Mechanistic insight into the induction of liver tissue-resident memory CD8+ T cells by glycolipid-peptide vaccination

Authors: Chua, Yu Cheng ^{1, 9}, Draper, Sarah L. ^{2, 9}, Le, Shirley ¹, de Menezes, Maria N. ¹, Ganley, Mitch ¹, Ge, Zhengyu ¹, Lee, Ariane ¹, Phabmixay, Taylah ¹, Hirschmann, Daria ¹, Robinson, Sage A. ³, Tan, Peck Szee ⁴, Tullett, Kirsteen M. ⁴, Anderson, Regan J. ², Jayasinghe, Dhilshan ⁵, Cozijnsen, Anton ⁶, Lahoud, Mireille H. ⁴, Caminschi, Irina ^{1, 4}, Beattie, Lynette ¹, McFadden, Geoffrey I. ⁶, Larsen, David S. ³, Kaisho, Tsuneyasu ⁷, Gras, Stephanie ^{4, 5}, Hermans, Ian F. ⁸, Compton, Benjamin J. ², Heath, William R. ^{1, 10}, Painter, Gavin F. ^{2, 10}, Holz, Lauren E. ^{1, 10, 11, ∗}

Source: In Cell Reports 25 February 2025 44(2)

CD4+ T cells reactive to a hybrid peptide from insulin-chromogranin A adopt a distinct effector fate and are pathogenic in autoimmune diabetes

Authors: Mitchell, Jason S. ^{1, 8}, Spanier, Justin A. ^{1, 2, 3, 8}, Dwyer, Alexander J. ^{1, 2, 8}, Knutson, Todd P. ⁴, Alkhatib, Mohannad H. ^{1, 2}, Qian, Gina ^{1, 2}, Weno, Matthew E. ^{1, 2}, Chen, Yixin ^{1, 2}, Shaheen, Zachary R. ^{1, 7}, Tucker, Christopher G. ^{1, 2}, Kangas, Takashi O. ^{1, 2}, Morales, Milagros Silva ^{1, 2}, Silva, Nubia ², Kaisho, Tsuneyasu ⁶, Farrar, Michael A. ^{1, 5}, Fife, Brian T. ^{1, 2, 3, 9, ∗}

Source: In Immunity 8 October 2024 57(10):2399-2415

A stress sensor, IRE1α, is required for bacterial-exotoxin-induced interleukin-1β production in tissue-resident macrophages

Authors: Sasaki, Izumi ^{1, 21, ∗}, Fukuda-Ohta, Yuri ^{1, 2}, Nakai, Chihiro ¹, Wakaki-Nishiyama, Naoko ¹, Okamoto, Chizuyo ¹, Okuzaki, Daisuke ³, Morita, Shuhei ⁴, Kaji, Shiori ⁵, Furuta, Yuki ⁶, Hemmi, Hiroaki ^{1, 7}, Kato, Takashi ¹, Yamamoto, Asumi ¹, Tosuji, Emi ⁸, Saitoh, Shin-Ichiroh ⁹, Tanaka, Takashi ¹⁰, Hoshino, Katsuaki ¹¹, Fukuda, Shinji ^{12, 13, 14, 15}, Miyake, Kensuke ¹⁶, Kuroda, Etsushi ¹⁷, Ishii, Ken J. ¹⁸, Iwawaki, Takao ¹⁹, Furukawa, Koichi ²⁰, Kaisho, Tsuneyasu ^{1, ∗∗}

Source: In Cell Reports 23 April 2024 43(4)

TLR9-independent CD8+ T cell responses in hepatic AAV gene transfer through IL-1R1-MyD88 signaling

Authors: Kumar, Sandeep R.P. ¹, Biswas, Moanaro ¹, Cao, Di ¹, Arisa, Sreevani ¹, Muñoz-Melero, Maite ¹, Lam, Anh K. ¹, Piñeros, Annie R. ¹, Kapur, Reuben ¹, Kaisho, Tsuneyasu ², Kaufman, Randal J. ³, Xiao, Weidong ¹, Shayakhmetov, Dmitry M. ⁴, Terhorst, Cox ⁵, de Jong, Ype P. ⁶, Herzog, Roland W. ^{1, ∗}

Source: In Molecular Therapy 7 February 2024 32(2):325-339

Tmem45b is essential for inflammation- and tissue injury–induced mechanical pain hypersensitivity

Authors: Tanioku, Tadashi, Nishibata, Masayuki, Tokinaga, Yasuyuki, Konno, Kohtaro, Watanabe, Masahiko, Hemmi, Hiroaki, Fukuda-Ohta, Yuri, Kaisho, Tsuneyasu, Furue, Hidemasa, Kawamata, Tomoyuki

Source: Proceedings of the National Academy of Sciences of the United States of America, 2022 Nov 01. 119(45), 1-11.

