CD8+ T cell priming that is required for curative intratumorally anchored anti-4-1BB immunotherapy is constrained by Tregs

Authors: Joseph R. Palmeri, Brianna M. Lax, Joshua M. Peters, Lauren Duhamel, Jordan A. Stinson, Luciano Santollani, Emi A. Lutz, William Pinney, Bryan D. Bryson, K. Dane Wittrup

Source: Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/8e65e3d9cba14ba3930a59f163a199fe

Ablative radiotherapy improves survival but does not cure autochthonous mouse models of prostate and colorectal cancer

Authors: Daniel R. Schmidt, Iva Monique T. Gramatikov, Allison Sheen, Christopher L. Williams, Martina Hurwitz, Laura E. Dodge, Edward Holupka, W. S. Kiger, Milton R. Cornwall-Brady, Wei Huang, Howard H. Mak, Kathleen S Cormier, Charlene Condon, K. Dane Wittrup, Ömer H. Yilmaz, Mary Ann Stevenson, Julian D. Down, Scott R. Floyd, Jatin Roper, Matthew G. Vander Heiden

Source: Communications Medicine, Vol 3, Iss 1, Pp 1-20 (2023)

Subject Terms: Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2730-664X

Access URL: https://doaj.org/article/e2abc75b55aa4454ae9d147cefaedee3

Overcoming lung cancer immunotherapy resistance by combining nontoxic variants of IL-12 and IL-2

Authors: Brendan L. Horton, Alicia D. D’Souza, Maria Zagorulya, Chloe V. McCreery, Gita C. Abhiraman, Lora Picton, Allison Sheen, Yash Agarwal, Noor Momin, K. Dane Wittrup, Forest M. White, K. Christopher Garcia, Stefani Spranger

Source: JCI Insight, Vol 8, Iss 19 (2023)

Subject Terms: Immunology, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2379-3708

Access URL: https://doaj.org/article/e315efdb0cc249018ebbc3ca54aedce4

Tumor-localized catalases can fail to alter tumor growth and transcriptional profiles in subcutaneous syngeneic mouse tumor models

Authors: Allison Sheen, Yash Agarwal, Keith M. Cheah, Sarah C. Cowles, Jordan A. Stinson, Joseph R. Palmeri, Hadley D. Sikes, K. Dane Wittrup

Source: Redox Biology, Vol 64, Iss , Pp 102766- (2023)

Subject Terms: Catalase, Tumor-localized, Cancer, Transcriptional profile, RNAseq, Redox-directed therapies, Medicine (General), R5-920, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2213231723001672; https://doaj.org/toc/2213-2317

Access URL: https://doaj.org/article/bdc02fa1657a4226b9e43defbfbf2f40

Maximizing response to intratumoral immunotherapy in mice by tuning local retention

Authors: Noor Momin, Joseph R. Palmeri, Emi A. Lutz, Noor Jailkhani, Howard Mak, Anthony Tabet, Magnolia M. Chinn, Byong H. Kang, Virginia Spanoudaki, Richard O. Hynes, K. Dane Wittrup

Source: Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/29c0b5b17b1041eaaa47f6822400abb3

An affinity threshold for maximum efficacy in anti-PD-1 immunotherapy

Authors: Sarah C. Cowles, Allison Sheen, Luciano Santollani, Emi A. Lutz, Brianna M. Lax, Joseph R. Palmeri, Gordon J. Freeman, K. Dane Wittrup

Source: mAbs, Vol 14, Iss 1 (2022)

Subject Terms: PD-1, antibody, affinity, pharmacokinetic modeling, cancer immunotherapy, Therapeutics. Pharmacology, RM1-950, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://doaj.org/toc/1942-0862; https://doaj.org/toc/1942-0870

Access URL: https://doaj.org/article/a3566e931b5d476ea29616b10d00f10c

Identification of Highly Cross-Reactive Mimotopes for a Public T Cell Response in Murine Melanoma

Authors: Beth E. Grace, Coralie M. Backlund, Duncan M. Morgan, Byong H. Kang, Nishant K. Singh, Brooke D. Huisman, C. Garrett Rappazzo, Kelly D. Moynihan, Laura Maiorino, Connor S. Dobson, Taeyoon Kyung, Khloe S. Gordon, Patrick V. Holec, Overbeck C. Takou Mbah, Daniel Garafola, Shengwei Wu, J. Christopher Love, K. Dane Wittrup, Darrell J. Irvine, Michael E. Birnbaum

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: mimotope, endogenous retrovirus, T cell receptor, antigen, melanoma, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.886683/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/974ae2fd3083480d86e6565189e0552e

Directed evolution of broadly crossreactive chemokine-blocking antibodies efficacious in arthritis

Authors: Alessandro Angelini, Yoshishige Miyabe, Daniel Newsted, Byron H. Kwan, Chie Miyabe, Ryan L. Kelly, Misha N. Jamy, Andrew D. Luster, K. Dane Wittrup

Source: Nature Communications, Vol 9, Iss 1, Pp 1-18 (2018)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/c0b1123a348f40e095ceb7693a617ee1

