The proteolytic airway environment associated with pneumonia acts as a barrier for treatment with anti-infective antibodies

Authors: Blin, Timothée, Parent, Christelle, Pichon, Gabrielle, Guillon, Antoine, Jouan, Youenn, Allouchi, Hassan, Aubrey, Nicolas, Boursin, Fanny, Domain, Roxane, Korkmaz, Baris, Sécher, Thomas, Heuzé-Vourc'h, Nathalie

Source: In European Journal of Pharmaceutics and Biopharmaceutics February 2024 195

Awake prone positioning for COVID-19 acute hypoxaemic respiratory failure: a randomised, controlled, multinational, open-label meta-trial

Authors: Li, Jie, Mirza, Sara, Vines, David, Elshafei, Ahmad A, Scott, Brady J, Weiss, Tyler, Kaur, Ramandeep, Harnois, Lauren J, Miller, Amanda, Cerda, Flor, Klein, Andrew, Burd, Jacob R, Posa-Kearney, Kathleen, Trump, Matthew, Jackson, Julie, Oetting, Trevor, Greenwood, Mark, Hazel, Lindsay, Kingery, Lisa, Mogri, Idrees, Morris, Lindsey, Moon, Joon Yong, Garnett, Julianne, Jia, Shijing, Nelson, Kristine, McNicholas, Bairbre, Cosgrave, David, Giacomini, Camilla, Laffey, John, Brennan, Aoife, Judge, Conor, Kernan, Maeve, Kelly, Claire, Ranjan, Ritika, Casey, Siobhan, O'Connell, Kevin, Newell, Evelyn, Gallagher, David, Nichol, Alistair, Curley, Ger, Estrada, Miguel Ibarra, García-Salcido, Roxana, Vargas-Obieta, Alexandra, Aguirre-Avalos, Guadalupe, Aguirre-Díaz, Sara A, Alcántar-Vallín, Luz, Alvarado-Padilla, Montserrat, Chávez-Peña, Quetzalcóatl, López-Pulgarín, José A, Mijangos-Méndez, Julio C, Marín-Rosales, Miguel, García-Alvarado, Jorge E, Baltazar-González, Oscar G, González-Guerrero, Maura C, Gutiérrez Ramírez, Paola G, Pavlov, Ivan, Gilman, Sean, Plamondon, Patrice, Roy, Rachel, Jayaraman, Dev, Shahin, Jason, Ragoshai, Raham, Kaur, Aasmine, Campisi, Josie, Dahine, Joseph, Perron, Stefanie, Achouri, Slimane, Racette, Ronald, Kulenkamp, Anne, Roca, Oriol, Pacheco, Andrés, García-de-Acilu, Marina, Masclans, Joan R, Dot, Irene, Perez, Yonatan, Bodet-Contentin, Laetitia, Garot, Denis, Ehrmann, Stephan, Mercier, Emmanuelle, Salmon Gandonnière, Charlotte, Morisseau, Marlène, Jouan, Youenn, Darwiche, Walid, Legras, Annick, Guillon, Antoine, Tavernier, Elsa, Dequin, Pierre-François, Tellier, Anne-Charlotte, Reignier, Jean, Lascarrou, Jean-Baptiste, Seguin, Amélie, Desmedt, Luc, Canet, Emmanuel, Guitton, Christophe, Marnai, Rémy, Callahan, Jean-Christophe, Landais, Mickaël, Chudeau, Nicolas, Darreau, Cédric, Tirot, Patrice, Saint Martin, Marjorie, Le Moal, Charlene, Nay, Mai-Anh, Muller, Grégoire, Jacquier, Sophie, Prat, Gwenaël, Bailly, Pierre, Ferrière, Nicola, Thille, Arnaud W, Frat, Jean-Pierre, Dellamonica, Jean, Saccheri, Clément, Buscot, Matthieu, Plantefève, Gaëtan, Contou, Damien, Roux, Damien, Ricard, Jean-Damien, Federici, Laura, Zucman, Noémie, Freita Ramos, Santiago, Amouretti, Marc, Besset, Sébastien, Gernez, Coralie, Delbove, Agathe, Voiriot, Guillaume, Elabbadi, Alexandre, Fartoukh, Muriel, Nseir, Saad, Préau, Sébastien, Favory, Raphaël, Pierre, Alexandre, Sement, Arnaud, Terzi, Nicolas, Sigaud, Florian, Candille, Clara, Turbil, Emanuele, Maizel, Julien, Brault, Clément, Zerbib, Yoan, Joret, Aurélie, Daubin, Cédric, Lefebvre, Laurent, Giraud, Alais, Auvet, Adrien, Vinsonneau, Christophe, Marzouk, Mehdi, Quenot, Jean-Pierre, Andreu, Pascal, Labruyère, Marie, Roudaut, Jean-Baptiste, Aptel, François, Boyer, Alexandre, Boyer, Philippe, Lacherade, Jean-Claude, Hille, Hugo, Bouteloup, Marie, Jeannot, Matthieu, Feller, Marc, Grillet, Guillaume, Levy, Bruno, Kimmoun, Antoine, Ibarra-Estrada, Miguel ^*, Garcia-Salcido, Roxana, Trump, Matthew W, Laffey, John G

