Immunogenic recombinant Mayaro virus-like particles present natively assembled glycoprotein

Authors: Young Chan Kim, Yasunori Watanabe, Lücke Arlen-Celina, Xiyong Song, Raquel de Oliveira Souza, Robert Stass, Sasha R. Azar, Shannan L. Rossi, Carla Claser, Beate Mareike Kümmerer, Max Crispin, Thomas A. Bowden, Juha T. Huiskonen, Arturo Reyes-Sandoval

Source: npj Vaccines, Vol 9, Iss 1, Pp 1-13 (2024)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2059-0105

Access URL: https://doaj.org/article/f627b3457b3f428e9321dc4ba98941aa

Structural characterization and epitope mapping of the AAVX affinity purification ligand

Authors: Mario Mietzsch, Manasi Kamat, Kari Basso, Paul Chipman, Juha T. Huiskonen, Robert McKenna

Source: Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 4, Pp 101377- (2024)

Subject Terms: adeno-associated virus, gene therapy, capsid, cryo-EM, AAVX, affinity chromatography, Genetics, QH426-470, Cytology, QH573-671

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2329050124001931; https://doaj.org/toc/2329-0501

Access URL: https://doaj.org/article/031149bf4c274a369e897231d5c06b1f

Community recommendations on cryoEM data archiving and validation

Authors: Gerard J. Kleywegt, Paul D. Adams, Sarah J. Butcher, Catherine L. Lawson, Alexis Rohou, Peter B. Rosenthal, Sriram Subramaniam, Maya Topf, Sanja Abbott, Philip R. Baldwin, John M. Berrisford, Gérard Bricogne, Preeti Choudhary, Tristan I. Croll, Radostin Danev, Sai J. Ganesan, Timothy Grant, Aleksandras Gutmanas, Richard Henderson, J. Bernard Heymann, Juha T. Huiskonen, Andrei Istrate, Takayuki Kato, Gabriel C. Lander, Shee-Mei Lok, Steven J. Ludtke, Garib N. Murshudov, Ryan Pye, Grigore D. Pintilie, Jane S. Richardson, Carsten Sachse, Osman Salih, Sjors H. W. Scheres, Gunnar F. Schroeder, Carlos Oscar S. Sorzano, Scott M. Stagg, Zhe Wang, Rangana Warshamanage, John D. Westbrook, Martyn D. Winn, Jasmine Y. Young, Stephen K. Burley, Jeffrey C. Hoch, Genji Kurisu, Kyle Morris, Ardan Patwardhan, Sameer Velankar

Source: IUCrJ, Vol 11, Iss 2, Pp 140-151 (2024)

Subject Terms: cryogenic-specimen electron microscopy, data archiving, validation, quality control, electron microscopy data bank, protein data bank, single-particle cryoem, databases, bioinformatics, structure determination, Crystallography, QD901-999

File Description: electronic resource

Relation: http://scripts.iucr.org/cgi-bin/paper?S2052252524001246; https://doaj.org/toc/2052-2525

Access URL: https://doaj.org/article/0e43f020fe4a4894b6f5aa6a5fd3dc2f

Nanobody engineering for SARS-CoV-2 neutralization and detection

Authors: Liina Hannula, Suvi Kuivanen, Jonathan Lasham, Ravi Kant, Lauri Kareinen, Mariia Bogacheva, Tomas Strandin, Tarja Sironen, Jussi Hepojoki, Vivek Sharma, Petri Saviranta, Anja Kipar, Olli Vapalahti, Juha T. Huiskonen, Ilona Rissanen

Source: Microbiology Spectrum, Vol 12, Iss 4 (2024)

Subject Terms: SARS-CoV-2, nanobody, virus neutralization, protein engineering, diagnostics, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2165-0497

Access URL: https://doaj.org/article/cecbf8f257de4f2482e0413c26276bab

The Structure of Spiroplasma Virus 4: Exploring the Capsid Diversity of the Microviridae

Authors: Mario Mietzsch, Shweta Kailasan, Antonette Bennett, Paul Chipman, Bentley Fane, Juha T. Huiskonen, Ian N. Clarke, Robert McKenna

