Plug and play virus-like particles for the generation of anti-toxin antibodies

Authors: Rebecca J. Edge, Amy E. Marriott, Emma L. Stars, Rohit N. Patel, Mark C. Wilkinson, Lloyd D.W. King, Julien Slagboom, Choo Hock Tan, Kavi Ratanabanangkoon, Simon J. Draper, Stuart Ainsworth

Source: Toxicon: X, Vol 23, Iss , Pp 100204- (2024)

Subject Terms: Toxicology. Poisons, RA1190-1270

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2590171024000213; https://doaj.org/toc/2590-1710

Access URL: https://doaj.org/article/7786c6bea5b54487a9ec625049f911c8

Development of a membrane-disruption assay using phospholipid vesicles as a proxy for the detection of cellular membrane degradation

Authors: Mátyás A. Bittenbinder, Eric Wachtel, Daniel Da Costa Pereira, Julien Slagboom, Nicholas R. Casewell, Paul Jennings, Jeroen Kool, Freek J. Vonk

Source: Toxicon: X, Vol 22, Iss , Pp 100197- (2024)

Subject Terms: Envenoming, Snakebite, Cell membrane, Toxin, Cytotoxicity, Phospholipase, Toxicology. Poisons, RA1190-1270

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2590171024000146; https://doaj.org/toc/2590-1710

Access URL: https://doaj.org/article/ac6aba6cfeab4a96a279562411acc225

Nanofractionation Analytics for Comparing MALDI-MS and ESI-MS Data of Viperidae Snake Venom Toxins

Authors: Haifeng Xu, Jesse Mastenbroek, Natascha T. B. Krikke, Susan El-Asal, Rama Mutlaq, Nicholas R. Casewell, Julien Slagboom, Jeroen Kool

Source: Toxins, Vol 16, Iss 8, p 370 (2024)

Subject Terms: viperid venoms, ESI-MS, MALDI-MS, intact MS comparison, plasma coagulation, Medicine

File Description: electronic resource

Relation: https://www.mdpi.com/2072-6651/16/8/370; https://doaj.org/toc/2072-6651

Access URL: https://doaj.org/article/1612c90600294f029906cff47b513f1b

Aligning Post-Column ESI-MS, MALDI-MS, and Coagulation Bioassay Data of Naja spp., Ophiophagus hannah, and Pseudonaja textillis Venoms Chromatographically to Assess MALDI-MS and ESI-MS Complementarity with Correlation of Bioactive Toxins to Mass Spectrometric Data

Authors: Haifeng Xu, Susan El-Asal, Hafsa Zakri, Rama Mutlaq, Natascha T. B. Krikke, Nicholas R. Casewell, Julien Slagboom, Jeroen Kool

Source: Toxins, Vol 16, Iss 9, p 379 (2024)

Subject Terms: plotted matrix-assisted laser desorption ionization (MALDI-MS) chromatograms, electrospray ionization (ESI) MS-extracted ion currents (EICs), plasma coagulation bioassay chromatograms, nanofractionation analytics, chromatographic alignment, Medicine

File Description: electronic resource

Relation: https://www.mdpi.com/2072-6651/16/9/379; https://doaj.org/toc/2072-6651

Access URL: https://doaj.org/article/f960ed61b658483b92275372ca9ec5ed

High throughput identification of human monoclonal antibodies and heavy-chain-only antibodies to treat snakebite

Authors: Julien Slagboom, Abigail H. Lewis, Wietse M. Schouten, Rien van Haperen, Mieke Veltman, Mátyás A. Bittenbinder, Freek J. Vonk, Nicholas R. Casewell, Frank Grosveld, Dubravka Drabek, Jeroen Kool

Source: Toxicon: X, Vol 21, Iss , Pp 100185- (2024)

Subject Terms: Toxicology. Poisons, RA1190-1270

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S259017102400002X; https://doaj.org/toc/2590-1710

Access URL: https://doaj.org/article/aa72a3429ba844ee87def2003bd12c3d

Qualitative Profiling of Venom Toxins in the Venoms of Several Bothrops Species Using High-Throughput Venomics and Coagulation Bioassaying

Authors: Dimoetsha J. C. Weekers, Luis L. Alonso, Anniek X. Verstegen, Julien Slagboom, Jeroen Kool

Source: Toxins, Vol 16, Iss 7, p 300 (2024)

Subject Terms: HPLC-MS, high-throughput venomics, Bothrops viper venom, coagulation bioassay, Medicine

File Description: electronic resource

Relation: https://www.mdpi.com/2072-6651/16/7/300; https://doaj.org/toc/2072-6651

Access URL: https://doaj.org/article/912b6f11b53c46fb82a89d7ee432bcaf

Development of a high-throughput in vitro screening method for the assessment of cell-damaging activities of snake venoms.

