Ex vivo modelling of cardiac injury identifies ferroptosis-related pathways as a potential therapeutic avenue for translational medicine

Authors: Abbas, Naisam, Bentele, Marco, Waleczek, Florian J.G., Fuchs, Maximilian, Just, Annette, Pfanne, Angelika, Pich, Andreas, Linke, Sophie, Neumüller, Susanne, Stucki-Koch, Angelika, Jordan, Maria, Perbellini, Filippo, Werlein, Christopher, Korte, Wilhelm, Ius, Fabio, Ruhparwar, Arjang, Weber, Natalie, Fiedler, Jan, Thum, Thomas

Source: In Journal of Molecular and Cellular Cardiology November 2024 196:125-140

Prolonged Hypoxia in Rat Living Myocardial Slices Affects Function, Expression, and Structure.

Authors: Waleczek, Florian J. G., Cipriano, Giuseppe, Haas, Jonas A., Garg, Ankita, Pfanne, Angelika, Just, Annette, Neumüller, Susanne, Hegermann, Jan, Pich, Andreas, Radocaj, Ante, Xiao, Ke, Weber, Natalie, Thum, Thomas

Source: International Journal of Molecular Sciences; Jan2025, Vol. 26 Issue 1, p218, 19p

Subject Terms: PROTEOMICS, MYOCARDIAL ischemia, CORONARY disease, REACTIVE oxygen species, DRUG development

Combined high-throughput library screening and next generation RNA sequencing uncover microRNAs controlling human cardiac fibroblast biology

Authors: Schimmel, Katharina, Stojanović, Stevan D., Huang, Cheng-Kai, Jung, Mira, Meyer, Martin H., Xiao, Ke, Grote-Levi, Lea, Bär, Christian, Pfanne, Angelika, Mitzka, Saskia, Just, Annette, Geffers, Robert, Bock, Katharina, Kenneweg, Franziska, Kleemiß, Felix, Falk, Christine S., Fiedler, Jan, Thum, Thomas

Source: In Journal of Molecular and Cellular Cardiology January 2021 150:91-100

Pleiotropic cardiac functions controlled by ischemia-induced lncRNA H19

Authors: Hobuß, Lisa, Foinquinos, Ariana, Jung, Mira, Kenneweg, Franziska, Xiao, Ke, Wang, Yong, Zimmer, Karina, Remke, Janet, Just, Annette, Nowak, Juliette, Schmidt, Arne, Pich, Andreas, Mazlan, Stephane, Reamon-Buettner, Stella M., Ramos, Gustavo Campos, Frantz, Stefan, Viereck, Janika, Loyer, Xavier, Boulanger, Chantal, Wollert, Kai C., Fiedler, Jan, Thum, Thomas

Source: In Journal of Molecular and Cellular Cardiology September 2020 146:43-59

Long Noncoding RNA-Enriched Vesicles Secreted by Hypoxic Cardiomyocytes Drive Cardiac Fibrosis

Authors: Kenneweg, Franziska, Bang, Claudia, Xiao, Ke, Boulanger, Chantal M., Loyer, Xavier, Mazlan, Stephane, Schroen, Blanche, Hermans-Beijnsberger, Steffie, Foinquinos, Ariana, Hirt, Marc N., Eschenhagen, Thomas, Funcke, Sandra, Stojanovic, Stevan, Genschel, Celina, Schimmel, Katharina, Just, Annette, Pfanne, Angelika, Scherf, Kristian, Dehmel, Susann, Raemon-Buettner, Stella M., Fiedler, Jan, Thum, Thomas

Source: In Molecular Therapy - Nucleic Acids 6 December 2019 18:363-374

Natural Compound Library Screening Identifies New Molecules for the Treatment of Cardiac Fibrosis and Diastolic Dysfunction

Authors: Schimmel, Katharina, Jung, Mira, Foinquinos, Ariana, José, Gorka San, Beaumont, Javier, Bock, Katharina, Grote-Levi, Lea, Xiao, Ke, Bär, Christian, Pfanne, Angelika, Just, Annette, Zimmer, Karina, Ngoy, Soeun, López, Begoña, Ravassa, Susana, Samolovac, Sabine, Janssen-Peters, Heike, Remke, Janet, Scherf, Kristian, Dangwal, Seema, Piccoli, Maria-Teresa, Kleemiss, Felix, Kreutzer, Fabian Philipp, Kenneweg, Franziska, Leonardy, Julia, Hobuß, Lisa, Santer, Laura, Do, Quoc-Tuan, Geffers, Robert, Braesen, Jan Hinrich, Schmitz, Jessica, Brandenberger, Christina, Müller, Dominik N., Wilck, Nicola, Kaever, Volkhard, Bähre, Heike, Batkai, Sandor, Fiedler, Jan, Alexander, Kevin M., Wertheim, Bradley M., Fisch, Sudeshna, Liao, Ronglih, Diez, Javier, González, Arantxa, Thum, Thomas

Source: Circulation. 141(9):751-767

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100188863604.0x000001&indx=1&recIds=ETOCvdc_100188863604.0x000001

SGLT2 inhibitors attenuate endothelial to mesenchymal transition and cardiac fibroblast activation.

