Deep Learning–Enabled Diagnosis of Liver Adenocarcinoma

Authors: Albrecht, Thomas, Rossberg, Annik, Albrecht, Jana Dorothea, Nicolay, Jan Peter, Straub, Beate Katharina, Gerber, Tiemo Sven, Albrecht, Michael, Brinkmann, Fritz, Charbel, Alphonse, Schwab, Constantin, Schreck, Johannes, Brobeil, Alexander, Flechtenmacher, Christa, von Winterfeld, Moritz, Köhler, Bruno Christian, Springfeld, Christoph, Mehrabi, Arianeb, Singer, Stephan, Vogel, Monika Nadja, Neumann, Olaf, Stenzinger, Albrecht, Schirmacher, Peter, Weis, Cleo-Aron, Roessler, Stephanie, Kather, Jakob Nikolas, Goeppert, Benjamin

Source: In Gastroenterology November 2023 165(5):1262-1275

Gene expression-based prediction of pazopanib efficacy in sarcoma

Authors: Heilig, Christoph E., Laßmann, Andreas, Mughal, Sadaf S., Mock, Andreas, Pirmann, Sebastian, Teleanu, Veronica, Renner, Marcus, Andresen, Carolin, Köhler, Bruno C., Aybey, Bogac, Bauer, Sebastian, Siveke, Jens T., Hamacher, Rainer, Folprecht, Gunnar, Richter, Stephan, Schröck, Evelin, Brandts, Christian H., Ahrens, Marit, Hohenberger, Peter, Egerer, Gerlinde, Kindler, Thomas, Boerries, Melanie, Illert, Anna L., von Bubnoff, Nikolas, Apostolidis, Leonidas, Jost, Philipp J., Westphalen, C. Benedikt, Weichert, Wilko, Keilholz, Ulrich, Klauschen, Frederick, Beck, Katja, Winter, Ulrike, Richter, Daniela, Möhrmann, Lino, Bitzer, Michael, Schulze-Osthoff, Klaus, Brors, Benedikt, Mechtersheimer, Gunhild, Kreutzfeldt, Simon, Heining, Christoph, Lipka, Daniel B., Stenzinger, Albrecht, Schlenk, Richard F., Horak, Peter, Glimm, Hanno, Hübschmann, Daniel, Fröhling, Stefan

Source: In European Journal of Cancer September 2022 172:107-118

Stereotactic body radiotherapy with carbon ions as local ablative treatment in patients with primary liver cancer.

Authors: Hoffmeister-Wittmann, Paula, Hoegen-Saßmannshausen, Philipp, Wicklein, Livia, Weykamp, Fabian, Seidensaal, Katharina, Springfeld, Christoph, Dill, Michael T., Longerich, Thomas, Schirmacher, Peter, Mehrabi, Arianeb, Mathy, René Michael, Köhler, Bruno C., Debus, Jürgen, Herfarth, Klaus, Liermann, Jakob

Source: Radiation Oncology; 2/18/2025, Vol. 20 Issue 1, p1-11, 11p

Subject Terms: HEAVY ion radiotherapy, CANCER patients, MEDICAL sciences, LINEAR energy transfer, POISONS

Bcl‐xL as prognostic marker and potential therapeutic target in cholangiocarcinoma

Authors: Hoffmeister‐Wittmann, Paula, Mock, Andreas, Nichetti, Federico, Korell, Felix, Heilig, Christoph E., Scherr, Anna‐Lena, Günther, Michael, Albrecht, Thomas, Kelmendi, Eblina, Xu, Kaiyu, Nader, Luisa, Kessler, Annika, Schmitt, Nathalie, Fritzsche, Sarah, Weiler, Sofia, Sobol, Benjamin, Stenzinger, Albrecht, Boeck, Stefan, Westphalen, Christoph B., Schulze‐Osthoff, Klaus, Trojan, Jörg, Kindler, Thomas, Weichert, Wilko, Spiekermann, Karsten, Bitzer, Michael, Folprecht, Gunnar, Illert, Anna L., Boerries, Melanie, Klauschen, Frederick, Ochsenreither, Sebastian, Siveke, Jens, Bauer, Sebastian, Glimm, Hanno, Brors, Benedikt, Hüllein, Jennifer, Hübschmann, Daniel, Uhrig, Sebastian, Horak, Peter, Kreutzfeldt, Simon, Banales, Jesus M., Springfeld, Christoph, Jäger, Dirk, Schirmacher, Peter, Roessler, Stephanie, Ormanns, Steffen, Goeppert, Benjamin, Fröhling, Stefan, Köhler, Bruno C.

