Diploid and tetraploid genomes of Acorus and the evolution of monocots

Authors: Liang Ma, Ke-Wei Liu, Zhen Li, Yu-Yun Hsiao, Yiying Qi, Tao Fu, Guang-Da Tang, Diyang Zhang, Wei-Hong Sun, Ding-Kun Liu, Yuanyuan Li, Gui-Zhen Chen, Xue-Die Liu, Xing-Yu Liao, Yu-Ting Jiang, Xia Yu, Yang Hao, Jie Huang, Xue-Wei Zhao, Shijie Ke, You-Yi Chen, Wan-Lin Wu, Jui-Ling Hsu, Yu-Fu Lin, Ming-Der Huang, Chia-Ying Li, Laiqiang Huang, Zhi-Wen Wang, Xiang Zhao, Wen-Ying Zhong, Dong-Hui Peng, Sagheer Ahmad, Siren Lan, Ji-Sen Zhang, Wen-Chieh Tsai, Yves Van de Peer, Zhong-Jian Liu

Source: Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/f784835a070d47aa885d536529e2f73f

The Combination of a Novel GLUT1 Inhibitor and Cisplatin Synergistically Inhibits Breast Cancer Cell Growth By Enhancing the DNA Damaging Effect and Modulating the Akt/mTOR and MAPK Signaling Pathways

Authors: Hao-Cheng Weng, Chieh-Ju Sung, Jui-Ling Hsu, Wohn-Jenn Leu, Jih-Hwa Guh, Fan-Lu Kung, Lih-Ching Hsu

Source: Frontiers in Pharmacology, Vol 13 (2022)

Subject Terms: breast cancer, cisplatin, GLUT1 inhibitor, oxidative stress, DNA damage, Akt/mTOR and MAPK signaling pathways, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2022.879748/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/87867dc881c5485886ec66bb7c2bddb4

Evaluation of the Anticancer Activity of a Bile Acid-Dihydroartemisinin Hybrid Ursodeoxycholic-Dihydroartemisinin in Hepatocellular Carcinoma Cells

Authors: Tzu-En Huang, Yi-Ning Deng, Jui-Ling Hsu, Wohn-Jenn Leu, Elena Marchesi, Massimo L. Capobianco, Paolo Marchetti, Maria Luisa Navacchia, Jih-Hwa Guh, Daniela Perrone, Lih-Ching Hsu

Source: Frontiers in Pharmacology, Vol 11 (2020)

Subject Terms: hepatocellular carcinoma, bile acid-dihydroartemisinin hybrid, G0/G1 arrest, apoptosis, reactive oxygen species, mitochondrial membrane potential loss, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2020.599067/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/311890ab56b4453cad17527f699ccc44

Phosphodiesterase Type 5 Inhibitors Synergize Vincristine in Killing Castration-Resistant Prostate Cancer Through Amplifying Mitotic Arrest Signaling

Authors: Jui-Ling Hsu, Wohn-Jenn Leu, Lih-Ching Hsu, Chen-Hsun Ho, Shih-Ping Liu, Jih-Hwa Guh

Source: Frontiers in Oncology, Vol 10 (2020)

Subject Terms: sildenafil, vincristine, castration-resistant prostate cancer, spindle assembly checkpoint, kinetochore tension, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fonc.2020.01274/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/dd23ac1a86c643c987fc66a50d488968

The Combination of MK-2206 and WZB117 Exerts a Synergistic Cytotoxic Effect Against Breast Cancer Cells

Authors: Yu-Liang Li, Hao-Cheng Weng, Jui-Ling Hsu, Shu-Wha Lin, Jih-Hwa Guh, Lih-Ching Hsu

Source: Frontiers in Pharmacology, Vol 10 (2019)

Subject Terms: MK-2206, WZB117, Akt, GLUT1, DNA damage and repair, breast cancer, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fphar.2019.01311/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/3a50f21e63c74ef78a9a85f4b0c12b5b

Autophagic Activation and Decrease of Plasma Membrane Cholesterol Contribute to Anticancer Activities in Non-Small Cell Lung Cancer

Authors: Jui-Ling Hsu, Wohn-Jenn Leu, Nan-Shan Zhong, Jih-Hwa Guh

Source: Molecules, Vol 26, Iss 19, p 5967 (2021)