Authors: Schmidt, Kevin, Schmidt, Arne, Groß, Sonja, Just, Annette, Pfanne, Angelika, Fuchs, Maximilian, Jordan, Maria, Mohr, Elisa, Pich, Andreas, Fiedler, Jan, Thum, Thomas

Source: Scientific Reports; 7/16/2024, Vol. 14 Issue 1, p1-15, 15p

Subject Terms: SODIUM-glucose cotransporter 2 inhibitors, SODIUM-glucose cotransporters, FIBROBLASTS, HEART cells, ENDOTHELIAL cells, OXYGEN consumption

Therapeutic modulation of RNA-binding protein Rbm38 facilitates re-endothelialization after arterial injury

Authors: Sonnenschein, Kristina, Fiedler, Jan, Pfanne, Angelika, Just, Annette, Mitzka, Saskia, Geffers, Robert, Pich, Andreas, Bauersachs, Johann, Thum, Thomas

Source: Cardiovascular research. 115(12):1804-1810

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100096839986.0x000001&indx=1&recIds=ETOCvdc_100096839986.0x000001

Identification of miR-143 as a Major Contributor for Human Stenotic Aortic Valve Disease

Authors: Fiedler, Jan, Park, Da-Hee, Hobuß, Lisa, Anaraki, Parnian Kalbasi, Pfanne, Angelika, Just, Annette, Mitzka, Saskia, Dumler, Inna, Weidemann, Frank, Hilfiker, Andres, Thum, Thomas

Source: Journal of cardiovascular translational research. 12(5):447-458

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100124765468.0x000001&indx=1&recIds=ETOCvdc_100124765468.0x000001

miRNome Profiling of Purified Endoderm and Mesoderm Differentiated from hESCs Reveals Functions of miR-483-3p and miR-1263 for Cell-Fate Decisions

Authors: Ishikawa, Daichi, Diekmann, Ulf, Fiedler, Jan, Just, Annette, Thum, Thomas, Lenzen, Sigurd, Naujok, Ortwin

Source: In Stem Cell Reports 14 November 2017 9(5):1588-1603

Blood-based protein profiling identifies serum protein c-KIT as a novel biomarker for hypertrophic cardiomyopathy

Authors: Sonnenschein, Kristina, Fiedler, Jan, de Gonzalo-Calvo, David, Xiao, Ke, Pfanne, Angelika, Just, Annette, Zwadlo, Carolin, Soltani, Samira, Bavendiek, Udo, Kraft, Theresia, Dos Remedios, Cristobal, Cebotari, Serghei, Bauersachs, Johann, Thum, Thomas

Source: Scientific reports. 11(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100193131948.0x000001&indx=1&recIds=ETOCvdc_100193131948.0x000001

Hypoxic preconditioning of macrophages as therapeutic strategy for ischemic cardiac injury

Authors: Sansonetti, Marida, Waleczek, Florian, Thum, Sabrina, Pfanne, Angelika, Just, Annette, Jung, Mira, Thum, Thomas

Source: Journal of molecular and cellular cardiology. 173(S):S74-S75

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194322154.0x000001&indx=1&recIds=ETOCvdc_100194322154.0x000001

Inhibition of miR-21: cardioprotective effects in human failing myocardium ex vivo.

Authors: Abbas, Naisam, Haas, Jonas A, Xiao, Ke, Fuchs, Maximilian, Just, Annette, Pich, Andreas, Perbellini, Filippo, Werlein, Christopher, Ius, Fabio, Ruhparwar, Arjang, Fiedler, Jan, Weber, Natalie, Thum, Thomas

Source: European Heart Journal; 6/7/2024, Vol. 45 Issue 22, p2016-2018, 3p

Subject Terms: MICRORNA, MYOCARDIUM, NEOVASCULARIZATION, GENE expression

Development of Long Noncoding RNA-Based Strategies to Modulate Tissue Vascularization

Authors: Fiedler, Jan, Breckwoldt, Kaja, Remmele, Christian W., Hartmann, Dorothee, Dittrich, Marcus, Pfanne, Angelika, Just, Annette, Xiao, Ke, Kunz, Meik, Müller, Tobias, Hansen, Arne, Geffers, Robert, Dandekar, Thomas, Eschenhagen, Thomas, Thum, Thomas

Source: Journal of the American College of Cardiology. 66(18):2005-2015

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100065277874.0x000001&indx=1&recIds=ETOCvdc_100065277874.0x000001

Cardiac endurance training alters plasma profiles of circular RNA MBOAT2.

Authors: Meinecke, Anna, Mitzka, Saskia, Just, Annette, Cushman, Sarah, Stojanović, Stevan D., Ke Xiao, Mooren, Frank C., Fiedler, Jan, Thum, Thomas

Source: American Journal of Physiology: Heart & Circulatory Physiology; Jul2020, Vol. 319 Issue 1, pH13-H21, 9p

Subject Terms: CIRCULAR RNA, MARATHON running, ENDURANCE athletes, NON-coding RNA, EXERCISE, PHYSICAL activity

Inflammatory Drivers of Cardiovascular Disease: Molecular Characterization of Senescent Coronary Vascular Smooth Muscle Cells.

Authors: Stojanović, Stevan D., Fuchs, Maximilian, Kunz, Meik, Xiao, Ke, Just, Annette, Pich, Andreas, Bauersachs, Johann, Fiedler, Jan, Sedding, Daniel, Thum, Thomas

Source: Frontiers in Physiology; 5/25/2020, Vol. 11, p1-10, 10p

Subject Terms: VASCULAR smooth muscle, CONTRACTILE proteins, MUSCLE cells, CELLULAR aging, CARDIOVASCULAR diseases, CORONARY disease, ATHEROSCLEROSIS

This result is not displayed to guests.
Login for full access.

This result is not displayed to guests.
Login for full access.

This result is not displayed to guests.
Login for full access.

This result is not displayed to guests.
Login for full access.