Primary Roles of Branched Chain Amino Acids (BCAAs) and Their Metabolism in Physiology and Metabolic Disorders

Authors: Tomoki Bo, Junichi Fujii

Source: Molecules, Vol 30, Iss 1, p 56 (2024)

Subject Terms: branched chain aminotransferase, branched chain α-keto acid dehydrogenase, ketogenesis, gluconeogenesis, diabetes, cancer, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/30/1/56; https://doaj.org/toc/1420-3049

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Ascorbic Acid Protects Bone Marrow from Oxidative Stress and Transient Elevation of Corticosterone Caused by X-ray Exposure in Akr1a-Knockout Mice

Authors: Tomoki Bo, Hidekazu Nohara, Ken-ichi Yamada, Satoshi Miyata, Junichi Fujii

Source: Antioxidants, Vol 13, Iss 2, p 152 (2024)

Subject Terms: reactive oxygen species, adrenal, adrenocorticotropic hormone, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.mdpi.com/2076-3921/13/2/152; https://doaj.org/toc/2076-3921

Access URL: https://doaj.org/article/12bafdf87f684e69a99f583999c65f13

The Emerging Roles of γ-Glutamyl Peptides Produced by γ-Glutamyltransferase and the Glutathione Synthesis System

Authors: Yoshitaka Ikeda, Junichi Fujii

Source: Cells, Vol 12, Iss 24, p 2831 (2023)

Subject Terms: cysteine, glutamic acid, L-5-oxoproline, γ-glutamylcyclotransferase, calcium-sensing receptor, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/12/24/2831; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/c40ed2875d2c403e95ab5ee7a8aa3a4b

Biological Action of Singlet Molecular Oxygen from the Standpoint of Cell Signaling, Injury and Death

Authors: Junichi Fujii, Yuya Soma, Yumi Matsuda

Source: Molecules, Vol 28, Iss 10, p 4085 (2023)

Subject Terms: photodynamic therapy, ultraviolet, endoperoxides, lipid peroxidation, apoptosis, ferroptosis, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/28/10/4085; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/6b45d9d572bf464cb56d51d0c430f7a8

Loss of Peroxiredoxin IV Protects Mice from Azoxymethane/Dextran Sulfate Sodium-Induced Colorectal Cancer Development

Authors: Pratik Thapa, Hong Jiang, Na Ding, Yanning Hao, Aziza Alshahrani, Eun Y. Lee, Junichi Fujii, Qiou Wei

Source: Antioxidants, Vol 12, Iss 3, p 677 (2023)

Subject Terms: peroxiredoxin, sulfiredoxin, colorectal cancer, redox, oxidative stress, tumorigenesis, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.mdpi.com/2076-3921/12/3/677; https://doaj.org/toc/2076-3921

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Critical Role of the Sulfiredoxin-Peroxiredoxin IV Axis in Urethane-Induced Non-Small Cell Lung Cancer

Authors: Yanning Hao, Hong Jiang, Pratik Thapa, Na Ding, Aziza Alshahrani, Junichi Fujii, Michel B. Toledano, Qiou Wei

Source: Antioxidants, Vol 12, Iss 2, p 367 (2023)

Subject Terms: sulfiredoxin, peroxiredoxin, lung cancer, tumorigenesis, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.mdpi.com/2076-3921/12/2/367; https://doaj.org/toc/2076-3921

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Involvement of Nitric Oxide in Protecting against Radical Species and Autoregulation of M1-Polarized Macrophages through Metabolic Remodeling

Authors: Junichi Fujii, Tsukasa Osaki

Source: Molecules, Vol 28, Iss 2, p 814 (2023)

Subject Terms: NOS2, tricarboxylic acid cycle, urea cycle, aconitase, polyamines, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/28/2/814; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/6e6afa20d4fb4535b1aba5de9d583085

LAT1 inhibitor JPH203 sensitizes cancer cells to radiation by enhancing radiation-induced cellular senescence

Authors: Tomoki Bo, Sho Kobayashi, Osamu Inanami, Junichi Fujii, Osamu Nakajima, Tsunekata Ito, Hironobu Yasui

Source: Translational Oncology, Vol 14, Iss 11, Pp 101212- (2021)

Subject Terms: Cancer metabolism, JPH203, LAT1, Neutral amino acids, Radiation, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1936523321002047; https://doaj.org/toc/1936-5233

Access URL: https://doaj.org/article/2b874841681c4b269ee36071d16dabfa

Hinokitiol and pyrrolidone carboxylate zinc or corn oligosaccharides: A Synergistic approach to combating scalp microorganisms in seborrheic dermatitis.

