Long-Term Immune Consequences of Initial SARS-CoV-2 A.23.1 Exposure: A Longitudinal Study of Antibody Responses and Cross-Neutralization in a Ugandan Cohort

Authors: Gerald Kevin Oluka, Jackson Sembera, Joseph Ssebwana Katende, Violet Ankunda, Laban Kato, Ashwini Kurshan, Carl Graham, Jeffrey Seow, Katie J. Doores, Michael H. Malim, Julie M. Fox, Pontiano Kaleebu, Jennifer Serwanga

Source: Vaccines, Vol 13, Iss 2, p 143 (2025)

Subject Terms: immune imprinting, SARS-CoV-2 A.23.1 variant, cross-neutralization, antibody dynamics, neutralizing titers, antigenic surveillance, Medicine

File Description: electronic resource

Relation: https://www.mdpi.com/2076-393X/13/2/143; https://doaj.org/toc/2076-393X

Access URL: https://doaj.org/article/519c7d3ecf3a4d05bb00b541737d3366

Spike protein is a key target for stronger and more persistent T-cell responses—a study of mild and asymptomatic SARS-CoV-2 infection

Authors: Ivan Ssali, Susan Mugaba, Arthur Kalyebi Watelo, Juliana Bemanzi, Joseph Ssebwana Katende, Gerald Kevin Oluka, Violet Ankunda, Claire Baine, Laban Kato, Nathan Onyachi, Moses Muwanga, Mark Jjuuko, John Kayiwa, Christopher Nsereko, Betty Oliver Auma, Daniela Weiskopf, Alessandro Sette, Tom Lutalo, Monica Musenero, Pontiano Kaleebu, Jennifer Serwanga

Source: International Journal of Infectious Diseases, Vol 136, Iss , Pp 49-56 (2023)

Subject Terms: Mild and asymptomatic COVID-19, Spike protein, IFN-γ, Immunodominance, Long-term immunity, Hematological parameters, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1201971223007142; https://doaj.org/toc/1201-9712

Access URL: https://doaj.org/article/cbaf82e9d50547daa18c5ec0a1588d8b

The single-dose Janssen Ad26.COV2.S COVID-19 vaccine elicited robust and persistent anti-spike IgG antibody responses in a 12-month Ugandan cohort

Authors: Jennifer Serwanga, Laban Kato, Gerald Kevin Oluka, Violet Ankunda, Jackson Sembera, Claire Baine, Isaac Kitabye, Angela Namuyanja, Solomon Opio, Joseph Ssebwana Katende, Peter Ejou, The COVID-19 Immunoprofiling Team, Pontiano Kaleebu

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: Janssen Ad26.COV2.S vaccine, SARS-CoV-2 immunity, spike protein antibodies, nucleocapsid protein antibodies, Ugandan vaccine cohort, single-dose vaccination, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1384668/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/1db485c38c5a405ea296012ef5315fec

The subdued post-boost spike-directed secondary IgG antibody response in Ugandan recipients of the Pfizer-BioNTech BNT162b2 vaccine has implications for local vaccination policies

Authors: Violet Ankunda, Joseph Ssebwana Katende, Gerald Kevin Oluka, Jackson Sembera, Claire Baine, Geoffrey Odoch, Peter Ejou, Laban Kato, The COVID-19 Immunoprofiling Team, Pontiano Kaleebu, Jennifer Serwanga, Christine Hermilia Akoli, Angela Namuyanja, Solomon Opio, Arthur Watelo Kalyebi, Ivan Ssali, Ben Gombe, Susan Mugaba, Hellen Nantambi

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: Pfizer BioNTech BNT162b2 COVID-19 vaccine, longitudinal antibody responses, Sub-Saharan African populations, seropositivity classification, booster dose, breakthrough infections, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1325387/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/749743b1ec32400191b68e3c3266412d

Sustained S-IgG and S-IgA antibodies to Moderna’s mRNA-1273 vaccine in a Sub-Saharan African cohort suggests need for booster timing reconsiderations

Authors: Jennifer Serwanga, Violet Ankunda, Joseph Ssebwana Katende, Claire Baine, Gerald Kevin Oluka, Geoffrey Odoch, Hellen Nantambi, Susan Mugaba, Angella Namuyanja, Ivan Ssali, Peter Ejou, Laban Kato, The COVID-19 Immunoprofiling Team, Monica Musenero, Pontiano Kaleebu, Jackson Sembera, Betty Oliver Auma, Solomon Opio, Ben Gombe

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: long-term immunogenicity, mRNA-1273 vaccine, Sub-Saharan vaccine response, S-IgG and S-IgA antibodies, vaccine-induced immunity, antibody persistence, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1348905/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/4193f652b87f48fe898580c284e37647

Persistent and robust antibody responses to ChAdOx1-S Oxford-AstraZeneca (ChAdOx1-S, Covishield) SARS-CoV-2 vaccine observed in Ugandans across varied baseline immune profiles.

