Enhanced brain delivery and antiproliferative activity of resveratrol using milk-derived exosomes

Authors: María Ángeles Ávila-Gálvez, Beatriz Garay-Mayol, Juan Antonio Giménez-Bastida, María del Carmen López de las Hazas, Carmen Mazarío-Gárgoles, Maria Alexandra Brito, Alberto Dávalos, Juan Carlos Espín, Antonio González-Sarrías

Source: Journal of Agriculture and Food Research, Vol 18, Iss , Pp 101370- (2024)

Subject Terms: Exosome, Nanocarrier, Polyphenol, Resveratrol, Brain cancer, Blood-brain barrier, Agriculture (General), S1-972, Nutrition. Foods and food supply, TX341-641

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666154324004071; https://doaj.org/toc/2666-1543

Access URL: https://doaj.org/article/369671571ba04b79a3dfb9c8c8e5ccd2

Mitophagy curtails cytosolic mtDNA-dependent activation of cGAS/STING inflammation during aging

Authors: Juan Ignacio Jiménez-Loygorri, Beatriz Villarejo-Zori, Álvaro Viedma-Poyatos, Juan Zapata-Muñoz, Rocío Benítez-Fernández, María Dolores Frutos-Lisón, Francisco A. Tomás-Barberán, Juan Carlos Espín, Estela Area-Gómez, Aurora Gomez-Duran, Patricia Boya

Source: Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/28bf1444304f436f93a7c072feecb944

Effects of a (poly)phenol-rich berry mix on gas production in healthy individuals: An integrated clinical, metagenomic, and metabolomic proof-of-concept study

Authors: Claudia Barber, Carlos Sabater, María Dolores Frutos, Fernando Vallejo, Denis Guyonnet, Noëmie Daniel, Francisco Guarner, Juan Carlos Espín, Abelardo Margolles, Fernando Azpiroz

Source: Journal of Functional Foods, Vol 113, Iss , Pp 106032- (2024)

Subject Terms: Polyphenol, Prebiotic, Microbiota, Metagenomics, Metabolomics, Digestive sensation, Nutrition. Foods and food supply, TX341-641

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1756464624000343; https://doaj.org/toc/1756-4646

Access URL: https://doaj.org/article/3b3496f736b546d7b9ea060e51e1e796

Therapeutic potential of plant-derived extracellular vesicles as nanocarriers for exogenous miRNAs

Authors: María-Carmen López de las Hazas, Joao Tomé-Carneiro, Lorena del Pozo-Acebo, Andrea del Saz-Lara, Luis A. Chapado, Livia Balaguer, Enrique Rojo, Juan Carlos Espín, Carmen Crespo, Diego A. Moreno, Cristina García-Viguera, José M. Ordovás, Francesco Visioli, Alberto Dávalos

Source: Pharmacological Research, Vol 198, Iss , Pp 106999- (2023)

Subject Terms: Extracellular vesicles, MiRNAs, Exosomes, Plant-derived, RNA-seq, Drug delivery, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1043661823003559; https://doaj.org/toc/1096-1186

Access URL: https://doaj.org/article/5d333e40a2bc4921ac03a35fab16f939

Adjuvant pomegranate juice intake improves the inflammatory status of hospitalized COVID-19 patients: A randomized and placebo-controlled trial

Authors: Mojtaba Yousefi, Mohammadreza Sadriirani, Sara Mahmoodi, Bahar Samimi, Azizollah Pourmahmoudi, Mahboobe Hosseinikia, Omid Sadeghi, Narges Roustaei, Zaker Saeedinezhad, Juan Carlos Espín, Somaye Ansari, Seyed Bahman Panahande

Source: Complementary Therapies in Medicine, Vol 75, Iss , Pp 102958- (2023)

Subject Terms: COVID-19, SARS-CoV-2 coronavirus, Pomegranate, Inflammation, Complete blood count, Other systems of medicine, RZ201-999

