Alpha-synuclein inclusion responsive microglia are resistant to CSF1R inhibition

Authors: Anna C. Stoll, Christopher J. Kemp, Joseph R. Patterson, Michael Kubik, Nathan Kuhn, Matthew Benskey, Megan F. Duffy, Kelvin C. Luk, Caryl E. Sortwell

Source: Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-17 (2024)

Subject Terms: PLX3397, Neuroinflammation, Parkinson’s disease, Synucleinopathy, Major-histocompatibility complex-II, Neurodegeneration, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1742-2094

Access URL: https://doaj.org/article/5679db2e702a49868c1ad5fd724f257f

Transcriptomic profiling of early synucleinopathy in rats induced with preformed fibrils

Authors: Joseph R. Patterson, Joseph Kochmanski, Anna C. Stoll, Michael Kubik, Christopher J. Kemp, Megan F. Duffy, Kajene Thompson, Jacob W. Howe, Allyson Cole-Strauss, Nathan C. Kuhn, Kathryn M. Miller, Seth Nelson, Christopher U. Onyekpe, John S. Beck, Scott E. Counts, Alison I. Bernstein, Kathy Steece-Collier, Kelvin C. Luk, Caryl E. Sortwell

Source: npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-17 (2024)

Subject Terms: Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2373-8057

Access URL: https://doaj.org/article/8bde4016617e4debb09532f2fc4a2cc0

Neuroinflammatory gene expression profiles of reactive glia in the substantia nigra suggest a multidimensional immune response to alpha synuclein inclusions

Authors: Anna C. Stoll, Christopher J. Kemp, Joseph R. Patterson, Jacob W. Howe, Kathy Steece-Collier, Kelvin C. Luk, Caryl E. Sortwell, Matthew J. Benskey

Source: Neurobiology of Disease, Vol 191, Iss , Pp 106411- (2024)

Subject Terms: Glia, Microglia, Astrocyte, Alpha-synuclein, Neuroinflammation, Parkinson's disease, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S096999612400010X; https://doaj.org/toc/1095-953X

Access URL: https://doaj.org/article/f5390f22412347b4b85630400c80d5a3

Beta2-adrenoreceptor agonist clenbuterol produces transient decreases in alpha-synuclein mRNA but no long-term reduction in protein

Authors: Joseph R. Patterson, Warren D. Hirst, Jacob W. Howe, Christopher P. Russell, Allyson Cole-Strauss, Christopher J. Kemp, Megan F. Duffy, Jared Lamp, Andrew Umstead, Michael Kubik, Anna C. Stoll, Irving E. Vega, Kathy Steece-Collier, Yi Chen, Anne C. Campbell, Catherine L. Nezich, Kelly E. Glajch, Caryl E. Sortwell

Source: npj Parkinson's Disease, Vol 8, Iss 1, Pp 1-14 (2022)

Subject Terms: Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2373-8057

Access URL: https://doaj.org/article/1490e19ae927454fbbfea97a835eff52

Developmental exposure to the organochlorine pesticide dieldrin causes male-specific exacerbation of α-synuclein-preformed fibril-induced toxicity and motor deficits

Authors: Aysegul O. Gezer, Joseph Kochmanski, Sarah E. VanOeveren, Allyson Cole-Strauss, Christopher J. Kemp, Joseph R. Patterson, Kathryn M. Miller, Nathan C. Kuhn, Danielle E. Herman, Alyssa McIntire, Jack W. Lipton, Kelvin C. Luk, Sheila M. Fleming, Caryl E. Sortwell, Alison I. Bernstein

Source: Neurobiology of Disease, Vol 141, Iss , Pp 104947- (2020)

Subject Terms: Parkinson's, Pesticide, Synuclein, Neurotoxicity, Neuroinflammation, Sex differences, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0969996120302229; https://doaj.org/toc/1095-953X

Access URL: https://doaj.org/article/212f253653d444c5bfd9ea221a1eac9e

Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration

Authors: Megan F. Duffy, Timothy J. Collier, Joseph R. Patterson, Christopher J. Kemp, Kelvin C. Luk, Malú G. Tansey, Katrina L. Paumier, Nicholas M. Kanaan, D. Luke Fischer, Nicole K. Polinski, Olivia L. Barth, Jacob W. Howe, Nishant N. Vaikath, Nour K. Majbour, Omar M. A. El-Agnaf, Caryl E. Sortwell