Source: Viruses, Vol 16, Iss 7, p 1103 (2024)

Subject Terms: Microviridae, bacteriophage, cryo-EM, capsid, Spiroplasma virus 4 (SpV4), chlamydia phage 2 (ChP2), Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4915/16/7/1103; https://doaj.org/toc/1999-4915

Access URL: https://doaj.org/article/d837cfe946374f07a31dec158ee1e2b4

Intranasal trimeric sherpabody inhibits SARS-CoV-2 including recent immunoevasive Omicron subvariants

Authors: Anna R. Mäkelä, Hasan Uğurlu, Liina Hannula, Ravi Kant, Petja Salminen, Riku Fagerlund, Sanna Mäki, Anu Haveri, Tomas Strandin, Lauri Kareinen, Jussi Hepojoki, Suvi Kuivanen, Lev Levanov, Arja Pasternack, Rauno A. Naves, Olli Ritvos, Pamela Österlund, Tarja Sironen, Olli Vapalahti, Anja Kipar, Juha T. Huiskonen, Ilona Rissanen, Kalle Saksela

Source: Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/326654b56d2c4bd89b56074f0855fd2f

Cryo-EM structure of ssDNA bacteriophage ΦCjT23 provides insight into early virus evolution

Authors: Nejc Kejzar, Elina Laanto, Ilona Rissanen, Vahid Abrishami, Muniyandi Selvaraj, Sylvain Moineau, Janne Ravantti, Lotta-Riina Sundberg, Juha T. Huiskonen

Source: Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/c7224ae517ba4a8ba95ba5fac309a824

Structural basis of rapid actin dynamics in the evolutionarily divergent Leishmania parasite

Authors: Tommi Kotila, Hugo Wioland, Muniyandi Selvaraj, Konstantin Kogan, Lina Antenucci, Antoine Jégou, Juha T. Huiskonen, Guillaume Romet-Lemonne, Pekka Lappalainen

Source: Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/b51e8c37b37c487a80e957a5cb198fc3

MANF regulates neuronal survival and UPR through its ER-located receptor IRE1α

Authors: Vera Kovaleva, Li-Ying Yu, Larisa Ivanova, Olesya Shpironok, Jinhan Nam, Ave Eesmaa, Esa-Pekka Kumpula, Sven Sakson, Urve Toots, Mart Ustav, Juha T. Huiskonen, Merja H. Voutilainen, Päivi Lindholm, Mati Karelson, Mart Saarma

Source: Cell Reports, Vol 42, Iss 2, Pp 112066- (2023)

Subject Terms: CP: Neuroscience, CP: Molecular biology, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124723000773; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/5219a8ab6680491fa637a30370d90b44

The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K

Authors: Simon R. Bushell, Ashley C. W. Pike, Maria E. Falzone, Nils J. G. Rorsman, Chau M. Ta, Robin A. Corey, Thomas D. Newport, John C. Christianson, Lara F. Scofano, Chitra A. Shintre, Annamaria Tessitore, Amy Chu, Qinrui Wang, Leela Shrestha, Shubhashish M. M. Mukhopadhyay, James D. Love, Nicola A. Burgess-Brown, Rebecca Sitsapesan, Phillip J. Stansfeld, Juha T. Huiskonen, Paolo Tammaro, Alessio Accardi, Elisabeth P. Carpenter

Source: Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/602dd2cc133c49529d8807b7b0d875ca

Structural Basis for a Neutralizing Antibody Response Elicited by a Recombinant Hantaan Virus Gn Immunogen

Authors: Ilona Rissanen, Stefanie A. Krumm, Robert Stass, Annalis Whitaker, James E. Voss, Emily A. Bruce, Sylvia Rothenberger, Stefan Kunz, Dennis R. Burton, Juha T. Huiskonen, Jason W. Botten, Thomas A. Bowden, Katie J. Doores

Source: mBio, Vol 12, Iss 4 (2021)

Subject Terms: glycoprotein, hantavirus, neutralizing antibody, structure, zoonosis, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2150-7511