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0965229923000456; https://doaj.org/toc/0965-2299

Access URL: https://doaj.org/article/967bd3efe63949149d8a0cf3e0ed86f0

Author Correction: Mitophagy curtails cytosolic mtDNA-dependent activation of cGAS/STING inflammation during aging

Authors: Juan Ignacio Jiménez-Loygorri, Beatriz Villarejo-Zori, Álvaro Viedma-Poyatos, Juan Zapata-Muñoz, Rocío Benítez-Fernández, María Dolores Frutos-Lisón, Francisco A. Tomás-Barberán, Juan Carlos Espín, Estela Area-Gómez, Aurora Gomez-Duran, Patricia Boya

Source: Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/f616f1b3148e4e6a9d735457dc48560f

Ellagic acid and its metabolites urolithins A/B ameliorate most common disease phenotypes in cellular and mouse models for lysosomal storage disorders by enhancing extracellular vesicle secretion

Authors: Beatriz Soto-Huelin, Bohdan Babiy, Oscar Pastor, Mario Díaz-García, Ana Toledano-Zaragoza, María Dolores Frutos, Juan Carlos Espín, Francisco A. Tomás-Barberán, Rebeca Busto, María Dolores Ledesma

Source: Neurobiology of Disease, Vol 182, Iss , Pp 106141- (2023)

Subject Terms: Extracellular vesicles, Polyphenols, Lysosomal storage disorders, Niemann pick, Brain, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0969996123001559; https://doaj.org/toc/1095-953X

Access URL: https://doaj.org/article/41ec54e488d340289457ccc81c47e41e

Physiological concentrations of phytosterols enhance the apoptotic effects of 5-fluorouracil in colon cancer cells

Authors: Andrea Álvarez-Sala, María Ángeles Ávila-Gálvez, Antonio Cilla, Reyes Barberá, Guadalupe Garcia-Llatas, Juan Carlos Espín, Antonio González-Sarrías

Source: Journal of Functional Foods, Vol 49, Iss , Pp 52-60 (2018)

Subject Terms: Phytosterols, Colon cancer cells, 5-fluorouracil, Cell cycle, Apoptosis, Drug sensitivity, Nutrition. Foods and food supply, TX341-641

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1756464618304225; https://doaj.org/toc/1756-4646

Access URL: https://doaj.org/article/a171dda76e50434c9e64335da87ead77

An Integrative Approach to Characterize the Early Phases of Dimethylhydrazine-Induced Colorectal Carcinogenesis in the Rat

Authors: Rita Silva-Reis, Catarina Castro-Ribeiro, Mariana Gonçalves, Tiago Ferreira, Maria João Pires, Carlos E. Iglesias-Aguirre, Adrián Cortés-Martín, María V. Selma, Juan Carlos Espín, Elisabete Nascimento-Gonçalves, Alexandra Moreira-Pais, Maria J. Neuparth, Francisco Peixoto, Eduardo Rosa, Adelina Gama, Rita Ferreira, Paula A. Oliveira, Ana I. Faustino-Rocha

Source: Biomedicines, Vol 10, Iss 2, p 409 (2022)

Subject Terms: gut microbiota, inflammation, oxidative stress, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2227-9059/10/2/409; https://doaj.org/toc/2227-9059

Access URL: https://doaj.org/article/83b529c8948c410a8b6e2797c1f9c450

Flaxseed-enriched diets change milk concentration of the antimicrobial danofloxacin in sheep

Authors: Jon Andoni Otero, Dafne García-Mateos, Indira Alvarez-Fernández, Rocío García-Villalba, Juan Carlos Espín, Ana Isabel Álvarez, Gracia Merino

Source: BMC Veterinary Research, Vol 14, Iss 1, Pp 1-8 (2018)

Subject Terms: Danofloxacin, Mammary, Flaxseed, Enterolactone, Enterodiol, Milk residues, Veterinary medicine, SF600-1100

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12917-018-1341-3; https://doaj.org/toc/1746-6148