Source: Liver international. 42(12):2855-2870

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100168408872.0x000001&indx=1&recIds=ETOCvdc_100168408872.0x000001

MGMT inactivation as a new biomarker in patients with advanced biliary tract cancers

Authors: Niger, Monica, Nichetti, Federico, Casadei‐Gardini, Andrea, Morano, Federica, Pircher, Chiara, Tamborini, Elena, Perrone, Federica, Canale, Matteo, Lipka, Daniel B., Vingiani, Andrea, Agnelli, Luca, Dobberkau, Anna, Hüllein, Jennifer, Korell, Felix, Heilig, Christoph E., Pusceddu, Sara, Corti, Francesca, Droz, Michele, Ulivi, Paola, Prisciandaro, Michele, Antista, Maria, Bini, Marta, Cattaneo, Laura, Milione, Massimo, Glimm, Hanno, Köhler, Bruno C., Pruneri, Giancarlo, Hübschmann, Daniel, Fröhling, Stefan, Mazzaferro, Vincenzo, Pietrantonio, Filippo, Di Bartolomeo, Maria, Braud, Filippo

Source: Molecular oncology. 16(14):2733-2746

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100167236486.0x000001&indx=1&recIds=ETOCvdc_100167236486.0x000001

MCL1 Is Required for Maintenance of Intestinal Homeostasis and Prevention of Carcinogenesis in Mice

Authors: Healy, Marc E., Boege, Yannick, Hodder, Michael C., Böhm, Friederike, Malehmir, Mohsen, Scherr, Anna-Lena, Jetzer, Jasna, Chan, Lap Kwan, Parrotta, Rossella, Jacobs, Kurt, Clerbaux, Laure-Alix, Kreutzer, Susanne, Campbell, Andrew, Gilchrist, Ella, Gilroy, Kathryn, Rodewald, Ann-Katrin, Honcharova-Biletska, Hanna, Schimmer, Roman, Vélez, Karelia, Büeler, Simone, Cammareri, Patrizia, Kalna, Gabriela, Wenning, Anna S., McCoy, Kathy D., Gomez de Agüero, Mercedes, Schulze-Bergkamen, Henning, Klose, Christoph S.N., Unger, Kristian, Macpherson, Andrew J., Moor, Andreas E., Köhler, Bruno, Sansom, Owen J., Heikenwälder, Mathias, Weber, Achim

Source: In Gastroenterology July 2020 159(1):183-199

Completion rate and impact on physician–patient relationship of video consultations in medical oncology: a randomised controlled open-label trial

Authors: Walle, Thomas, Erdal, Erkin, Mühlsteffen, Leon, Singh, Hans Martin, Gnutzmann, Editha, Grün, Barbara, Hofmann, Helene, Ivanova, Alexandra, Köhler, Bruno Christian, Korell, Felix, Mavratzas, Athanasios, Mock, Andreas, Pixberg, Constantin, Schult, David, Starke, Helen, Steinebrunner, Niels, Woydack, Lena, Schneeweiss, Andreas, Dietrich, Mareike, Jäger, Dirk, Krisam, Johannes, Kather, Jakob N., Winkler, Eva C.

Source: In ESMO Open 2020 5(6)

MiRNA profiling of biliary intraepithelial neoplasia reveals stepwise tumorigenesis in distal cholangiocarcinoma via the miR‐451a/ATF2 axis

Authors: Loeffler, Moritz A, Hu, Jun, Kirchner, Martina, Wei, Xiyang, Xiao, Yi, Albrecht, Thomas, De La Torre, Carolina, Sticht, Carsten, Banales, Jesus M, Vogel, Monika N, Pathil‐Warth, Anita, Mehrabi, Arianeb, Hoffmann, Katrin, Rupp, Christian, Köhler, Bruno, Springfeld, Christoph, Schirmacher, Peter, Ji, Junfang, Roessler, Stephanie, Goeppert, Benjamin

Source: Journal of pathology. 252(3):239-251

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100111124238.0x000001&indx=1&recIds=ETOCvdc_100111124238.0x000001

HER2 gene (ERBB2) amplification is a low-frequency driver with potential predictive value in gallbladder carcinoma