Authors: Akihiro Michihara, Hiroshi Matsuoka, Junichi Fujii, Chiharu Furukawa, Xianting Lin, Jianzhong Yang

Source: Fundamental Toxicological Sciences; 2024, Vol. 11 Issue 5, p233-241, 9p

Subject Terms: SEBORRHEIC dermatitis, MALASSEZIA, STAPHYLOCOCCUS aureus, STAPHYLOCOCCUS epidermidis, ATOPIC dermatitis

Nitric oxide produced by NOS2 copes with the cytotoxic effects of superoxide in macrophages

Authors: Sho Kobayashi, Takujiro Homma, Junichi Fujii

Source: Biochemistry and Biophysics Reports, Vol 26, Iss , Pp 100942- (2021)

Subject Terms: Macrophage, Nitric oxide, Superoxide, NOS2, SOD1, Biology (General), QH301-705.5, Biochemistry, QD415-436

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2405580821000364; https://doaj.org/toc/2405-5808

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Ascorbate Is a Primary Antioxidant in Mammals

Authors: Junichi Fujii, Tsukasa Osaki, Tomoki Bo

Source: Molecules, Vol 27, Iss 19, p 6187 (2022)

Subject Terms: ascorbate, GULO, RGN, AKR1A, antioxidant, radical scavenging, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/27/19/6187; https://doaj.org/toc/1420-3049

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Methionine Deprivation Reveals the Pivotal Roles of Cell Cycle Progression in Ferroptosis That Is Induced by Cysteine Starvation

Authors: Takujiro Homma, Sho Kobayashi, Junichi Fujii

Source: Cells, Vol 11, Iss 10, p 1603 (2022)

Subject Terms: ferroptosis, glutathione, cell cycle, methionine, cysteine, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/11/10/1603; https://doaj.org/toc/2073-4409

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Superoxide Radicals in the Execution of Cell Death

Authors: Junichi Fujii, Takujiro Homma, Tsukasa Osaki

Source: Antioxidants, Vol 11, Iss 3, p 501 (2022)

Subject Terms: superoxide, ferroptosis, radical electron, nitric oxide, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.mdpi.com/2076-3921/11/3/501; https://doaj.org/toc/2076-3921

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Pleiotropic Actions of Aldehyde Reductase (AKR1A)

Authors: Junichi Fujii, Takujiro Homma, Satoshi Miyata, Motoko Takahashi

Source: Metabolites, Vol 11, Iss 6, p 343 (2021)

Subject Terms: Akr1a, Akr1b, reductive detoxification, glycation, ascorbate synthesis, S-nitrosylation, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-1989/11/6/343; https://doaj.org/toc/2218-1989

Access URL: https://doaj.org/article/9db845b68e3547c69aa8797874e244f4

Roles of Antioxidative Enzymes in Wound Healing

Authors: Toshihiro Kurahashi, Junichi Fujii

Source: Journal of Developmental Biology, Vol 3, Iss 2, Pp 57-70 (2015)

Subject Terms: cutaneous wound healing, reactive oxygen species, antioxidative enzyme, redox balance, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.mdpi.com/2221-3759/3/2/57; https://doaj.org/toc/2221-3759

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Overexpression of Peroxiredoxin 4 Affects Intestinal Function in a Dietary Mouse Model of Nonalcoholic Fatty Liver Disease.

Authors: Aya Nawata, Hirotsugu Noguchi, Yuichi Mazaki, Toshihiro Kurahashi, Hiroto Izumi, Ke-Yong Wang, Xin Guo, Hidetaka Uramoto, Kimitoshi Kohno, Hatsumi Taniguchi, Yoshiya Tanaka, Junichi Fujii, Yasuyuki Sasaguri, Akihide Tanimoto, Toshiyuki Nakayama, Sohsuke Yamada

Source: PLoS ONE, Vol 11, Iss 4, p e0152549 (2016)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC4818088?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/b352f5b7fe644fcaa0f3a987744c42ae

Prdx4 is a compartment-specific H2O2 sensor that regulates neurogenesis by controlling surface expression of GDE2.

Authors: Ye Yan, Wladyka, Cynthia, Junichi Fujii, Sockanathan, Shanthini

Source: Nature Communications; May2015, Vol. 6 Issue 5, p1-12, 12p, 1 Color Photograph, 6 Graphs

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B- to Plasma-Cell Terminal Differentiation Entails Oxidative Stress and Profound Reshaping of the Antioxidant Responses.

Authors: Milena Bertolotti, Sun Hee Yim, Jose M. Garcia-Manteiga, Silvia Masciarelli, Yoo-Jin Kim, Min-Hee Kang, Yoshihito Iuchi, Junichi Fujii, Roberta Vené, Anna Rubartelli, Sue Goo Rhee, Roberto Sitia

Source: Antioxidants & Redox Signaling; Oct2010, Vol. 13 Issue 8, p1133-1144, 12p

Rescue of anaemia and autoimmune responses in SOD1-deficient mice by transgenic expression of human SOD1 in erythrocytes.

Authors: Yoshihito Iuchi, Futoshi Okada, Rina Takamiya, Noriko Kibe, Satoshi Tsunoda, Osamu Nakajima, Kazuyo Toyoda, Ritsuko Nagae, Makoto Suematsu, Tomoyoshi Soga, Koji Uchida, Junichi Fujii

Source: Biochemical Journal; Aug2009, Vol. 422 Issue 2, p313-320, 8p

Subject Terms: AUTOIMMUNE diseases, OXIDATIVE stress, ERYTHROCYTES, SUPEROXIDE dismutase, ANEMIA, ETIOLOGY of diseases, AUTOANTIBODIES, TRANSGENE expression, LABORATORY mice, GENETICS