SLFN11-mediated ribosome biogenesis impairment induces TP53-independent apoptosis

Authors: Ogawa, Akane ^{1, 16}, Izumikawa, Keiichi ^{2, 16}, Tate, Sota ^{3, 4, 16}, Isoyama, Sho ⁵, Mori, Masaru ¹, Fujiwara, Kohei ⁴, Watanabe, Soyoka ¹, Ohga, Takayuki ², Jo, Ukhyun ⁶, Taniyama, Daiki ⁶, Kitajima, Shojiro ¹, Tanaka, Soichiro ¹, Onji, Hiroshi ⁴, Kageyama, Shun-Ichiro ⁷, Yamamoto, Gaku ⁸, Saito, Hitoshi ⁸, Morita, Tomoko Yamamori ⁸, Okada, Masayasu ^{9, 10}, Natsumeda, Manabu ^{9, 11}, Nagahama, Masami ², Kobayashi, Junya ^{12, 13}, Ohashi, Akihiro ⁸, Sasanuma, Hiroyuki ¹⁴, Higashiyama, Shigeki ^{3, 4, 15}, Dan, Shingo ⁵, Pommier, Yves ^{6, ∗}, Murai, Junko ^{1, 3, 4, 12, 17, ∗∗}

Source: In Molecular Cell 6 March 2025 85(5):894-912

Detection of HPV DNA in Saliva of Patients with HPV-Associated Oropharyngeal Cancer Treated with Radiotherapy.

Authors: Motegi, Atsushi^1,2 (AUTHOR) amotegi@ncc.go.jp, Kageyama, Shun-ichiro^1,2 (AUTHOR), Kashima, Yukie³ (AUTHOR), Hirata, Hidenari¹ (AUTHOR), Hojo, Hidehiro¹ (AUTHOR), Nakamura, Masaki¹ (AUTHOR), Fujisawa, Takeshi¹ (AUTHOR), Enokida, Tomohiro⁴ (AUTHOR), Tahara, Makoto⁴ (AUTHOR), Matsuura, Kazuto⁵ (AUTHOR), Zenda, Sadamoto^1,2 (AUTHOR)

Source: Current Oncology. Aug2024, Vol. 31 Issue 8, p4397-4405. 9p.

Subject Terms: *OROPHARYNGEAL cancer, *INDUCTION chemotherapy, *HUMAN papillomavirus, *CANCER radiotherapy, *DNA sequencing

Detection of Pretreatment Circulating Tumor DNA Predicts Recurrence after High-Dose Proton Beam Therapy for Early-Stage Non-Small Cell Lung Cancer

Authors: Nakamura, Masaki, Kageyama, Shun-Ichiro, Hirata, Hidenari, Tochinai, Taku, Hojo, Hidehiro, Motegi, Atsushi, Kanai, Akinori, Suzuki, Yutaka, Tsuchihara, Katsuya, Akimoto, Tetsuo

Source: International journal of radiation oncology, biology, physics. 116(5):1085-1090

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194267218.0x000001&indx=1&recIds=ETOCvdc_100194267218.0x000001

SpatialKNifeY (SKNY): Extending from spatial domain to surrounding area to identify microenvironment features with single-cell spatial omics data.

Authors: Sakai, Shunsuke A., Nomura, Ryosuke, Nagasawa, Satoi, Chi, SungGi, Suzuki, Ayako, Suzuki, Yutaka, Imai, Mitsuho, Nakamura, Yoshiaki, Yoshino, Takayuki, Ishikawa, Shumpei, Tsuchihara, Katsuya, Kageyama, Shun-Ichiro, Yamashita, Riu

Source: PLoS Computational Biology; 2/18/2025, Vol. 21 Issue 2, p1-22, 22p

Subject Terms: CANCER invasiveness, METASTASIS, TUMOR microenvironment, CANCER cells, COLORECTAL cancer

Impacts of the STING‐IFNAR1‐STAT1‐IRF1 pathway on the cellular immune reaction induced by fractionated irradiation

Authors: Du, Junyan, Kageyama, Shun‐Ichiro, Yamashita, Riu, Hirata, Hidenari, Hakozaki, Yumi, Okumura, Masayuki, Motegi, Atsushi, Hojo, Hidehiro, Nakamura, Masaki, Hirano, Yasuhiro, Sunakawa, Hironori, Minamide, Tatsunori, Kotani, Daisuke, Tanaka, Kosuke, Yano, Tomonori, Kojima, Takashi, Ohashi, Akihiro, Tsuchihara, Katsuya, Akimoto, Tetsuo

Source: Cancer science. 113(4):1352-1361

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100146272810.0x000001&indx=1&recIds=ETOCvdc_100146272810.0x000001

Radiation pneumonitis after palliative radiotherapy in cancer patients with interstitial lung disease

