High immunoglobulin-M levels to oxidation-specific epitopes are associated with lower risk of acute myocardial infarction

Authors: Adam Taleb, Peter Willeit, Shahzada Amir, Thomas Perkmann, Maria Ozsvar Kozma, Martin L. Watzenböck, Christoph J. Binder, Joseph L. Witztum, Sotirios Tsimikas

Source: Journal of Lipid Research, Vol 64, Iss 6, Pp 100391- (2023)

Subject Terms: oxidation, immunoglobulin, myocardial infarction, Biochemistry, QD415-436

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0022227523000640; https://doaj.org/toc/0022-2275

Access URL: https://doaj.org/article/7e13b8f6a4a1409992df716051956c85

The TBK1/IKKε inhibitor amlexanox improves dyslipidemia and prevents atherosclerosis

Authors: Peng Zhao, Xiaoli Sun, Zhongji Liao, Hong Yu, Dan Li, Zeyang Shen, Christopher K. Glass, Joseph L. Witztum, Alan R. Saltiel

Source: JCI Insight, Vol 7, Iss 17 (2022)

Subject Terms: Metabolism, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2379-3708

Access URL: https://doaj.org/article/fc33a0413edb494fa587070ff0965270

Development and validation of an isoform-independent monoclonal antibody–based ELISA for measurement of lipoprotein(a)

Authors: Santica M. Marcovina, Nazanin Navabi, Serena Allen, Ayelet Gonen, Joseph L. Witztum, Sotirios Tsimikas

Source: Journal of Lipid Research, Vol 63, Iss 8, Pp 100239- (2022)

Subject Terms: lipoprotein(a), monoclonal antibody, isoform, kringle, cardiovascular disease, aortic stenosis, Biochemistry, QD415-436

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0022227522000724; https://doaj.org/toc/0022-2275

Access URL: https://doaj.org/article/6f168a3e03d846e9bed1e4e54bf094ec

Interventional hepatic apoC-III knockdown improves atherosclerotic plaque stability and remodeling by triglyceride lowering

Authors: Bastian Ramms, Sohan Patel, Xiaoli Sun, Ariane R. Pessentheiner, G. Michelle Ducasa, Adam E. Mullick, Richard G. Lee, Rosanne M. Crooke, Sotirios Tsimikas, Joseph L. Witztum, Philip L.S.M. Gordts

Source: JCI Insight, Vol 7, Iss 13 (2022)

Subject Terms: Metabolism, Vascular biology, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2379-3708

Access URL: https://doaj.org/article/d3c85ea05ac64087a50365d3f59dcc54

B-1b Cells Have Unique Functional Traits Compared to B-1a Cells at Homeostasis and in Aged Hyperlipidemic Mice With Atherosclerosis

Authors: Prasad Srikakulapu, Tanyaporn Pattarabanjird, Aditi Upadhye, Sai Vineela Bontha, Victoria Osinski, Melissa A. Marshall, James Garmey, Justine Deroissart, Thomas A. Prohaska, Joseph L. Witztum, Christoph J. Binder, Nichol E. Holodick, Thomas L. Rothstein, Coleen A. McNamara

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: B-1 cells, IgM antibodies, IgHV sequencing, aging, CCR6, atherosclerosis, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.909475/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/286501d5bfa64c20ac2f25408827ca76

Generation and characterization of LPA-KIV9, a murine monoclonal antibody binding a single site on apolipoprotein (a)

Authors: Ayelet Gonen, Xiaohong Yang, Calvin Yeang, Elena Alekseeva, Marlys Koschinsky, Joseph L. Witztum, Michael Boffa, Sotirios Tsimikas

Source: Journal of Lipid Research, Vol 61, Iss 9, Pp 1263-1270 (2020)

Subject Terms: lipoprotein (a), monoclonal antibody, isoform, kringle, cardiovascular disease, aortic stenosis, Biochemistry, QD415-436

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0022227520436910; https://doaj.org/toc/0022-2275

Access URL: https://doaj.org/article/d3ae9551f9854ddb99fa732ebadefc2a

In memoriam: Judith A. Berliner, Ph.D.

Authors: Mete Civelek, Alan M. Fogelman, Catherine C. Hedrick, Aldons J. Lusis, Casey E. Romanoski, Joseph L. Witztum

Source: Journal of Lipid Research, Vol 63, Iss 4, Pp 100180- (2022)

Subject Terms: Biochemistry, QD415-436

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S002222752200013X; https://doaj.org/toc/0022-2275

Access URL: https://doaj.org/article/9195fa147a91497c9578e36c6dc5e092

Potent reduction of plasma lipoprotein (a) with an antisense oligonucleotide in human subjects does not affect ex vivo fibrinolysis

Authors: Michael B. Boffa, Tanya T. Marar, Calvin Yeang, Nicholas J. Viney, Shuting Xia, Joseph L. Witztum, Marlys L. Koschinsky, Sotirios Tsimikas