An engineered protein antagonist of K-Ras/B-Raf interaction

Authors: Monique J. Kauke, Michael W. Traxlmayr, Jillian A. Parker, Jonathan D. Kiefer, Ryan Knihtila, John McGee, Greg Verdine, Carla Mattos, K. Dane Wittrup

Source: Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/2ce4911947be421fa5711cae0ecd11de

Order of administration of combination cytokine therapies can decouple toxicity from efficacy in syngeneic mouse tumor models

Authors: Adrienne Rothschilds, Alice Tzeng, Naveen K. Mehta, Kelly D. Moynihan, Darrell J. Irvine, K. Dane Wittrup

Source: OncoImmunology, Vol 8, Iss 5 (2019)

Subject Terms: dose scheduling, timing, toxicity, cytokines, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-402X

Access URL: https://doaj.org/article/3c09185fb806448ab21692bf83a7b761

Combining the Specific Anti-MUC1 Antibody TAB004 and Lip-MSA-IL-2 Limits Pancreatic Cancer Progression in Immune Competent Murine Models of Pancreatic Ductal Adenocarcinoma

Authors: Didier Dréau, Laura Jeffords Moore, Mike Wu, Lopa Das Roy, Lloye Dillion, Travis Porter, Rahul Puri, Noor Momin, K. Dane Wittrup, Pinku Mukherjee

Source: Frontiers in Oncology, Vol 9 (2019)

Subject Terms: ADCC, Antibody, IL-2, Immunocompetent, Immunotherapy, MUC1, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fonc.2019.00330/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/0ff0a231afde4b4188e2a8e5fb5f02f8

A Flow Cytometric Assay for Screening Improved Heterologous Protein Secretion in Yeast.

Authors: J. Andy Rakestraw, Angelin R. Baskaran, K. Dane Wittrup

Source: Biotechnology Progress; Aug2006, Vol. 22 Issue 4, p1200-1208, 9p

Subject Terms: BIOLOGICAL transport, CELLS, CELL membranes, YEAST

1011 The signal strength of signal 2 and 3 during T cell priming affect the functional fate of an anti-tumor T cell response

Authors: Stefani Spranger, Duncan Morgan, Vidit Bhandarkar, Teresa Dinter, Lorelai Pop, Emi A Lutz, K Dane Wittrup, J Christopher Love

Source: Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/41fff98a5033441f91c62d9827421db7

1094 Collagen-anchored IL-2 and IL-12 cytokines potentiate anti-tumor immunity in advanced canine cancers

Authors: Noor Momin, K Dane Wittrup, Jordan A Stinson, Matheus Moreno M Passos Barbosa, Allison Sheen, Jordan Hampel, Elizabeth Fink, Rebecca Kamerer, Jonathan Samuelson, Rebecca Bernstein, Timothy Fan

Source: Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/507acb8003e64bd99bc67468f7c5774d

947 The activation states of tumor-resident type 2 dendritic cells impact the strength of ovarian cancer immune responses

Authors: Stefani Spranger, Fiona Chatterjee, Emi A Lutz, K Dane Wittrup, Vincent Butty

Source: Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/6dc269b32ba745f0a6c2088e09067bb6

1093 CLN-617 combines IL-2 and IL-12 in a single molecule to optimally balance safety and efficacy upon intratumoral injection

Authors: Naveen K Mehta, Patrick A Baeuerle, Jennifer S Michaelson, Laura Liu, K Dane Wittrup, Kristan A Meetze, Irina M Shapiro, Kavya Rakhra

Source: Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/2ffcd943e44c4402ad7217e0983a64c5

1224 Tregs constrain CD8 + T cell priming required for curative intratumorally anchored anti-4–1BB immunotherapy

Authors: Emi A Lutz, K Dane Wittrup, Joseph R Palmeri, Brianna M Lax, Josh M Peters, Lauren Duhamel, Jordan A Stinson, Luciano Santollani, William Pinney, Bryan D Bryson

Source: Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/1d4f4929a5304e66974b9d6a359dc8a4

Immunotherapy-induced antibodies to endogenous retroviral envelope glycoprotein confer tumor protection in mice.

Authors: Byong H Kang, Noor Momin, Kelly D Moynihan, Murillo Silva, Yingzhong Li, Darrell J Irvine, K Dane Wittrup

Source: PLoS ONE, Vol 16, Iss 4, p e0248903 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/71a03d82b9834e24a26869f51fafa8cd

A Nonpolycationic Fully Proteinaceous Multiagent System for Potent Targeted Delivery of siRNA

Authors: David V Liu, Nicole J Yang, K Dane Wittrup

Source: Molecular Therapy: Nucleic Acids, Vol 3, Iss C (2014)

Subject Terms: cholesterol-dependent cytolysin, dsRBD, protein-based siRNA delivery, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S216225311630302X; https://doaj.org/toc/2162-2531

Access URL: https://doaj.org/article/a9df14352b8146aca5bff68fc97be7ec