Authors: Okumura, Masayuki, Hojo, Hidehiro, Nakamura, Masaki, Hiyama, Takashi, Nakamura, Naoki, Zenda, Sadamoto, Motegi, Atsushi, Hirano, Yasuhiro, Kageyama, Shun-Ichiro, Parshuram, Raturi Vijay, Fujisawa, Takeshi, Kuno, Hirofumi, Akimoto, Tetsuo

Source: In Radiotherapy and Oncology August 2021 161:47-54

Identification of the mutation signature of the cancer genome caused by irradiation

Authors: Kageyama, Shun-Ichiro, Du, Junyan, Kaneko, Syuzo, Hamamoto, Ryuji, Yamaguchi, Shigeo, Yamashita, Riu, Okumura, Masayuki, Motegi, Atsushi, Hojo, Hidehiro, Nakamura, Masaki, Tsuchihara, Katsuya, Akimoto, Tetsuo

Source: In Radiotherapy and Oncology February 2021 155:10-16

Comparative analysis of the immune responses in cancer cells irradiated with X-ray, proton and carbon-ion beams

Authors: Du, Junyan, Kageyama, Shun-Ichiro, Hirata, Hidenari, Motegi, Atsushi, Nakamura, Masaki, Hirano, Yasuhiro, Okumura, Masayuki, Yamashita, Riu, Tsuchihara, Katsuya, Hojo, Hidehiro, Hirayama, Ryoichi, Akimoto, Tetsuo

Source: Biochemical and biophysical research communications. 585:55-60

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100178924846.0x000001&indx=1&recIds=ETOCvdc_100178924846.0x000001

Impact of Proton Beam Irradiation of an Anatomic Subsegment of the Liver for Hepatocellular Carcinoma

Authors: Hojo, Hidehiro, Raturi, Vijay, Nakamura, Naoki, Arahira, Satoko, Akita, Tsunemichi, Mitsunaga, Shuichi, Nakamura, Masaki, Motegi, Atsushi, Kageyama, Shun-ichiro, Zenda, Sadamoto, Okumura, Masayuki, Ikeda, Masafumi, Akimoto, Tetsuo

Source: In Practical Radiation Oncology July-August 2020 10(4):e264-e271

Impact of EGFR Mutation and ALK Translocation on Recurrence Pattern After Definitive Chemoradiotherapy for Inoperable Stage III Non-squamous Non–small-cell Lung Cancer

Authors: Nakamura, Masaki, Kageyama, Shun-ichiro, Niho, Seiji, Okumura, Masayuki, Hojo, Hidehiro, Motegi, Atsushi, Nakamura, Naoki, Zenda, Sadamoto, Yoh, Kiyotaka, Goto, Koichi, Akimoto, Tetsuo

Source: In Clinical Lung Cancer May 2019 20(3):e256-e264

Differences in failure patterns according to the EGFR mutation status after proton beam therapy for early stage non-small cell lung cancer

Authors: Nakamura, Masaki, Kageyama, Shun-ichiro, Udagawa, Hibiki, Zenke, Yoshitaka, Yoh, Kiyotaka, Niho, Seiji, Hojo, Hidehiro, Motegi, Atsushi, Kirita, Keisuke, Matsumoto, Singo, Goto, Koichi, Akimoto, Tetsuo

Source: Radiotherapy and oncology. 149:14-17

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100119244064.0x000001&indx=1&recIds=ETOCvdc_100119244064.0x000001

PARP inhibitor olaparib sensitizes esophageal carcinoma cells to fractionated proton irradiation

Authors: Kageyama, Shun-ichiro, Junyan, Du, Hojo, Hidehiro, Motegi, Atsushi, Nakamura, Masaki, Tsuchihara, Katsuya, Akimoto, Tetsuo

Source: Journal of radiation research. 61(2):177-186

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100100476606.0x000001&indx=1&recIds=ETOCvdc_100100476606.0x000001

Efficacy and safety of accelerated fractionated radiotherapy without elective nodal irradiation for T3N0 glottic cancer without vocal cord fixation

Authors: Okumura, Masayuki, Motegi, Atsushi, Zenda, Sadamoto, Nakamura, Naoki, Hojo, Hidehiro, Nakamura, Masaki, Hirano, Yasuhiro, Kageyama, Shun‐ichiro, Arahira, Satoko, Parshuram, Raturi Vijay, Kuno, Hirofumi, Hayashi, Ryuichi, Tahara, Makoto, Itoh, Yoshiyuki, Naganawa, Shinji, Akimoto, Tetsuo

Source: Head & neck. 42(8):1775-1782

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100107537850.0x000001&indx=1&recIds=ETOCvdc_100107537850.0x000001

Effect of 5-fluorouracil on cellular response to proton beam in esophageal cancer cell lines according to the position of spread-out Bragg peak

Authors: Hojo, Hidehiro, Dohmae, Takeshi, Hotta, Kenji, Kageyama, Shun-Ichiro, Baba, Hiromi, Kohno, Ryosuke, Motegi, Atsushi, Tsuchihara, Katsuya, Akimoto, Tetsuo

Source: Acta oncologica. 58(4):475-482

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100104135335.0x000001&indx=1&recIds=ETOCvdc_100104135335.0x000001

Long‐term outcomes of patients with oral cavity cancer receiving postoperative radiotherapy after salvage neck dissection for cervical lymph node recurrence.