Subject Terms: para-toluenesulfonamide, Akt/mTOR/p70S6K pathway, plasma membrane cholesterol, autophagy, non-small cell lung cancer, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/26/19/5967; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/0770d624bb1d4ed394ad37c29e9bf129

Chalcones Display Anti-NLRP3 Inflammasome Activity in Macrophages through Inhibition of Both Priming and Activation Steps—Structure-Activity-Relationship and Mechanism Studies

Authors: Wohn-Jenn Leu, Jung-Chun Chu, Jui-Ling Hsu, Chi-Min Du, Yi-Huei Jiang, Lih-Ching Hsu, Wei-Jan Huang, Jih-Hwa Guh

Source: Molecules, Vol 25, Iss 24, p 5960 (2020)

Subject Terms: chalcone, NLRP3 inflammasome, structure-activity relationship, NF-ĸB, ATP, K+ efflux, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/25/24/5960; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/6c068a267a3649be80837d5cfc800d68

The (+)-Brevipolide H Displays Anticancer Activity against Human Castration-Resistant Prostate Cancer: The Role of Oxidative Stress and Akt/mTOR/p70S6K-Dependent Pathways in G1 Checkpoint Arrest and Apoptosis

Authors: Yi-Hua Sheng, Wohn-Jenn Leu, Ching-Nung Chen, Jui-Ling Hsu, Ying-Tung Liu, Lih-Ching Hsu, Duen-Ren Hou, Jih-Hwa Guh

Source: Molecules, Vol 25, Iss 12, p 2929 (2020)

Subject Terms: (+)-brevipolide H, G1 checkpoint arrest, oxidative stress, Akt/mTOR/p70S6K-dependent pathway, mitochondrial dysfunction, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/25/12/2929; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/30456e7ce9ab42cc99420318dff299c4

Phosphodiesterase Type 5 (PDE5) Inhibitors Sensitize Topoisomerase II Inhibitors in Killing Prostate Cancer Through PDE5-Independent Impairment of HR and NHEJ DNA Repair Systems

Authors: Jo-Fan Chang, Jui-Ling Hsu, Yi-Hua Sheng, Wohn-Jenn Leu, Chia-Chun Yu, She-Hung Chan, Mei-Ling Chan, Lih-Ching Hsu, Shih-Ping Liu, Jih-Hwa Guh

Source: Frontiers in Oncology, Vol 8 (2019)

Subject Terms: phosphodiesterase type 5 inhibitor, PDE5-independent, topoisomerase II inhibitor, homologous recombination DNA repair, non-homologous end joining DNA repair, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fonc.2018.00681/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/3a701bd102534e719249fe95c6948b24

Para-Toluenesulfonamide Induces Anti-tumor Activity Through Akt-Dependent and -Independent mTOR/p70S6K Pathway: Roles of Lipid Raft and Cholesterol Contents

Authors: Jui-Ling Hsu, Wohn-Jenn Leu, Lih-Ching Hsu, Shih-Ping Liu, Nan-Shan Zhong, Jih-Hwa Guh

Source: Frontiers in Pharmacology, Vol 9 (2018)

Subject Terms: para-toluenesulfonamide, Akt/mTOR/p70S6K pathway, lipid raft, cholesterol, castration-resistant prostate cancer, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fphar.2018.01223/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/b8822ca5ee1a4e4eaea64528320dfbe8

Design and synthesis of novel HDAC6 inhibitor dimer as HDAC6 degrader for cancer treatment by palladium catalysed dimerisation

Authors: Ching Lin, Jui-Ling Hsu, Yu-Tung Hsu, Kuo-Chen Fan, Sian-Siou Wu, Miao-Hsia Lin, Jih-Hwa Guh, Chao-Wu Yu

Source: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 40, Iss 1 (2025)

Subject Terms: HDAC6, protein degrader, anticancer, palladium, coupling, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

Access URL: https://doaj.org/article/895901e5a30c40acb9f6f6690346b2b2

NPRL-Z-1, as a new topoisomerase II poison, induces cell apoptosis and ROS generation in human renal carcinoma cells.

Authors: Szu-Ying Wu, Shiow-Lin Pan, Zhi-Yan Xiao, Jui-Ling Hsu, Mei-Chuan Chen, Kuo-Hsiung Lee, Che-Ming Teng

Source: PLoS ONE, Vol 9, Iss 11, p e112220 (2014)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC4221609?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/c6044d2a3c5343389dd366326dafd764

Reevesioside A, a cardenolide glycoside, induces anticancer activity against human hormone-refractory prostate cancers through suppression of c-myc expression and induction of G1 arrest of the cell cycle.

