Targeting eEF1A reprograms translation and uncovers broad-spectrum antivirals against cap or m6A protein synthesis routes

Authors: Elisa Molina Molina, Joan Josep Bech-Serra, Eloi Franco-Trepat, Ignasi Jarne, Daniel Perez-Zsolt, Roger Badia, Eva Riveira-Muñoz, Edurne Garcia-Vidal, Lluís Revilla, Sandra Franco, Ferran Tarrés-Freixas, Núria Roca, Gerardo Ceada, Karl Kochanowski, Dàlia Raïch-Regué, Itziar Erkizia, Rytis Boreika, Antoni E. Bordoy, Laia Soler, Sonia Guil, Jorge Carrillo, Julià Blanco, Miguel Ángel Martínez, Roger Paredes, Alejandro Losada, Pablo Aviles, Carmen Cuevas, Júlia Vergara-Alert, Joaquim Segalés, Bonaventura Clotet, Ester Ballana, Carolina de la Torre, Nuria Izquierdo-Useros

Source: Nature Communications, Vol 16, Iss 1, Pp 1-17 (2025)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/8f85394d674b4daf93c359016ba55f79

Long-lasting antibody B-cell responses to SARS-CoV-2 three years after the onset of the pandemic

Authors: Luis M. Molinos-Albert, Rocío Rubio, Carla Martín-Pérez, Edwards Pradenas, Cèlia Torres, Alfons Jiménez, Mar Canyelles, Marta Vidal, Diana Barrios, Silvia Marfil, Ester Aparicio, Anna Ramírez-Morros, Benjamin Trinité, Josep Vidal-Alaball, Pere Santamaria, Pau Serra, Luis Izquierdo, Ruth Aguilar, Anna Ruiz-Comellas, Julià Blanco, Carlota Dobaño, Gemma Moncunill

Source: Cell Reports, Vol 44, Iss 4, Pp 115498- (2025)

Subject Terms: CP: Immunology, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124725002694; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/4c14b3d9f838478d81fb4193b9f44774

Proteomics of circulating extracellular vesicles reveals diverse clinical presentations of COVID-19 but fails to identify viral peptides

Authors: Melisa Gualdrón-López, Alberto Ayllon-Hermida, Núria Cortes-Serra, Patricia Resa-Infante, Joan Josep Bech-Serra, Iris Aparici-Herraiz, Marc Nicolau-Fernandez, Itziar Erkizia, Lucia Gutierrez-Chamorro, Silvia Marfil, Edwards Pradenas, Carlos Ávila Nieto, Bernat Cucurull, Sergio Montaner-Tarbés, Magdalena Muelas, Ruth Sotil, Ester Ballana, Victor Urrea, Lorenzo Fraile, Maria Montoya, Julia Vergara, Joaquim Segales, Jorge Carrillo, Nuria Izquierdo-Useros, Julià Blanco, Carmen Fernandez-Becerra, Carolina de La Torre, Maria-Jesus Pinazo, Javier Martinez-Picado, Hernando A. del Portillo

Source: Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)

Subject Terms: COVID-19 patients, SARS-CoV-2, antibody response, extracellular vesicles, immunocapture (CD9), ganglioside-capture (CD169/Siglec-1), Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcimb.2024.1442743/full; https://doaj.org/toc/2235-2988

Access URL: https://doaj.org/article/2056b388ea7e4fd6b5f14e14cc08dc15

NSGS mice humanized with cord blood mononuclear cells show sustained and functional myeloid–lymphoid representation with limited graft-versus-host disease

Authors: Jorge Carrillo, Julià Blanco, Manel Juan, Pablo Menendez, Rosario Aschero, Alba Martínez-Moreno, Carla Panisello, Heleia Roca Ho, Aida Falgas, Europa Azucena González-Navarro, Julieta Carabelli, Edwards Pradenas, María Lázaro-Díez, Julia G Prado, Ángel M Carcaboso, Clara Bueno