Authors: Albrecht, Thomas, Rausch, Melina, Roessler, Stephanie, Geissler, Veronika, Albrecht, Michael, Halske, Christine, Seifert, Carolin, Renner, Marcus, Singer, Stephan, Mehrabi, Arianeb, Vogel, Monika Nadja, Pathil-Warth, Anita, Busch, Elena, Köhler, Bruno, Rupp, Christian, Weiss, Karl Heinz, Springfeld, Christoph, Röcken, Christoph, Schirmacher, Peter, Goeppert, Benjamin

Source: Virchows Archiv. 476(6):871-880

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100168022236.0x000001&indx=1&recIds=ETOCvdc_100168022236.0x000001

Nuclear Translocation of RELB Is Increased in Diseased Human Liver and Promotes Ductular Reaction and Biliary Fibrosis in Mice

Authors: Elßner, Christin, Goeppert, Benjamin, Longerich, Thomas, Scherr, Anna-Lena, Stindt, Jan, Nanduri, Lahiri Kanth, Rupp, Christian, Kather, Jakob Nikolas, Schmitt, Nathalie, Kautz, Nicole, Breuhahn, Kai, Ismail, Lars, Heide, Danijela, Hetzer, Jenny, García-Beccaria, María, Hövelmeyer, Nadine, Waisman, Ari, Urbanik, Toni, Mueller, Sebastian, Gdynia, Georg, Banales, Jesus M., Roessler, Stephanie, Schirmacher, Peter, Jäger, Dirk, Schölch, Sebastian, Keitel, Verena, Heikenwalder, Mathias, Schulze-Bergkamen, Henning, Köhler, Bruno Christian

Source: In Gastroenterology March 2019 156(4):1190-1205

Developing survival prediction models in colorectal cancer using epigenome-wide DNA methylation data from whole blood.

Authors: Fan, Ziwen, Edelmann, Dominic, Yuan, Tanwei, Köhler, Bruno Christian, Hoffmeister, Michael, Brenner, Hermann

Source: NPJ Precision Oncology; 9/6/2024, p1-9, 9p

Subject Terms: EPIGENOMICS, DNA methylation, COLORECTAL cancer, PREDICTION models, GENOME-wide association studies, BLOOD collection

Prognostic Impact of Carboxylesterase 2 in Cholangiocarcinoma

Authors: Goeppert, Benjamin, Renner, Marcus, Singer, Stephan, Albrecht, Thomas, Zhang, Qiangnu, Mehrabi, Arianeb, Pathil, Anita, Springfeld, Christoph, Köhler, Bruno, Rupp, Christian, Weiss, Karl, Kühl, Anja, Arsenic, Ruza, Pape, Ulrich, Vogel, Arndt, Schirmacher, Peter, Roessler, Stephanie, Utku, Nalân

Source: Scientific reports. 9(1):1-11

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100127968906.0x000001&indx=1&recIds=ETOCvdc_100127968906.0x000001

Mismatch repair deficiency is a rare but putative therapeutically relevant finding in non-liver fluke associated cholangiocarcinoma

Authors: Goeppert, Benjamin, Roessler, Stephanie, Renner, Marcus, Singer, Stephan, Mehrabi, Arianeb, Vogel, Monika, Pathil, Anita, Czink, Elena, Köhler, Bruno, Springfeld, Christoph, Pfeiffenberger, Jan, Rupp, Christian, Weiss, Karl, Schirmacher, Peter, von Knebel Doeberitz, Magnus, Kloor, Matthias

Source: British journal of cancer. 120(1):109-114

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100102165500.0x000001&indx=1&recIds=ETOCvdc_100102165500.0x000001

Low frequency of mismatch repair deficiency in gallbladder cancer

Authors: Goeppert, Benjamin, Roessler, Stephanie, Renner, Marcus, Loeffler, Moritz, Singer, Stephan, Rausch, Melina, Albrecht, Thomas, Mehrabi, Arianeb, Vogel, Monika, Pathil, Anita, Czink, Elena, Köhler, Bruno, Springfeld, Christoph, Rupp, Christian, Weiss, Karl, Schirmacher, Peter, Knebel Doeberitz, Magnus, Kloor, Matthias

Source: Diagnostic pathology. 14(1):1-6

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100187436354.0x000001&indx=1&recIds=ETOCvdc_100187436354.0x000001

Programmed cell death ligand 1 (PD-L1, CD274) in cholangiocarcinoma – correlation with clinicopathological data and comparison of antibodies

Authors: Kriegsmann, Mark, Roessler, Stephanie, Kriegsmann, Katharina, Renner, Marcus, Longuespée, Rémi, Albrecht, Thomas, Loeffler, Moritz, Singer, Stephan, Mehrabi, Arianeb, Vogel, Monika, Pathil, Anita, Köhler, Bruno, Springfeld, Christoph, Rupp, Christian, Weiss, Karl, Goeppert, Benjamin

Source: BMC cancer. 19(1):1-10

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100185476219.0x000001&indx=1&recIds=ETOCvdc_100185476219.0x000001

A new biomarker panel for differential diagnosis of cholangiocarcinoma: Results from an exploratory analysis.