Access URL: https://doaj.org/article/8158d1583f5740d28a81b0585998504e

The Breast Cancer Resistance Protein (BCRP/ABCG2) influences the levels of enterolignans and their metabolites in plasma, milk and mammary gland

Authors: Dafne García-Mateos, Rocío García-Villalba, José Angel Marañón, Juan Carlos Espín, Gracia Merino, Ana I. Álvarez

Source: Journal of Functional Foods, Vol 35, Iss , Pp 648-654 (2017)

Subject Terms: Enterolactone, Enterodiol, ABCG2, Milk, Mammary gland, Gut microbiota, Nutrition. Foods and food supply, TX341-641

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1756464617303547; https://doaj.org/toc/1756-4646

Access URL: https://doaj.org/article/942577d04d914990a9099106e0610a06

Kinetic disposition of dietary polyphenols and methylxanthines in the rat mammary tissue

Authors: María Ángeles Ávila-Gálvez, María Romo-Vaquero, Antonio González-Sarrías, Juan Carlos Espín

Source: Journal of Functional Foods, Vol 61, Iss , Pp - (2019)

Subject Terms: Mammary tissue, Methylxanthine, Polyphenol, Breast cancer, Resveratrol, Plant extract, Nutrition. Foods and food supply, TX341-641

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1756464619304402; https://doaj.org/toc/1756-4646

Access URL: https://doaj.org/article/d2de3b757f6e4f2fb58ed294e24ec095

New Insights into the Metabolism of the Flavanones Eriocitrin and Hesperidin: A Comparative Human Pharmacokinetic Study

Authors: María Ángeles Ávila-Gálvez, Juan Antonio Giménez-Bastida, Antonio González-Sarrías, Juan Carlos Espín

Source: Antioxidants, Vol 10, Iss 3, p 435 (2021)

Subject Terms: flavanones, citrus, hesperidin, eriocitrin, hesperetin metabolites, eriodictyol metabolites, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.mdpi.com/2076-3921/10/3/435; https://doaj.org/toc/2076-3921

Access URL: https://doaj.org/article/efd082c0430644c4893edb4e448946a6

Identifying the limits for ellagic acid bioavailability: A crossover pharmacokinetic study in healthy volunteers after consumption of pomegranate extracts

Authors: Antonio González-Sarrías, Rocío García-Villalba, M. Ángeles Núñez-Sánchez, Joao Tomé-Carneiro, Pilar Zafrilla, Juana Mulero, Francisco A. Tomás-Barberán, Juan Carlos Espín

Source: Journal of Functional Foods, Vol 19, Iss , Pp 225-235 (2015)

Subject Terms: Bioavailability, Ellagic acid, Pharmacokinetics, Pomegranate, Punicalagin, Urolithins, Nutrition. Foods and food supply, TX341-641

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1756464615004363; https://doaj.org/toc/1756-4646

Access URL: https://doaj.org/article/bcedc1d4c3d3401aa8d42213e113d58b

There is No Distinctive Gut Microbiota Signature in the Metabolic Syndrome: Contribution of Cardiovascular Disease Risk Factors and Associated Medication

Authors: Adrián Cortés-Martín, Carlos E. Iglesias-Aguirre, Amparo Meoro, María Victoria Selma, Juan Carlos Espín

Source: Microorganisms, Vol 8, Iss 3, p 416 (2020)

Subject Terms: gut microbiota, metabolic syndrome, obesity, cardiovascular risk, drug treatment, diabetes, dyslipidemia, hypertension, precision medicine, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2076-2607/8/3/416; https://doaj.org/toc/2076-2607

Access URL: https://doaj.org/article/a42529a449ec4310b565a71925caab60

Inhibition of gastric lipase as a mechanism for body weight and plasma lipids reduction in Zucker rats fed a rosemary extract rich in carnosic acid.