Source: In The Lancet Respiratory Medicine December 2021 9(12):1387-1395

Inhaled bacteriophage therapy in a porcine model of pneumonia caused by Pseudomonas aeruginosa during mechanical ventilation

Authors: Guillon, Antoine, Pardessus, Jeoffrey, L'Hostis, Guillaume, Fevre, Cindy, Barc, Celine, Dalloneau, Emilie, Jouan, Youenn, Bodier‐Montagutelli, Elsa, Perez, Yonatan, Thorey, Camille, Mereghetti, Laurent, Cabrera, Maria, Riou, Mickaël, Vecellio, Laurent, Le Guellec, Sandrine, Heuzé‐Vourc'h, Nathalie

Source: British journal of pharmacology. 178(18):3829-3842

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100129010319.0x000001&indx=1&recIds=ETOCvdc_100129010319.0x000001

IFN-γ primes bone marrow neutrophils to acquire regulatory functions in severe viral respiratory infections.

Authors: Creusat, Florent^1,2, Jouan, Youenn^1,2,3,4, Gonzalez, Loïc^1,2, Barsac, Emilie^1,2, Ilango, Guy^1,2, Lemoine, Roxane^2,5, Soulard, Daphnée⁶, Hankard, Antoine^1,2, Boisseau, Chloé^1,2, Guillon, Antoine^1,2,3, Qiaochu Lin⁷, Herbozo, Carolina de Amat⁷, Sencio, Valentin⁶, Winter, Nathalie⁸, Sizaret, Damien^1,2,9, Trottein, François⁶, Si-Tahar, Mustapha^1,2, Briard, Benoit^1,2, Mallevaey, Thierry⁷, Faveeuw, Christelle⁶

Source: Science Advances. 10/11/2024, Vol. 10 Issue 41, p1-16. 16p.

Subject Terms: *PROGRAMMED death-ligand 1, *BONE marrow, *RESPIRATORY infections, *VIRUS diseases, *DRUG resistance in microorganisms

High Dimensional Single-Cell Analysis Reveals iNKT Cell Developmental Trajectories and Effector Fate Decision

Authors: Baranek, Thomas, Lebrigand, Kevin, de Amat Herbozo, Carolina, Gonzalez, Loïc, Bogard, Gemma, Dietrich, Céline, Magnone, Virginie, Boisseau, Chloé, Jouan, Youenn, Trottein, François, Si-Tahar, Mustapha, Leite-de-Moraes, Maria, Mallevaey, Thierry, Paget, Christophe

Source: In Cell Reports 8 September 2020 32(10)

Interleukin-7 protects against bacterial respiratory infection by promoting IL-17A-producing innate T-cell response