Source: Journal for ImmunoTherapy of Cancer, Vol 12, Iss 10 (2024)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/12/10/e009198.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/bed49f3854d84262911d96cc974169ac

Immunization with V987H-stabilized Spike glycoprotein protects K18-hACE2 mice and golden Syrian hamsters upon SARS-CoV-2 infection

Authors: Carlos Ávila-Nieto, Júlia Vergara-Alert, Pep Amengual-Rigo, Erola Ainsua-Enrich, Marco Brustolin, María Luisa Rodríguez de la Concepción, Núria Pedreño-Lopez, Jordi Rodon, Victor Urrea, Edwards Pradenas, Silvia Marfil, Ester Ballana, Eva Riveira-Muñoz, Mònica Pérez, Núria Roca, Ferran Tarrés-Freixas, Guillermo Cantero, Anna Pons-Grífols, Carla Rovirosa, Carmen Aguilar-Gurrieri, Raquel Ortiz, Ana Barajas, Benjamin Trinité, Rosalba Lepore, Jordana Muñoz-Basagoiti, Daniel Perez-Zsolt, Nuria Izquierdo-Useros, Alfonso Valencia, Julià Blanco, Victor Guallar, Bonaventura Clotet, Joaquim Segalés, Jorge Carrillo

Source: Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/417894952ca54f88947455ec8d336df7

Immunisation efficacy of a stabilised SARS-CoV-2 spike glycoprotein in two geriatric animal models

Authors: Carla Usai, Erola Ainsua-Enrich, Victor Urrea Gales, Edwards Pradenas, Cristina Lorca-Oró, Ferran Tarrés-Freixas, Núria Roca, Mónica Pérez, Carlos Ávila-Nieto, María Luisa Rodríguez de la Concepción, Núria Pedreño-Lopez, Julieta Carabelli, Benjamin Trinité, Ester Ballana, Eva Riveira-Muñoz, Nuria Izquierdo-Useros, Bonaventura Clotet, Julià Blanco, Victor Guallar, Guillermo Cantero, Júlia Vergara-Alert, Jorge Carrillo, Joaquim Segalés

Source: npj Vaccines, Vol 9, Iss 1, Pp 1-12 (2024)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2059-0105

Access URL: https://doaj.org/article/f305a783ac09456b913d3b908a30b8e8

A monoclonal antibody targeting a large surface of the receptor binding motif shows pan-neutralizing SARS-CoV-2 activity

Authors: Leire de Campos-Mata, Benjamin Trinité, Andrea Modrego, Sonia Tejedor Vaquero, Edwards Pradenas, Anna Pons-Grífols, Natalia Rodrigo Melero, Diego Carlero, Silvia Marfil, César Santiago, Dàlia Raïch-Regué, María Teresa Bueno-Carrasco, Ferran Tarrés-Freixas, Ferran Abancó, Victor Urrea, Nuria Izquierdo-Useros, Eva Riveira-Muñoz, Ester Ballana, Mónica Pérez, Júlia Vergara-Alert, Joaquim Segalés, Carlo Carolis, Rocío Arranz, Julià Blanco, Giuliana Magri

Source: Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/e88c94774f434c16bec8caaf30b4258f

Virus-like particle-mediated delivery of structure-selected neoantigens demonstrates immunogenicity and antitumoral activity in mice

Authors: Ana Barajas, Pep Amengual-Rigo, Anna Pons-Grífols, Raquel Ortiz, Oriol Gracia Carmona, Victor Urrea, Nuria de la Iglesia, Juan Blanco-Heredia, Carla Anjos-Souza, Ismael Varela, Benjamin Trinité, Ferran Tarrés-Freixas, Carla Rovirosa, Rosalba Lepore, Miguel Vázquez, Leticia de Mattos-Arruda, Alfonso Valencia, Bonaventura Clotet, Carmen Aguilar-Gurrieri, Victor Guallar, Jorge Carrillo, Julià Blanco

