Maturation and detoxification of synphilin-1 inclusion bodies regulated by sphingolipids

Authors: Xiuling Cao, Xiang Wu, Lei Zhao, Ju Zheng, Xuejiao Jin, Xinxin Hao, Joris Winderickx, Shenkui Liu, Lihua Chen, Beidong Liu

Source: eLife, Vol 12 (2025)

Subject Terms: synphilin-1, sphingolipids, inclusion bodies, imaging-based screen, mitochondrion, mammalian cells, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/92180; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/127b4aa837f24430a33ce632db5b3d41

Lsm7 phase-separated condensates trigger stress granule formation

Authors: Michelle Lindström, Lihua Chen, Shan Jiang, Dan Zhang, Yuan Gao, Ju Zheng, Xinxin Hao, Xiaoxue Yang, Arpitha Kabbinale, Johannes Thoma, Lisa C. Metzger, Deyuan Y. Zhang, Xuefeng Zhu, Huisheng Liu, Claes M. Gustafsson, Björn M. Burmann, Joris Winderickx, Per Sunnerhagen, Beidong Liu

Source: Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/d71ce27c6c484392bb1b4ccaad1798bc

Snf1/AMPK fine-tunes TORC1 signaling in response to glucose starvation

Authors: Marco Caligaris, Raffaele Nicastro, Zehan Hu, Farida Tripodi, Johannes Erwin Hummel, Benjamin Pillet, Marie-Anne Deprez, Joris Winderickx, Sabine Rospert, Paola Coccetti, Jörn Dengjel, Claudio De Virgilio

Source: eLife, Vol 12 (2023)

Subject Terms: Snf1, TORC1, AMPK, glucose starvation, cell signaling, proteomics, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/84319; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/c6ca36d295b042ff8c55d125be0af3da

The nutrient-responsive CDK Pho85 primes the Sch9 kinase for its activation by TORC1.

Authors: Marie-Anne Deprez, Marco Caligaris, Joëlle Rosseels, Riko Hatakeyama, Ruben Ghillebert, Belém Sampaio-Marques, Kaivalya Mudholkar, Elja Eskes, Els Meert, Christian Ungermann, Paula Ludovico, Sabine Rospert, Claudio De Virgilio, Joris Winderickx

Source: PLoS Genetics, Vol 19, Iss 2, p e1010641 (2023)

Subject Terms: Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1553-7390; https://doaj.org/toc/1553-7404

Access URL: https://doaj.org/article/71004d8ca5c847a0974bb273b721ec79

The Yeast Protein Kinase Sch9 Functions as a Central Nutrient-Responsive Hub That Calibrates Metabolic and Stress-Related Responses

Authors: Marco Caligaris, Belém Sampaio-Marques, Riko Hatakeyama, Benjamin Pillet, Paula Ludovico, Claudio De Virgilio, Joris Winderickx, Raffaele Nicastro

Source: Journal of Fungi, Vol 9, Iss 8, p 787 (2023)

Subject Terms: Sch9, TORC1, SNF1, Pkh1, Pkh2, Pkh3, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2309-608X/9/8/787; https://doaj.org/toc/2309-608X

Access URL: https://doaj.org/article/443fa78c018749b7a995d97fa075201a

Inter-organellar Communication in Parkinson's and Alzheimer's Disease: Looking Beyond Endoplasmic Reticulum-Mitochondria Contact Sites

Authors: Stephanie Vrijsen, Céline Vrancx, Mara Del Vecchio, Johannes V. Swinnen, Patrizia Agostinis, Joris Winderickx, Peter Vangheluwe, Wim Annaert

Source: Frontiers in Neuroscience, Vol 16 (2022)

Subject Terms: endolysosome, mitochondria, neurodegenerative disease, inter-organellar communication, lipid metabolism, membrane contact site, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fnins.2022.900338/full; https://doaj.org/toc/1662-453X

Access URL: https://doaj.org/article/71b18339eb854ed494b75e0a5a5c3764

Editorial: Yeast Differentiation: From Cell-to-Cell Heterogeneity to Replicative Aging and Regulated Cell Death