Access URL: https://www.jstor.org/stable/27209312

Factor VIII trafficking to CD4+ T cells shapes its immunogenicity and requires several types of antigen-presenting cells

Authors: Kaczmarek, Radoslaw, Piñeros, Annie R., Patterson, Paige E., Bertolini, Thais B., Perrin, George Q., Sherman, Alexandra, Born, Jameson, Arisa, Sreevani, Arvin, Matthew C., Kamocka, Malgorzata M., Martinez, Michelle M., Dunn, Kenneth W., Quinn, Sean M., Morris, Johnathan J., Wilhelm, Amelia R., Kaisho, Tsuneyasu, Munoz-Melero, Maite, Biswas, Moanaro, Kaplan, Mark H., Linnemann, Amelia K., George, Lindsey A., Camire, Rodney M., Herzog, Roland W.

Source: In Blood 20 July 2023 142(3):290-305

XCR1+ DCs are critical for T cell-mediated immunotherapy of chronic viral infections

Authors: Domenjo-Vila, Eva, Casella, Valentina, Iwabuchi, Ryutaro, Fossum, Even, Pedragosa, Mireia, Castellví, Quim, Cebollada Rica, Paula, Kaisho, Tsuneyasu, Terahara, Kazutaka, Bocharov, Gennady, Argilaguet, Jordi, Meyerhans, Andreas

Source: In Cell Reports 28 February 2023 42(2)

Androgen-regulated MafB drives cell migration via MMP11-dependent extracellular matrix remodeling in mice

Authors: Alcantara, Mellissa C., Suzuki, Kentaro, Acebedo, Alvin R., Kajioka, Daiki, Hirohata, Satoshi, Kaisho, Tsuneyasu, Hatano, Yu, Yamagata, Kazuo, Takahashi, Satoru, Yamada, Gen

Source: In iScience 22 December 2022 25(12)

Thymic epithelial cells co-opt lineage-defining transcription factors to eliminate autoreactive T cells

Authors: Michelson, Daniel A., Hase, Koji, Kaisho, Tsuneyasu, Benoist, Christophe, Mathis, Diane

Source: In Cell 7 July 2022 185(14):2542-2558

Type 1 conventional dendritic cells maintain and guide the differentiation of precursors of exhausted T cells in distinct cellular niches

Authors: Dähling, Sabrina, Mansilla, Ana Maria, Knöpper, Konrad, Grafen, Anika, Utzschneider, Daniel T., Ugur, Milas, Whitney, Paul G., Bachem, Annabell, Arampatzi, Panagiota, Imdahl, Fabian, Kaisho, Tsuneyasu, Zehn, Dietmar, Klauschen, Frederick, Garbi, Natalio, Kallies, Axel, Saliba, Antoine-Emmanuel, Gasteiger, Georg, Bedoui, Sammy, Kastenmüller, Wolfgang

Source: In Immunity 12 April 2022 55(4):656-670

Type I interferon mediated induction of somatostatin leads to suppression of ghrelin and appetite thereby promoting viral immunity in mice

Authors: Stutte, Susanne, Ruf, Janina, Kugler, Ina, Ishikawa-Ankerhold, Hellen, Parzefall, Andreas, Marconi, Peggy, Maeda, Takahiro, Kaisho, Tsuneyasu, Krug, Anne, Popper, Bastian, Lauterbach, Henning, Colonna, Marco, von Andrian, Ulrich, Brocker, Thomas

Source: In Brain Behavior and Immunity July 2021 95:429-443

The inhibitory receptor TIM-3 limits activation of the cGAS-STING pathway in intra-tumoral dendritic cells by suppressing extracellular DNA uptake

Authors: de Mingo Pulido, Álvaro, Hänggi, Kay, Celias, Daiana P., Gardner, Alycia, Li, Jie, Batista-Bittencourt, Bruna, Mohamed, Eslam, Trillo-Tinoco, Jimena, Osunmakinde, Olabisi, Peña, Reymi, Onimus, Alexis, Kaisho, Tsuneyasu, Kaufmann, Johanna, McEachern, Kristen, Soliman, Hatem, Luca, Vincent C., Rodriguez, Paulo C., Yu, Xiaoqing, Ruffell, Brian

Source: In Immunity 8 June 2021 54(6):1154-1167

Immunogenic tumor cell death promotes dendritic cell migration and inhibits tumor growth via enhanced T cell immunity