Source: Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-14 (2024)

Subject Terms: Neoantigen, Cancer vaccine, Virus-like particle, Immunotherapy, T cell response, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1479-5876

Access URL: https://doaj.org/article/83a923e41a4c4f16982d7a9a094b4b9c

Safety and immunogenicity of a recombinant protein RBD fusion heterodimer vaccine against SARS-CoV-2

Authors: Lorna Leal, Judit Pich, Laura Ferrer, Jocelyn Nava, Ruth Martí-Lluch, Ignasi Esteban, Edwards Pradenas, Dàlia Raïch-Regué, Antoni Prenafeta, Karla Escobar, Carmen Pastor, Marc Ribas-Aulinas, Benjamin Trinitè, Jordana Muñoz-Basagoiti, Gemma Domenech, Bonaventura Clotet, Júlia Corominas, Aida Corpes-Comes, Carme Garriga, Antonio Barreiro, Nuria Izquierdo-Useros, Joan Albert Arnaiz, Alex Soriano, José Ríos, Marga Nadal, Montserrat Plana, Julià Blanco, Teresa Prat, Elia Torroella, Rafel Ramos, HIPRA-HH-1 study group

Source: npj Vaccines, Vol 8, Iss 1, Pp 1-12 (2023)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2059-0105

Access URL: https://doaj.org/article/0a20f98d912343ffad1efe821c52c851

Impact of chemotherapy and/or immunotherapy on neutralizing antibody response to SARS‐CoV‐2 mRNA‐1237 vaccine in patients with solid tumors

Authors: Eudald Felip, Edwards Pradenas, Margarita Romeo, Silvia Marfil, Benjamin Trinité, Víctor Urrea, Ainhoa Hernández, Ester Ballana, Marc Cucurull, Lourdes Mateu, Marta Massanella, Bonaventura Clotet, Teresa Morán, Julià Blanco

Source: Molecular Oncology, Vol 17, Iss 4, Pp 686-694 (2023)

Subject Terms: adverse reactions, anticancer therapy, cancer, COVID‐19, moderna vaccine, neutralizing antibodies, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1574-7891; https://doaj.org/toc/1878-0261

Access URL: https://doaj.org/article/cb23f6b2bc0042d091babfcdf72a34a2

An engineered HIV-1 Gag-based VLP displaying high antigen density induces strong antibody-dependent functional immune responses

Authors: Ferran Tarrés-Freixas, Carmen Aguilar-Gurrieri, María Luisa Rodríguez de la Concepción, Victor Urrea, Benjamin Trinité, Raquel Ortiz, Edwards Pradenas, Pau Blanco, Sílvia Marfil, Luis Manuel Molinos-Albert, Ana Barajas, Anna Pons-Grífols, Carlos Ávila-Nieto, Ismael Varela, Laura Cervera, Sònia Gutiérrez-Granados, María Mercedes Segura, Francesc Gòdia, Bonaventura Clotet, Jorge Carrillo, Julià Blanco

Source: npj Vaccines, Vol 8, Iss 1, Pp 1-13 (2023)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2059-0105

Access URL: https://doaj.org/article/20b68eeb7d6f4ecfa2c0a0005799608d

Novel Spike-stabilized trimers with improved production protect K18-hACE2 mice and golden Syrian hamsters from the highly pathogenic SARS-CoV-2 Beta variant