Authors: Hassane, Maya, Jouan, Youenn, Creusat, Florent, Soulard, Daphnée, Boisseau, Chloé, Gonzalez, Loïc, Patin, Emmanuel C., Heuzé-Vourc'h, Nathalie, Sirard, Jean-Claude, Faveeuw, Christelle, Trottein, François, Si-Tahar, Mustapha, Baranek, Thomas, Paget, Christophe

Source: In Mucosal Immunology January 2020 13(1):128-139

Preoperative Chemerin Level Is Predictive of Inflammatory Status 1 Year After Bariatric Surgery

Authors: Jouan, Youenn, Blasco, Hélène, Bongrani, Alice, Couet, Charles, Dupont, Joëlle, Maillot, François

Source: Obesity surgery. 30(10):3852-3861

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100171602266.0x000001&indx=1&recIds=ETOCvdc_100171602266.0x000001

Innate immune response in acute critical illness: a narrative review.

Authors: Stiel, Laure, Gaudet, Alexandre, Thietart, Sara, Vallet, Hélène, Bastard, Paul, Voiriot, Guillaume, Oualha, Mehdi, Sarton, Benjamine, Kallel, Hatem, Brechot, Nicolas, Kreitmann, Louis, Benghanem, Sarah, Joffre, Jérémie, Jouan, Youenn

Source: Annals of Intensive Care; 9/4/2024, Vol. 14 Issue 1, p1-16, 16p

Subject Terms: MITOCHONDRIA, IMMUNOSUPPRESSIVE agents, CATASTROPHIC illness, DECISION making, IMMUNE system, AGING, IMMUNOLOGIC receptors, NATURAL immunity, INDIVIDUALIZED medicine, INFLAMMATION, CRITICAL care medicine, THROMBOSIS, PHENOTYPES, IMMUNOMODULATORS

Rapid detection of bacterial meningitis using a point-of-care glucometer

Authors: Rousseau, Geoffroy, Asmolov, Romain, Grammatico-Guillon, Leslie, Auvet, Adrien, Laribi, Said, Garot, Denis, Jouan, Youenn, Dequin, Pierre-François, Guillon, Antoine

Source: European journal of emergency medicine. 26(1):41-46

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100075942675.0x000001&indx=1&recIds=ETOCvdc_100075942675.0x000001

Lack of impact of iodinated contrast media on kidney cell-cycle arrest biomarkers in critically ill patients

Authors: Rouve, Emmanuelle, Lakhal, Karim, Salmon Gandonnière, Charlotte, Jouan, Youenn, Bodet-Contentin, Laetitia, Ehrmann, Stephan

Source: BMC nephrology. 19(1):1-7

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100185396506.0x000001&indx=1&recIds=ETOCvdc_100185396506.0x000001

Pseudomonas aeruginosa proteolytically alters the interleukin 22-dependent lung mucosal defense

Authors: Guillon, Antoine, Brea, Deborah, Morello, Eric, Tang, Aihua, Jouan, Youenn, Ramphal, Reuben, Korkmaz, Brice, Perez-Cruz, Magdiel, Trottein, Francois, O'Callaghan, Richard J., Gosset, Philippe, Si-Tahar, Mustapha

Source: Virulence. 8(6):810-820

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100049255587.0x000001&indx=1&recIds=ETOCvdc_100049255587.0x000001

Critically ill SARS-CoV-2-infected patients are not stratified as sepsis by the qSOFA

Authors: Ferreira, Marion, Blin, Timothee, Collercandy, Nived, Szychowiak, Piotr, Dequin, Pierre-François, Jouan, Youenn, Guillon, Antoine

Source: Annals of intensive care. 10(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100172308446.0x000001&indx=1&recIds=ETOCvdc_100172308446.0x000001

Long-term survival of elderly patients after intensive care unit admission for acute respiratory infection: a population-based, propensity score-matched cohort study

Authors: Guillon, Antoine, Hermetet, Coralie, Barker, Kimberly A., Jouan, Youenn, Gaborit, Christophe, Ehrmann, Stephan, Le Manach, Yannick, Dequin, Pierre-François, Grammatico-Guillon, Leslie

Source: Critical care. 24(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100171992141.0x000001&indx=1&recIds=ETOCvdc_100171992141.0x000001

Hydrocortisone rapidly and significantly reduces the IL-6 level in blood and lungs of patients with COVID-19-related ARDS.

