An abdominal obesity missense variant in the adipocyte thermogenesis gene TBX15 is implicated in adaptation to cold in Finns

Authors: Deal, Milena, Kar, Asha, Lee, Seung Hyuk T., Alvarez, Marcus, Rajkumar, Sandhya, Arasu, Uma Thanigai, Kaminska, Dorota, Männistö, Ville, Heinonen, Sini, van der Kolk, Birgitta W., Säiläkivi, Ulla, Saarinen, Tuure, Juuti, Anne, Pihlajamäki, Jussi, Kaikkonen, Minna U., Laakso, Markku, Pietiläinen, Kirsi H., Pajukanta, Päivi

Source: In The American Journal of Human Genetics 7 November 2024 111(11):2542-2560

Single nucleus RNA-sequencing integrated into risk variant colocalization discovers 17 cell-type-specific abdominal obesity genes for metabolic dysfunction-associated steatotic liver disease

Authors: Lee, Seung Hyuk T., Garske, Kristina M., Arasu, Uma Thanigai, Kar, Asha, Miao, Zong, Alvarez, Marcus, Koka, Amogha, Darci-Maher, Nicholas, Benhammou, Jihane N., Pan, David Z., Örd, Tiit, Kaminska, Dorota, Männistö, Ville, Heinonen, Sini, Wabitsch, Martin, Laakso, Markku, Agopian, Vatche G., Pisegna, Joseph R., Pietiläinen, Kirsi H., Pihlajamäki, Jussi, Kaikkonen, Minna U., Pajukanta, Päivi

Source: In eBioMedicine August 2024 106

Transcriptomic and spatial dissection of human ex vivo right atrial tissue reveals proinflammatory microvascular changes in ischemic heart disease

Authors: Linna-Kuosmanen, Suvi, Schmauch, Eloi, Galani, Kyriakitsa, Ojanen, Johannes, Boix, Carles A., Örd, Tiit, Toropainen, Anu, Singha, Prosanta K., Moreau, Pierre R., Harju, Kristiina, Blazeski, Adriana, Segerstolpe, Åsa, Lahtinen, Veikko, Hou, Lei, Kang, Kai, Meibalan, Elamaran, Agudelo, Leandro Z., Kokki, Hannu, Halonen, Jari, Jalkanen, Juho, Gunn, Jarmo, MacRae, Calum A., Hollmén, Maija, Hartikainen, Juha E.K., Kaikkonen, Minna U., García-Cardeña, Guillermo, Tavi, Pasi, Kiviniemi, Tuomas, Kellis, Manolis

Source: In Cell Reports Medicine 21 May 2024 5(5)

Genetic variation drives differences in obesity-related gene regulation

Authors: Kaikkonen, Minna U.

Source: In Trends in Genetics April 2024 40(4):296-298

Oncogenic KEAP1 mutations activate TRAF2-NFκB signaling to prevent apoptosis in lung cancer cells

Authors: Deen, Ashik Jawahar, Adinolfi, Simone, Härkönen, Jouni, Patinen, Tommi, Liu, Xiaonan, Laitinen, Tuomo, Takabe, Piia, Kainulainen, Kirsi, Pasonen-Seppänen, Sanna, Gawriyski, Lisa M., Arasu, Uma Thanigai, Selvarajan, Ilakya, Mäkinen, Petri, Laitinen, Hanna, Kansanen, Emilia, Kaikkonen, Minna U., Poso, Antti, Varjosalo, Markku, Levonen, Anna-Liisa

Source: In Redox Biology February 2024 69

ApoA-I Nanotherapy Rescues Postischemic Vascular Maladaptation by Modulating Endothelial Cell and Macrophage Phenotypes in Type 2 Diabetic Mice

Authors: Babu, Mohan, Devi, Durga, Mäkinen, Petri, Örd, Tiit, Aavik, Einari, Kaikkonen, Minna, Ylä-Herttuala, Seppo

Source: Arteriosclerosis, thrombosis, and vascular biology. 43(1):e46-e61

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100195074604.0x000001&indx=1&recIds=ETOCvdc_100195074604.0x000001

Exploring the genetic basis of coronary artery disease using functional genomics

Authors: López Rodríguez, Maykel, Arasu, Uma Thanigai, Kaikkonen, Minna U.