Authors: J. Marie Hardwick, Dmitry Knorre, Zdena Palkova, Joris Winderickx

Source: Frontiers in Cell and Developmental Biology, Vol 9 (2022)

Subject Terms: yeast, programmed cell death, biofilm, heterogeneity, differentiation, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2021.823447/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/986937437bcc499ebf7882c8f764ff50

Sphingolipids and Inositol Phosphates Regulate the Tau Protein Phosphorylation Status in Humanized Yeast

Authors: Francisca Randez-Gil, Lino Bojunga, Francisco Estruch, Joris Winderickx, Maurizio Del Poeta, Jose A. Prieto

Source: Frontiers in Cell and Developmental Biology, Vol 8 (2020)

Subject Terms: Saccharomyces cerevisiae, 1-IP7, Pho85, ceramide, Sit4, Ypk1, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2020.592159/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/c86081aa29014a8d99917c9d39db9ed6

The elusive tau molecular structures: can we translate the recent breakthroughs into new targets for intervention?

Authors: Yann Fichou, Youssra K. Al-Hilaly, François Devred, Caroline Smet-Nocca, Philipp O. Tsvetkov, Joke Verelst, Joris Winderickx, Nick Geukens, Eugeen Vanmechelen, Audrey Perrotin, Louise Serpell, Bernard J Hanseeuw, Miguel Medina, Luc Buée, Isabelle Landrieu

Source: Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-17 (2019)

Subject Terms: Tauopathies, Alzheimer’s disease, tau structure, tau aggregation, Alzheimer’s disease diagnosis, Amyloid, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s40478-019-0682-x; https://doaj.org/toc/2051-5960

Access URL: https://doaj.org/article/bb3797785c9b48ec921123c85a95810a

Decreased Vacuolar Ca2+ Storage and Disrupted Vesicle Trafficking Underlie Alpha-Synuclein-Induced Ca2+ Dysregulation in S. cerevisiae

Authors: Geert Callewaert, Petra D’hooge, Tien-Yang Ma, Mara Del Vecchio, Vincent Van Eyck, Vanessa Franssens, Joris Winderickx

Source: Frontiers in Genetics, Vol 11 (2020)

Subject Terms: yeast, Saccharomyces cerevisiae, α-synuclein, Ca2+ signaling, vesicle trafficking, pore formation, Genetics, QH426-470

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fgene.2020.00266/full; https://doaj.org/toc/1664-8021

Access URL: https://doaj.org/article/ba0d6b1586cd4b95b0bba4a6db6e416b

Modifying Rap1-signalling by targeting Pde6δ is neuroprotective in models of Alzheimer’s disease

Authors: Michael Dumbacher, Tom Van Dooren, Katrien Princen, Koen De Witte, Mélissa Farinelli, Sam Lievens, Jan Tavernier, Wim Dehaen, Stefaan Wera, Joris Winderickx, Sara Allasia, Amuri Kilonda, Stéphane Spieser, Arnaud Marchand, Patrick Chaltin, Casper C. Hoogenraad, Gerard Griffioen

Source: Molecular Neurodegeneration, Vol 13, Iss 1, Pp 1-21 (2018)

Subject Terms: Alzheimer’s disease, Hyperexcitability, Neuroprotection, Pde6δ, Rap1, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13024-018-0283-3; https://doaj.org/toc/1750-1326

Access URL: https://doaj.org/article/d568da05c95f4ce298de12d9db169d2b

pH homeostasis links the nutrient sensing PKA/TORC1/Sch9 ménage-à-trois to stress tolerance and longevity

Authors: Marie-Anne Deprez, Elja Eskes, Tobias Wilms, Paula Ludovico, Joris Winderickx

Source: Microbial Cell, Vol 5, Iss 3, Pp 119-136 (2018)

Subject Terms: yeast, ageing, longevity, pH, V-ATPase, Pma1, PKA, TORC1, Sch9, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://microbialcell.com/researcharticles/ph-homeostasis-links-the-nutrient-sensing-pka-torc1-sch9-menage-a-trois-to-stress-tolerance-and-longevity/; https://doaj.org/toc/2311-2638