Authors: Carlos Ávila-Nieto, Júlia Vergara-Alert, Pep Amengual-Rigo, Erola Ainsua-Enrich, Marco Brustolin, María Luisa Rodríguez de la Concepción, Núria Pedreño-Lopez, Jordi Rodon, Victor Urrea, Edwards Pradenas, Silvia Marfil, Ester Ballana, Eva Riveira-Muñoz, Mònica Pérez, Núria Roca, Ferran Tarrés-Freixas, Julieta Carabelli, Guillermo Cantero, Anna Pons-Grífols, Carla Rovirosa, Carmen Aguilar-Gurrieri, Raquel Ortiz, Ana Barajas, Benjamin Trinité, Rosalba Lepore, Jordana Muñoz-Basagoiti, Daniel Perez-Zsolt, Nuria Izquierdo-Useros, Alfonso Valencia, Julià Blanco, Bonaventura Clotet, Victor Guallar, Joaquim Segalés, Jorge Carrillo

Source: Frontiers in Immunology, Vol 14 (2023)

Subject Terms: COVID-19, SARS-CoV-2, vaccine, neutralizing antibodies, humoral response, Spike glycoprotein, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1291972/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/8d145e1f4f964517b358c973214ef36f

Omicron XBB.1.16-Adapted Vaccine for COVID-19: Interim Immunogenicity and Safety Clinical Trial Results

Authors: María Jesús López Fernández, Silvia Narejos, Antoni Castro, José María Echave-Sustaeta, María José Forner, Eunate Arana-Arri, José Molto, Laia Bernad, Raúl Pérez-Caballero, Julia G. Prado, Dàlia Raïch-Regué, Rytis Boreika, Nuria Izquierdo-Useros, Benjamin Trinité, Julià Blanco, Joan Puig-Barberà, Silvina Natalini Martínez

Source: Vaccines, Vol 12, Iss 8, p 840 (2024)

Subject Terms: JN.1, XBB.1.16, adapted vaccine, SARS-CoV-2 vaccine, adjuvanted protein vaccine, booster vaccine, Medicine

File Description: electronic resource

Relation: https://www.mdpi.com/2076-393X/12/8/840; https://doaj.org/toc/2076-393X

Access URL: https://doaj.org/article/03e5acd3e60440fba94d5eb1a33afd0f

Production and Immunogenicity of FeLV Gag-Based VLPs Exposing a Stabilized FeLV Envelope Glycoprotein

Authors: Raquel Ortiz, Ana Barajas, Anna Pons-Grífols, Benjamin Trinité, Ferran Tarrés-Freixas, Carla Rovirosa, Víctor Urrea, Antonio Barreiro, Anna Gonzalez-Tendero, Maria Rovira-Rigau, Maria Cardona, Laura Ferrer, Bonaventura Clotet, Jorge Carrillo, Carmen Aguilar-Gurrieri, Julià Blanco

Source: Viruses, Vol 16, Iss 6, p 987 (2024)

Subject Terms: Env, vaccine, virus-like particle (VLP), FeLV, SOSIP, veterinary science, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4915/16/6/987; https://doaj.org/toc/1999-4915

Access URL: https://doaj.org/article/28f6dcb59e8c49f0b75c64e52e01d415

Demonstration of Antibodies Against SARS-CoV-2, Neutralizing or Binding, in Seroconversion Panels After mRNA-1273, BNT-162b2, and Ad26.COV2.S Vaccine Administration

Authors: Francisco Belda BSc, MS, PhD, Oscar Mora BPharm, Monica Lopez-Martinez PhD, Nerea Torres PhD, Ana Vivanco BSc, Silvia Marfil BSc, Edwards Pradenas PhD, Marta Massanella PhD, Julià Blanco PhD, Rebecca Christie BS, Michael Crowley BBA

Source: Plasmatology, Vol 17 (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://doaj.org/toc/2634-8535

Access URL: https://doaj.org/article/5784d93a91a3451b9625bca989b3aa01

Nucleic Acid Vaccines Encoding Proteins and Virus-like Particles for HIV Prevention

Authors: Ferran Tarrés-Freixas, Bonaventura Clotet, Jorge Carrillo, Julià Blanco

Source: Vaccines, Vol 12, Iss 3, p 298 (2024)