Source: Atherosclerosis. 374:87-98

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194186313.0x000001&indx=1&recIds=ETOCvdc_100194186313.0x000001

Dissecting the polygenic basis of atherosclerosis via disease-associated cell state signatures

Authors: Örd, Tiit, Lönnberg, Tapio, Nurminen, Valtteri, Ravindran, Aarthi, Niskanen, Henri, Kiema, Miika, Õunap, Kadri, Maria, Maleeha, Moreau, Pierre R., Mishra, Pashupati P., Palani, Senthil, Virta, Jenni, Liljenbäck, Heidi, Aavik, Einari, Roivainen, Anne, Ylä-Herttuala, Seppo, Laakkonen, Johanna P., Lehtimäki, Terho, Kaikkonen, Minna U.

Source: American journal of human genetics. 110(5):722-740

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100189289960.0x000001&indx=1&recIds=ETOCvdc_100189289960.0x000001

Genetic Regulation of SMC Gene Expression and Splicing Predict Causal CAD Genes

Authors: Aherrahrou, Rédouane, Lue, Dillon, Perry, R. Noah, Aberra, Yonathan Tamrat, Khan, Mohammad Daud, Soh, Joon Yuhl, Örd, Tiit, Singha, Prosanta, Yang, Qianyi, Gilani, Huda, Benavente, Ernest Diez, Wong, Doris, Hinkle, Jameson, Ma, Lijiang, Sheynkman, Gloria M., den Ruijter, Hester M., Miller, Clint L., Björkegren, Johan L.M., Kaikkonen, Minna U., Civelek, Mete

Source: Circulation research. 132(3):323-338

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100183974984.0x000001&indx=1&recIds=ETOCvdc_100183974984.0x000001

Hypoxic regulation of hypoxia inducible factor 1 alpha via antisense transcription

Authors: Downes, Nicholas, Niskanen, Henri, Tomas Bosch, Vanesa, Taipale, Mari, Godiwala, Mehvash, Väänänen, Mari-Anna, Turunen, Tiia A., Aavik, Einari, Laham-Karam, Nihay, Ylä-Herttuala, Seppo, Kaikkonen, Minna U.

Source: In Journal of Biological Chemistry November 2023 299(11)

Cross-tissue omics analysis discovers ten adipose genes encoding secreted proteins in obesity-related non-alcoholic fatty liver disease

Authors: Darci-Maher, Nicholas, Alvarez, Marcus, Arasu, Uma Thanigai, Selvarajan, Ilakya, Lee, Seung Hyuk T., Pan, David Z., Miao, Zong, Das, Sankha Subhra, Kaminska, Dorota, Örd, Tiit, Benhammou, Jihane N., Wabitsch, Martin, Pisegna, Joseph R., Männistö, Ville, Pietiläinen, Kirsi H., Laakso, Markku, Sinsheimer, Janet S., Kaikkonen, Minna U., Pihlajamäki, Jussi, Pajukanta, Päivi

Source: In eBioMedicine June 2023 92

A pan-cancer analysis shows immunoevasive characteristics in NRF2 hyperactive squamous malignancies

Authors: Härkönen, Jouni, Pölönen, Petri, Deen, Ashik Jawahar, Selvarajan, Ilakya, Teppo, Hanna-Riikka, Dimova, Elitsa Y., Kietzmann, Thomas, Ahtiainen, Maarit, Väyrynen, Juha P., Väyrynen, Sara A., Elomaa, Hanna, Tynkkynen, Niko, Eklund, Tiia, Kuopio, Teijo, Talvitie, Eva-Maria, Taimen, Pekka, Kallajoki, Markku, Kaikkonen, Minna U., Heinäniemi, Merja, Levonen, Anna-Liisa

Source: In Redox Biology May 2023 61

Functional noncoding SNPs in human endothelial cells fine-map vascular trait associations

Authors: Toropainen, Anu, Stolze, Lindsey K., Örd, Tiit, Whalen, Michael B., Torrell, Paula Martí, Link, Verena M., Kaikkonen, Minna U., Romanoski, Casey E.

Source: Genome research. 32(3):409-424

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN628812923&indx=1&recIds=ETOCRN628812923

The mechanisms of Chr.9p21.3 risk locus in coronary artery disease: where are we today?

Authors: Ruotsalainen, Anna-Kaisa, Kettunen, Sanna, Suoranta, Tuisku, Kaikkonen, Minna U., Ylä-Herttuala, Seppo, Aherrahrou, Rédouane

Source: American Journal of Physiology: Heart & Circulatory Physiology; Feb2025, Vol. 328 Issue 2, pH196-H208, 13p

Subject Terms: LINCRNA, CORONARY artery disease, SINGLE nucleotide polymorphisms, GENETIC variation, CIRCULAR RNA

QClus: a droplet filtering algorithm for enhanced snRNA-seq data quality in challenging samples.