Authors: Wohn-Jenn Leu, Hsun-Shuo Chang, She-Hung Chan, Jui-Ling Hsu, Chia-Chun Yu, Lih-Ching Hsu, Ih-Sheng Chen, Jih-Hwa Guh

Source: PLoS ONE, Vol 9, Iss 1, p e87323 (2014)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3903642?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/48bc6de0cab044a5b752cb618d06a070

Genome-wide identification and characterization of TCP genes involved in ovule development of Phalaenopsis equestris.

Authors: Yu-Fu Lin, You-Yi Chen, Yu-Yun Hsiao, Ching-Yu Shen, Jui-Ling Hsu, Chuan-Ming Yeh, Nobutaka Mitsuda, Masaru Ohme-Takagi, Zhong-Jian Liu, Wen-Chieh Tsai

Source: Journal of Experimental Botany; Sep2016, Vol. 67 Issue 17, p5051-5066, 16p

Subject Terms: GENOMES, PHALAENOPSIS, ORCHIDS, PLANT growth, PLANT development

Application of ABC in hot spring country inn.

Authors: Wen-Hsien Tsai¹, Jui-Ling Hsu², Chia-Hsin Chen³, Yu-Wei Chou¹, Sin-Jin Lin¹, Wan-Rung Lin¹

Source: International Journal of Management & Enterprise Development. 2010, Vol. 8 Issue 2, p152-174. 23p.

Subject Terms: *Activity-based costing

Examining the implementation risks affecting different aspects of Enterprise Resource Planning project success.

Authors: Wen-Hsien Tsai, Sin-Jin Lin, Jau-Yang Liu, Kuen-Chang Lee, Wan-Rung Lin, Jui-Ling Hsu

Source: 2010 40th International Conference on Computers & Industrial Engineering (CIE); 2010, p1-6, 6p

KUD773, a phenylthiazole derivative, displays anticancer activity in human hormone-refractory prostate cancers through inhibition of tubulin polymerization and anti-Aurora A activity.

Authors: Chia-Chun Yu, Shih-Ping Liu, Jui-Ling Hsu, Hsu, John T. A., Kudryavtsev, Konstantin V., Jih-Hwa Guh

Source: Journal of Biomedical Science; 2015, Vol. 22 Issue 1, p42-64, 23p, 1 Color Photograph, 3 Black and White Photographs, 3 Graphs

Subject Terms: PROSTATE cancer, TUBULINS, POLYMERIZATION, HORMONE therapy, PHOSPHOPROTEINS, APOPTOSIS, PHOSPHORYLATION

Increased sensitivity of Hep G2 cells toward the cytotoxicity of cisplatin by the treatment of piper betel leaf extract.

Authors: Shun-Chieh Young, Chau-Jong Wang, Jeng-Dong Hsu, Jui-Ling Hsu, Fen-Pi Chou

Source: Archives of Toxicology; Jun2006, Vol. 80 Issue 6, p319-327, 9p, 2 Diagrams, 1 Chart, 5 Graphs

Subject Terms: CHINESE medicine, PIPER betle, GLUTATHIONE transferase, CISPLATIN, MULTIDRUG resistance, CHEMICAL inhibitors, ANTIMUTAGENS, ANTINEOPLASTIC agents

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A novel small molecule hybrid of vorinostat and DACA displays anticancer activity against human hormone-refractory metastatic prostate cancer through dual inhibition of histone deacetylase and topoisomerase I.

Authors: Chia-Chun Yu¹, Shiow-Lin Pan², Shi-Wei Chao³, Shih-Ping Liu⁴, Jui-Ling Hsu¹, Yu-Chen Yang⁵, Tsia-Kun Li⁵, Wei-Jan Huang³ wjhuang@tmu.edu.tw, Jih-Hwa Guh¹ jhguh@ntu.edu.tw

Source: Biochemical Pharmacology. Aug2014, Vol. 90 Issue 3, p320-330. 11p.

Subject Terms: *ANTINEOPLASTIC agents, *PROSTATE cancer, *METASTASIS, *HISTONE deacetylase, *DNA topoisomerase I, *CELL lines