Access URL: https://doaj.org/article/6eaa58a0a4f7402bbba69d7e206da652

New perspectives from South-Y-East, not all about death. A report of the 12th lnternational Meeting on Yeast Apoptosis in Bari, Italy, May 14th-18th, 2017

Authors: Nicoletta Guaragnella, Mariarita Stirpe, William Burhans, Manuela Côrte-Real, Campbell Gourlay, Paula Ludovico, Frank Madeo, Dina Petranovic, Joris Winderickx, Cristina Mazzoni, Sergio Giannattasio

Source: Microbial Cell, Vol 5, Iss 2, Pp 112-115 (2018)

Subject Terms: yeast, cell death, aging, autophagy, mitochondria, stress response, system biology, drug discovery, disease model, bioprocess engineering, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://microbialcell.com/researcharticles/new-perspectives-from-south-y-east-not-all-about-deatha-report-of-the-12th-lnternational-meeting-on-yeast-apoptosis-in-bari-italy-may-14th-18th-2017/; https://doaj.org/toc/2311-2638

Access URL: https://doaj.org/article/2a7bb58c51f74050add8c28e373a176d

Guidelines and recommendations on yeast cell death nomenclature

Authors: Didac Carmona-Gutierrez, Maria Anna Bauer, Andreas Zimmermann, Andrés Aguilera, Nicanor Austriaco, Kathryn Ayscough, Rena Balzan, Shoshana Bar-Nun, Antonio Barrientos, Peter Belenky, Marc Blondel, Ralf J. Braun, Michael Breitenbach, William C. Burhans, Sabrina Büttner, Duccio Cavalieri, Michael Chang, Katrina F. Cooper, Manuela Côrte-Real, Vítor Costa, Christophe Cullin, Ian Dawes, Jörn Dengjel, Martin B. Dickman, Tobias Eisenberg, Birthe Fahrenkrog, Nicolas Fasel, Kai-Uwe Fröhlich, Ali Gargouri, Sergio Giannattasio, Paola Goffrini, Campbell W. Gourlay, Chris M. Grant, Michael T. Greenwood, Nicoletta Guaragnella, Thomas Heger, Jürgen Heinisch, Eva Herker, Johannes M. Herrmann, Sebastian Hofer, Antonio Jiménez-Ruiz, Helmut Jungwirth, Katharina Kainz, Dimitrios P. Kontoyiannis, Paula Ludovico, Stéphen Manon, Enzo Martegani, Cristina Mazzoni, Lynn A. Megeney, Chris Meisinger, Jens Nielsen, Thomas Nyström, Heinz D. Osiewacz, Tiago F. Outeiro, Hay-Oak Park, Tobias Pendl, Dina Petranovic, Stephane Picot, Peter Polčic, Mark Ramsdale, Mark Rinnerthaler, Patrick Rockenfeller, Christoph Ruckenstuhl, Raffael Schaffrath, Maria Segovia, Fedor F. Severin, Amir Sharon, Stephan J. Sigrist, Cornelia Sommer-Ruck, Maria João Sousa, Johan M. Thevelein, Karin Thevissen, Vladimir Titorenko, Michel B. Toledano, Mick Tuite, F.-Nora Vögtle, Benedikt Westermann, Joris Winderickx, Silke Wissing, Stefan Wölfl, Zhaojie J. Zhang, Richard Y. Zhao, Bing Zhou, Lorenzo Galluzzi, Guido Kroemer, Frank Madeo

Source: Microbial Cell, Vol 5, Iss 1, Pp 4-31 (2018)

Subject Terms: accidental cell death, apoptosis, autophagic cell death, autophagy, caspases, mitochondrial membrane permeabilization, mitotic catastrophe, model organism, necrosis, reactive oxygen species, regulated cell death, Saccharomyces cerevisiae, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://microbialcell.com/researcharticles/guidelines-and-recommendations-on-yeast-cell-death-nomenclature/; https://doaj.org/toc/2311-2638

Access URL: https://doaj.org/article/7204719614c446e08c16d57347cd80b5

A Novel Tau Antibody Detecting the First Amino-Terminal Insert Reveals Conformational Differences Among Tau Isoforms