Authors: Jennifer Serwanga, Gerald Kevin Oluka, Claire Baine, Violet Ankunda, Jackson Sembera, Laban Kato, Joseph Ssebwana Katende, Geoffrey Odoch, Betty Oliver Auma, Ben Gombe, COVID-19 Immunoprofiling Team, Monica Musenero, Pontiano Kaleebu

Source: PLoS ONE, Vol 19, Iss 7, p e0303113 (2024)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/97ffa7599c1441e4807481d7a29eb2bb

Sustained spike-specific IgG antibodies following CoronaVac (Sinovac) vaccination in sub-Saharan Africa, but increased breakthrough infections in baseline spike-naive individuals

Authors: Jackson Sembera, Claire Baine, Violet Ankunda, Joseph Ssebwana Katende, Gerald Kevin Oluka, Christine Hermilia Akoli, Laban Kato, Geoffrey Odoch, Peter Ejou, Solomon Opio, Monica Musenero, The COVID-19 Immunoprofiling Team, Pontiano Kaleebu, Jennifer Serwanga

Source: Frontiers in Immunology, Vol 14 (2023)

Subject Terms: CoronaVac, COVID-19, antibody concentrations, seropositivity, antibody persistence, breakthrough infections, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1255676/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/fd22ad6deacf4d7ba908cf15ff6472fc

Seroprevalence and durability of antibody responses to AstraZeneca vaccination in Ugandans with prior mild or asymptomatic COVID-19: implications for vaccine policy

Authors: Jennifer Serwanga, Claire Baine, Susan Mugaba, Violet Ankunda, Betty Oliver Auma, Gerald Kevin Oluka, Laban Kato, Isaac Kitabye, Jackson Sembera, Geoffrey Odoch, Peter Ejou, Amina Nalumansi, Ben Gombe, Monica Musenero, Pontiano Kaleebu, the COVID-19 Immunoprofiling Team, Christine Hermilia Akoli, Deus Mwesigwa, Ivan Ssali, Hellen Nantambi, Angela Namuyanja, Solomon Opio, Arthur Watelo Kalyebi, Joseph Ssebwana Katende

Source: Frontiers in Immunology, Vol 14 (2023)

Subject Terms: AstraZeneca vaccine, hybrid immunity, IgG, IgM, and IgA antibody responses, Ugandan population, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1183983/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/12ba7b1e3b934d3ea067f47b5d80e727

Pre-pandemic SARS-CoV-2-specific IFN-γ and antibody responses were low in Ugandan samples and significantly reduced in HIV-positive specimens

Authors: Hellen Nantambi, Jackson Sembera, Violet Ankunda, Ivan Ssali, Arthur Watelo Kalyebi, Gerald Kevin Oluka, Laban Kato, Bahemuka Ubaldo, Freddie Kibengo, Joseph Ssebwana Katende, Ben Gombe, Claire Baine, Geoffrey Odoch, Susan Mugaba, Obondo James Sande, The COVID-19 Immunoprofiling Team, Pontiano Kaleebu, Jennifer Serwanga

Source: Frontiers in Immunology, Vol 14 (2023)

Subject Terms: SARS-CoV-2, Common-cold coronaviruses, sero-crossreactivity, Pre-existing IFN-γ, Sub-Saharan Africa, Disease severity, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1148877/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/546f6a4b64e04285a89374a02f81b4d1

Optimisation and Validation of a conventional ELISA and cut-offs for detecting and quantifying anti-SARS-CoV-2 Spike, RBD, and Nucleoprotein IgG, IgM, and IgA antibodies in Uganda

Authors: Gerald Kevin Oluka, Patricia Namubiru, Laban Kato, Violet Ankunda, Ben Gombe, Matthew Cotten, The COVID-19 Immunoprofiling Team, Monica Musenero, Pontiano Kaleebu, Julie Fox, Jennifer Serwanga, Claire Baine, Jackson Sembera, Susan Mugaba, Christine Hermilia Akoli, Geoffrey Odoch, Deus Mwesigwa, Peter Ejou, Joseph Ssebwana Katende

Source: Frontiers in Immunology, Vol 14 (2023)

Subject Terms: SARS-CoV-2, spike-protein, Nucleoprotein, RBD, ELISA validation and optimization, antibody seropositivity cut-offs, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1113194/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/eade7db238e74c73973a178e6839d878

Rapid, early, and potent Spike-directed IgG, IgM, and IgA distinguish asymptomatic from mildly symptomatic COVID-19 in Uganda, with IgG persisting for 28 months

Authors: Jennifer Serwanga, Violet Ankunda, Jackson Sembera, Laban Kato, Gerald Kevin Oluka, Claire Baine, Geoffrey Odoch, John Kayiwa, Betty Oliver Auma, Mark Jjuuko, Christopher Nsereko, Matthew Cotten, Nathan Onyachi, Moses Muwanga, Tom Lutalo, Julie Fox, Monica Musenero, Pontiano Kaleebu, The COVID-19 Immunoprofiling Team, Patricia Namubiru, Hermilia Christine Akoli, Susan Mugaba, Amina Nalumansi, Kibengo Freddie, Deus Mwesigwa, Joseph Ssebwana Katende

Source: Frontiers in Immunology, Vol 14 (2023)

Subject Terms: SARS-CoV-2 antibody persistence, Spike and RBD, nucleoprotein, mild and asymptomatic COVID-19, IgG, IgM, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1152522/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/8d0ed8976a684d0e97e34dc7c9ba05d2