Source: Journal of Lipid Research, Vol 60, Iss 12, Pp 2082-2089 (2019)

Subject Terms: apolipoprotein(a), thrombosis, atherosclerotic cardiovascular disease, Biochemistry, QD415-436

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0022227520310464; https://doaj.org/toc/0022-2275

Access URL: https://doaj.org/article/28dfa1e214734075affad1972af7235c

ApoC-III ASO promotes tissue LPL activity in the absence of apoE-mediated TRL clearance

Authors: Bastian Ramms, Sohan Patel, Chelsea Nora, Ariane R. Pessentheiner, Max W. Chang, Courtney R. Green, Gregory J. Golden, Patrick Secrest, Ronald M. Krauss, Christian M. Metallo, Christopher Benner, Veronica J. Alexander, Joseph L. Witztum, Sotirios Tsimikas, Jeffrey D. Esko, Philip L.S.M. Gordts

Source: Journal of Lipid Research, Vol 60, Iss 8, Pp 1379-1395 (2019)

Subject Terms: lipid metabolism, apolipoprotein C-III, apolipoprotein E, triglyceride-rich lipoprotein clearance, fatty acids, lipase, Biochemistry, QD415-436

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0022227520322331; https://doaj.org/toc/0022-2275

Access URL: https://doaj.org/article/79b2fc472cb54420abab601c33268491

Lipoprotein(a), Oxidized Phospholipids, and Aortic Valve Microcalcification Assessed by 18F-Sodium Fluoride Positron Emission Tomography and Computed Tomography

Authors: Audrey-Anne Després, BSc, Nicolas Perrot, MSc, Anthony Poulin, MD, Lionel Tastet, MSc, Mylène Shen, MSc, Hao Yu Chen, MSc, Raphaëlle Bourgeois, MSc, Mikaël Trottier, MD, Michel Tessier, MD, Jean Guimond, MD, Maxime Nadeau, TIM, James C. Engert, PhD, Sébastien Thériault, MD, MSc, Yohan Bossé, PhD, Joseph L. Witztum, MD, Patrick Couture, MD, Patrick Mathieu, MD, MSc, Marc R. Dweck, MD, Sotirios Tsimikas, MD, George Thanassoulis, MD, Philippe Pibarot, PhD, DVM, Marie-Annick Clavel, PhD, DVM, Benoit J. Arsenault, PhD

Source: CJC Open, Vol 1, Iss 3, Pp 131-140 (2019)

Subject Terms: Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589790X19300216; https://doaj.org/toc/2589-790X

Access URL: https://doaj.org/article/3ecc4f1cde6447aa92f6bf6f6a3e3623

Novel method for quantification of lipoprotein(a)-cholesterol: implications for improving accuracy of LDL-C measurements

Authors: Calvin Yeang, Joseph L. Witztum, Sotirios Tsimikas

Source: Journal of Lipid Research, Vol 62, Iss , Pp 100053- (2021)

Subject Terms: lipoprotein(a), low density lipoprotein, cholesterol, biomarker, cardiovascular disease risk, therapy, Biochemistry, QD415-436

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0022227521000341; https://doaj.org/toc/0022-2275

Access URL: https://doaj.org/article/615be8f28e424120957595e6d6cd41ff

A monoclonal antibody to assess oxidized cholesteryl esters associated with apoAI and apoB-100 lipoproteins in human plasma1[S]

Authors: Ayelet Gonen, Soo-Ho Choi, Phuong Miu, Colin Agatisa-Boyle, Daniel Acks, Angela M. Taylor, Coleen A. McNamara, Sotirios Tsimikas, Joseph L. Witztum, Yury I. Miller

Source: Journal of Lipid Research, Vol 60, Iss 2, Pp 436-445 (2019)

Subject Terms: apolipoprotein AI, apolipoprotein B-100, biomarker, oxidation-specific epitope, Biochemistry, QD415-436

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0022227520326559; https://doaj.org/toc/0022-2275

Access URL: https://doaj.org/article/38f157d445104522a281cd7d67c6c008

CX3CL1-Fc treatment prevents atherosclerosis in Ldlr KO mice

Authors: Matthew Riopel, Melanie Vassallo, Erik Ehinger, Jennifer Pattison, Karen Bowden, Holger Winkels, Maria Wilson, Ron de Jong, Sanjay Patel, Deepika Balakrishna, James Bilakovics, Andrea Fanjul, Artur Plonowski, Christopher J. Larson, Klaus Ley, Pedro Cabrales, Joseph L. Witztum, Jerrold M. Olefsky, Yun Sok Lee

Source: Molecular Metabolism, Vol 20, Iss , Pp 89-101 (2019)

Subject Terms: Internal medicine, RC31-1245

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2212877818306197; https://doaj.org/toc/2212-8778