Authors: Matyas A Bittenbinder, Liliana Capinha, Daniel Da Costa Pereira, Julien Slagboom, Bas van de Velde, Nicholas R Casewell, Paul Jennings, Jeroen Kool, Freek J Vonk

Source: PLoS Neglected Tropical Diseases, Vol 17, Iss 8, p e0011564 (2023)

Subject Terms: Arctic medicine. Tropical medicine, RC955-962, Public aspects of medicine, RA1-1270

File Description: electronic resource

Relation: https://doaj.org/toc/1935-2727; https://doaj.org/toc/1935-2735

Access URL: https://doaj.org/article/f4755132d35c47b589db91777a013bdd

Studying Venom Toxin Variation Using Accurate Masses from Liquid Chromatography–Mass Spectrometry Coupled with Bioinformatic Tools

Authors: Luis L. Alonso, Jory van Thiel, Julien Slagboom, Nathan Dunstan, Cassandra M. Modahl, Timothy N. W. Jackson, Saer Samanipour, Jeroen Kool

Source: Toxins, Vol 16, Iss 4, p 181 (2024)

Subject Terms: LC-MS, snake venom, high throughput, data analysis, Medicine

File Description: electronic resource

Relation: https://www.mdpi.com/2072-6651/16/4/181; https://doaj.org/toc/2072-6651

Access URL: https://doaj.org/article/9990a06817e94667b17a6686411c559a

Analytical Size Exclusion Chromatography Coupled with Mass Spectrometry in Parallel with High-Throughput Venomics and Bioassaying for Venom Profiling

Authors: Sedef Terzioglu, Mátyás A. Bittenbinder, Julien Slagboom, Bas van de Velde, Nicholas R. Casewell, Jeroen Kool

Source: Toxins, Vol 15, Iss 9, p 552 (2023)

Subject Terms: snakebite, coagulopathy, size exclusion chromatography, mass spectrometry, snake venomics, Daboia russelii, Medicine

File Description: electronic resource

Relation: https://www.mdpi.com/2072-6651/15/9/552; https://doaj.org/toc/2072-6651

Access URL: https://doaj.org/article/787287c84d904eea8d28ed617d50d9c4

Neutralising effects of small molecule toxin inhibitors on nanofractionated coagulopathic Crotalinae snake venoms

Authors: Chunfang Xie, Julien Slagboom, Laura-Oana Albulescu, Govert W. Somsen, Freek J. Vonk, Nicholas R. Casewell, Jeroen Kool

Source: Acta Pharmaceutica Sinica B, Vol 10, Iss 10, Pp 1835-1845 (2020)

Subject Terms: Snakebite, Antivenom, Varespladib, Marimastat, Dimercaprol, Chelators, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S221138352030705X; https://doaj.org/toc/2211-3835

Access URL: https://doaj.org/article/61d3b6b1ec4647a09b7106d2b3c0676a

Monitoring Snake Venom-Induced Extracellular Matrix Degradation and Identifying Proteolytically Active Venom Toxins Using Fluorescently Labeled Substrates

Authors: Mátyás A. Bittenbinder, Nick D. Bergkamp, Julien Slagboom, Jan Paul M. Bebelman, Nicholas R. Casewell, Marco H. Siderius, Martine J. Smit, Jeroen Kool, Freek J. Vonk

Source: Biology, Vol 12, Iss 6, p 765 (2023)

Subject Terms: snakebite, tissue-damaging activities, extracellular matrix, protease, SVMP, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2079-7737/12/6/765; https://doaj.org/toc/2079-7737

Access URL: https://doaj.org/article/f9e79332668545178e61ab84f5cb989e

Application of an Extracellular Matrix-Mimicking Fluorescent Polymer for the Detection of Proteolytic Venom Toxins

Authors: Eric Wachtel, Matyas A. Bittenbinder, Bas van de Velde, Julien Slagboom, Axel de Monts de Savasse, Luis L. Alonso, Nicholas R. Casewell, Freek J. Vonk, Jeroen Kool

Source: Toxins, Vol 15, Iss 4, p 294 (2023)

Subject Terms: snakebite, toxins, SVMP, extracellular matrix, cytotoxicity, tissue damage, Medicine

File Description: electronic resource

Relation: https://www.mdpi.com/2072-6651/15/4/294; https://doaj.org/toc/2072-6651

Access URL: https://doaj.org/article/df8a65ad150346649043fa585e91e25c

Metabolome-Based Classification of Snake Venoms by Bioinformatic Tools

Authors: Luis L. Alonso, Julien Slagboom, Nicholas R. Casewell, Saer Samanipour, Jeroen Kool

Source: Toxins, Vol 15, Iss 2, p 161 (2023)

Subject Terms: venom variation, metabolomics, data analysis, script-controlled peak integration, Medicine

File Description: electronic resource

Relation: https://www.mdpi.com/2072-6651/15/2/161; https://doaj.org/toc/2072-6651

Access URL: https://doaj.org/article/d07532633fe34a54a38ffb1c05fdcc39

Highly Evolvable: Investigating Interspecific and Intraspecific Venom Variation in Taipans (Oxyuranus spp.) and Brown Snakes (Pseudonaja spp.)