Authors: Fujisawa, Takeshi, Motegi, Atsushi, Hirata, Hidenari, Zenda, Sadamoto, Hojo, Hidehiro, Nakamura, Masaki, Oyoshi, Hidekazu, Tomizawa, Kento, Zhou, Yuzheng, Fukushi, Keiko, Kageyama, Shun‐Ichiro, Enokida, Tomohiro, Okano, Susumu, Tahara, Makoto, Shinozaki, Takeshi, Hayashi, Ryuichi, Matsuura, Kazuto, Akimoto, Tetsuo

Source: Head & Neck; Mar2024, Vol. 46 Issue 3, p541-551, 11p

Subject Terms: NECK dissection, LYMPHADENECTOMY, ORAL cancer, RADIOTHERAPY, OVERALL survival

Accelerated three‐dimensional conformal radiotherapy for early‐stage glottic cancer in reducing dose to the internal carotid artery and pharyngeal constrictor muscles.

Authors: Tomizawa, Kento, Motegi, Atsushi, Oyoshi, Hidekazu, Fujisawa, Takeshi, Zenda, Sadamoto, Zhou, Yuzheng, Nakamura, Masaki, Hirata, Hidenari, Hojo, Hidehiro, Kageyama, Shun‐ichiro, Hirotaki, Kouta, Matsuura, Kazuto, Akimoto, Tetsuo

Source: Head & Neck; Feb2024, Vol. 46 Issue 2, p239-248, 10p

Subject Terms: INTERNAL carotid artery, PHARYNGEAL muscles, RADIOTHERAPY, PROGRESSION-free survival

Immune Checkpoint for a Kidney Cancer and Other Cancers

Authors: Kageyama, Shun-ichiro

Source: Gan to kagaku ryōhō. 43(6):672-677

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN606845910&indx=1&recIds=ETOCRN606845910

Prediction of postoperative recurrence by integrating preoperative ctDNA levels and tumor metastasis volume in patients (pts) with colorectal cancer (CRC) with resectable lung or liver metastasis.

Authors: Oyoshi, Hidekazu, Bando, Hideaki, Yamashita, Riu, Kageyama, Shun-ichiro, Horasawa, Satoshi, Nakamura, Masaki, Fujisawa, Takeshi, Tomizawa, Kento, Motegi, Atsushi, Mishima, Saori, Kotani, Daisuke, Taniguchi, Hiroya, Oki, Eiji, Takemasa, Ichiro, Kato, Takeshi, Nakamura, Yoshiaki, Mori, Masaki, Jurdi, Adham A, Liu, Minetta C., Yoshino, Takayuki

Source: Journal of Clinical Oncology; 2024 Supplement 3, Vol. 42, p183-183, 235p

CDC7 inhibition induces replication stress-mediated aneuploid cells with an inflammatory phenotype sensitizing tumors to immune checkpoint blockade.

Authors: Morita, Tomoko Yamamori, Yu, Jie, Kashima, Yukie, Kamata, Ryo, Yamamoto, Gaku, Minamide, Tatsunori, Mashima, Chiaki, Yoshiya, Miyuki, Sakae, Yuta, Yamauchi, Toyohiro, Hakozaki, Yumi, Kageyama, Shun-ichiro, Nakamura, Akito, Lightcap, Eric, Tanaka, Kosuke, Niu, Huifeng, Kannan, Karuppiah, Ohashi, Akihiro

Source: Nature Communications; 11/18/2023, Vol. 14 Issue 1, p1-21, 21p

Subject Terms: PROGRAMMED cell death 1 receptors, IMMUNOSENESCENCE, IMMUNE checkpoint proteins, IMMUNOREGULATION, TUMOR-infiltrating immune cells, PHENOTYPES, IMMUNE checkpoint inhibitors

TENERGY: multicenter phase II study of Atezolizumab monotherapy following definitive Chemoradiotherapy with 5-FU plus Cisplatin in patients with unresectable locally advanced esophageal squamous cell carcinoma

Authors: Bando, Hideaki, Kotani, Daisuke, Tsushima, Takahiro, Hara, Hiroki, Kadowaki, Shigenori, Kato, Ken, Chin, Keisho, Yamaguchi, Kensei, Kageyama, Shun-ichiro, Hojo, Hidehiro, Nakamura, Masaki, Tachibana, Hidenobu, Wakabayashi, Masashi, Fukutani, Miki, Togashi, Yosuke, Fuse, Nozomu, Nishikawa, Hiroyoshi, Kojima, Takashi

Source: BMC cancer. 20(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100171662237.0x000001&indx=1&recIds=ETOCvdc_100171662237.0x000001