Source: Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-18 (2018)

Subject Terms: Neuroinflammation, Parkinson’s disease, Animal models, Synucleinopathy, Microglia, Major-histocompatibility complex-II, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12974-018-1171-z; https://doaj.org/toc/1742-2094

Access URL: https://doaj.org/article/78b82214e6ad41e9bc7e34dc3be1cf71

Induction of alpha-synuclein pathology in the enteric nervous system of the rat and non-human primate results in gastrointestinal dysmotility and transient CNS pathology

Authors: Fredric P. Manfredsson, Kelvin C. Luk, Matthew J. Benskey, Aysegul Gezer, Joanna Garcia, Nathan C. Kuhn, Ivette M. Sandoval, Joseph R. Patterson, Alana O'Mara, Reid Yonkers, Jeffrey H. Kordower

Source: Neurobiology of Disease, Vol 112, Iss , Pp 106-118 (2018)

Subject Terms: Alpha-synuclein, Enteric nervous system, Parkinson's disease, Enteric dysfunction, Prion spread, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0969996118300081; https://doaj.org/toc/1095-953X

Access URL: https://doaj.org/article/f50155d733b64563810a3844d88653e2

Time course and magnitude of alpha-synuclein inclusion formation and nigrostriatal degeneration in the rat model of synucleinopathy triggered by intrastriatal α-synuclein preformed fibrils

Authors: Joseph R. Patterson, Megan F. Duffy, Christopher J. Kemp, Jacob W. Howe, Timothy J. Collier, Anna C. Stoll, Kathryn M. Miller, Pooja Patel, Nathan Levine, Darren J. Moore, Kelvin C. Luk, Sheila M. Fleming, Nicholas M. Kanaan, Katrina L. Paumier, Omar M.A. El-Agnaf, Caryl E. Sortwell

Source: Neurobiology of Disease, Vol 130, Iss , Pp 104525- (2019)

Subject Terms: Alpha-Synuclein, Preformed fibrils, Synucleinopathy, Parkinson's disease, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0969996119301937; https://doaj.org/toc/1095-953X

Access URL: https://doaj.org/article/758f84c3154542e3af56b5659a3f143d

Quality Over Quantity: Advantages of Using Alpha-Synuclein Preformed Fibril Triggered Synucleinopathy to Model Idiopathic Parkinson’s Disease

Authors: Megan F. Duffy, Timothy J. Collier, Joseph R. Patterson, Christopher J. Kemp, D. Luke Fischer, Anna C. Stoll, Caryl E. Sortwell

Source: Frontiers in Neuroscience, Vol 12 (2018)

Subject Terms: Parkinson’s disease, alpha-synuclein, preformed fibrils, synucleinopathy, animal models, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fnins.2018.00621/full; https://doaj.org/toc/1662-453X

Access URL: https://doaj.org/article/8a2f96a907344e10961e70c441a8467a

Correction to: Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration

Authors: Megan F. Duffy, Timothy J. Collier, Joseph R. Patterson, Christopher J. Kemp, Kelvin C. Luk, Malú G. Tansey, Katrina L. Paumier, Nicholas M. Kanaan, D. Luke Fischer, Nicole K. Polinski, Olivia L. Barth, Jacob W. Howe, Nishant N. Vaikath, Nour K. Majbour, Omar M. A. El-Agnaf, Caryl E. Sortwell

Source: Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-1 (2018)

Subject Terms: Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12974-018-1202-9; https://doaj.org/toc/1742-2094

Access URL: https://doaj.org/article/be17cb9e75054c85be402f41c4ea1d84

Generation of Alpha-Synuclein Preformed Fibrils from Monomers and Use In Vivo

Authors: Joseph R. Patterson, author¹, Nicole K. Polinski, author², Megan F. Duffy, author^{1, 3}, Christopher J. Kemp, author¹, Kelvin C. Luk, author⁴, Laura A. Volpicelli-Daley, author⁵, Nicholas M. Kanaan, author¹, Caryl E. Sortwell, author^{1, 3, 6}

Source: Journal of Visualized Experiments. (148)

Availability: http://www.jove.com/video/59758

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