Safety, pharmacokinetics and CNS distribution of tralesinidase alfa administered via intracerebroventricular infusion to juvenile cynomolgus monkeys

Authors: Jason Pinkstaff, Emma McCullagh, Anita Grover, Andrew C. Melton, Anu Cherukuri, Jill CM Wait, Annalisa Nguyen, Mark T. Butt, Jami L. Trombley, Randall P. Reed, Eric.L. Adams, Robert B. Boyd, Sundeep Chandra, Joshua Henshaw, Charles A. O’Neill, Eric Zanelli, Joseph Kovalchin

Source: Toxicology Reports, Vol 10, Iss , Pp 357-366 (2023)

Subject Terms: MPS IIIB, Sanfilippo syndrome, NAGLU, Intracerebroventricular, Enzyme replacement therapy, Toxicology. Poisons, RA1190-1270

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2214750023000288; https://doaj.org/toc/2214-7500

Access URL: https://doaj.org/article/cfbd12d153c245b5adea0f11f64be6c8

A phase I/II study on intracerebroventricular tralesinidase alfa in patients with Sanfilippo syndrome type B

Authors: Nicole Muschol, Anja Koehn, Katharina von Cossel, Ilyas Okur, Fatih Ezgu, Paul Harmatz, Maria J. de Castro Lopez, Maria Luz Couce, Shuan-Pei Lin, Spyros Batzios, Maureen Cleary, Martha Solano, Igor Nestrasil, Brian Kaufman, Adam J. Shaywitz, Stephen M. Maricich, Bernice Kuca, Joseph Kovalchin, Eric Zanelli

Source: The Journal of Clinical Investigation, Vol 133, Iss 2 (2023)

Subject Terms: Neuroscience, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1558-8238

Access URL: https://doaj.org/article/3ded75f715844309990af3452c9afcb6

Macrophage-specific chemokines induced via innate immunity by amino acid copolymers and their role in EAE.

Authors: Joseph Kovalchin, Jeffrey Krieger, Michelle Genova, Norio Kawamoto, Michael Augustyniak, Kathryn Collins, Troy Bloom, Allyson Masci, Tara Hittinger, Ingrid Dufour, Jack L Strominger, Eric Zanelli

Source: PLoS ONE, Vol 6, Iss 12, p e26274 (2011)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3240613?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/f4cfbffef4684307ab08efd695f6a2ba