Authors: Köhler, Bruno, Bes, Marta, Chan, Henry Lik-Yuen, Esteban, Juan Ignacio, Piratvisuth, Teerha, Sukeepaisarnjaroen, Wattana, Tanwandee, Tawesak, Thongsawat, Satawat, Mang, Anika, Morgenstern, David, Swiatek-de Lange, Magdalena, Dayyani, Farshid

Source: International Journal of Biological Markers; Jun2024, Vol. 39 Issue 2, p107-117, 11p

Caspase‐8 in endothelial cells maintains gut homeostasis and prevents small bowel inflammation in mice

Authors: Tisch, Nathalie, Mogler, Carolin, Stojanovic, Ana, Luck, Robert, Korhonen, Emilia A, Ellerkmann, Alexander, Adler, Heike, Singhal, Mahak, Schermann, Géza, Erkert, Lena, Patankar, Jay V, Karakatsani, Andromachi, Scherr, Anna‐Lena, Fuchs, Yaron, Cerwenka, Adelheid, Wirtz, Stefan, Köhler, Bruno Christian, Augustin, Hellmut G, Becker, Christoph, Schmidt, Thomas, Ruiz de Almodóvar, Carmen

Source: EMBO molecular medicine. 14(6)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100161060323.0x000001&indx=1&recIds=ETOCvdc_100161060323.0x000001

A new biomarker panel for differential diagnosis of cholangiocarcinoma: results from an exploratory analysis

Authors: Köhler, Bruno, Bes, Marta, Chan, Henry LY, Esteban Mur, Juan Ignacio, Piratvisuth, Teerha, Sukeepaisarnjaroen, Wattana, Tanwandee, Tawesak, Mang, Anika, Morgenstern, David, Lange, Magdalena Swiatek-de, Dayyani, Farshid

Source: Journal of hepatology. 78(S1):S506-S507

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100195505314.0x000001&indx=1&recIds=ETOCvdc_100195505314.0x000001

RELB activation drives tumour aggressiveness and predicts prognosis in hepatocellular carcinoma

Authors: Nader, Luisa, Nichetti, Federico, Scherr, Anna-Lena, Elssner, Christin, Ridder, Dirk, Fritzsche, Sarah, Weiler, Sofia, Albrecht, Thomas, Kessler, Annika, Schmitt, Nathalie, Korell, Felix, Ye, Liangtao, Urbanik, Toni, Heilig, Christoph, Rahbari, Mohammad, Brandl, Lydia, Springfeld, Christoph, Longerich, Thomas, Schulze-Bergkamen, Henning, Jäger, Dirk, Fröhling, Stefan, Schirmacher, Peter, Straub, Beate, Weber, Achim, Heikenwälder, Mathias, de Toni, Enrico, Goeppert, Benjamin, Roessler, Stephanie, Breuhahn, Kai, Köhler, Bruno

Source: Journal of hepatology. 77(S1):S655-S656

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100167008302.0x000001&indx=1&recIds=ETOCvdc_100167008302.0x000001

Discovery of a haptoglobin glycopeptides biomarker panel for early diagnosis of hepatocellular carcinoma.

Authors: Kohansal-Nodehi, Mahdokht, Lange, Magdalena Swiatek-de, Kroeniger, Konstantin, Rolny, Vinzent, Tabaré, Glòria, Piratvisuth, Teerha, Tanwandee, Tawesak, Thongsawat, Satawat, Sukeepaisarnjaroen, Wattana, Esteban, Juan Ignacio, Bes, Marta, Köhler, Bruno, Henry Lik-Yuen Chan, Busskamp, Holger

Source: Frontiers in Oncology; 2023, p1-14, 14p

Subject Terms: GLYCOPEPTIDES, EARLY diagnosis, LIQUID chromatography-mass spectrometry, RECEIVER operating characteristic curves, BIOMARKERS