Authors: Jory van Thiel, Luis L. Alonso, Julien Slagboom, Nathan Dunstan, Roel M. Wouters, Cassandra M. Modahl, Freek J. Vonk, Timothy N. W. Jackson, Jeroen Kool

Source: Toxins, Vol 15, Iss 1, p 74 (2023)

Subject Terms: snake venom, venom variation, evolvability, liquid chromatography, mass spectrometry, Medicine

File Description: electronic resource

Relation: https://www.mdpi.com/2072-6651/15/1/74; https://doaj.org/toc/2072-6651

Access URL: https://doaj.org/article/b7100fa090eb4e798f6caea896e6292f

A Combined Bioassay and Nanofractionation Approach to Investigate the Anticoagulant Toxins of Mamba and Cobra Venoms and Their Inhibition by Varespladib

Authors: Arif Arrahman, Taline D. Kazandjian, Kristina B. M. Still, Julien Slagboom, Govert W. Somsen, Freek J. Vonk, Nicholas R. Casewell, Jeroen Kool

Source: Toxins, Vol 14, Iss 11, p 736 (2022)

Subject Terms: snakebite, coagulopathy, varespladib, marimastat, Dendroaspis, Naja, Medicine

File Description: electronic resource

Relation: https://www.mdpi.com/2072-6651/14/11/736; https://doaj.org/toc/2072-6651

Access URL: https://doaj.org/article/5c1b8f5d1d7b4c71865060f67e731bd9

High throughput screening and identification of coagulopathic snake venom proteins and peptides using nanofractionation and proteomics approaches.

Authors: Julien Slagboom, Marija Mladić, Chunfang Xie, Taline D Kazandjian, Freek Vonk, Govert W Somsen, Nicholas R Casewell, Jeroen Kool

Source: PLoS Neglected Tropical Diseases, Vol 14, Iss 4, p e0007802 (2020)

Subject Terms: Arctic medicine. Tropical medicine, RC955-962, Public aspects of medicine, RA1-1270

File Description: electronic resource

Relation: https://doaj.org/toc/1935-2727; https://doaj.org/toc/1935-2735

Access URL: https://doaj.org/article/db84340e92474074a8a0fa671ebe61e4

A Decoy-Receptor Approach Using Nicotinic Acetylcholine Receptor Mimics Reveals Their Potential as Novel Therapeutics Against Neurotoxic Snakebite

Authors: Laura-Oana Albulescu, Taline Kazandjian, Julien Slagboom, Ben Bruyneel, Stuart Ainsworth, Jaffer Alsolaiss, Simon C. Wagstaff, Gareth Whiteley, Robert A. Harrison, Chris Ulens, Jeroen Kool, Nicholas R. Casewell

Source: Frontiers in Pharmacology, Vol 10 (2019)

Subject Terms: nicotinic acetylcholine receptors (nAChR), long-chain three-finger toxins (3FTx), acetylcholine binding proteins (AChBPs), snake venom neurotoxins, envenoming, therapeutics, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fphar.2019.00848/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/6cb9f077e2d54ee6afc67e236ac79fab

Varespladib Inhibits the Phospholipase A2 and Coagulopathic Activities of Venom Components from Hemotoxic Snakes

Authors: Chunfang Xie, Laura-Oana Albulescu, Kristina B. M. Still, Julien Slagboom, Yumei Zhao, Zhengjin Jiang, Govert W. Somsen, Freek J. Vonk, Nicholas R. Casewell, Jeroen Kool

Source: Biomedicines, Vol 8, Iss 6, p 165 (2020)

Subject Terms: varespladib, nanofractionation, PLA2 activity, coagulopathic toxicity, neutralization, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2227-9059/8/6/165; https://doaj.org/toc/2227-9059

Access URL: https://doaj.org/article/b55a59bd56e14f879e316a41da2553ad

Antivenom Neutralization of Coagulopathic Snake Venom Toxins Assessed by Bioactivity Profiling Using Nanofractionation Analytics

Authors: Chunfang Xie, Julien Slagboom, Laura-Oana Albulescu, Ben Bruyneel, Kristina B. M. Still, Freek J. Vonk, Govert W. Somsen, Nicholas R. Casewell, Jeroen Kool

Source: Toxins, Vol 12, Iss 1, p 53 (2020)

Subject Terms: antivenom, nanofractionation, coagulation, anticoagulation, snakebite, Medicine

File Description: electronic resource

Relation: https://www.mdpi.com/2072-6651/12/1/53; https://doaj.org/toc/2072-6651

Access URL: https://doaj.org/article/6612a5701c8447eb9ebfc535982fc95d

Multipurpose HTS Coagulation Analysis: Assay Development and Assessment of Coagulopathic Snake Venoms

Authors: Kristina B. M. Still, Randjana S. S. Nandlal, Julien Slagboom, Govert W. Somsen, Nicholas R. Casewell, Jeroen Kool

Source: Toxins, Vol 9, Iss 12, p 382 (2017)

Subject Terms: snake venoms, blood coagulation, coagulation bioassay, high-throughput screening, mass spectrometry, liquid chromatography, Medicine

File Description: electronic resource

Relation: https://www.mdpi.com/2072-6651/9/12/382; https://doaj.org/toc/2072-6651

Access URL: https://doaj.org/article/3e6147aa818048239f9463057448c71d