Authors: María Romo Vaquero, María-Josefa Yáñez-Gascón, Rocío García Villalba, Mar Larrosa, Emilie Fromentin, Alvin Ibarra, Marc Roller, Francisco Tomás-Barberán, Juan Carlos Espín de Gea, María-Teresa García-Conesa

Source: PLoS ONE, Vol 7, Iss 6, p e39773 (2012)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22745826/?tool=EBI; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/2b0e95e137d748309f2c5fdaa444ee49

Zoonotic Potential of Chronic Wasting Disease after Adaptation in Intermediate Species

Authors: Tomás Barrio, Sylvie L. Benestad, Jean-Yves Douet, Alvina Huor, Séverine Lugan, Naïma Aron, Hervé Cassard, Juan Carlos Espinosa, Alicia Otero, Rosa Bolea, Juan María Torres, Olivier Andréoletti

Source: Emerging Infectious Diseases, Vol 30, Iss 12, Pp 2691-2694 (2024)

Subject Terms: prions, prion disease, chronic wasting disease, European moose, transmission barrier, enhanced zoonotic potential, Medicine, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: https://wwwnc.cdc.gov/eid/article/30/12/24-0536_article; https://doaj.org/toc/1080-6040; https://doaj.org/toc/1080-6059

Access URL: https://doaj.org/article/55e00fa14ecd4a1191c0ace39ac0bdfc

Classical BSE dismissed as the cause of CWD in Norwegian red deer despite strain similarities between both prion agents

Authors: Alba Marín-Moreno, Sylvie L. Benestad, Tomas Barrio, Laura Pirisinu, Juan Carlos Espinosa, Linh Tran, Alvina Huor, Michele Angelo Di Bari, Hasier Eraña, Ben C. Maddison, Claudia D’Agostino, Natalia Fernández-Borges, Sara Canoyra, Nuria Jerez-Garrido, Joaquín Castilla, John Spiropoulos, Keith Bishop, Kevin C. Gough, Romolo Nonno, Jorn Våge, Olivier Andréoletti, Juan María Torres

Source: Veterinary Research, Vol 55, Iss 1, Pp 1-16 (2024)

Subject Terms: Prion, chronic wasting disease, CWD, bovine spongiform encephalopathy, BSE, phenotypical convergence, Veterinary medicine, SF600-1100

File Description: electronic resource

Relation: https://doaj.org/toc/1297-9716

Access URL: https://doaj.org/article/51a3b8f500ba47a290cef12832a53307

Estilo de Liderazgo para la Innovación: Presentación de un nuevo constructo y validación de una escala para medirlo

Authors: Francoise Contreras, Juan Carlos Espinosa, Utz Dornberger

Source: Estudios Gerenciales, Vol 38, Iss 163, Pp 151-160 (2022)

Subject Terms: liderazgo para la innovación, innovación individual, liderazgo, comportamiento innovador en el trabajo, construcción de escalas, validación de escalas, Business, HF5001-6182

File Description: electronic resource

Relation: https://www.icesi.edu.co/revistas/index.php/estudios_gerenciales/article/view/4763; https://doaj.org/toc/0123-5923

Access URL: https://doaj.org/article/a1d8b5fedd924f2c9d309cd986b68e70

Homozygous R136S mutation in PRNP gene causes inherited early onset prion disease

Authors: Teresa Ximelis, Alba Marín-Moreno, Juan Carlos Espinosa, Hasier Eraña, Jorge M. Charco, Isabel Hernández, Carmen Riveira, Daniel Alcolea, Eva González-Roca, Iban Aldecoa, Laura Molina-Porcel, Piero Parchi, Marcello Rossi, Joaquín Castilla, Raquel Ruiz-García, Ellen Gelpi, Juan María Torres, Raquel Sánchez-Valle

Source: Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-13 (2021)

Subject Terms: Gene PRNP, GSS, Homozygous, Neuropathology, Prion, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1758-9193

Access URL: https://doaj.org/article/b9c9bc10cfc34c4daf0749b1769b7f52