Access URL: https://doaj.org/article/9aa1e09a965d493391f4ff36b42d349a

Oxidation-specific epitopes restrain bone formation

Authors: Elena Ambrogini, Xuchu Que, Shuling Wang, Fumihiro Yamaguchi, Robert S. Weinstein, Sotirios Tsimikas, Stavros C. Manolagas, Joseph L. Witztum, Robert L. Jilka

Source: Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/3b5383334d33469ca0d3bacfa1e40cd6

Longitudinal Assessment of Lipoprotein(a) Levels in Perinatally HIV-Infected Children and Adolescents

Authors: Jason G. van Genderen, Malon Van den Hof, Claudia G. de Boer, Hans P. G. Jansen, Sander J. H. van Deventer, Sotirios Tsimikas, Joseph L. Witztum, John J. P. Kastelein, Dasja Pajkrt

Source: Viruses, Vol 13, Iss 10, p 2067 (2021)

Subject Terms: human immunodeficiency virus, cardiovascular disease, apolipoproteins dyslipidemia, atherosclerotic cardiovascular disease, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4915/13/10/2067; https://doaj.org/toc/1999-4915

Access URL: https://doaj.org/article/e7fc141841c847bf85d41fbf0d24e115

Lipoprotein(a)-Associated Molecules Are Prominent Components in Plasma and Valve Leaflets in Calcific Aortic Valve Stenosis

Authors: Michael Torzewski, MD, Amir Ravandi, MD, PhD, Calvin Yeang, MD, PhD, Andrea Edel, PhD, Rahul Bhindi, MD, Stefan Kath, MD, Laura Twardowski, MD, Jens Schmid, PhD, Xiaohong Yang, BS, Ulrich F.W. Franke, MD, Joseph L. Witztum, MD, Sotirios Tsimikas, MD

Source: JACC: Basic to Translational Science, Vol 2, Iss 3, Pp 229-240 (2017)

Subject Terms: Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2452302X17300943; https://doaj.org/toc/2452-302X

Access URL: https://doaj.org/article/88fd2ded79124fbb9b597e0ee5828fcf

Erratum: A monoclonal antibody to assess oxidized cholesteryl esters associated with apoAI and apoB-100 lipoproteins in human plasma

Authors: Ayelet Gonen, Soo-Ho Choi, Phuong Miu, Colin Agatisa-Boyle, Daniel Acks, Angela M. Taylor, Coleen A. McNamara, Sotirios Tsimikas, Joseph L. Witztum, Yury I. Miller

Source: Journal of Lipid Research, Vol 60, Iss 11, Pp 1979- (2019)

Subject Terms: Biochemistry, QD415-436

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0022227520322963; https://doaj.org/toc/0022-2275

Access URL: https://doaj.org/article/1e90d6418d044607a68e53286e242ce5

Apolipoprotein Profiles in Very Preterm and Term‐Born Preschool Children

Authors: Anna Posod, Raimund Pechlaner, Xiaoke Yin, Sean Anthony Burnap, Sophia Julia Kiechl, Johann Willeit, Joseph L. Witztum, Manuel Mayr, Stefan Kiechl, Ursula Kiechl‐Kohlendorfer

Source: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 8 (2019)

Subject Terms: apolipoprotein, cardiovascular disease, pediatrics, prematurity, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://doaj.org/toc/2047-9980

Access URL: https://doaj.org/article/6f06d3c9df4b4f46be4dbfd8e3531255

Reduction in lipoprotein-associated apoC-III levels following volanesorsen therapy: phase 2 randomized trial results1

Authors: Xiaohong Yang, Sang-Rok Lee, Yun-Seok Choi, Veronica J. Alexander, Andres Digenio, Qingqing Yang, Yury I. Miller, Joseph L. Witztum, Sotirios Tsimikas

Source: Journal of Lipid Research, Vol 57, Iss 4, Pp 706-713 (2016)

Subject Terms: hypertriglyceridemia, triglycerides, remnant lipoproteins, antisense oligonucleotides, cardiovascular disease, familial chylomicronemia syndrome, Biochemistry, QD415-436

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0022227520354250; https://doaj.org/toc/0022-2275

Access URL: https://doaj.org/article/40bbe240a7034b35bb4e01f1c165f503

Population and assay thresholds for the predictive value of lipoprotein (a) for coronary artery disease: the EPIC-Norfolk Prospective Population Study1

Authors: Rutger Verbeek, S. Matthijs Boekholdt, Robert M. Stoekenbroek, G. Kees Hovingh, Joseph L. Witztum, Nicholas J. Wareham, Manjinder S. Sandhu, Kay-Tee Khaw, Sotirios Tsimikas

Source: Journal of Lipid Research, Vol 57, Iss 4, Pp 697-705 (2016)

Subject Terms: atherosclerosis, aortic stenosis, risk factor, Biochemistry, QD415-436

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0022227520354249; https://doaj.org/toc/0022-2275

Access URL: https://doaj.org/article/78b990008e3b48ec84b0268fa8d51181