Bente Jespersen, Martin J. Hoogduijn

Source: Frontiers in Immunology, Vol 10 (2019)

Subject Terms: mesenchymal stromal cells, normothermic machine perfusion, kidney repair, endothelial cells, suspension conditions, perfusion fluid, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fimmu.2019.00765/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/15f641d19fb8414eae3adfd895e368fa