Proteostasis perturbation of N-Myc leveraging HSP70 mediated protein turnover improves treatment of neuroendocrine prostate cancer

Authors: Pengfei Xu, Joy C. Yang, Bo Chen, Shu Ning, Xiong Zhang, Leyi Wang, Christopher Nip, Yuqiu Shen, Oleta T. Johnson, Gabriela Grigorean, Brett Phinney, Liangren Liu, Qiang Wei, Eva Corey, Clifford G. Tepper, Hong-Wu Chen, Christopher P. Evans, Marc A. Dall’Era, Allen C. Gao, Jason E. Gestwicki, Chengfei Liu

Source: Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/7245d627558b40309015d3fca64f4865

Activation of neural lineage networks and ARHGEF2 in enzalutamide-resistant and neuroendocrine prostate cancer and association with patient outcomes

Authors: Shu Ning, Jinge Zhao, Alan P. Lombard, Leandro S. D’Abronzo, Amy R. Leslie, Masuda Sharifi, Wei Lou, Chengfei Liu, Joy C. Yang, Christopher P. Evans, Eva Corey, Hong-Wu Chen, Aiming Yu, Paramita M. Ghosh, Allen C. Gao

Source: Communications Medicine, Vol 2, Iss 1, Pp 1-12 (2022)

Subject Terms: Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2730-664X

Access URL: https://doaj.org/article/23a69cb8d6894a2792a756ea7fe5a961

Allosteric inhibition of HSP70 in collaboration with STUB1 augments enzalutamide efficacy in antiandrogen resistant prostate tumor and patient-derived models

Authors: Pengfei Xu, Joy C. Yang, Shu Ning, Bo Chen, Christopher Nip, Qiang Wei, Liangren Liu, Oleta T. Johnson, Allen C. Gao, Jason E. Gestwicki, Christopher P. Evans, Chengfei Liu

Source: Pharmacological Research, Vol 189, Iss , Pp 106692- (2023)

Subject Terms: Prostate cancer, Enzalutamide resistance, HSP70, STUB1, Androgen receptor variant, Patient-derived model, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1043661823000488; https://doaj.org/toc/1096-1186

Access URL: https://doaj.org/article/0aa5beefd47948149ef46484906a60a3

The Immunotherapy and Immunosuppressive Signaling in Therapy-Resistant Prostate Cancer

Authors: Pengfei Xu, Logan J. Wasielewski, Joy C. Yang, Demin Cai, Christopher P. Evans, William J. Murphy, Chengfei Liu

Source: Biomedicines, Vol 10, Iss 8, p 1778 (2022)

Subject Terms: prostate cancer, immunotherapy, immunosuppressive signaling, tumor immune microenvironment, checkpoint inhibitor, therapy resistance, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2227-9059/10/8/1778; https://doaj.org/toc/2227-9059

Access URL: https://doaj.org/article/3a3654ce0e524217895a066031c11c82

Proteostasis by STUB1/HSP70 complex controls sensitivity to androgen receptor targeted therapy in advanced prostate cancer

Authors: Chengfei Liu, Wei Lou, Joy C. Yang, Liangren Liu, Cameron M. Armstrong, Alan P. Lombard, Ruining Zhao, Onika D. V. Noel, Clifford G. Tepper, Hong-Wu Chen, Marc Dall’Era, Christopher P. Evans, Allen C. Gao

Source: Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/a5238e051d1c4725877bc665524a75c3

KDM4A Coactivates E2F1 to Regulate the PDK-Dependent Metabolic Switch between Mitochondrial Oxidation and Glycolysis

Authors: Ling-Yu Wang, Chiu-Lien Hung, Yun-Ru Chen, Joy C. Yang, Junjian Wang, Mel Campbell, Yoshihiro Izumiya, Hong-Wu Chen, Wen-Ching Wang, David K. Ann, Hsing-Jien Kung

Source: Cell Reports, Vol 16, Iss 11, Pp 3016-3027 (2016)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124716310646; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/d8929b5dd7de42458a3bca31f0b46884

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895 Immunosuppressive signaling is activated in enzalutamide resistant prostate cancer

Authors: Bo Chen, William Murphy, Pengfei Xu, Chengfei Liu, Joy C Yang, Christopher Nip, Christopher P Evans, Leyi Wang, Jonathan EVan Dyke

Source: Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/0bf9acbb33b04596bda11be828834d66

Androgen receptor blockade resistance with enzalutamide in prostate cancer results in immunosuppressive alterations in the tumor immune microenvironment

Authors: Bo Chen, William J Murphy, Xiong Zhang, Pengfei Xu, Chengfei Liu, Joy C Yang, Christopher Nip, Jonathan E Van Dyke, Hong-Wu Chen, Christopher P Evans

Source: Journal for ImmunoTherapy of Cancer, Vol 11, Iss 5 (2023)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/11/5/e006581.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/8f5213ee1f4342c4a2bb4d14ef4772c7

CTA095, a novel Etk and Src dual inhibitor, induces apoptosis in prostate cancer cells and overcomes resistance to Src inhibitors.

Authors: Wenchang Guo, Ruiwu Liu, Gaurav Bhardwaj, Ai-Hong Ma, Chun Changou, Joy C Yang, Yuanpei Li, Caihong Feng, Yan Luo, Anisha Mazloom, Eduardo Sanchez, Yan Wang, Wenzhe Huang, Randen Patterson, Christopher P Evans, Kit S Lam, Hsing-Jien Kung

Source: PLoS ONE, Vol 8, Iss 8, p e70910 (2013)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3744530?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/847de7c6ffd142fb90d6021c6ca3066d