Authors: Joke Verelst, Nick Geukens, Sabiha Eddarkaoui, Dorien Vliegen, Elien De Smidt, Joëlle Rosseels, Vanessa Franssens, Sofie Molenberghs, Cindy Francois, Erik Stoops, Maria Bjerke, Sebastiaan Engelborghs, Mohamed Laghmouchi, Sofie Carmans, Luc Buée, Eugeen Vanmechelen, Joris Winderickx, Debby Thomas

Source: Frontiers in Molecular Biosciences, Vol 7 (2020)

Subject Terms: yeast, Saccharomyces cerevisiae, Tau, Tau isoforms, monoclonal antibodies, conformational differences, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fmolb.2020.00048/full; https://doaj.org/toc/2296-889X

Access URL: https://doaj.org/article/db17ced278244261bbf0ac1d62a52471

The Role of Sch9 and the V-ATPase in the Adaptation Response to Acetic Acid and the Consequences for Growth and Chronological Lifespan

Authors: Marie-Anne Deprez, Jeroen M. Maertens, Lisbeth Olsson, Maurizio Bettiga, Joris Winderickx

Source: Microorganisms, Vol 9, Iss 9, p 1871 (2021)

Subject Terms: acetic acid stress, nutrient signalling, pH homeostasis, growth, chronological lifespan, lipidomics, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2076-2607/9/9/1871; https://doaj.org/toc/2076-2607

Access URL: https://doaj.org/article/9ad2a06b902d4559b12611f16cd01051

Neuroserpin Inclusion Bodies in a FENIB Yeast Model

Authors: Valentina Vapore, Corrado Mazzaglia, Diego Sibilia, Mara Del Vecchio, Gernot Fruhmann, Marta Valenti, Elena Miranda, Teresa Rinaldi, Joris Winderickx, Cristina Mazzoni

Source: Microorganisms, Vol 9, Iss 7, p 1498 (2021)

Subject Terms: yeast, neurodegeneration, FENIB, protein aggregation, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2076-2607/9/7/1498; https://doaj.org/toc/2076-2607

Access URL: https://doaj.org/article/7726b019a1154a09aed2e73f897d20c7

The Impact of ESCRT on Aβ1-42 Induced Membrane Lesions in a Yeast Model for Alzheimer’s Disease

Authors: Gernot Fruhmann, Christelle Marchal, Hélène Vignaud, Mathias Verduyckt, Nicolas Talarek, Claudio De Virgilio, Joris Winderickx, Christophe Cullin

Source: Frontiers in Molecular Neuroscience, Vol 11 (2018)

Subject Terms: Aβ42, amyloid beta, Alzheimer’s disease, ESCRT, membrane repair, Saccharomyces cerevisiae, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fnmol.2018.00406/full; https://doaj.org/toc/1662-5099

Access URL: https://doaj.org/article/8210f0613e764d12900ed77caddc46f9

A Mitochondria-Associated Oxidative Stress Perspective on Huntington’s Disease

Authors: Ju Zheng, Joris Winderickx, Vanessa Franssens, Beidong Liu

Source: Frontiers in Molecular Neuroscience, Vol 11 (2018)

Subject Terms: Huntington’s disease, Huntingtin, neurodegeneration, yeast, oxidative stress, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fnmol.2018.00329/full; https://doaj.org/toc/1662-5099

Access URL: https://doaj.org/article/b20d7af25a7b4646b293ad59846e65fa

The peptidyl prolyl cis/trans isomerase Pin1/Ess1 inhibits phosphorylation and toxicity of tau in a yeast model for Alzheimer’s disease

Authors: Ann De Vos, Tine Bynens, Joëlle Rosseels, Catherina Coun, Julia Ring, Frank Madeo, Marie-Christine Galas, Joris Winderickx, Vanessa Franssens

Source: AIMS Molecular Science, Vol 2, Iss 2, Pp 144-160 (2015)

Subject Terms: Pin1, tau, yeast, phosphorylation, Alzheimer’s dis, Alzheimer’s disease, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.aimspress.com/article/10.3934/molsci.2015.2.144/fulltext.html; https://doaj.org/toc/2372-028X; https://doaj.org/toc/2372-0301

Access URL: https://doaj.org/article/c8a76f21c85a42998ca66af75fafd9c6