Authors: Moriya, Taiki, Kitagawa, Kurumi, Hayakawa, Yuuki, Hemmi, Hiroaki, Kaisho, Tsuneyasu, Ueha, Satoshi, Ikebuchi, Ryoyo, Yasuda, Ippei, Nakanishi, Yasutaka, Honda, Tetsuya, Matsushima, Koji, Kabashima, Kenji, Ueda, Mizuki, Kusumoto, Yutaka, Chtanova, Tatyana, Tomura, Michio

Source: In iScience 21 May 2021 24(5)

Microfold cell-dependent antigen transport alleviates infectious colitis by inducing antigen-specific cellular immunity

Authors: Nakamura, Yutaka, Mimuro, Hitomi, Kunisawa, Jun, Furusawa, Yukihiro, Takahashi, Daisuke, Fujimura, Yumiko, Kaisho, Tsuneyasu, Kiyono, Hiroshi, Hase, Koji

Source: In Mucosal Immunology July 2020 13(4):679-690

Type I Interferon Delivery by iPSC-Derived Myeloid Cells Elicits Antitumor Immunity via XCR1+ Dendritic Cells

Authors: Tsuchiya, Nobuhiro, Zhang, Rong, Iwama, Tatsuaki, Ueda, Norihiro, Liu, Tianyi, Tatsumi, Minako, Sasaki, Yutaka, Shimoda, Ranmaru, Osako, Yuki, Sawada, Yu, Kubo, Yosuke, Miyashita, Azusa, Fukushima, Satoshi, Cheng, Zhao, Nakaki, Ryo, Takubo, Keiyo, Okada, Seiji, Kaneko, Shin, Ihn, Hironobu, Kaisho, Tsuneyasu, Nishimura, Yasuharu, Senju, Satoru, Endo, Itaru, Nakatsura, Tetsuya, Uemura, Yasushi

Source: In Cell Reports 1 October 2019 29(1):162-175

Hyperglycemia Is Associated with Psoriatic Inflammation in Both Humans and Mice

Authors: Ikumi, Kyoko, Odanaka, Mizuyu, Shime, Hiroaki, Imai, Masaki, Osaga, Satoshi, Taguchi, Osamu, Nishida, Emi, Hemmi, Hiroaki, Kaisho, Tsuneyasu, Morita, Akimichi, Yamazaki, Sayuri

Source: In Journal of Investigative Dermatology June 2019 139(6):1329-1338

Heme ameliorates dextran sodium sulfate-induced colitis through providing intestinal macrophages with noninflammatory profiles

Authors: Kayama, Hisako, Kohyama, Masako, Okuzaki, Daisuke, Motooka, Daisuke, Barman, Soumik, Okumura, Ryu, Muneta, Masato, Hoshino, Katsuaki, Sasaki, Izumi, Ise, Wataru, Matsuno, Hiroshi, Nishimura, Junichi, Kurosaki, Tomohiro, Nakamura, Shota, Arase, Hisashi, Kaisho, Tsuneyasu, Takeda, Kiyoshi

Source: Proceedings of the National Academy of Sciences of the United States of America, 2018 Aug . 115(33), 8418-8423.

Access URL: https://www.jstor.org/stable/26530253

Selective Contribution of IFN-α/β Signaling to the Maturation of Dendritic Cells Induced by Double-Stranded RNA or Viral Infection

Authors: Honda, Kenya, Sakaguchi, Shinya, Nakajima, Chigusa, Watanabe, Ai, Yanai, Hideyuki, Matsumoto, Misako, Ohteki, Toshiaki, Kaisho, Tsuneyasu, Takaoka, Akinori, Akira, Shizuo, Seya, Tsukasa, Taniguchi, Tadatsugu

Source: Proceedings of the National Academy of Sciences of the United States of America, 2003 Sep . 100(19), 10872-10877.

Access URL: https://www.jstor.org/stable/3147397

Role of Adaptor TRIF in the MyD88-Independent Toll-like Receptor Signaling Pathway

Authors: Yamamoto, Masahiro, Sato, Shintaro, Hemmi, Hiroaki, Hoshino, Katsuaki, Kaisho, Tsuneyasu, Sanjo, Hideki, Takeuchi, Osamu, Sugiyama, Masanaka, Okabe, Masaru, Takeda, Kiyoshi, Akira, Shizuo

Source: Science, 2003 Aug 01. 301(5633), 640-643.

Access URL: https://www.jstor.org/stable/3834886

Mast Cells Are Crucial for Induction of Group 2 Innate Lymphoid Cells and Clearance of Helminth Infections

Authors: Shimokawa, Chikako, Kanaya, Takashi, Hachisuka, Masami, Ishiwata, Kenji, Hisaeda, Hajime, Kurashima, Yosuke, Kiyono, Hiroshi, Yoshimoto, Tomohiro, Kaisho, Tsuneyasu, Ohno, Hiroshi

Source: In Immunity 16 May 2017 46(5):863-874