Authors: Schmauch, Eloi, Ojanen, Johannes, Galani, Kyriakitsa, Jalkanen, Juho, Harju, Kristiina, Hollmén, Maija, Kokki, Hannu, Gunn, Jarmo, Halonen, Jari, Hartikainen, Juha, Kiviniemi, Tuomas, Tavi, Pasi, Kaikkonen, Minna U, Kellis, Manolis, Linna-Kuosmanen, Suvi

Source: Nucleic Acids Research; 1/13/2025, Vol. 53 Issue 1, p1-13, 13p

Progression of herpesvirus infection remodels mitochondrial organization and metabolism.

Authors: Leclerc, Simon¹, Gupta, Alka¹, Ruokolainen, Visa¹, Chen, Jian-Hua², Kunnas, Kari¹, Ekman, Axel A.^1,2, Niskanen, Henri³, Belevich, Ilya⁴, Vihinen, Helena⁴, Turkki, Paula⁵, Perez-Berna, Ana J.⁶, Kapishnikov, Sergey⁷, Mäntylä, Elina⁵, Harkiolaki, Maria⁸, Dufour, Eric⁵, Hytönen, Vesa^5,9, Pereiro, Eva⁶, McEnroe, Tony⁷, Fahy, Kenneth⁷, Kaikkonen, Minna U.³

Source: PLoS Pathogens; 4/15/2024, Vol. 20 Issue 4, p1-28, 28p

The corepressors GPS2 and SMRT control enhancer and silencer remodeling via eRNA transcription during inflammatory activation of macrophages

Authors: Huang, Zhiqiang, Liang, Ning, Goñi, Saioa, Damdimopoulos, Anastasios, Wang, Cheng, Ballaire, Raphaelle, Jager, Jennifer, Niskanen, Henri, Han, Hongya, Jakobsson, Tomas, Bracken, Adrian P., Aouadi, Myriam, Venteclef, Nicolas, Kaikkonen, Minna U., Fan, Rongrong, Treuter, Eckardt

Source: In Molecular Cell 4 March 2021 81(5):953-968

Integrative analysis of liver-specific non-coding regulatory SNPs associated with the risk of coronary artery disease

Authors: Selvarajan, Ilakya, Toropainen, Anu, Garske, Kristina M., López Rodríguez, Maykel, Ko, Arthur, Miao, Zong, Kaminska, Dorota, Õunap, Kadri, Örd, Tiit, Ravindran, Aarthi, Liu, Oscar H., Moreau, Pierre R., Jawahar Deen, Ashik, Männistö, Ville, Pan, Calvin, Levonen, Anna-Liisa, Lusis, Aldons J., Heikkinen, Sami, Romanoski, Casey E., Pihlajamäki, Jussi, Pajukanta, Päivi, Kaikkonen, Minna U.

Source: In The American Journal of Human Genetics 4 March 2021 108(3):411-430

Polycomb Repressive Complex 2 Regulates Genes Necessary for Intestinal Microfold Cell (M Cell) Development

Authors: George, Joel Johnson, Oittinen, Mikko, Martin-Diaz, Laura, Zapilko, Veronika, Iqbal, Sharif, Rintakangas, Terhi, Arrojo Martins, Fábio Tadeu, Niskanen, Henri, Katajisto, Pekka, Kaikkonen, Minna U., Viiri, Keijo

Source: In Cellular and Molecular Gastroenterology and Hepatology 2021 12(3):873-889

Profiling of Primary and Mature miRNA Expression in Atherosclerosis-Associated Cell Types

Authors: Moreau, Pierre R., Tomas Bosch, Vanesa, Bouvy-Liivrand, Maria, Õunap, Kadri, Örd, Tiit, Pulkkinen, Heidi H., Pölönen, Petri, Heinäniemi, Merja, Ylä-Herttuala, Seppo, Laakkonen, Johanna P., Linna-Kuosmanen, Suvi, Kaikkonen, Minna U.

Source: Arteriosclerosis, thrombosis, and vascular biology. 41(7):2149-2167

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100195068856.0x000001&indx=1&recIds=ETOCvdc_100195068856.0x000001