Authors: Guillon, Antoine, Jouan, Youenn, Kassa-Sombo, Arthur, Paget, Christophe, Dequin, Pierre-François

Source: Critical Care; 3/28/2024, Vol. 28 Issue 1, p1-3, 3p

Effects of mean arterial pressure on arousal in sedated ventilated patients with septic shock: a SEPSISPAM post hoc exploratory study

Authors: Jouan, Youenn, Seegers, Valérie, Meziani, Ferhat, Grelon, Fabien, Megarbane, Bruno, Anguel, Nadia, Mira, Jean-Paul, Dequin, Pierre-François, Gergaud, Soizic, Weiss, Nicolas, Legay, François, Le Tulzo, Yves, Conrad, Marie, Robert, René, Gonzalez, Frédéric, Guitton, Christophe, Tamion, Fabienne, Tonnelier, Jean-Marie, Guezennec, Pierre, Van Der Linden, Thierry, Vieillard-Baron, Antoine, Radermacher, Peter, Asfar, Pierre

Source: Annals of intensive care. 9(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100129334339.0x000001&indx=1&recIds=ETOCvdc_100129334339.0x000001

Healthcare trajectories before and after critical illness: population-based insight on diverse patients clusters

Authors: Jouan, Youenn, Grammatico-Guillon, Leslie, Teixera, Noémie, Hassen-Khodja, Claire, Gaborit, Christophe, Salmon-Gandonnière, Charlotte, Guillon, Antoine, Ehrmann, Stephan

Source: Annals of intensive care. 9(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100129333383.0x000001&indx=1&recIds=ETOCvdc_100129333383.0x000001

The positive impact of COVID-19 on critical care: from unprecedented challenges to transformative changes, from the perspective of young intensivists.

Authors: Hermann, Bertrand, Benghanem, Sarah, Jouan, Youenn, Lafarge, Antoine, Beurton, Alexandra

Source: Annals of Intensive Care; 4/11/2023, Vol. 13 Issue 1, p1-14, 14p

Subject Terms: CRITICAL care medicine, COVID-19 pandemic, COMMUNICATION ethics, COVID-19, PHYSICIANS

Ten-year trends in intensive care admissions for respiratory infections in the elderly

Authors: Laporte, Lucile, Hermetet, Coralie, Jouan, Youenn, Gaborit, Christophe, Rouve, Emmanuelle, Shea, Kimberly M., Si-Tahar, Mustapha, Dequin, Pierre-François, Grammatico-Guillon, Leslie, Guillon, Antoine

Source: Annals of intensive care. 8(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100129335762.0x000001&indx=1&recIds=ETOCvdc_100129335762.0x000001

Chronic critical illness and post-intensive care syndrome: from pathophysiology to clinical challenges.

Authors: Voiriot, Guillaume, Oualha, Mehdi, Pierre, Alexandre, Salmon-Gandonnière, Charlotte, Gaudet, Alexandre, Jouan, Youenn, Kallel, Hatem, Radermacher, Peter, Vodovar, Dominique, Sarton, Benjamine, Stiel, Laure, Bréchot, Nicolas, Préau, Sébastien, Joffre, Jérémie

Source: Annals of Intensive Care; 7/2/2022, Vol. 12 Issue 1, p1-14, 14p

Subject Terms: CRITICALLY ill, CHRONIC diseases, MUSCULAR atrophy, INTENSIVE care units, PATHOLOGICAL physiology, ACUTE kidney failure

Risks Associated with Obese Patient Handling in Emergency Prehospital Care

Authors: Réminiac, François, Jouan, Youenn, Cazals, Xavier, Bodin, Jean-François, Dequin, Pierre-François, Guillon, Antoine

Source: Prehospital emergency care. 18(4):555-557

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100103926859.0x000001&indx=1&recIds=ETOCvdc_100103926859.0x000001