Subject Terms: AIDS, mRNA, DNA, VLP, antibody, bNAbs, Medicine

File Description: electronic resource

Relation: https://www.mdpi.com/2076-393X/12/3/298; https://doaj.org/toc/2076-393X

Access URL: https://doaj.org/article/a1c57334548a4784911a7fc097efcb2a

Glucocorticoids’ treatment impairs the medium-term immunogenic response to SARS-CoV-2 mRNA vaccines in Systemic Lupus Erythematosus patients

Authors: Silvia Garcia-Cirera, Joan Calvet, Antoni Berenguer-Llergo, Edwards Pradenas, Silvia Marfil, Marta Massanella, Lourdes Mateu, Benjamin Trinité, Maria Llop, Marta Arévalo, Carlos Galisteo, Cristóbal Orellana, Rafael Gómez, María Nieves Gómez-Gerique, Inma Carmona, Bonaventura Clotet, Julià Blanco, Jordi Gratacós

Source: Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/4e0f7fe7af794e2382f8fe911f0bbf38

Preclinical evaluation of PHH-1V vaccine candidate against SARS-CoV-2 in non-human primates

Authors: Antoni Prenafeta, Gregori Bech-Sàbat, Alexandra Moros, Antonio Barreiro, Alex Fernández, Manuel Cañete, Mercè Roca, Luis González-González, Carme Garriga, Joachim Confais, Marion Toussenot, Hugues Contamin, Andrés Pizzorno, Manuel Rosa-Calatrava, Edwards Pradenas, Silvia Marfil, Julià Blanco, Paula Cebollada Rica, Marta Sisteré-Oró, Andreas Meyerhans, Cristina Lorca, Joaquim Segalés, Teresa Prat, Ricard March, Laura Ferrer

Source: iScience, Vol 26, Iss 7, Pp 107224- (2023)

Subject Terms: Health sciences, Immunology, Immune response, Microbiology, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004223013019; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/9369697d1b964e229177289631f80d99

Macrophage CD5L is a target for cancer immunotherapyResearch in context

Authors: Lidia Sanchez-Moral, Tony Paul, Clara Martori, Joan Font-Díaz, Lucía Sanjurjo, Gemma Aran, Érica Téllez, Julià Blanco, Jorge Carrillo, Masaoki Ito, Martina Tuttolomondo, Henrik J. Ditzel, Caterina Fumagalli, Gustavo Tapia, Julia Sidorova, Helena Masnou, Marco-Antonio Fernández-Sanmartín, Juan-José Lozano, Cristina Vilaplana, Alhelí Rodriguez-Cortés, Carolina Armengol, Annabel F. Valledor, Leonor Kremer, Maria-Rosa Sarrias

Source: EBioMedicine, Vol 91, Iss , Pp 104555- (2023)

Subject Terms: CD5L, Immunotherapy, Lung adenocarcinoma, Macrophage, Monoclonal antibody, Scavenger receptor cysteine rich, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396423001202; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/36b0af9808e741e2b4807b241a0bfa38

Impact of hybrid immunity booster vaccination and Omicron breakthrough infection on SARS-CoV-2 VOCs cross-neutralization

Authors: Edwards Pradenas, Silvia Marfil, Víctor Urrea, Macedonia Trigueros, Tetyana Pidkova, Anna Pons-Grífols, Raquel Ortiz, Carla Rovirosa, Ferran Tarrés-Freixas, Carmen Aguilar-Gurrieri, Ruth Toledo, Anna Chamorro, Marc Noguera-Julian, Lourdes Mateu, Ignacio Blanco, Eulàlia Grau, Marta Massanella, Jorge Carrillo, Bonaventura Clotet, Benjamin Trinité, Julià Blanco

Source: iScience, Vol 26, Iss 4, Pp 106457- (2023)

Subject Terms: Biochemistry, Immune response, Microbiology, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004223005345; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/ed779693fcf8488dabf045c750cc1a87