Access URL: https://doaj.org/article/1f67558141a14b57a4f6668f7781b182

Assembly of complex viruses exemplified by a halophilic euryarchaeal virus

Authors: Luigi De Colibus, Elina Roine, Thomas S. Walter, Serban L. Ilca, Xiangxi Wang, Nan Wang, Alan M. Roseman, Dennis Bamford, Juha T. Huiskonen, David I. Stuart

Source: Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/c49688e838814e378948c888e788bdd5

The structure of a prokaryotic viral envelope protein expands the landscape of membrane fusion proteins

Authors: Kamel El Omari, Sai Li, Abhay Kotecha, Thomas S. Walter, Eduardo A. Bignon, Karl Harlos, Pentti Somerharju, Felix De Haas, Daniel K. Clare, Mika Molin, Felipe Hurtado, Mengqiu Li, Jonathan M. Grimes, Dennis H. Bamford, Nicole D. Tischler, Juha T. Huiskonen, David I. Stuart, Elina Roine

Source: Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/31855e58b674426b946b1b8cc027fb2e

Mycobacterium tuberculosis CarD, an essential global transcriptional regulator forms amyloid-like fibrils

Authors: Gundeep Kaur, Soni Kaundal, Srajan Kapoor, Jonathan M. Grimes, Juha T. Huiskonen, Krishan Gopal Thakur

Source: Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/a9492ed5026b4972a6e8434e695cc730

Shielding and activation of a viral membrane fusion protein

Authors: Steinar Halldorsson, Sai Li, Mengqiu Li, Karl Harlos, Thomas A. Bowden, Juha T. Huiskonen

Source: Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/875fd015c6954da8bc20cc2adff407bf

Unique architecture of thermophilic archaeal virus APBV1 and its genome packaging

Authors: Denis Ptchelkine, Ashley Gillum, Tomohiro Mochizuki, Soizick Lucas-Staat, Ying Liu, Mart Krupovic, Simon E. V. Phillips, David Prangishvili, Juha T. Huiskonen

Source: Nature Communications, Vol 8, Iss 1, Pp 1-6 (2017)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/2658d6e813804f9a970e1412f0a78165

Rules of engagement between αvβ6 integrin and foot-and-mouth disease virus

Authors: Abhay Kotecha, Quan Wang, Xianchi Dong, Serban L. Ilca, Marina Ondiviela, Rao Zihe, Julian Seago, Bryan Charleston, Elizabeth E. Fry, Nicola G. A. Abrescia, Timothy A. Springer, Juha T. Huiskonen, David I. Stuart

Source: Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/7cc85a0a325f47d7981c002ee69ab865

Near-atomic structure of Japanese encephalitis virus reveals critical determinants of virulence and stability

Authors: Xiangxi Wang, Shi-Hua Li, Ling Zhu, Qing-Gong Nian, Shuai Yuan, Qiang Gao, Zhongyu Hu, Qing Ye, Xiao-Feng Li, Dong-Yang Xie, Neil Shaw, Junzhi Wang, Thomas S. Walter, Juha T. Huiskonen, Elizabeth E. Fry, Cheng-Feng Qin, David I. Stuart, Zihe Rao

Source: Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/ed5e43459e464ee6a6602a849e5c6e81

Double-stranded RNA virus outer shell assembly by bona fide domain-swapping

Authors: Zhaoyang Sun, Kamel El Omari, Xiaoyu Sun, Serban L. Ilca, Abhay Kotecha, David I. Stuart, Minna M. Poranen, Juha T. Huiskonen

Source: Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/b16852baa490454d977d1b4fd2e495b0

A Molecular-Level Account of the Antigenic Hantaviral Surface

Authors: Sai Li, Ilona Rissanen, Antra Zeltina, Jussi Hepojoki, Jayna Raghwani, Karl Harlos, Oliver G. Pybus, Juha T. Huiskonen, Thomas A. Bowden

Source: Cell Reports, Vol 15, Iss 5, Pp 959-967 (2016)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124716303849; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/2d7f19f22de2439fada439d2843905af